Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila

A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster

(2019) Sven Lang et al.   PLoS Genetics

Drosophila Insulin-Like Peptides DILP2 and DILP5 Differentially Stimulate Cell Signaling and Glycogen Phosphorylase to Regulate Longevity

(2018) Stephanie Post et al.   Frontiers in Endocrinology

Genetic Dissection of Nutrition-Induced Plasticity in Insulin/Insulin-Like Growth Factor Signaling and Median Life Span in aDrosophilaMultiparent Population

(2017) Patrick D. Stanley et al.   GENETICS

A Metabolomic Signature of Acute Caloric Restriction

(2017) Tinh-Hai Collet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genetic Dissection of Nutrition-Induced Plasticity in Insulin/Insulin-Like Growth Factor Signaling and Median Life Span in aDrosophilaMultiparent Population

(2017) Patrick D. Stanley et al.   GENETICS

Perceptive costs of reproduction drive ageing and physiology in male Drosophila

(2017) Zachary M. Harvanek et al.   Nature Ecology & Evolution

Mitochondrial metabolites extend lifespan

(2016) Robert J. Mishur et al.   AGING CELL

Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts

(2016) Ying Ann Chiao et al.   Aging-US

Dietary Protein, Metabolism, and Aging

(2016) George A. Soultoukis et al.   Annual Review of Biochemistry

Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila

(2016) Christopher S. Nelson et al.   BMC GENOMICS

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction

(2016) Lei Hou et al.   Cell Metabolism

Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila

(2016) Subhash D. Katewa et al.   Cell Metabolism

Drosophila larval to pupal switch under nutrient stress requires IP3R/Ca2+ signalling in glutamatergic interneurons

(2016) Siddharth Jayakumar et al.   eLife

The effects of age and dietary restriction on the tissue-specific metabolome ofDrosophila

(2015) Matthew J. Laye et al.   AGING CELL

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age

(2015) Ziv Zwighaft et al.   Cell Metabolism

Effect of Dietary Sodium Restriction on Human Urinary Metabolomic Profiles

(2015) K. L. Jablonski et al.   Clinical Journal of the American Society of Nephrology

Phototransduction Influences Metabolic Flux and Nucleotide Metabolism in Mouse Retina

(2015) Jianhai Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Youth in Middle Age: Predicting Aging in Caenorhabditis elegans Using Metabolomics

(2015) Sarah K. Davies et al.   JOURNAL OF PROTEOME RESEARCH

Longevity GWAS Using theDrosophilaGenetic Reference Panel

(2015) Dobril K. Ivanov et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition

(2015) Henrik Sperber et al.   NATURE CELL BIOLOGY

Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila

(2015) Monica Dus et al.   NEURON

Gustatory and metabolic perception of nutrient stress inDrosophila

(2015) Nancy J. Linford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster

(2015) Adam J. Dobson et al.   Nature Communications

The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster

(2015) Hiroko Sano et al.   PLoS Genetics

CCHamide-2 Is an Orexigenic Brain-Gut Peptide in Drosophila

(2015) Guilin R. Ren et al.   PLoS One

Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly,Drosophila melanogaster

(2014) Jessica M. Hoffman et al.   AGING CELL

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice

(2014) Mariona Jové et al.   AGING CELL

Sensing of Amino Acids in a Dopaminergic Circuitry Promotes Rejection of an Incomplete Diet in Drosophila

(2014) Marianne Bjordal et al.   CELL

A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary methionine restriction in rats

(2014) Sujoy Ghosh et al.   FASEB JOURNAL

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

(2014) W. Huang et al.   GENOME RESEARCH

Metabolomics Analysis Uncovers That Dietary Restriction Buffers Metabolic Changes Associated with Aging in Caenorhabditis elegans

(2014) Clément Pontoizeau et al.   JOURNAL OF PROTEOME RESEARCH

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

(2014) Randall M. Chin et al.   NATURE

Four GABAergic Interneurons Impose Feeding Restraint in Drosophila

(2014) Allan-Hermann Pool et al.   NEURON

Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits

(2014) Mary F. Durham et al.   Nature Communications

Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation

(2014) Andrei S Avanesov et al.   eLife

The First International Mini-Symposium on Methionine Restriction and Lifespan

(2014) Gene P. Ables et al.   Frontiers in Genetics

Molecular mechanisms underlying genotype-dependent responses to dietary restriction

(2013) Jennifer Schleit et al.   AGING CELL

Bombesin receptor subtype-3 (BRS-3), a novel candidate as therapeutic molecular target in obesity and diabetes

(2013) Irene Ramos-Álvarez et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Chronic caloric restriction partially protects against age-related alteration in serum metabolome

(2012) Jennifer M. De Guzman et al.   AGE

A metabolic signature predicts biological age in mice

(2012) Antonia Tomás-Loba et al.   AGING CELL

Comparative and meta-analytic insights into life extension via dietary restriction

(2012) Shinichi Nakagawa et al.   AGING CELL

The Drosophila melanogaster Genetic Reference Panel

(2012) Trudy F. C. Mackay et al.   NATURE

Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster

(2012) Allison L. Weber et al.   PLoS One

Dissecting the Gene Network of Dietary Restriction to Identify Evolutionarily Conserved Pathways and New Functional Genes

(2012) Daniel Wuttke et al.   PLoS Genetics

Fat maintenance is a predictor of the murine lifespan response to dietary restriction

(2011) Chen-Yu Liao et al.   AGING CELL

An integrative approach to ortholog prediction for disease-focused and other functional studies

(2011) Yanhui Hu et al.   BMC BIOINFORMATICS

Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila

(2011) Louise Y. Cheng et al.   CELL

Genetic variation of dietary restriction and the effects of nutrient-free water and amino acid supplements on lifespan and fecundity of Drosophila

(2011) KENNETH B. DICK et al.   Genetics Research

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

Environmental metabolomics links genotype to phenotype and predicts genotype abundance in wild plant populations

(2011) Katie J. Field et al.   PHYSIOLOGIA PLANTARUM

Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans

(2010) Laurent Mouchiroud et al.   AGING CELL

Metscape: a Cytoscape plug-in for visualizing and interpreting metabolomic data in the context of human metabolic networks

(2010) Jing Gao et al.   BIOINFORMATICS

The Complex Genetic Architecture of the Metabolome

(2010) Eva K. F. Chan et al.   PLoS Genetics

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

(2009) Chen-Yu Liao et al.   AGING CELL

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates

(2009) Serge Rezzi et al.   EXPERIMENTAL GERONTOLOGY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

(2009) Richard C. Grandison et al.   NATURE

A genome-wide perspective of genetic variation in human metabolism

(2009) Thomas Illig et al.   NATURE GENETICS

A network biology approach to aging in yeast

(2009) D. R. Lorenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum

(2008) Christian Gieger et al.   PLoS Genetics