Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging

(2020) Haopeng Xiao et al.   CELL

Single-Cell Transcriptomic Atlas of Primate Ovarian Aging

(2020) Si Wang et al.   CELL

Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

(2020) Estela González‐Gualda et al.   AGING CELL

Resveratrol inhibits adipocyte differentiation and cellular senescence of human bone marrow stromal stem cells

(2020) Dalia Ali et al.   BONE

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

(2020) Marcus Ruscetti et al.   CELL

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

(2020) Leena P. Bharath et al.   Cell Metabolism

Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

(2020) Yusheng Cai et al.   CELL RESEARCH

Immunosuppression for hyperinflammation in COVID-19: a double-edged sword?

(2020) Andrew I Ritchie et al.   LANCET

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

The role of cellular senescence in ageing and endocrine disease

(2020) Sundeep Khosla et al.   Nature Reviews Endocrinology

Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases

(2020) Shuling Song et al.   TRENDS IN BIOCHEMICAL SCIENCES

Reducing Senescent Cell Burden in Aging and Disease

(2020) Robert J. Pignolo et al.   TRENDS IN MOLECULAR MEDICINE

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

(2020) Yonghan He et al.   Nature Communications

Geriatric fragility fractures are associated with a human skeletal stem cell defect

(2020) Thomas H. Ambrosi et al.   AGING CELL

Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action

(2020) Federico Pietrocola et al.   Autophagy

Compounds that extend longevity are protective in neurodegenerative diseases and provide a novel treatment strategy for these devastating disorders

(2020) Sonja K. Soo et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging

(2020) Young-Kyoung Ryu et al.   NEUROPHARMACOLOGY

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

(2019) Mikolaj Ogrodnik et al.   Cell Metabolism

Growth suppression by dual BRAF(V600E) and NRAS(Q61) oncogene expression is mediated by SPRY4 in melanoma

(2019) Raj Kumar et al.   ONCOGENE

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Evaluation of the Mrp2-mediated flavonoid-drug interaction potential of quercetin in rats and in vitro models

(2019) Ju-Hee Oh et al.   Asian Journal of Pharmaceutical Sciences

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

(2019) Didac Carmona-Gutierrez et al.   Nature Communications

Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescence

(2019) Xiuhua Xu et al.   Cell Death & Disease

Cell cycle plasticity driven by MTOR signaling: integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer

(2019) Erik S. Knudsen et al.   ONCOGENE

Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis

(2019) Nayuta Saito et al.   JOURNAL OF IMMUNOLOGY

Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans

(2019) JoshuaN Farr et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The curcumin analog EF24 is a novel senolytic agent

(2019) Wen Li et al.   Aging-US

Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction

(2019) Anna Walaszczyk et al.   AGING CELL

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

(2019) Allyson K. Palmer et al.   AGING CELL

Aged-senescent cells contribute to impaired heart regeneration

(2019) Fiona C. Lewis-McDougall et al.   AGING CELL

RB constrains lineage fidelity and multiple stages of tumour progression and metastasis

(2019) David M. Walter et al.   NATURE

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

(2019) Larissa G.P. Langhi Prata et al.   SEMINARS IN IMMUNOLOGY

Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro

(2019) Hosni Cherif et al.   Journal of Clinical Medicine

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

(2019) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

Age-Dependent Levels of Protein Kinase Cs in Brain: Reduction of Endogenous Mechanisms of Neuroprotection

(2019) Donatella Pastore et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states

(2019) Marianne Stemann Andersen et al.   NATURE CELL BIOLOGY

Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin

(2019) Seo Rin Kim et al.   Translational Research

Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

(2019) Liping Deng et al.   Nature Communications

Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD‐L1)‐mediated immunosuppression

(2019) Qixia Xu et al.   AGING CELL

Cellular senescence: at the nexus between ageing and diabetes

(2019) Allyson K. Palmer et al.   DIABETOLOGIA

Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer

(2019) Diletta Di Mitri et al.   Cell Reports

Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

(2019) Sonja Suvakov et al.   Biology of Sex Differences

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long‐lived and cancer‐resistant subterranean wild rodent, Spalax

(2019) Amani Odeh et al.   AGING CELL

Ets2 suppresses inflammatory cytokines through MAPK/NF-κB signaling and directly binds to the IL-6 promoter in macrophages

(2019) Xianwei Ma et al.   Aging-US

Targeting senescent cells in translational medicine

(2019) Marta Paez‐Ribes et al.   EMBO Molecular Medicine

Lipid signalling drives proteolytic rewiring of mitochondria by YME1L

(2019) Thomas MacVicar et al.   NATURE

Effect of piperine and quercetin alone or in combination with marbofloxacin on CYP3A37 and MDR1 mRNA expression levels in broiler chickens

(2019) Harshad B. Patel et al.   RESEARCH IN VETERINARY SCIENCE

To help aging populations, classify organismal senescence

(2019) Stuart R. G. Calimport et al.   SCIENCE

Identification and characterization of Cardiac Glycosides as senolytic compounds

(2019) Francisco Triana-Martínez et al.   Nature Communications

Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer’s Disease Pathogenesis

(2019) Anushka Chakravorty et al.   Frontiers in Aging Neuroscience

Functions of p53 in pluripotent stem cells

(2019) Xuemei Fu et al.   Protein & Cell

Aging induced by D-galactose aggravates cardiac dysfunction via exacerbating mitochondrial dysfunction in obese insulin-resistant rats

(2019) Cherry Bo-Htay et al.   GeroScience

Measuring biological aging in humans: A quest

(2019) Luigi Ferrucci et al.   AGING CELL

Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis

(2019) Christina D. Camell et al.   Cell Metabolism

Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis

(2019) Daniel J. Tyrrell et al.   CIRCULATION RESEARCH

Developmental ROS individualizes organismal stress resistance and lifespan

(2019) Daphne Bazopoulou et al.   NATURE

Undulating changes in human plasma proteome profiles across the lifespan

(2019) Benoit Lehallier et al.   NATURE MEDICINE

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage

(2019) Emma Bolderson et al.   Nature Communications

The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy

(2019) Caroline Kumsta et al.   Nature Communications

Comprehensive longitudinal study of epigenetic mutations in aging

(2019) Yunzhang Wang et al.   Clinical Epigenetics

Senescence marker activin A is increased in human diabetic kidney disease: association with kidney function and potential implications for therapy

(2019) Xiaohui Bian et al.   BMJ Open Diabetes Research & Care

Oxidation resistance 1 is a novel senolytic target

(2018) Xin Zhang et al.   AGING CELL

RASSF1A Deficiency Enhances RAS-Driven Lung Tumorigenesis

(2018) M. Lee Schmidt et al.   CANCER RESEARCH

A versatile drug delivery system targeting senescent cells

(2018) Daniel Muñoz‐Espín et al.   EMBO Molecular Medicine

Down-regulation of intracellular anti-apoptotic proteins, particularly c-FLIP by therapeutic agents; the novel view to overcome resistance to TRAIL

(2018) Ali Hassanzadeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Strategies targeting cellular senescence

(2018) Yossi Ovadya et al.   JOURNAL OF CLINICAL INVESTIGATION

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

(2018) Boyi Zhang et al.   Nature Communications

Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype

(2018) Christopher D. Wiley et al.   Scientific Reports

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

There’s no limit to longevity, says study that revives human lifespan debate

(2018) Elie Dolgin   NATURE

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Facing up to the global challenges of ageing

(2018) Linda Partridge et al.   NATURE

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

Hyperoxia-Induced Cellular Senescence in Fetal Airway Smooth Muscle Cells

(2018) Pavan Parikh et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance

(2018) Fei Chen et al.   Nature Communications

Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function

(2018) Matthew Wortham et al.   Cell Reports

Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer

(2018) Kristina Kovacovicova et al.   Frontiers in Oncology

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

(2017) Birgit Ritschka et al.   GENES & DEVELOPMENT

An OFF–ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in Vivo

(2017) Beatriz Lozano-Torres et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Biphasic Modeling of Mitochondrial Metabolism Dysregulation during Aging

(2017) Darren J. Baker et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Progressive slowdown/prevention of cellular senescence by CD9-targeted delivery of rapamycin using lactose-wrapped calcium carbonate nanoparticles

(2017) Raj Kumar Thapa et al.   Scientific Reports

Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways

(2016) Lisa A. Lesniewski et al.   AGING CELL

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

(2016) Yingying Wang et al.   Aging-US

NKG2D ligands mediate immunosurveillance of senescent cells

(2016) Adi Sagiv et al.   Aging-US

Conserved and novel functions of programmed cellular senescence during vertebrate development

(2016) Hongorzul Davaapil et al.   DEVELOPMENT

Ameliorative effect of lotus seedpod proanthocyanidins on cognitive impairment and brain aging induced by d-galactose

(2016) Yu-Shi Gong et al.   EXPERIMENTAL GERONTOLOGY

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

(2016) Jutta Zimmer et al.   MOLECULAR CELL

Evidence for a limit to human lifespan

(2016) Xiao Dong et al.   NATURE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

SFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironment

(2016) Y Sun et al.   ONCOGENE

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

(2016) N. Tasdemir et al.   Cancer Discovery

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts

(2015) Hyun Lim et al.   BIOCHEMICAL PHARMACOLOGY

Clinical strategies and animal models for developing senolytic agents

(2015) James L. Kirkland et al.   EXPERIMENTAL GERONTOLOGY

ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development

(2015) Shundong Cang et al.   Journal of Hematology & Oncology

Linking Cancer Metabolism to DNA Repair and Accelerated Senescence

(2015) E. V. Efimova et al.   MOLECULAR CANCER RESEARCH

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Translational strategies in aging and age-related disease

(2015) Mary Armanios et al.   NATURE MEDICINE

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Recurrent turnover of senescent cells during regeneration of a complex structure

(2015) Maximina H Yun et al.   eLife

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Glucosamine protects nucleus pulposus cells and induces autophagy via the mTOR-dependent pathway

(2014) LiBo Jiang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Immunosurveillance of senescent cells: the bright side of the senescence program

(2013) Adi Sagiv et al.   BIOGERONTOLOGY

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Metformin limits ceramide-induced senescence in C2C12 myoblasts

(2013) Kavita S. Jadhav et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Digitalis Toxicity: A Fading but Crucial Complication to Recognize

(2012) Eric H. Yang et al.   AMERICAN JOURNAL OF MEDICINE

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B

(2012) Yu Sun et al.   NATURE MEDICINE

Granule exocytosis mediates immune surveillance of senescent cells

(2012) A Sagiv et al.   ONCOGENE

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Activation of p53 by Nutlin-3a Induces Apoptosis and Cellular Senescence in Human Glioblastoma Multiforme

(2011) Ruth Villalonga-Planells et al.   PLoS One

Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence

(2009) Peter D. Adams   MOLECULAR CELL

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY