The design of reversible hydrogels to capture extracellular matrix dynamics

Mobility of the Arg-Gly-Asp ligand on the outermost surface of biomaterials suppresses integrin-mediated mechanotransduction and subsequent cell functions

(2015) Sachiro Kakinoki et al.   Acta Biomaterialia

Injectable Hydrogels with In Situ Double Network Formation Enhance Retention of Transplanted Stem Cells

(2015) Lei Cai et al.   ADVANCED FUNCTIONAL MATERIALS

Morphology Controlled Poly(aminophenylboronic acid) Nanostructures as Smart Substrates for Enhanced Capture and Release of Circulating Tumor Cells

(2015) Jun Ouyang et al.   ADVANCED FUNCTIONAL MATERIALS

Direct 3D Printing of Shear-Thinning Hydrogels into Self-Healing Hydrogels

(2015) Christopher B. Highley et al.   ADVANCED MATERIALS

Adaptable Hydrogel Networks with Reversible Linkages for Tissue Engineering

(2015) Huiyuan Wang et al.   ADVANCED MATERIALS

Molecular Encryption and Reconfiguration for Remodeling of Dynamic Hydrogels

(2015) Shihui Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photoresponsive Elastic Properties of Azobenzene-Containing Poly(ethylene-glycol)-Based Hydrogels

(2015) Adrianne M. Rosales et al.   BIOMACROMOLECULES

Dynamic stiffening of poly(ethylene glycol)-based hydrogels to direct valvular interstitial cell phenotype in a three-dimensional environment

(2015) Kelly M. Mabry et al.   BIOMATERIALS

A near-infrared light-controlled system for reversible presentation of bioactive ligands using polypeptide-engineered functionalized gold nanorods

(2015) Jie Yang et al.   CHEMICAL COMMUNICATIONS

Noninvasive and Reversible Cell Adhesion and Detachment via Single-Wavelength Near-Infrared Laser Mediated Photoisomerization

(2015) Wei Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

(2015) Brendon M. Baker et al.   NATURE MATERIALS

A photoreversible protein-patterning approach for guiding stem cell fate in three-dimensional gels

(2015) Cole A. DeForest et al.   NATURE MATERIALS

Dynamic phototuning of 3D hydrogel stiffness

(2015) Ryan S. Stowers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Continuous liquid interface production of 3D objects

(2015) J. R. Tumbleston et al.   SCIENCE

PW1/Peg3 expression regulates key properties that determine mesoangioblast stem cell competence

(2015) Chiara Bonfanti et al.   Nature Communications

Carborane–β-cyclodextrin complexes as a supramolecular connector for bioactive surfaces

(2015) P. Neirynck et al.   Journal of Materials Chemistry B

Selective Proteolytic Degradation of Guest–Host Assembled, Injectable Hyaluronic Acid Hydrogels

(2015) Christopher B. Rodell et al.   ACS Biomaterials-Science & Engineering

Selective Proteolytic Degradation of Guest–Host Assembled, Injectable Hyaluronic Acid Hydrogels

(2015) Christopher B. Rodell et al.   ACS Biomaterials Science & Engineering

Rationally Designed Dynamic Protein Hydrogels with Reversibly Tunable Mechanical Properties

(2014) Na Kong et al.   ADVANCED FUNCTIONAL MATERIALS

Shear-Thinning Supramolecular Hydrogels with Secondary Autonomous Covalent Crosslinking to Modulate Viscoelastic Properties In Vivo

(2014) Christopher B. Rodell et al.   ADVANCED FUNCTIONAL MATERIALS

Spatiotemporally Controllable and Cytocompatible Approach Builds 3D Cell Culture Matrix by Photo-Uncaged-Thiol Michael Addition Reaction

(2014) Zhenzhen Liu et al.   ADVANCED MATERIALS

Photo-Click Living Strategy for Controlled, Reversible Exchange of Biochemical Ligands

(2014) Navakanth R. Gandavarapu et al.   ADVANCED MATERIALS

3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs

(2014) David B. Kolesky et al.   ADVANCED MATERIALS

Injectable In Situ Self-Cross-Linking Hydrogels Based on Poly(l-glutamic acid) and Alginate for Cartilage Tissue Engineering

(2014) Shifeng Yan et al.   BIOMACROMOLECULES

Engineering Complementary Hydrophobic Interactions to Control β-Hairpin Peptide Self-Assembly, Network Branching, and Hydrogel Properties

(2014) Sameer Sathaye et al.   BIOMACROMOLECULES

About supramolecular systems for dynamically probing cells

(2014) Jenny Brinkmann et al.   CHEMICAL SOCIETY REVIEWS

Bis-Aliphatic Hydrazone-Linked Hydrogels Form Most Rapidly at Physiological pH: Identifying the Origin of Hydrogel Properties with Small Molecule Kinetic Studies

(2014) Daniel D. McKinnon et al.   CHEMISTRY OF MATERIALS

Hydrogels in a historical perspective: From simple networks to smart materials

(2014) Sytze J. Buwalda et al.   JOURNAL OF CONTROLLED RELEASE

Dynamic Introduction of Cell Adhesive Factor via Reversible Multicovalent Phenylboronic Acid/cis-Diol Polymeric Complexes

(2014) Guoqing Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Supramolecular Host–Guest Carrier System for Growth Factors Employing VHH Fragments

(2014) Jordi Cabanas-Danés et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidatively Responsive Chain Extension to Entangle Engineered Protein Hydrogels

(2014) Shengchang Tang et al.   MACROMOLECULES

Advances in fluorescence labeling strategies for dynamic cellular imaging

(2014) Kevin M Dean et al.   Nature Chemical Biology

Light-triggered in vivo activation of adhesive peptides regulates cell adhesion, inflammation and vascularization of biomaterials

(2014) Ted T. Lee et al.   NATURE MATERIALS

Mechanical memory and dosing influence stem cell fate

(2014) Chun Yang et al.   NATURE MATERIALS

Measuring cellular forces using bis-aliphatic hydrazone crosslinked stress-relaxing hydrogels

(2014) D. D. McKinnon et al.   Soft Matter

Free-surface molecular command systems for photoalignment of liquid crystalline materials

(2014) Kei Fukuhara et al.   Nature Communications

An Integrated Microfluidic Chip System for Single-Cell Secretion Profiling of Rare Circulating Tumor Cells

(2014) Yuliang Deng et al.   Scientific Reports

Directing Stem Cell Differentiation by Changing the Molecular Mobility of Supramolecular Surfaces

(2014) Ji-Hun Seo et al.   Advanced Healthcare Materials

Three-dimensional hMSC motility within peptide-functionalized PEG-based hydrogels of varying adhesivity and crosslinking density

(2013) Kyle A. Kyburz et al.   Acta Biomaterialia

Specific Capture and Release of Circulating Tumor Cells Using Aptamer-Modified Nanosubstrates

(2013) Qinglin Shen et al.   ADVANCED MATERIALS

3D Graphene Oxide-Polymer Hydrogel: Near-Infrared Light-Triggered Active Scaffold for Reversible Cell Capture and On-Demand Release

(2013) Wen Li et al.   ADVANCED MATERIALS

Biophysically Defined and Cytocompatible Covalently Adaptable Networks as Viscoelastic 3D Cell Culture Systems

(2013) Daniel D. McKinnon et al.   ADVANCED MATERIALS

Wavelength-Controlled Photocleavage for the Orthogonal and Sequential Release of Multiple Proteins

(2013) Malar A. Azagarsamy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dynamic Display of Bioactivity through Host-Guest Chemistry

(2013) Job Boekhoven et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Programmable Display of DNA–Protein Chimeras for Controlling Cell–Hydrogel Interactions via Reversible Intermolecular Hybridization

(2013) Zhaoyang Zhang et al.   BIOMACROMOLECULES

Rational Design of Network Properties in Guest–Host Assembled and Shear-Thinning Hyaluronic Acid Hydrogels

(2013) Christopher B. Rodell et al.   BIOMACROMOLECULES

Digital microfabrication of user-defined 3D microstructures in cell-laden hydrogels

(2013) Pranav Soman et al.   BIOTECHNOLOGY AND BIOENGINEERING

Photodegradable Supramolecular Hydrogels with Fluorescence Turn-On Reporter for Photomodulation of Cellular Microenvironments

(2013) Mingtao He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dual-Responsive Surfaces Modified with Phenylboronic Acid-Containing Polymer Brush To Reversibly Capture and Release Cancer Cells

(2013) Hongliang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inducing Rapid Cellular Response on RGD-Binding Threaded Macromolecular Surfaces

(2013) Ji-Hun Seo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Future role of MR elastography in tissue engineering and regenerative medicine

(2013) Shadi F. Othman et al.   Journal of Tissue Engineering and Regenerative Medicine

In situ cell manipulation through enzymatic hydrogel photopatterning

(2013) Katarzyna A. Mosiewicz et al.   NATURE MATERIALS

Role of the extracellular matrix in regulating stem cell fate

(2013) Fiona M. Watt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In Situ Supramolecular Assembly and Modular Modification of Hyaluronic Acid Hydrogels for 3D Cellular Engineering

(2012) Kyeng Min Park et al.   ACS Nano

Design of three-dimensional engineered protein hydrogels for tailored control of neurite growth

(2012) Kyle J. Lampe et al.   Acta Biomaterialia

Responsive polymeric delivery systems

(2012) Joseph Kost et al.   ADVANCED DRUG DELIVERY REVIEWS

Reinforcement of Shear Thinning Protein Hydrogels by Responsive Block Copolymer Self-Assembly

(2012) Matthew J. Glassman et al.   ADVANCED FUNCTIONAL MATERIALS

Three-Dimensional Biomimetic Patterning in Hydrogels to Guide Cellular Organization

(2012) James C. Culver et al.   ADVANCED MATERIALS

Covalent Adaptable Networks: Reversible Bond Structures Incorporated in Polymer Networks

(2012) Christopher N. Bowman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fully defined in situ cross-linkable alginate and hyaluronic acid hydrogels for myocardial tissue engineering

(2012) Julia Dahlmann et al.   BIOMATERIALS

Supramolecular polymeric hydrogels

(2012) Eric A. Appel et al.   CHEMICAL SOCIETY REVIEWS

High-throughput approaches for the analysis of extrinsic regulators of stem cell fate

(2012) Adrian Ranga et al.   CURRENT OPINION IN CELL BIOLOGY

The mechanical memory of lung myofibroblasts

(2012) Jenna L. Balestrini et al.   Integrative Biology

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Macroscopic Volume Change of Dynamic Hydrogels Induced by Reversible DNA Hybridization

(2012) Lu Peng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Programmable Hydrogels for Controlled Cell Catch and Release Using Hybridized Aptamers and Complementary Sequences

(2012) Zhaoyang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Facilely prepared inexpensive and biocompatible self-healing hydrogel: a new injectable cell therapy carrier

(2012) Bin Yang et al.   Polymer Chemistry

Hydrogels locked by molecular recognition aiming at responsiveness and functionality

(2012) Xiaojuan Liao et al.   Polymer Chemistry

Bioinspired multivalent DNA network for capture and release of cells

(2012) W. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monitoring degradation of matrix metalloproteinases-cleavable PEG hydrogels via multiple particle tracking microrheology

(2012) Kelly M. Schultz et al.   Soft Matter

Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics

(2012) Murat Guvendiren et al.   Nature Communications

Moving from static to dynamic complexity in hydrogel design

(2012) Jason A. Burdick et al.   Nature Communications

Bioorthogonal Click Chemistry: An Indispensable Tool to Create Multifaceted Cell Culture Scaffolds

(2012) Malar A. Azagarsamy et al.   ACS Macro Letters

Protein-Engineered Injectable Hydrogel to Improve Retention of Transplanted Adipose-Derived Stem Cells

(2012) Andreina Parisi-Amon et al.   Advanced Healthcare Materials

Physically Associated Synthetic Hydrogels with Long-Term Covalent Stabilization for Cell Culture and Stem Cell Transplantation

(2011) Jianjun Zhang et al.   ADVANCED MATERIALS

Photoreversible Patterning of Biomolecules within Click-Based Hydrogels

(2011) Cole A. DeForest et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regenerative Biomaterials that “Click”: Simple, Aqueous-Based Protocols for Hydrogel Synthesis, Surface Immobilization, and 3D Patterning

(2011) Chelsea M. Nimmo et al.   BIOCONJUGATE CHEMISTRY

Affinity Peptides Protect Transforming Growth Factor Beta During Encapsulation in Poly(ethylene glycol) Hydrogels

(2011) Joshua D. McCall et al.   BIOMACROMOLECULES

The influence of substrate creep on mesenchymal stem cell behaviour and phenotype

(2011) Andrew. R. Cameron et al.   BIOMATERIALS

Injectable shear-thinning hydrogels engineered with a self-assembling Dock-and-Lock mechanism

(2011) Hoang D. Lu et al.   BIOMATERIALS

Spatially controlled simultaneous patterning of multiple growth factors in three-dimensional hydrogels

(2011) Ryan G. Wylie et al.   NATURE MATERIALS

Alginate: Properties and biomedical applications

(2011) Kuen Yong Lee et al.   PROGRESS IN POLYMER SCIENCE

Emerging area: biomaterials that mimic and exploit protein motion

(2011) William L. Murphy   Soft Matter

Bioinspired Materials for Controlling Stem Cell Fate

(2010) Omar Z. Fisher et al.   ACCOUNTS OF CHEMICAL RESEARCH

Mechanical Properties of Cellularly Responsive Hydrogels and Their Experimental Determination

(2010) April M. Kloxin et al.   ADVANCED MATERIALS

Photoswitchable Supramolecular Hydrogels Formed by Cyclodextrins and Azobenzene Polymers

(2010) Shingo Tamesue et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydrolytically Degradable Poly(Ethylene Glycol) Hydrogel Scaffolds with Tunable Degradation and Mechanical Properties

(2010) Silviya P. Zustiak et al.   BIOMACROMOLECULES

Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2

(2010) J. Patterson et al.   BIOMATERIALS

Integration of statistical modeling and high-content microscopy to systematically investigate cell–substrate interactions

(2010) Wen Li Kelly Chen et al.   BIOMATERIALS

Polysaccharide-modified synthetic polymeric biomaterials

(2010) Aaron D. Baldwin et al.   BIOPOLYMERS

The 12th–14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain

(2010) Mikaël M. Martino et al.   FASEB JOURNAL

Stress-relaxation behavior in gels with ionic and covalent crosslinks

(2010) Xuanhe Zhao et al.   JOURNAL OF APPLIED PHYSICS

Dynamic Presentation of Immobilized Ligands Regulated through Biomolecular Recognition

(2010) Bo Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

(2010) Nathaniel Huebsch et al.   NATURE MATERIALS

Measurement of mechanical tractions exerted by cells in three-dimensional matrices

(2010) Wesley R Legant et al.   NATURE METHODS

Nanotechnological strategies for engineering complex tissues

(2010) Tal Dvir et al.   Nature Nanotechnology

Microfluidic fabrication of smart microgels from macromolecular precursors

(2010) Sebastian Seiffert et al.   POLYMER

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Dynamic Stiffness of the Substrates on Neurite Outgrowth by Using a DNA-Crosslinked Hydrogel

(2010) Frank Xue Jiang et al.   TISSUE ENGINEERING PART A

High content screening: seeing is believing

(2010) Fabian Zanella et al.   TRENDS IN BIOTECHNOLOGY

Controlling Affinity Binding with Peptide-Functionalized Poly(ethylene glycol) Hydrogels

(2009) Chien-Chi Lin et al.   ADVANCED FUNCTIONAL MATERIALS

Hydrogels in Regenerative Medicine

(2009) Brandon V. Slaughter et al.   ADVANCED MATERIALS

Dynamic Hydrogels: Switching of 3D Microenvironments Using Two-Component Naturally Derived Extracellular Matrices

(2009) Brian M. Gillette et al.   ADVANCED MATERIALS

A pH-Triggered, Fast-Responding DNA Hydrogel

(2009) Enjun Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Constructing and Exploiting the Fluorescent Protein Paintbox (Nobel Lecture)

(2009) Roger Y. Tsien   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells

(2009) Lisa A. Gurski et al.   BIOMATERIALS

Stimuli-responsive interfaces and systems for the control of protein–surface and cell–surface interactions

(2009) Martin A. Cole et al.   BIOMATERIALS

Injectable in situ forming biodegradable chitosan–hyaluronic acid based hydrogels for cartilage tissue engineering

(2009) Huaping Tan et al.   BIOMATERIALS

The influence of degradation characteristics of hyaluronic acid hydrogels on in vitro neocartilage formation by mesenchymal stem cells

(2009) Cindy Chung et al.   BIOMATERIALS

Reversible hydrogel formation driven by protein–peptide–specific interaction and chondrocyte entrapment

(2009) Fuyu Ito et al.   BIOMATERIALS

The relationship between fibroblast growth and the dynamic stiffnesses of a DNA crosslinked hydrogel

(2009) Frank X. Jiang et al.   BIOMATERIALS

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Complexity in biomaterials for tissue engineering

(2009) Elsie S. Place et al.   NATURE MATERIALS

Two-component protein-engineered physical hydrogels for cell encapsulation

(2009) Cheryl T. S. Wong Po Foo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Future perspectives and recent advances in stimuli-responsive materials

(2009) Debashish Roy et al.   PROGRESS IN POLYMER SCIENCE

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

(2009) April M. Kloxin et al.   SCIENCE

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Phototriggering of Cell Adhesion by Caged Cyclic RGD Peptides

(2008) Svea Petersen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Three-dimensional extracellular matrix-directed cardioprogenitor differentiation: Systematic modulation of a synthetic cell-responsive PEG-hydrogel

(2008) Thomas P. Kraehenbuehl et al.   BIOMATERIALS

Non-cytotoxic, in situ gelable hydrogels composed of N-carboxyethyl chitosan and oxidized dextran

(2008) Lihui Weng et al.   BIOMATERIALS

Mapping Local Matrix Remodeling Induced by a Migrating Tumor Cell Using Three-Dimensional Multiple-Particle Tracking

(2008) Ryan J. Bloom et al.   BIOPHYSICAL JOURNAL

Smart Hydrogels Containing Adenylate Kinase: Translating Substrate Recognition into Macroscopic Motion

(2008) Weiwei Yuan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stop-flow lithography to generate cell-laden microgel particles

(2008) Priyadarshi Panda et al.   LAB ON A CHIP

Fabrication of monodisperse thermosensitive microgels and gel capsules in microfluidic devices

(2008) Rhutesh K. Shah et al.   Soft Matter