Down-regulation of intracellular anti-apoptotic proteins, particularly c-FLIP by therapeutic agents; the novel view to overcome resistance to TRAIL

HDACis (class I), cancer stem cell, and phytochemicals: Cancer therapy and prevention implications

(2018) Sahar Bayat et al.   BIOMEDICINE & PHARMACOTHERAPY

Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells

(2018) Jalal Choupani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MiR-126 reverses drug resistance to TRAIL through inhibiting the expression of c-FLIP in cervical cancer

(2017) Weijiang Zhang et al.   GENE

The Effect of Metformin on Oncological Outcomes in Patients With Cervical Cancer With Type 2 Diabetes Mellitus

(2017) Jitti Hanprasertpong et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Volasertib Enhances Sensitivity to TRAIL in Renal Carcinoma Caki Cells through Downregulation of c-FLIP Expression

(2017) Mi-Yeon Jeon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Safety of intraoperative chemotherapy with 5-FU for colorectal cancer patients receiving curative resection: a randomized, multicenter, prospective, phase III IOCCRC trial (IOCCRC)

(2017) Rong-xin Zhang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

ERK-dependent mTOR pathway is involved in berberine-induced autophagy in hepatic steatosis

(2017) Qin He et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Accelerated versus standard epirubicin followed by cyclophosphamide, methotrexate, and fluorouracil or capecitabine as adjuvant therapy for breast cancer in the randomised UK TACT2 trial (CRUK/05/19): a multicentre, phase 3, open-label, randomised, controlled trial

(2017) David Cameron et al.   LANCET ONCOLOGY

Inhibition of c-REL using siRNA increased apoptosis and decreased proliferation in pre-B ALL blasts: Therapeutic implications

(2017) Seyedeh Momeneh Mohammadi et al.   LEUKEMIA RESEARCH

Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling

(2017) Georg Emons et al.   MOLECULAR CANCER RESEARCH

Effect of evodiamine and berberine on the interaction between DNMTs and target microRNAs during malignant transformation of the colon by TGF-β1

(2017) Chao Huang et al.   ONCOLOGY REPORTS

Osthole enhances TRAIL-mediated apoptosis through downregulation of c-FLIP expression in renal carcinoma Caki cells

(2017) Kyoung-Jin Min et al.   ONCOLOGY REPORTS

Novel proteasome inhibitor delanzomib sensitizes cervical cancer cells to doxorubicin-induced apoptosis via stabilizing tumor suppressor proteins in the p53 pathway

(2017) Kevin Y. Guo et al.   Oncotarget

The loss-of-function of DNA methyltransferase 1 by siRNA impairs the growth of non-small cell lung cancer with alleviated side effects via reactivation of RASSF1A and APC in vitro and vivo

(2017) Qi Lai et al.   Oncotarget

Effects and Mechanisms of Metformin on the Proliferation of Esophageal Cancer Cells In Vitro and In Vivo

(2017) Jian-Cai Tang et al.   Cancer Research and Treatment

Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells

(2017) Nathan P. Ward et al.   PLoS One

The effect of quercetin nanoparticle on cervical cancer progression by inducing apoptosis, autophagy and anti-proliferation via JAK2 suppression

(2016) Cheng-lin Luo et al.   BIOMEDICINE & PHARMACOTHERAPY

Fructose sensitizes Jurkat cells oxidative stress-induced apoptosis via caspase-dependent and caspase-independent mechanisms

(2016) Viviana Diaz-Aguirre et al.   CELL BIOLOGY INTERNATIONAL

A combined approach against tumorigenesis using glucose deprivation and mitochondrial complex 1 inhibition by rotenone

(2016) Nupur Rani Agarwal et al.   CELL BIOLOGY INTERNATIONAL

Peritoneal dialysis treatment of metformin-associated lactic acidosis in a diabetic nephropathy patient


(2016) Jianjun Gao et al.   CLINICAL NEPHROLOGY

The Role of NF-κB Inhibitors in Cell Response to Radiation

(2016) Sajjad Molavi Pordanjani et al.   CURRENT MEDICINAL CHEMISTRY

Quercetin inhibits the growth of human gastric cancer stem cells by inducing mitochondrial-dependent apoptosis through the inhibition of PI3K/Akt signaling

(2016) Xinsheng Shen et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Overcoming resistance to TRAIL-induced apoptosis in solid tumor cells by simultaneously targeting death receptors, c-FLIP and IAPs

(2016) YING HUANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL-induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells

(2016) SEEMA-MARIA NATHWANI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Rotenone induces apoptosis in human lung cancer cells by regulating autophagic flux

(2016) Wensi Hu et al.   IUBMB LIFE

Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (V): coumarins and alkaloids from Boenninghausenia japonica and Ruta graveolens

(2016) Daisuke Nakano et al.   Journal of Natural Medicines

Phase I trial of dose-escalating metronomic temozolomide plus bevacizumab and bortezomib for patients with recurrent glioblastoma

(2016) D. Jay McCracken et al.   JOURNAL OF NEURO-ONCOLOGY

Synergistic cell death in FLT3-ITD positive acute myeloid leukemia by combined treatment with metformin and 6-benzylthioinosine

(2016) Himalee S. Sabnis et al.   LEUKEMIA RESEARCH

Effect of evodiamine on the proliferation and apoptosis of A549 human lung cancer cells

(2016) Li Lin et al.   Molecular Medicine Reports

Relationship Between Metformin Use and Recurrence and Survival in Patients With Resected Stage III Colon Cancer Receiving Adjuvant Chemotherapy: Results From North Central Cancer Treatment Group N0147 (Alliance)

(2016) P. P. Singh et al.   ONCOLOGIST

Combination of the histone deacetylase inhibitor depsipeptide and 5-fluorouracil upregulates major histocompatibility complex class II and p21 genes and activates caspase-3/7 in human colon cancer HCT-116 cells

(2016) Kouji Okada et al.   ONCOLOGY REPORTS

Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo

(2016) Daniel R. Ram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

(2016) Lomeli R. Carpio et al.   Science Signaling

A novel derivative of tetrandrine (H1) induces endoplasmic reticulum stress-mediated apoptosis and prosurvival autophagy in human non-small cell lung cancer cells

(2016) Yidan Lin et al.   TUMOR BIOLOGY

Activation of autophagy flux by metformin downregulates cellular FLICE–like inhibitory protein and enhances TRAIL- induced apoptosis

(2016) Uddin Nazim et al.   Oncotarget

YM155 sensitizes TRAIL-induced apoptosis through cathepsin S-dependent down-regulation of Mcl-1 and NF-κB-mediated down-regulation of c-FLIP expression in human renal carcinoma Caki cells

(2016) Seon Min Woo et al.   Oncotarget

Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy

(2016) Gertrud Knoll et al.   Oncotarget

The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration

(2016) Michael S. Becker et al.   Oncotarget

Icariside II overcomes TRAIL resistance of melanoma cells through ROS-mediated downregulation of STAT3/cFLIP signaling

(2016) Juan Du et al.   Oncotarget

Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway

(2016) Jiwei Wang et al.   Oncotarget

Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

(2016) Lomeli R. Carpio et al.   Science Signaling

Anthracycline Drugs on Modified Surface of Quercetin-Loaded Polymer Nanoparticles: A Dual Drug Delivery Model for Cancer Treatment

(2016) Chabita Saha et al.   PLoS One

The Proteasome Inhibitor Bortezomib Affects Chondrosarcoma Cells via the Mitochondria-Caspase Dependent Pathway and Enhances Death Receptor Expression and Autophagy

(2016) Birgit Lohberger et al.   PLoS One

hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells

(2016) Xuejuan Gao et al.   Scientific Reports

Synergistic effects of combined treatment with histone deacetylase inhibitor suberoylanilide hydroxamic acid and TRAIL on human breast cancer cells

(2016) Weiqiang Zhou et al.   Scientific Reports

Inhibition of c-FLIP by RNAi Enhances Sensitivity of the Human Osteogenic Sarcoma Cell Line U2OS to TRAILInduced Apoptosis

(2015) Ya-Ping Zhang et al.   Asian Pacific Journal of Cancer Prevention

Restoration of TRAIL-induced apoptosis in resistant human pancreatic cancer cells by a novel FAK inhibitor, PH11

(2015) P. Dao et al.   CANCER LETTERS

Icaritin Sensitizes Human Glioblastoma Cells to TRAIL-Induced Apoptosis

(2015) Hongxing Han et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression

(2015) Min Ae Han et al.   CHEMICO-BIOLOGICAL INTERACTIONS

HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL

(2015) R. Carson et al.   CLINICAL CANCER RESEARCH

The overriding of TRAIL resistance by the histone deacetylase inhibitor MS-275 involves c-myc up-regulation in cutaneous, uveal, and mucosal melanoma

(2015) Mario Venza et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Novel Radiolytic Rotenone Derivative, Rotenoisin B with Potent Anti-Carcinogenic Activity in Hepatic Cancer Cells

(2015) Srilatha Badaboina et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy-Mediated Degradation of IAPs and c-FLIPL Potentiates Apoptosis Induced by Combination of TRAIL and Chal-24

(2015) Jennings Xu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dopamine D2 receptor blocker thioridazine induces cell death in human uterine cervical carcinoma cell line SiHa

(2015) Min Mao et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Pure total flavonoids from Citrus paradisi Macfadyen act synergistically with arsenic trioxide in inducing apoptosis of Kasumi-1 leukemia cells in vitro

(2015) Bo Wang et al.   Journal of Zhejiang University-SCIENCE B

Dopamine receptor antagonist thioridazine inhibits tumor growth in a murine breast cancer model

(2015) TAO YIN et al.   Molecular Medicine Reports

5-Fluorouracil preferentially sensitizes mutant KRAS non-small cell lung carcinoma cells to TRAIL-induced apoptosis

(2015) Haizhen Wang et al.   Molecular Oncology

Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity

(2015) L O'Leary et al.   ONCOGENE

Combined treatment with ABT-737 and VX-680 induces apoptosis in Bcl-2- and c-FLIP-overexpressing breast carcinoma cells

(2015) JUNG EUN CHOI et al.   ONCOLOGY REPORTS

Medicarpin and millepurpan, two flavonoids isolated from Medicago sativa, induce apoptosis and overcome multidrug resistance in leukemia P388 cells

(2015) Grégory Gatouillat et al.   PHYTOMEDICINE

The Neuroprotective Role of Ferrostatin-1 Under Rotenone-Induced Oxidative Stress in Dopaminergic Neuroblastoma Cells

(2015) Parijat Kabiraj et al.   PROTEIN JOURNAL

Temozolomide sensitizes stem-like cells of glioma spheres to TRAIL-induced apoptosis via upregulation of casitas B-lineage lymphoma (c-Cbl) protein

(2015) Jing Zhitao et al.   TUMOR BIOLOGY

Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion

(2015) A Morlé et al.   Cell Death & Disease

Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data

(2015) H-W Cheng et al.   Cell Death & Disease

The BET bromodomain inhibitor, JQ1, facilitates c-FLIP degradation and enhances TRAIL-induced apoptosis independent of BRD4 and c-Myc inhibition

(2015) Weilong Yao et al.   Oncotarget

Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cells

(2015) Kyong-Jin Jung et al.   Oncotarget

Activation of AKR1C1/ERβ induces apoptosis by downregulation of c-FLIP in prostate cancer cells: A prospective therapeutic opportunity

(2015) Huiyoung Yun et al.   Oncotarget

Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells

(2015) Yukihiro Nishikawa et al.   PLoS One

Metformin sensitizes human bladder cancer cells to TRAIL-induced apoptosis through mTOR/S6K1-mediated downregulation of c-FLIP

(2014) Tao Zhang et al.   ANTI-CANCER DRUGS

MUC16 mucin (CA125) attenuates TRAIL-induced apoptosis by decreasing TRAIL receptor R2 expression and increasing c-FLIP expression

(2014) Isabelle Matte et al.   BMC CANCER

Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the Death Receptor pathway

(2014) Zhiyu Chen et al.   CANCER LETTERS

Kurarinone Synergizes TRAIL-Induced Apoptosis in Gastric Cancer Cells

(2014) Wenchao Zhou et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Dicoumarol sensitizes renal cell carcinoma Caki cells to TRAIL-induced apoptosis through down-regulation of Bcl-2, Mcl-1 and c-FLIP in a NQO1-independent manner

(2014) Eun Jung Park et al.   EXPERIMENTAL CELL RESEARCH

Evodiamine Induces Apoptosis and Enhances TRAIL-Induced Apoptosis in Human Bladder Cancer Cells through mTOR/S6K1-Mediated Downregulation of Mcl-1

(2014) Tao Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bortezomib Sensitizes Primary Meningioma Cells to TRAIL-Induced Apoptosis by Enhancing Formation of the Death-Inducing Signaling Complex

(2014) Ronald Koschny et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Evodiamine sensitizes U87 glioblastoma cells to TRAIL via the death receptor pathway

(2014) MUHAMMAD KHAN et al.   Molecular Medicine Reports

Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells by attenuating the inhibition of caspase-8 through cellular FLICE-like-inhibitory protein downregulation

(2014) ZHOU LUAN et al.   Molecular Medicine Reports

Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer

(2014) JIASHENG MU et al.   ONCOLOGY REPORTS

Gingerol sensitizes TRAIL-induced apoptotic cell death of glioblastoma cells

(2014) Dae-Hee Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondrial inhibitor sensitizes non-small-cell lung carcinoma cells to TRAIL-induced apoptosis by reactive oxygen species and Bcl-XL/p53-mediated amplification mechanisms

(2014) Y-L Shi et al.   Cell Death & Disease

Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L)

(2014) K-j Min et al.   Cell Death & Disease

Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway

(2014) R Trivedi et al.   Cell Death & Disease

Wogonin enhances antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo through ROS-mediated downregulation of cFLIPL and IAP proteins

(2013) Lan Yang et al.   APOPTOSIS

Monensin, a polyether ionophore antibiotic, overcomes TRAIL resistance in glioma cells via endoplasmic reticulum stress, DR5 upregulation and c-FLIP downregulation

(2013) Mi Jin Yoon et al.   CARCINOGENESIS

Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1

(2013) J Lemke et al.   CELL DEATH AND DIFFERENTIATION

Sorafenib and HDAC inhibitors synergize with TRAIL to kill tumor cells

(2013) Hossein A. Hamed et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sensitization of TRAIL-induced apoptosis in human hepatocellular carcinoma HepG2 cells by phytochemicals

(2013) Reem N. Abou El Naga et al.   LIFE SCIENCES

Combination of Ad-sTRAIL with the chemotherapeutic drug cisplatin synergistically enhances their pro-apoptotic ability in human breast cancer cells

(2013) XIANGPING LIU et al.   ONCOLOGY REPORTS

Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells

(2013) Licheng He et al.   TOXICOLOGY

Upregulation of c-FLIP-short in response to TRAIL promotes survival of NSCLC cells, which could be suppressed by inhibition of Ca2+/calmodulin signaling

(2013) V O Kaminskyy et al.   Cell Death & Disease

Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways

(2013) M van Dijk et al.   Cell Death & Disease

Amurensin G, a novel SIRT1 inhibitor, sensitizes TRAIL-resistant human leukemic K562 cells to TRAIL-induced apoptosis

(2012) Hak-Bong Kim et al.   BIOCHEMICAL PHARMACOLOGY

Anisomycin treatment enhances TRAIL-mediated apoptosis in renal carcinoma cells through the down-regulation of Bcl-2, c-FLIP(L) and Mcl-1

(2012) Bo Ram Seo et al.   BIOCHIMIE

Prognostic and therapeutic relevance of c-FLIP in acute myeloid leukaemia

(2012) Donal McLornan et al.   BRITISH JOURNAL OF HAEMATOLOGY

The Novel Akt Inhibitor API-1 Induces c-FLIP Degradation and Synergizes with TRAIL to Augment Apoptosis Independent of Akt Inhibition

(2012) B. Li et al.   Cancer Prevention Research

Elevation of c-FLIP in Castrate-Resistant Prostate Cancer Antagonizes Therapeutic Response to Androgen Receptor-Targeted Therapy

(2012) C. McCourt et al.   CLINICAL CANCER RESEARCH

Kurarinone promotes TRAIL-induced apoptosis by inhibiting NF-κB-dependent cFLIP expression in HeLa cells

(2012) Ok-Won Seo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Dioscin sensitizes cells to TRAIL-induced apoptosis through downregulation of c-FLIP and Bcl-2

(2012) YONG-SIK KIM et al.   ONCOLOGY REPORTS

Suppression of multidrug resistance by treatment with TRAIL in human ovarian and breast cancer cells with high level of c-Myc

(2011) Dae-Young Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis

(2011) E W Duiker et al.   BRITISH JOURNAL OF CANCER

Celecoxib Promotes c-FLIP Degradation through Akt-Independent Inhibition of GSK3

(2011) S. Chen et al.   CANCER RESEARCH

Paxilline enhances TRAIL-mediated apoptosis of glioma cellsviamodulation of c-FLIP, survivin and DR5

(2011) You Jung Kang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Pharmacologic downregulation of c-FLIPL restores juxtacrine death receptor-mediated apoptosis in cancer cells in a peritoneal carcinomatosis model

(2011) Yi Shen et al.   INTERNATIONAL JOURNAL OF CANCER

Rocaglamide and a XIAP inhibitor cooperatively sensitize TRAIL-mediated apoptosis in Hodgkin's lymphomas

(2011) Marco Giaisi et al.   INTERNATIONAL JOURNAL OF CANCER

Wogonin and Related Natural Flavones Overcome Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Protein Resistance of Tumors by Down-regulation of c-FLIP Protein and Up-regulation of TRAIL Receptor 2 Expression

(2011) Jie Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal Growth Factor Receptor-mediated Tissue Transglutaminase Overexpression Couples Acquired Tumor Necrosis Factor-related Apoptosis-inducing Ligand Resistance and Migration through c-FLIP and MMP-9 Proteins in Lung Cancer Cells

(2011) Zi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses isoproterenol-induced heart failure in rats via JNK and ERK1/2 pathways

(2011) Na Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Glucocorticoid receptor antagonist sensitizes TRAIL-induced apoptosis in renal carcinoma cells through up-regulation of DR5 and down-regulation of c-FLIP(L) and Bcl-2

(2011) Kyoung-jin Min et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The NEDD8-Activating Enzyme Inhibitor, MLN4924, Cooperates with TRAIL to Augment Apoptosis through Facilitating c-FLIP Degradation in Head and Neck Cancer Cells

(2011) L. Zhao et al.   MOLECULAR CANCER THERAPEUTICS

The Antidiabetic Drug Ciglitazone Induces High Grade Bladder Cancer Cells Apoptosis through the Up-Regulation of TRAIL

(2011) Marie-Laure Plissonnier et al.   PLoS One

TNFα-mediated apoptosis in human osteoarthritic chondrocytes sensitized by PI3K-NF-κB inhibitor, not mTOR inhibitor

(2011) Deling Li et al.   RHEUMATOLOGY INTERNATIONAL

The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis

(2011) Marianne van Dijk et al.   Cancers

Cathepsin E enhances anticancer activity of doxorubicin on human prostate cancer cells showing resistance to TRAIL-mediated apoptosis

(2010) Atsushi Yasukochi et al.   BIOLOGICAL CHEMISTRY

HDAC inhibitors with different gene regulation activities depend on the mitochondrial pathway for the sensitization of leukemic T cells to TRAIL-induced apoptosis

(2010) J.C. Morales et al.   CANCER LETTERS

Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia/lymphoma by translational suppression of c-FLIP expression

(2010) M Bleumink et al.   CELL DEATH AND DIFFERENTIATION

Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC level

(2010) A Morizot et al.   CELL DEATH AND DIFFERENTIATION

Compound C sensitizes Caki renal cancer cells to TRAIL-induced apoptosis through reactive oxygen species-mediated down-regulation of c-FLIPL and Mcl-1

(2010) Ji Hoon Jang et al.   EXPERIMENTAL CELL RESEARCH

Histone deacetylase inhibitor-induced sensitization to TNFα/TRAIL-mediated apoptosis in cervical carcinoma cells is dependent on HPV oncogene expression

(2010) Katalin Darvas et al.   INTERNATIONAL JOURNAL OF CANCER

Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins

(2010) Lee   INTERNATIONAL JOURNAL OF ONCOLOGY

Smac Mimetic Compounds Potentiate Interleukin-1β-mediated Cell Death

(2010) Herman H. Cheung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Death Ligand-Induced Apoptosis in Cutaneous SCC Cells by Treatment with Diclofenac/Hyaluronic Acid Correlates with Downregulation of c-FLIP

(2010) Lothar F. Fecker et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Quercetin enhances TRAIL-induced apoptosis in prostate cancer cells via increased protein stability of death receptor 5

(2010) Young-Hwa Jung et al.   LIFE SCIENCES

4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells

(2010) Khadijeh Bijangi-Vishehsaraei et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Bortezomib Sensitizes Human Renal Cell Carcinomas to TRAIL Apoptosis through Increased Activation of Caspase-8 in the Death-Inducing Signaling Complex

(2010) Alan D. Brooks et al.   MOLECULAR CANCER RESEARCH

c-FLIP Degradation Mediates Sensitization of Pancreatic Cancer Cells to TRAIL-Induced Apoptosis by the Histone Deacetylase Inhibitor LBH589

(2010) John Kauh et al.   PLoS One

A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein

(2009) N. Ueffing et al.   BLOOD

Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin

(2009) Dae-Hee Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Myricetin sensitizes malignant glioma cells to TRAIL-mediated apoptosis by down-regulation of the short isoform of FLIP and bcl-2

(2009) M.D. Siegelin et al.   CANCER LETTERS

Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulation of death receptor 5 (DR5) in human sarcoma HOS cells and human colon cancer HCT116 cells

(2009) Takeshi Hori et al.   CANCER LETTERS

Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression

(2009) J Y Zhu et al.   CELL DEATH AND DIFFERENTIATION

The histone deacetylase inhibitor suberoylanilide hydroxamic acid sensitises human hepatocellular carcinoma cells to TRAIL-induced apoptosis by TRAIL-DISC activation

(2009) Daniela Carlisi et al.   EUROPEAN JOURNAL OF CANCER

The contact allergen nickel sensitizes primary human endothelial cells and keratinocytes to TRAIL-mediated apoptosis

(2009) Marc Schmidt et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Resistance of Cutaneous Anaplastic Large-Cell Lymphoma Cells to Apoptosis by Death Ligands Is Enhanced by CD30-Mediated Overexpression of c-FLIP

(2009) Frank K. Braun et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The XIAP inhibitor Embelin enhances TRAIL-mediated apoptosis in malignant glioma cells by down-regulation of the short isoform of FLIP

(2009) M.D. Siegelin et al.   NEUROCHEMISTRY INTERNATIONAL

Genistein enhances proteasomal degradation of the short isoform of FLIP in malignant glioma cells and thereby augments TRAIL-mediated apoptosis

(2009) Markus David Siegelin et al.   NEUROSCIENCE LETTERS

Over-Expression of c-FLIP Confers the Resistance to TRAIL-Induced Apoptosis on Gallbladder Carcinoma

(2009) Huajie Zong et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Down-regulation of the De-ubiquitinating Enzyme Ubiquitin-specific Protease 2 Contributes to Tumor Necrosis Factor-α-induced Hepatocyte Survival

(2008) Florian Haimerl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sanguinarine-induced apoptosis: Generation of ROS, down-regulation of Bcl-2, c-FLIP, and synergy with TRAIL

(2008) Shin Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Involvement of c-FLIP and survivin down-regulation in flexible heteroarotinoid-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells

(2008) Y. Lin et al.   MOLECULAR CANCER THERAPEUTICS

Gli2 upregulates cFlip and renders basal cell carcinoma cells resistant to death ligand-mediated apoptosis

(2008) E Kump et al.   ONCOGENE

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

(2008) I Ben Sahra et al.   ONCOGENE

Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist

(2008) A. J. Frew et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA