Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer

Induction of cancer cell stemness by depletion of macrohistone H2A1 in hepatocellular carcinoma

(2018) Oriana Lo Re et al.   HEPATOLOGY

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Molecular therapies and precision medicine for hepatocellular carcinoma

(2018) Josep M. Llovet et al.   Nature Reviews Clinical Oncology

The Clinical Potential of Senolytic Drugs

(2017) James L. Kirkland et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Cellular senescence and tumor promotion: Is aging the key?

(2016) Natalia Loaiza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Impact of country of birth on age at the time of diagnosis of hepatocellular carcinoma in the United States

(2016) Ju Dong Yang et al.   CANCER

DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression

(2016) M. Borghesan et al.   CANCER RESEARCH

Efficacy and epigenetic interactions of novel DNA hypomethylating agent guadecitabine (SGI-110) in preclinical models of hepatocellular carcinoma

(2016) Simone Jueliger et al.   Epigenetics

Senescence in chronic liver disease: Is the future in aging?

(2016) Aloysious D. Aravinthan et al.   JOURNAL OF HEPATOLOGY

A Low Dose of Dietary Quercetin Fails to Protect against the Development of an Obese Phenotype in Mice

(2016) Reilly T. Enos et al.   PLoS One

MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis

(2015) Christine Podrini et al.   FASEB JOURNAL

Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation

(2015) Mehtap Kilic Eren et al.   PLoS One

Comparative study reveals better far-red fluorescent protein for whole body imaging

(2015) K.E. Luker et al.   Scientific Reports

HCC—subtypes, stratification and sorafenib

(2014) Gregory J. Gores   Nature Reviews Gastroenterology & Hepatology

Enhanced killing of therapy-induced senescent tumor cells by oncolytic measles vaccine viruses

(2013) Timo Weiland et al.   INTERNATIONAL JOURNAL OF CANCER

Immunopositivity for Histone MacroH2A1 Isoforms Marks Steatosis-Associated Hepatocellular Carcinoma

(2013) Francesca Rappa et al.   PLoS One

Loss of p16Ink4a Function Rescues Cellular Senescence Induced by Telomere Dysfunction

(2012) Xiufeng Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Doxorubicin Plus Sorafenib vs Doxorubicin Alone in Patients With Advanced Hepatocellular Carcinoma

(2010) Ghassan K. Abou-Alfa et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Rapid flow cytometric method for measuring senescence associated β-galactosidase activity in human fibroblasts

(2009) Gerard Noppe et al.   CYTOMETRY PART A

Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN

(2009) Manlio Vinciguerra et al.   JOURNAL OF HEPATOLOGY

Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes

(2008) Manlio Vinciguerra et al.   HEPATOLOGY

The Effect of Doxorubicin on MEK-ERK Signaling Predicts Its Efficacy in HCC

(2008) Jennifer Choi et al.   JOURNAL OF SURGICAL RESEARCH

PTEN Down-Regulation by Unsaturated Fatty Acids Triggers Hepatic Steatosis via an NF-κBp65/mTOR-Dependent Mechanism

(2007) Manlio Vinciguerra et al.   GASTROENTEROLOGY