Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

Metformin prolongs lifespan through remodeling the energy distribution strategy in silkworm, Bombyx mori

(2019) Jiangbo Song et al.   Aging-US

mTOR: A Cellular Regulator Interface in Health and Disease

(2019) Fahd Boutouja et al.   Cells

Dietary Restriction Extends Lifespan through Metabolic Regulation of Innate Immunity

(2019) Ziyun Wu et al.   Cell Metabolism

Anti-inflammatory action of β-hydroxybutyrate via modulation of PGC-1α and FoxO1, mimicking calorie restriction

(2019) Dae Hyun Kim et al.   Aging-US

Influence of Resveratrol on the Immune Response

(2019) Malaguarnera   Nutrients

Up-regulation of FOXO1 and reduced inflammation by β-hydroxybutyric acid are essential diet restriction benefits against liver injury

(2019) Tomoyuki Miyauchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Longevity: Lesson from Model Organisms

(2019) Giusi Taormina et al.   Genes

Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice

(2018) Melissa M. Page et al.   Aging-US

AMPK–Akt Double-Negative Feedback Loop in Breast Cancer Cells Regulates Their Adaptation to Matrix Deprivation

(2018) Manipa Saha et al.   CANCER RESEARCH

The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance

(2018) Fei Han et al.   Nature Communications

High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions

(2018) Birsen Elibol et al.   Frontiers in Endocrinology

Key proteins and pathways that regulate lifespan

(2017) Haihui Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Current State of NAD+ -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets

(2017) Matthias Schiedel et al.   MEDICINAL RESEARCH REVIEWS

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

(2017) Yang Zhao et al.   Molecular Cancer

Resveratrol inhibits proliferation and migration through SIRT1 mediated post-translational modification of PI3K/AKT signaling in hepatocellular carcinoma cells

(2017) Rongfei Chai et al.   Molecular Medicine Reports

NAD + in Aging: Molecular Mechanisms and Translational Implications

(2017) Evandro F. Fang et al.   TRENDS IN MOLECULAR MEDICINE

Therapeutic Versatility of Resveratrol Derivatives

(2017) Waqas Nawaz et al.   Nutrients

DAF-16/FOXO Transcription Factor in Aging and Longevity

(2017) Xiaojuan Sun et al.   Frontiers in Pharmacology

Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats

(2017) Shibin Ding et al.   PLoS One

Comparative idiosyncrasies in life extension by reduced mTOR signalling and its distinctiveness from dietary restriction

(2016) Michael Garratt et al.   AGING CELL

LncRNA mediated regulation of aging pathways in Drosophila melanogaster during dietary restriction

(2016) Deying Yang et al.   Aging-US

Effects of dietary restriction on adipose mass and biomarkers of healthy aging in human

(2016) Daniele Lettieri-Barbato et al.   Aging-US

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

(2016) Brian K. Kennedy et al.   Cell Metabolism

Brief Communication: SIR-2.1-dependent lifespan extension of Caenorhabditis elegans by oxyresveratrol and resveratrol

(2016) Jiyun Lee et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Preoperative dietary restriction reduces intimal hyperplasia and protects from ischemia-reperfusion injury

(2016) Christine R. Mauro et al.   JOURNAL OF VASCULAR SURGERY

Resveratrol Prevents Tumor Growth and Metastasis by Inhibiting Lymphangiogenesis and M2 Macrophage Activation and Differentiation in Tumor-associated Macrophages

(2016) Yoshiyuki Kimura et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The life-extending effect of dietary restriction requires Foxo3 in mice

(2015) Isao Shimokawa et al.   AGING CELL

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

(2015) Rute Martins et al.   AGING CELL

Lifespan and healthspan extension by resveratrol

(2015) Khushwant S. Bhullar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Modulation of SIRT1-Foxo1 Signaling axis by Resveratrol: Implications in Skeletal Muscle Aging and Insulin Resistance

(2015) Thomas K. Sin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

FOXO3: A Major Gene for Human Longevity - A Mini-Review

(2015) Brian J. Morris et al.   GERONTOLOGY

The essential role of FoxO6 phosphorylation in aging and calorie restriction

(2014) Dae Hyun Kim et al.   AGE

Regulation of Akt Signaling by Sirtuins

(2014) Vinodkumar B. Pillai et al.   CIRCULATION RESEARCH

Adamts1 Mediates Ethanol-Induced Alterations in Collagen and Elastin via a FoxO1-Sestrin3-AMPK Signaling Cascade in Myocytes

(2014) Ly Q Hong-Brown et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Fasting protects liver from ischemic injury through Sirt1-mediated downregulation of circulating HMGB1 in mice

(2014) Andreas Rickenbacher et al.   JOURNAL OF HEPATOLOGY

The mTOR Pathway Controls Cell Proliferation by Regulating the FoxO3a Transcription Factor via SGK1 Kinase

(2014) Shunsuke Mori et al.   PLoS One

Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver

(2013) Wilson C. Fok et al.   AGING CELL

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

(2013) Richard A. Miller et al.   AGING CELL

Sestrins Orchestrate Cellular Metabolism to Attenuate Aging

(2013) Jun Hee Lee et al.   Cell Metabolism

Metabolic Alterations Due to Caloric Restriction and Every Other Day Feeding in Normal and Growth Hormone Receptor Knockout Mice

(2013) Reyhan Westbrook et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A Dwarf Mouse Model With Decreased GH/IGF-1 Activity That Does Not Experience Life-Span Extension: Potential Impact of Increased Adiposity, Leptin, and Insulin With Advancing Age

(2013) D. E. Berryman et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Yin Yang 1 Deficiency in Skeletal Muscle Protects against Rapamycin-Induced Diabetic-like Symptoms through Activation of Insulin/IGF Signaling

(2012) Sharon M. Blättler et al.   Cell Metabolism

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

AMP-Activated Protein Kinase Regulation and Biological Actions in the Heart

(2012) Vlad G. Zaha et al.   CIRCULATION RESEARCH

Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila

(2012) Cathy Slack et al.   PLoS One

PI3K-PKB/Akt Pathway

(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

The Yeast Forkhead Transcription Factors Fkh1 and Fkh2 Regulate Lifespan and Stress Response Together with the Anaphase-Promoting Complex

(2012) Spike D. L. Postnikoff et al.   PLoS Genetics

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Regulation of FoxO transcription factors by acetylation and protein–protein interactions

(2011) Hiroaki Daitoku et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Interplay between FOXO, TOR, and Akt

(2011) Nissim Hay   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Akt, FoxO and regulation of apoptosis

(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes

(2011) S.-M. Lee et al.   DIABETOLOGIA

Age-associated decrease of SIRT1 expression in rat hippocampus

(2011) Ana Quintas et al.   EXPERIMENTAL GERONTOLOGY

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance

(2011) Rui-Hong Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease

(2011) Jaewon Chang et al.   NEUROBIOLOGY OF AGING

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

(2011) Nady Braidy et al.   PLoS One

Connecting serum IGF-1, body size, and age in the domestic dog

(2010) Kimberly A. Greer et al.   AGE

FoxO1 is involved in the antineoplastic effect of calorie restriction

(2010) Haruyoshi Yamaza et al.   AGING CELL

FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

(2010) Chia-Chen Chen et al.   DEVELOPMENTAL CELL

FOXO3a Regulates Glycolysis via Transcriptional Control of Tumor Suppressor TSC1

(2010) Shikha Khatri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin Supplementation and Life Span in Fischer-344 Rats

(2010) D. L. Smith et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

AMP-Activated Protein Kinase Inhibits IGF-I Signaling and Protein Synthesis in Vascular Smooth Muscle Cells via Stimulation of Insulin Receptor Substrate 1 S794 and Tuberous Sclerosis 2 S1345 Phosphorylation

(2010) Junyu Ning et al.   MOLECULAR ENDOCRINOLOGY

The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

(2010) C. Kenyon   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

(2010) Hiyaa Singhee Ghosh et al.   PLoS One

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

(2010) Brian Onken et al.   PLoS One

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

(2009) R. J. Shaw   Acta Physiologica

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways inC. elegans

(2009) Eric L. Greer et al.   AGING CELL

The effect of caloric restriction interventions on growth hormone secretion in nonobese men and women

(2009) Leanne M. Redman et al.   AGING CELL

Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice

(2009) James R. Mitchell et al.   AGING CELL

AMP-activated Protein Kinase and FoxO Transcription Factors in Dietary Restriction-induced Longevity

(2009) Eric L. Greer et al.   Annals of the New York Academy of Sciences

Mutual Dependence of Foxo3a and PGC-1α in the Induction of Oxidative Stress Genes

(2009) Yolanda Olmos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age

(2009) L. Sun et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Caenorhabditis elegans sirtuin gene, sir-2.1, is widely expressed and induced upon caloric restriction

(2009) Sophie Bamps et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response

(2008) Maria E. Giannakou et al.   AGING CELL

Drosophila lifespan control by dietary restriction independent of insulin-like signaling

(2008) Kyung-Jin Min et al.   AGING CELL

Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans

(2008) Luigi Fontana et al.   AGING CELL

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

Role of the GH/IGF-1 axis in lifespan and healthspan: Lessons from animal models

(2008) Darlene E. Berryman et al.   GROWTH HORMONE & IGF RESEARCH

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics