Quantifying forces in cell biology

Inferring cellular forces from image stacks

(2017) Jim H. Veldhuis et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cell-like pressure sensors reveal increase of mechanical stress towards the core of multicellular spheroids under compression

(2017) M. E. Dolega et al.   Nature Communications

Single Molecule Force Measurements in Living Cells Reveal a Minimally Tensioned Integrin State

(2016) Alice C. Chang et al.   ACS Nano

Inference of Internal Stress in a Cell Monolayer

(2016) Vincent Nier et al.   BIOPHYSICAL JOURNAL

Rickettsia Sca4 Reduces Vinculin-Mediated Intercellular Tension to Promote Spread

(2016) Rebecca L. Lamason et al.   CELL

A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time

(2016) Daeha Seo et al.   CELL

Measuring forces and stressesin situin living tissues

(2016) Kaoru Sugimura et al.   DEVELOPMENT

Nanoscale mechanics guides cellular decision making

(2016) Zainab Rahil et al.   Integrative Biology

For whom the cells pull: Hydrogel and micropost devices for measuring traction forces

(2016) Alexandre J.S. Ribeiro et al.   METHODS

Super-Resolved Traction Force Microscopy (STFM)

(2016) Huw Colin-York et al.   NANO LETTERS

Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

(2016) Yekaterina A. Miroshnikova et al.   NATURE CELL BIOLOGY

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

In vivo quantification of spatially varying mechanical properties in developing tissues

(2016) Friedhelm Serwane et al.   NATURE METHODS

Measuring cell-generated forces: a guide to the available tools

(2016) William J Polacheck et al.   NATURE METHODS

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

A toolbox to explore the mechanics of living embryonic tissues

(2016) Otger Campàs   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cell motility regulation on a stepped micro pillar array device (SMPAD) with a discrete stiffness gradient

(2016) Sujin Lee et al.   Soft Matter

Converging and Unique Mechanisms of Mechanotransduction at Adhesion Sites

(2016) Mitchell K.L. Han et al.   TRENDS IN CELL BIOLOGY

Confocal reference free traction force microscopy

(2016) Martin Bergert et al.   Nature Communications

The mechanical response of talin

(2016) Mingxi Yao et al.   Nature Communications

Localized force application reveals mechanically sensitive domains of Piezo1

(2016) Jason Wu et al.   Nature Communications

Work Done by Titin Protein Folding Assists Muscle Contraction

(2016) Jaime Andrés Rivas-Pardo et al.   Cell Reports

TissueMiner: A multiscale analysis toolkit to quantify how cellular processes create tissue dynamics

(2016) Raphaël Etournay et al.   eLife

Compressed sensing traction force microscopy

(2015) Jonatan Bohr Brask et al.   Acta Biomaterialia

Traction force microscopy on soft elastic substrates: A guide to recent computational advances

(2015) Ulrich S. Schwarz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanotransduction: use the force(s)

(2015) Ewa K. Paluch et al.   BMC BIOLOGY

Inter-Cellular Forces Orchestrate Contact Inhibition of Locomotion

(2015) John R. Davis et al.   CELL

Cortical Tension Allocates the First Inner Cells of the Mammalian Embryo

(2015) Chaminda R. Samarage et al.   DEVELOPMENTAL CELL

Lighting Up the Force: Investigating Mechanisms of Mechanotransduction Using Fluorescent Tension Probes

(2015) Carol Jurchenko et al.   MOLECULAR AND CELLULAR BIOLOGY

Titin-Based Nanoparticle Tension Sensors Map High-Magnitude Integrin Forces within Focal Adhesions

(2015) Kornelia Galior et al.   NANO LETTERS

YAP is essential for tissue tension to ensure vertebrate 3D body shape

(2015) Sean Porazinski et al.   NATURE

A molecular mechanotransduction pathway regulates collective migration of epithelial cells

(2015) Tamal Das et al.   NATURE CELL BIOLOGY

Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices

(2015) Haguy Wolfenson et al.   NATURE CELL BIOLOGY

Extracellular rigidity sensing by talin isoform-specific mechanical linkages

(2015) Katharina Austen et al.   NATURE CELL BIOLOGY

Traction microscopy to identify force modulation in subresolution adhesions

(2015) Sangyoon J Han et al.   NATURE METHODS

Three-dimensional force microscopy of cells in biopolymer networks

(2015) Julian Steinwachs et al.   NATURE METHODS

Noncontact three-dimensional mapping of intracellular hydromechanical properties by Brillouin microscopy

(2015) Giuliano Scarcelli et al.   NATURE METHODS

Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix

(2015) Kristopher E. Kubow et al.   Nature Communications

Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing

(2015) Mukund Gupta et al.   Nature Communications

Model-based Traction Force Microscopy Reveals Differential Tension in Cellular Actin Bundles

(2015) Jérôme R. D. Soiné et al.   PLoS Computational Biology

Unified quantitative characterization of epithelial tissue development

(2015) Boris Guirao et al.   eLife

Intercellular Stress Reconstitution from Traction Force Data

(2014) Juliane Zimmermann et al.   BIOPHYSICAL JOURNAL

Topographical control of multiple cell adhesion molecules for traction force microscopy

(2014) Samuel R. Polio et al.   Integrative Biology

Both contractile axial and lateral traction force dynamics drive amoeboid cell motility

(2014) Effie Bastounis et al.   JOURNAL OF CELL BIOLOGY

Rigidity sensing and adaptation through regulation of integrin types

(2014) Alberto Elosegui-Artola et al.   NATURE MATERIALS

A DNA-based molecular probe for optically reporting cellular traction forces

(2014) Brandon L Blakely et al.   NATURE METHODS

High Resolution, Large Deformation 3D Traction Force Microscopy

(2014) Jennet Toyjanova et al.   PLoS One

CellFIT: A Cellular Force-Inference Toolkit Using Curvilinear Cell Boundaries

(2014) G. Wayne Brodland et al.   PLoS One

Spatiotemporal control of epithelial remodeling by regulated myosin phosphorylation

(2014) K. E. Kasza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Traction force microscopy in physics and biology

(2014) Robert W. Style et al.   Soft Matter

DNA-based digital tension probes reveal integrin forces during early cell adhesion

(2014) Yun Zhang et al.   Nature Communications

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

(2014) Mingxi Yao et al.   Scientific Reports

Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1

(2013) Daniel E. Conway et al.   CURRENT BIOLOGY

The mechanical anisotropy in a tissue promotes ordering in hexagonal cell packing

(2013) Kaoru Sugimura et al.   DEVELOPMENT

A global pattern of mechanical stress polarizes cell divisions and cell shape in the growing Drosophila wing disc

(2013) Loïc LeGoff et al.   DEVELOPMENT

Molecular Tension Sensors Report Forces Generated by Single Integrin Molecules in Living Cells

(2013) Masatoshi Morimatsu et al.   NANO LETTERS

Tension-oriented cell divisions limit anisotropic tissue tension in epithelial spreading during zebrafish epiboly

(2013) Pedro Campinho et al.   NATURE CELL BIOLOGY

The cytoplasm of living cells behaves as a poroelastic material

(2013) Emad Moeendarbary et al.   NATURE MATERIALS

Quantifying cell-generated mechanical forces within living embryonic tissues

(2013) Otger Campàs et al.   NATURE METHODS

Monolayer Stress Microscopy: Limitations, Artifacts, and Accuracy of Recovered Intercellular Stresses

(2013) Dhananjay T. Tambe et al.   PLoS One

Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling

(2013) X. Wang et al.   SCIENCE

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Single-Cell Force Spectroscopy, an Emerging Tool to Quantify Cell Adhesion to Biomaterials

(2013) Anna V. Taubenberger et al.   TISSUE ENGINEERING PART B-REVIEWS

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Finding the weakest link – exploring integrin-mediated mechanical molecular pathways

(2012) Pere Roca-Cusachs et al.   JOURNAL OF CELL SCIENCE

United we stand – integrating the actin cytoskeleton and cell–matrix adhesions in cellular mechanotransduction

(2012) Ulrich S. Schwarz et al.   JOURNAL OF CELL SCIENCE

Mechanical state, material properties and continuous description of an epithelial tissue

(2012) I. Bonnet et al.   Journal of the Royal Society Interface

Bayesian inference of force dynamics during morphogenesis

(2012) Shuji Ishihara et al.   JOURNAL OF THEORETICAL BIOLOGY

Mechanical waves during tissue expansion

(2012) Xavier Serra-Picamal et al.   Nature Physics

Cells test substrate rigidity by local contractions on submicrometer pillars

(2012) S. Ghassemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch

(2012) N. Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterizing the mechanics of cultured cell monolayers

(2012) A. R. Harris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adhesion Functions in Cell Sorting by Mechanically Coupling the Cortices of Adhering Cells

(2012) J.-L. Maitre et al.   SCIENCE

Mechanical Control of Morphogenesis by Fat/Dachsous/Four-Jointed Planar Cell Polarity Pathway

(2012) F. Bosveld et al.   SCIENCE

Mechanical Stress Inference for Two Dimensional Cell Arrays

(2012) Kevin K. Chiou et al.   PLoS Computational Biology

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

MEMS sensors and microsystems for cell mechanobiology

(2011) Jagannathan Rajagopalan et al.   JOURNAL OF MICROMECHANICS AND MICROENGINEERING

Magnetic micropillars as a tool to govern substrate deformations

(2011) Jimmy le Digabel et al.   LAB ON A CHIP

Polar actomyosin contractility destabilizes the position of the cytokinetic furrow

(2011) Jakub Sedzinski et al.   NATURE

Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A

(2011) A. J. Ehrlicher et al.   NATURE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Collective cell guidance by cooperative intercellular forces

(2011) Dhananjay T. Tambe et al.   NATURE MATERIALS

Cysteine shotgun-mass spectrometry (CS-MS) reveals dynamic sequence of protein structure changes within mutant and stressed cells

(2011) C. C. Krieger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-ECM traction force modulates endogenous tension at cell-cell contacts

(2011) V. Maruthamuthu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plithotaxis and emergent dynamics in collective cellular migration

(2011) Xavier Trepat et al.   TRENDS IN CELL BIOLOGY

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

Long-Lived, High-Strength States of ICAM-1 Bonds to β2 Integrin, II: Lifetimes of LFA-1 Bonds Under Force in Leukocyte Signaling

(2010) Koji Kinoshita et al.   BIOPHYSICAL JOURNAL

Integration of contractile forces during tissue invagination

(2010) Adam C. Martin et al.   JOURNAL OF CELL BIOLOGY

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows

(2010) Mirjam Mayer et al.   NATURE

α-Catenin as a tension transducer that induces adherens junction development

(2010) Shigenobu Yonemura et al.   NATURE CELL BIOLOGY

Measurement of mechanical tractions exerted by cells in three-dimensional matrices

(2010) Wesley R Legant et al.   NATURE METHODS

Video force microscopy reveals the mechanics of ventral furrow invagination in Drosophila

(2010) G. W. Brodland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical tugging force regulates the size of cell-cell junctions

(2010) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Combining Laser Microsurgery and Finite Element Modeling to Assess Cell-Level Epithelial Mechanics

(2009) M. Shane Hutson et al.   BIOPHYSICAL JOURNAL

Live Cells Exert 3-Dimensional Traction Forces on Their Substrata

(2009) Sung Sik Hur et al.   Cellular and Molecular Bioengineering

Increased Cell Bond Tension Governs Cell Sorting at the Drosophila Anteroposterior Compartment Boundary

(2009) Katharina P. Landsberg et al.   CURRENT BIOLOGY

Myosin II Dynamics Are Regulated by Tension in Intercalating Cells

(2009) Rodrigo Fernandez-Gonzalez et al.   DEVELOPMENTAL CELL

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Mechanosensing in actin stress fibers revealed by a close correlation between force and protein localization

(2009) J. Colombelli et al.   JOURNAL OF CELL SCIENCE

Physical forces during collective cell migration

(2009) Xavier Trepat et al.   Nature Physics

Single-cell response to stiffness exhibits muscle-like behavior

(2009) D. Mitrossilis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying cellular traction forces in three dimensions

(2009) Stacey A. Maskarinec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibronectin forms the most extensible biological fibers displaying switchable force-exposed cryptic binding sites

(2009) E. Klotzsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clustering of  5 1 integrins determines adhesion strength whereas  v 3 and talin enable mechanotransduction

(2009) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Traction on Immobilized Netrin-1 Is Sufficient to Reorient Axons

(2009) S. W. Moore et al.   SCIENCE

A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ

(2008) Fanjie Meng et al.   FEBS Journal

Traction patterns of tumor cells

(2008) D. Ambrosi et al.   JOURNAL OF MATHEMATICAL BIOLOGY

Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis

(2008) Matteo Rauzi et al.   NATURE CELL BIOLOGY

Visualizing myosin-actin interaction with a genetically-encoded fluorescent strain sensor

(2008) S. Iwai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid signal transduction in living cells is a unique feature of mechanotransduction

(2008) S. Na et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Traction forces and rigidity sensing regulate cell functions

(2008) Marion Ghibaudo et al.   Soft Matter

High Resolution Traction Force Microscopy Based on Experimental and Computational Advances

(2007) Benedikt Sabass et al.   BIOPHYSICAL JOURNAL