The impact of low-protein high-carbohydrate diets on aging and lifespan

Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration

(2016) Sahar Emran et al.   Aging-US

Sex-specific effects of protein and carbohydrate intake on reproduction but not lifespan inDrosophila melanogaster

(2015) Kim Jensen et al.   AGING CELL

Putting the Balance Back in Diet

(2015) Stephen J. Simpson et al.   CELL

Target of rapamycin activation predicts lifespan in fruit flies

(2015) Filippo Scialò et al.   CELL CYCLE

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

(2015) P. Darrell Neufer et al.   Cell Metabolism

Nutrient balancing of the adult worker bumblebee (Bombus terrestris) depends on the dietary source of essential amino acids

(2015) D. Stabler et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Dietary protein:carbohydrate balance is a critical modulator of lifespan and reproduction in Drosophila melanogaster: A test using a chemically defined diet

(2015) Kwang Pum Lee   JOURNAL OF INSECT PHYSIOLOGY

Reconsidering the Role of Mitochondria in Aging

(2015) Marta Gonzalez-Freire et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity

(2015) Eric Ravussin et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Macronutrient balance, reproductive function, and lifespan in aging mice

(2015) Samantha M. Solon-Biet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effects of graded levels of calorie restriction: I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse

(2015) Sharon E. Mitchell et al.   Oncotarget

The effects of graded levels of calorie restriction: III. Impact of short term calorie and protein restriction on mean daily body temperature and torpor use in the C57BL/6 mouse

(2015) Sharon E. Mitchell et al.   Oncotarget

The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice

(2015) Sharon E. Mitchell et al.   Oncotarget

Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice

(2015) Samantha M. Solon-Biet et al.   Cell Reports

Mitochondrial uncoupling proteins and energy metabolism

(2015) Rosa A. Busiello et al.   Frontiers in Physiology

The dietary proportion of essential amino acids and Sir2 influence lifespan in the honeybee

(2014) Pier P. Paoli et al.   AGE

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

(2014) Evi M. Mercken et al.   AGING CELL

Nutritional balance of essential amino acids and carbohydrates of the adult worker honeybee depends on age

(2014) Pier P. Paoli et al.   AMINO ACIDS

Why do the well-fed appear to die young?

(2014) Margo I. Adler et al.   BIOESSAYS

The role of mitochondria in mTOR-regulated longevity

(2014) Yuehua Wei et al.   BIOLOGICAL REVIEWS

The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

(2014) Samantha M. Solon-Biet et al.   Cell Metabolism

Skeletal Muscle Mitochondria in the Elderly: Effects of Physical Fitness and Exercise Training

(2014) Nicholas T. Broskey et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Influence of Macronutrients on Splanchnic and Hepatic Lymphocytes in Aging Mice

(2014) David G. Le Couteur et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Perspective: Tricks of the trade

(2014) Stephen J. Simpson et al.   NATURE

Low Carbohydrate versus Isoenergetic Balanced Diets for Reducing Weight and Cardiovascular Risk: A Systematic Review and Meta-Analysis

(2014) Celeste E. Naude et al.   PLoS One

Towards a synthesis of frameworks in nutritional ecology: interacting effects of protein, carbohydrate and phosphorus on field cricket fitness

(2014) S. J. Harrison et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Protein and amino acid restriction, aging and disease: from yeast to humans

(2014) Hamed Mirzaei et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

G×G×E for Lifespan in Drosophila: Mitochondrial, Nuclear, and Dietary Interactions that Modify Longevity

(2014) Chen-Tseh Zhu et al.   PLoS Genetics

What are the roles of calorie restriction and diet quality in promoting healthy longevity?

(2013) Wanda Rizza et al.   AGEING RESEARCH REVIEWS

Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes

(2013) Olubukola Ajala et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Low-Carbohydrate Diets and All-Cause and Cause-Specific Mortality

(2013) Teresa T. Fung   ANNALS OF INTERNAL MEDICINE

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

High carbohydrate–low protein consumption maximizes Drosophila lifespan

(2013) Kimberley D. Bruce et al.   EXPERIMENTAL GERONTOLOGY

The Evolution of Research on Ageing and Nutrition

(2013) D. G. Le Couteur et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A holidic medium for Drosophila melanogaster

(2013) Matthew D W Piper et al.   NATURE METHODS

Effects of dietary protein to carbohydrate balance on energy intake, fat storage, and heat production in mice

(2013) Xin Huang et al.   Obesity

Low-Carbohydrate Diets and All-Cause Mortality: A Systematic Review and Meta-Analysis of Observational Studies

(2013) Hiroshi Noto et al.   PLoS One

Interactive effects of sex, social environment, dietary restriction, and methionine on survival and reproduction in fruit flies

(2012) Felix Zajitschek et al.   AGE

Comparative and meta-analytic insights into life extension via dietary restriction

(2012) Shinichi Nakagawa et al.   AGING CELL

Low-carbohydrate, high-protein score and mortality in a northern Swedish population-based cohort

(2012) L M Nilsson et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Responses of brown adipose tissue to diet-induced obesity, exercise, dietary restriction and ephedrine treatment

(2012) Nikki Slocum et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

The interplay among dietary fat, sugar, protein and açai (Euterpe oleracea Mart.) pulp in modulating lifespan and reproduction in a Tephritid fruit fly

(2012) Pablo Liedo et al.   EXPERIMENTAL GERONTOLOGY

Are sirtuins viable targets for improving healthspan and lifespan?

(2012) Joseph A. Baur et al.   NATURE REVIEWS DRUG DISCOVERY

Core temperature: a forgotten variable in energy expenditure and obesity?

(2012) L. Landsberg   Obesity Reviews

Ant workers die young and colonies collapse when fed a high-protein diet

(2012) A. Dussutour et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Low carbohydrate-high protein diet and incidence of cardiovascular diseases in Swedish women: prospective cohort study

(2012) P. Lagiou et al.   BMJ-British Medical Journal

The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster

(2011) Chunxu Wang et al.   AGE

Protein:carbohydrate ratios explain life span patterns found in Queensland fruit fly on diets varying in yeast:sugar ratios

(2011) Benjamin G. Fanson et al.   AGE

Of mice and men: The benefits of caloric restriction, exercise, and mimetics

(2011) Evi M. Mercken et al.   AGEING RESEARCH REVIEWS

Fat maintenance is a predictor of the murine lifespan response to dietary restriction

(2011) Chen-Yu Liao et al.   AGING CELL

Genetic variation of dietary restriction and the effects of nutrient-free water and amino acid supplements on lifespan and fecundity of Drosophila

(2011) KENNETH B. DICK et al.   Genetics Research

Balance Between Macronutrients Affects Life Span and Functional Senescence in Fruit Fly Drosophila melanogaster

(2011) O. V. Lushchak et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mediterranean and carbohydrate-restricted diets and mortality among elderly men: a cohort study in Sweden

(2010) Per Sjögren et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction

(2010) R. K. Minor et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mitochondrial uncoupling and lifespan

(2010) Shona A. Mookerjee et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Nutrients, not caloric restriction, extend lifespan in Queensland fruit flies (Bactrocera tryoni)

(2009) Benjamin G. Fanson et al.   AGING CELL

The importance of protein type and protein to carbohydrate ratio for survival and ovarian activation of caged honeybees (Apis mellifera scutellata)

(2009) Christian W.W. Pirk et al.   APIDOLOGIE

Healthy obesity

(2009) Rachel P Wildman   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Dietary Intake of Total, Animal, and Vegetable Protein and Risk of Type 2 Diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-NL Study

(2009) I. Sluijs et al.   DIABETES CARE

Prolongevity Effects of an Oregano and Cranberry Extract are Diet Dependent in the Mexican Fruit Fly (Anastrepha ludens)

(2009) Sige Zou et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

(2009) Richard C. Grandison et al.   NATURE

Water- and nutrient-dependent effects of dietary restriction on Drosophila lifespan

(2009) W. W. Ja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular effects of a low-carbohydrate high-protein diet

(2009) S. Y. Foo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Longevityfertility trade-offs in the tephritid fruit fly,Anastrepha ludens, across dietary-restriction gradients

(2008) James R. Carey et al.   AGING CELL

Dietary composition specifies consumption, obesity, and lifespan inDrosophila melanogaster

(2008) Danielle A. Skorupa et al.   AGING CELL

Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity

(2008) Camille C. Caldeira da Silva et al.   AGING CELL

Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction

(2008) Mónica López-Torres et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

Considerations on Temperature, Longevity and Aging

(2008) B. Conti   CELLULAR AND MOLECULAR LIFE SCIENCES

Sex-Specific Fitness Effects of Nutrient Intake on Reproduction and Lifespan

(2008) Alexei A. Maklakov et al.   CURRENT BIOLOGY

Mitochondrial biogenesis and healthy aging

(2008) Guillermo López-Lluch et al.   EXPERIMENTAL GERONTOLOGY

Systematic review of randomized controlled trials of low-carbohydrate vs. low-fat/low-calorie diets in the management of obesity and its comorbidities

(2008) M. Hession et al.   Obesity Reviews

Metabolism and Aging: Effects of Cold Exposure on Metabolic Rate, Body Composition, and Longevity in Mice

(2008) Lobke M. Vaanholt et al.   PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY

Lifespan and reproduction in Drosophila: New insights from nutritional geometry

(2008) K. P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA