Harnessing Mechanobiology for Tissue Engineering

Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities

(2020) Amy Y. Clark et al.   Nature Communications

An optochemical tool for light-induced dissociation of adherens junctions to control mechanical coupling between cells

(2020) Dirk Ollech et al.   Nature Communications

Relaxation of Extracellular Matrix Forces Directs Crypt Formation and Architecture in Intestinal Organoids

(2020) Ella A. Hushka et al.   Advanced Healthcare Materials

The stiffness of living tissues and its implications for tissue engineering

(2020) Carlos F. Guimarães et al.   Nature Reviews Materials

TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation

(2020) Sandip M. Swain et al.   JOURNAL OF CLINICAL INVESTIGATION

Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice

(2020) Krzysztof Krawczyk et al.   SCIENCE

Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells

(2020) Vincenza Caolo et al.   eLife

Controlled Apoptosis of Stromal Cells to Engineer Human Microlivers

(2020) Amanda X. Chen et al.   ADVANCED FUNCTIONAL MATERIALS

Transient Support from Fibroblasts is Sufficient to Drive Functional Vascularization in Engineered Tissues

(2020) Hyun‐Ho Greco Song et al.   ADVANCED FUNCTIONAL MATERIALS

Guiding Cell Network Assembly using Shape‐Morphing Hydrogels

(2020) John M. Viola et al.   ADVANCED MATERIALS

Generation of model tissues with dendritic vascular networks via sacrificial laser-sintered carbohydrate templates

(2020) Ian S. Kinstlinger et al.   Nature Biomedical Engineering

Buckling of an Epithelium Growing under Spherical Confinement

(2020) Anastasiya Trushko et al.   DEVELOPMENTAL CELL

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

(2020) Mikhail Nikolaev et al.   NATURE

Effects of extracellular matrix viscoelasticity on cellular behaviour

(2020) Ovijit Chaudhuri et al.   NATURE

Recapitulating macro-scale tissue self-organization through organoid bioprinting

(2020) Jonathan A. Brassard et al.   NATURE MATERIALS

Renal reabsorption in 3D vascularized proximal tubule models

(2019) Neil Y. C. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flow-enhanced vascularization and maturation of kidney organoids in vitro

(2019) Kimberly A. Homan et al.   NATURE METHODS

Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells

(2019) Elena Garreta et al.   NATURE MATERIALS

Self-organization and symmetry breaking in intestinal organoid development

(2019) Denise Serra et al.   NATURE

Multivascular networks and functional intravascular topologies within biocompatible hydrogels

(2019) Bagrat Grigoryan et al.   SCIENCE

Mechanochemical Feedback Loops in Development and Disease

(2019) Edouard Hannezo et al.   CELL

Integrins as biomechanical sensors of the microenvironment

(2019) Jenny Z. Kechagia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alveolar Stretch Activation of Endothelial Piezo1 Protects Adherens Junctions and Lung Vascular Barrier

(2019) Ming Zhong et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

(2019) Angel G. Solis et al.   NATURE

Niche stiffness underlies the ageing of central nervous system progenitor cells

(2019) Michael Segel et al.   NATURE

Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors

(2019) Wang Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels

(2019) Mark A. Skylar-Scott et al.   Science Advances

Optogenetic control of cofilin and αTAT in living cells using Z-lock

(2019) Orrin J. Stone et al.   Nature Chemical Biology

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

(2019) Andrew J. Haak et al.   Science Translational Medicine

Cellular responses to beating hydrogels to investigate mechanotransduction

(2019) Yashoda Chandorkar et al.   Nature Communications

Stimulation of Piezo1 by mechanical signals promotes bone anabolism

(2019) Xuehua Li et al.   eLife

Vascularized Liver Organoids Generated Using Induced Hepatic Tissue and Dynamic Liver-Specific Microenvironment as a Drug Testing Platform

(2018) Yoonhee Jin et al.   ADVANCED FUNCTIONAL MATERIALS

Mechanotransduction by the Actin Cytoskeleton: Converting Mechanical Stimuli into Biochemical Signals

(2018) Andrew R. Harris et al.   Annual Review of Biophysics

GPR68 Senses Flow and Is Essential for Vascular Physiology

(2018) Jie Xu et al.   CELL

Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme

(2018) Alex J. Hughes et al.   DEVELOPMENTAL CELL

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

(2018) Kacey Ronaldson-Bouchard et al.   NATURE

Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses

(2018) Carlos Pardo-Pastor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanogenetics for the remote and noninvasive control of cancer immunotherapy

(2018) Yijia Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guided morphogenesis through optogenetic activation of Rho signalling during early Drosophila embryogenesis

(2018) Emiliano Izquierdo et al.   Nature Communications

Mechanically induced development and maturation of human intestinal organoids in vivo

(2018) Holly M. Poling et al.   Nature Biomedical Engineering

The Hippo Pathway: Biology and Pathophysiology

(2018) Shenghong Ma et al.   Annual Review of Biochemistry

Asymmetry at cell-cell interfaces direct cell sorting, boundary formation, and tissue morphogenesis

(2017) Rosa Ventrella et al.   EXPERIMENTAL CELL RESEARCH

Optogenetic interrogation of integrin αVβ3 function in endothelial cells

(2017) Zhongji Liao et al.   JOURNAL OF CELL SCIENCE

Combination of biochemical and mechanical cues for tendon tissue engineering

(2017) Stefano Testa et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A non-canonical Notch complex regulates adherens junctions and vascular barrier function

(2017) William J. Polacheck et al.   NATURE

Synthetic hydrogels for human intestinal organoid generation and colonic wound repair

(2017) Ricardo Cruz-Acuña et al.   NATURE CELL BIOLOGY

Quantifying forces in cell biology

(2017) Pere Roca-Cusachs et al.   NATURE CELL BIOLOGY

Tension stimulation drives tissue formation in scaffold-free systems

(2017) Jennifer K. Lee et al.   NATURE MATERIALS

Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability

(2017) Shuoran Li et al.   NATURE MATERIALS

Designer biomaterials for mechanobiology

(2017) Linqing Li et al.   NATURE MATERIALS

Mechanical forces direct stem cell behaviour in development and regeneration

(2017) Kyle H. Vining et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Actomyosin Pulsing in Tissue Integrity Maintenance during Morphogenesis

(2017) Jonathan S. Coravos et al.   TRENDS IN CELL BIOLOGY

Mechanosensing and Mechanotransduction at Cell–Cell Junctions

(2017) Alpha S. Yap et al.   Cold Spring Harbor Perspectives in Biology

Matrix degradability controls multicellularity of 3D cell migration

(2017) Britta Trappmann et al.   Nature Communications

Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation

(2017) Amy Sutton et al.   Nature Communications

Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex

(2017) Martijn Gloerich et al.   Nature Communications

Optogenetic control of cellular forces and mechanotransduction

(2017) Léo Valon et al.   Nature Communications

YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

(2017) Antonio Totaro et al.   Nature Communications

Noncovalent Bonding of RGD and YIGSR to an Electrospun Poly(ε-Caprolactone) Conduit through Peptide Self-Assembly to Synergistically Promote Sciatic Nerve Regeneration in Rats

(2017) Lei Zhu et al.   Advanced Healthcare Materials

Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes

(2017) M Rocio Servin-Vences et al.   eLife

Stimulation of 3D osteogenesis by mesenchymal stem cells using a nanovibrational bioreactor

(2017) Penelope M. Tsimbouri et al.   Nature Biomedical Engineering

A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time

(2016) Daeha Seo et al.   CELL

Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation

(2016) Laralynne Przybyla et al.   Cell Stem Cell

The mechanical regulation of integrin–cadherin crosstalk organizes cells, signaling and forces

(2016) Keeley L. Mui et al.   JOURNAL OF CELL SCIENCE

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

(2016) ShengPeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Bidirectional electromagnetic control of the hypothalamus regulates feeding and metabolism

(2016) Sarah A. Stanley et al.   NATURE

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells

(2016) Brian D. Cosgrove et al.   NATURE MATERIALS

A practical guide to hydrogels for cell culture

(2016) Steven R Caliari et al.   NATURE METHODS

Biologic-free mechanically induced muscle regeneration

(2016) Christine A. Cezar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

The design of reversible hydrogels to capture extracellular matrix dynamics

(2016) Adrianne M. Rosales et al.   Nature Reviews Materials

An Optogenetic Method to Modulate Cell Contractility during Tissue Morphogenesis

(2015) Giorgia Guglielmi et al.   DEVELOPMENTAL CELL

Synthetic matrices reveal contributions of ECM biophysical and biochemical properties to epithelial morphogenesis

(2015) Nduka O. Enemchukwu et al.   JOURNAL OF CELL BIOLOGY

Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation

(2015) Nathaniel Huebsch et al.   NATURE MATERIALS

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

(2015) Brendon M. Baker et al.   NATURE MATERIALS

Nanoscale optomechanical actuators for controlling mechanotransduction in living cells

(2015) Zheng Liu et al.   NATURE METHODS

Piezo2 is the principal mechanotransduction channel for proprioception

(2015) Seung-Hyun Woo et al.   NATURE NEUROSCIENCE

Mechanically Activated Ion Channels

(2015) Sanjeev S. Ranade et al.   NEURON

A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity

(2015) Alec E. Cerchiari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical strain induces E-cadherin-dependent Yap1 and  -catenin activation to drive cell cycle entry

(2015) B. W. Benham-Pyle et al.   SCIENCE

Hippo Pathway Effectors Control Cardiac Progenitor Cell Fate by Acting as Dynamic Sensors of Substrate Mechanics and Nanostructure

(2014) Diogo Mosqueira et al.   ACS Nano

The cellular basis of tissue separation

(2014) F. Fagotto   DEVELOPMENT

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles

(2014) Sarah A Stanley et al.   NATURE MEDICINE

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification

(2014) S. Musah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading

(2014) C. J. O'Conor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Forces in Tissue Morphogenesis and Patterning

(2013) Carl-Philipp Heisenberg et al.   CELL

Engineering the matrix microenvironment for cell delivery and engraftment for tissue repair

(2013) Amy Y Cheng et al.   CURRENT OPINION IN BIOTECHNOLOGY

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

(2013) Sudhir Khetan et al.   NATURE MATERIALS

Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility

(2012) Mei Rosa Ng et al.   JOURNAL OF CELL BIOLOGY

Cadherin point mutations alter cell sorting and modulate GTPase signaling

(2012) H. Tabdili et al.   JOURNAL OF CELL SCIENCE

Cadherin-dependent differential cell adhesion in Xenopus causes cell sorting in vitro but not in the embryo

(2012) H. Ninomiya et al.   JOURNAL OF CELL SCIENCE

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia

(2012) George T. Eisenhoffer et al.   NATURE

A magnetic switch for the control of cell death signalling in in vitro and in vivo systems

(2012) Mi Hyeon Cho et al.   NATURE MATERIALS

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

(2012) Jordan S. Miller et al.   NATURE MATERIALS

Adhesion Functions in Cell Sorting by Mechanically Coupling the Cortices of Adhering Cells

(2012) J.-L. Maitre et al.   SCIENCE

Functional characterization of human coronary artery smooth muscle cells under cyclic mechanical strain in a degradable polyurethane scaffold

(2011) Soroor Sharifpoor et al.   BIOMATERIALS

Notch signalling stabilises boundary formation at the midbrain-hindbrain organiser

(2011) K. Tossell et al.   DEVELOPMENT

The effect of ultrasound stimulation on the gene and protein expression of chondrocytes seeded in chitosan scaffolds

(2011) Gulnara I. Hasanova et al.   Journal of Tissue Engineering and Regenerative Medicine

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Artificial Control of Cell Signaling and Growth by Magnetic Nanoparticles

(2010) Jae-Hyun Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Remote control of ion channels and neurons through magnetic-field heating of nanoparticles

(2010) Heng Huang et al.   Nature Nanotechnology

Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions

(2010) N. Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress

(2009) Suelhem A. Mendoza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue Stiffening

(2009) Eric A. Klein et al.   CURRENT BIOLOGY

A genetically encoded photoactivatable Rac controls the motility of living cells

(2009) Yi I. Wu et al.   NATURE

An actomyosin-based barrier inhibits cell mixing at compartmental boundaries in Drosophila embryos

(2009) Bruno Monier et al.   NATURE CELL BIOLOGY

The Role of Mechanical Loading in Ligament Tissue Engineering

(2009) Hugh A. Benhardt et al.   TISSUE ENGINEERING PART B-REVIEWS

Engineering amount of cell–cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton

(2008) Darren S. Gray et al.   EXPERIMENTAL CELL RESEARCH

Rationally Designed Integrin β3 Mutants Stabilized in the High Affinity Conformation

(2008) Bing-Hao Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pulsed contractions of an actin–myosin network drive apical constriction

(2008) Adam C. Martin et al.   NATURE

Tensile forces govern germ-layer organization in zebrafish

(2008) M. Krieg et al.   NATURE CELL BIOLOGY

Mechanotransduction in development: a growing role for contractility

(2008) Michele A. Wozniak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction gone awry

(2008) Diana E. Jaalouk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction in vascular physiology and atherogenesis

(2008) Cornelia Hahn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY