Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?

Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair

(2020) Bianca Marchetti et al.   AGING CELL

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

(2020) David Gate et al.   NATURE

Depletion of CD4 T cells provides therapeutic benefits in aged mice after ischemic stroke

(2020) Nia M. Harris et al.   EXPERIMENTAL NEUROLOGY

α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease

(2020) Cecilia S. Lindestam Arlehamn et al.   Nature Communications

Peripheral proinflammatory Th1/Th17 immune cell shift is linked to disease severity in amyotrophic lateral sclerosis

(2020) Mengmeng Jin et al.   Scientific Reports

Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms

(2019) Arsalan Alizadeh et al.   Frontiers in Neurology

Cytotoxic CD8+T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons

(2019) Emmanuelle Coque et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glial activation and inflammation along the Alzheimer’s disease continuum

(2019) Kaja Nordengen et al.   Journal of Neuroinflammation

Low-Dose Maraviroc, an Antiretroviral Drug, Attenuates the Infiltration of T Cells into the Central Nervous System and Protects the Nigrostriatum in Hemiparkinsonian Monkeys

(2019) Susanta Mondal et al.   JOURNAL OF IMMUNOLOGY

Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson’s Disease

(2019) Annika Sommer et al.   Cell Stem Cell

Single-cell analysis reveals T cell infiltration in old neurogenic niches

(2019) Ben W. Dulken et al.   NATURE

The Characterization of Regulatory T-Cell Profiles in Alzheimer’s Disease and Multiple Sclerosis

(2019) Fausta Ciccocioppo et al.   Scientific Reports

Autoimmunity After Ischemic Stroke and Brain Injury

(2019) Ehsan Javidi et al.   Frontiers in Immunology

Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species

(2019) Xu-Qiao Chen et al.   Frontiers in Neuroscience

Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

(2019) Björn Neumann et al.   Cell Stem Cell

B cells in autoimmune and neurodegenerative central nervous system diseases

(2019) Joseph J. Sabatino et al.   NATURE REVIEWS NEUROSCIENCE

Ischaemic stroke

(2019) Bruce C. V. Campbell et al.   Nature Reviews Disease Primers

Aging alters the immunological response to ischemic stroke

(2018) Rodney M. Ritzel et al.   ACTA NEUROPATHOLOGICA

Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging

(2018) Peggie Cheung et al.   CELL

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

(2018) Aleksandra Deczkowska et al.   CELL

Senescent B cells in aging and age-related diseases: Their role in the regulation of antibody responses

(2018) Daniela Frasca   EXPERIMENTAL GERONTOLOGY

Inflammation in CNS neurodegenerative diseases

(2018) Jodie Stephenson et al.   IMMUNOLOGY

Evaluation of regulatory T lymphocytes and IL2Ra and FOXP3 gene expression in peripheral mononuclear cells from patients with amyotrophic lateral sclerosis

(2018) Sara Rashid Chehreh Bargh et al.   IRISH JOURNAL OF MEDICAL SCIENCE

Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease

(2018) Rizwan S. Akhtar et al.   JOURNAL OF NEUROCHEMISTRY

Tolerogenic bone marrow-derived dendritic cells induce neuroprotective regulatory T cells in a model of Parkinson’s disease

(2018) Charles R. Schutt et al.   Molecular Neurodegeneration

Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study

(2018) Mario Merlini et al.   Neurodegenerative Diseases

A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice

(2018) Neha R. Deshpande et al.   PLoS One

Defective cholesterol clearance limits remyelination in the aged central nervous system

(2018) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Brain Ischemia Induces Diversified Neuroantigen-Specific T-Cell Responses That Exacerbate Brain Injury

(2018) Wei-Na Jin et al.   STROKE

Multiple Sclerosis Pathology

(2018) Hans Lassmann   Cold Spring Harbor Perspectives in Medicine

Unbiased transcriptomic analyses reveal distinct effects of immune deficiency in CNS function with and without injury

(2018) Dandan Luo et al.   Protein & Cell

Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis

(2018) Rebecca K. Sheean et al.   JAMA Neurology

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

Imbalance of Circulating Th17 and Regulatory T Cells in Alzheimer’s Disease: A Case Control Study

(2018) Timo Jan Oberstein et al.   Frontiers in Immunology

STROKE34 Study Protocol: A Randomized Controlled Phase IIa Trial of Intra-Arterial CD34+ Cells in Acute Ischemic Stroke

(2018) João Sargento-Freitas et al.   Frontiers in Neurology

Counteracting roles of MHCI and CD8+ T cells in the peripheral and central nervous system of ALS SOD1G93A mice

(2018) Giovanni Nardo et al.   Molecular Neurodegeneration

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

Peripheral immune system in aging and Alzheimer’s disease

(2018) Wei Cao et al.   Molecular Neurodegeneration

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

(2018) Minako Ito et al.   NATURE

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

(2018) Sara Bachiller et al.   Frontiers in Cellular Neuroscience

Tissue-resident memory T cells populate the human brain

(2018) Joost Smolders et al.   Nature Communications

Human peripheral late/exhausted memory B cells express a senescent-associated secretory phenotype and preferentially utilize metabolic signaling pathways

(2017) Daniela Frasca et al.   EXPERIMENTAL GERONTOLOGY

The chromatin accessibility signature of human immune aging stems from CD8+T cells

(2017) Duygu Ucar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement

(2017) Aarti Narang et al.   Journal of Neuroinflammation

Safety and efficacy of natalizumab in patients with acute ischaemic stroke (ACTION): a randomised, placebo-controlled, double-blind phase 2 trial

(2017) Jacob Elkins et al.   LANCET NEUROLOGY

T cells from patients with Parkinson’s disease recognize α-synuclein peptides

(2017) David Sulzer et al.   NATURE

Regulatory T cells promote myelin regeneration in the central nervous system

(2017) Yvonne Dombrowski et al.   NATURE NEUROSCIENCE

Regenerating CNS myelin — from mechanisms to experimental medicines

(2017) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis

(2017) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathology of Neurodegenerative Diseases

(2017) Brittany N. Dugger et al.   Cold Spring Harbor Perspectives in Biology

Signs and symptoms preceding the diagnosis of Alzheimer’s disease: a systematic scoping review of literature from 1937 to 2016

(2017) Fidelia Bature et al.   BMJ Open

Elevated Serum α-Synuclein Autoantibodies in Patients with Parkinson’s Disease Relative to Alzheimer’s Disease and Controls

(2017) Ali Shalash et al.   Frontiers in Neurology

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

Impaired toll like receptor-7 and 9 induced immune activation in chronic spinal cord injured patients contributes to immune dysfunction

(2017) Gozde Gucluler et al.   PLoS One

Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy

(2016) Cyril Laurent et al.   BRAIN

Regulatory T cells delay disease progression in Alzheimer-like pathology

(2016) Cira Dansokho et al.   BRAIN

Pathogenesis of amyotrophic lateral sclerosis

(2016) Sarah Morgan et al.   BRITISH MEDICAL BULLETIN

Aging of the immune system: Focus on inflammation and vaccination

(2016) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Treatment of traumatic brain injury with anti-inflammatory drugs

(2016) Peter J. Bergold   EXPERIMENTAL NEUROLOGY

Epigenetic changes in T-cell and monocyte signatures and production of neurotoxic cytokines in ALS patients

(2016) Larry Lam et al.   FASEB JOURNAL

Ageing and recurrent episodes of neuroinflammation promote progressive experimental autoimmune encephalomyelitis in Biozzi ABH mice

(2016) Laura A. N. Peferoen et al.   IMMUNOLOGY

Age-Associated Resident Memory CD8 T Cells in the Central Nervous System Are Primed To Potentiate Inflammation after Ischemic Brain Injury

(2016) Rodney M. Ritzel et al.   JOURNAL OF IMMUNOLOGY

Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration

(2016) Hongwei Qin et al.   JOURNAL OF NEUROSCIENCE

Down-regulation of B cell-related genes in peripheral blood leukocytes of Parkinson's disease patients with and without GBA mutations

(2016) Hila Kobo et al.   MOLECULAR GENETICS AND METABOLISM

Ageing, neurodegeneration and brain rejuvenation

(2016) Tony Wyss-Coray   NATURE

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

(2016) Vesna Pulko et al.   NATURE IMMUNOLOGY

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

Age at onset and Parkinson disease phenotype

(2016) Gennaro Pagano et al.   NEUROLOGY

B-Cell Depletion with CD20 Antibodies as New Approach in the Treatment of Inflammatory and Immunological Events Associated with Spinal Cord Injury

(2016) Giovanna Casili et al.   Neurotherapeutics

The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function

(2016) Samuel E. Marsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory neuroprotection following traumatic brain injury

(2016) M. V. Russo et al.   SCIENCE

Understanding the Role of T Cells in CNS Homeostasis

(2016) Erik Ellwardt et al.   TRENDS IN IMMUNOLOGY

Friend or foe: the dichotomous impact of T cells on neuro-de/re-generation during aging

(2016) Brandon Coder et al.   Oncotarget

Do human B-lymphocytes avoid aging until 60 years?

(2016) Andrea Knight et al.   Oncotarget

Neuroprotective effects of CD4+CD25+Foxp3+ regulatory T cells in a 3xTg-AD Alzheimer’s disease model

(2016) Hyunjung Baek et al.   Oncotarget

Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer’s disease

(2016) S-S Jiao et al.   Translational Psychiatry

Aging affects B-cell antigen receptor repertoire diversity in primary and secondary lymphoid tissues

(2015) Hilla Tabibian-Keissar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Development of stage-dependent glycans on the Fc domains of IgG antibodies of ALS animals

(2015) Meital Edri-Brami et al.   EXPERIMENTAL NEUROLOGY

MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4

(2015) James T. Walsh et al.   JOURNAL OF CLINICAL INVESTIGATION

Thymic Involution Perturbs Negative Selection Leading to Autoreactive T Cells That Induce Chronic Inflammation

(2015) Brandon D. Coder et al.   JOURNAL OF IMMUNOLOGY

Age-related changes in spleen of Dark Agouti rats immunized for experimental autoimmune encephalomyelitis

(2015) Jasmina Djikić et al.   JOURNAL OF NEUROIMMUNOLOGY

Experimental autoimmune encephalomyelitis and age-related correlations of NADPH oxidase, MMP-9, and cell adhesion molecules: The increased disease severity and blood–brain barrier permeability in middle-aged mice

(2015) Ji-Eun Seo et al.   JOURNAL OF NEUROIMMUNOLOGY

Transfer of Myelin-Reactive Th17 Cells Impairs Endogenous Remyelination in the Central Nervous System of Cuprizone-Fed Mice

(2015) E. G. Baxi et al.   JOURNAL OF NEUROSCIENCE

B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke

(2015) K. P. Doyle et al.   JOURNAL OF NEUROSCIENCE

Clinical correlation of peripheral CD4+-cell sub-sets, their imbalance and Parkinson's disease

(2015) YUHUA CHEN et al.   Molecular Medicine Reports

β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis

(2015) Lucas K Smith et al.   NATURE MEDICINE

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology

(2015) Kuti Baruch et al.   Nature Communications

Aging diminishes the resistance of AO rats to EAE: putative role of enhanced generation of GM-CSF Expressing CD4+ T cells in aged rats

(2015) Zorica Stojić-Vukanić et al.   Immunity & Ageing

Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis

(2014) Eimear Linehan et al.   AGING CELL

Modest familial risks for multiple sclerosis: a registry-based study of the population of Sweden

(2014) Helga Westerlind et al.   BRAIN

High TNF-α levels in resting B cells negatively correlate with their response

(2014) Daniela Frasca et al.   EXPERIMENTAL GERONTOLOGY

The paradox of chronic neuroinflammation, systemic immune suppression, autoimmunity after traumatic chronic spinal cord injury

(2014) Jan M. Schwab et al.   EXPERIMENTAL NEUROLOGY

T cell–derived interleukin (IL)-21 promotes brain injury following stroke in mice

(2014) Benjamin D.S. Clarkson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FTY720 does not protect from traumatic brain injury in mice despite reducing posttraumatic inflammation

(2014) Stine Mencl et al.   JOURNAL OF NEUROIMMUNOLOGY

Antigen Dependently Activated Cluster of Differentiation 8-Positive T Cells Cause Perforin-Mediated Neurotoxicity in Experimental Stroke

(2014) E. Mracsko et al.   JOURNAL OF NEUROSCIENCE

Evidence for peripheral immune activation in amyotrophic lateral sclerosis

(2014) Xueping Chen et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The prevalence of Parkinson's disease: A systematic review and meta-analysis

(2014) Tamara Pringsheim et al.   MOVEMENT DISORDERS

Risk of relapse phenotype recurrence in multiple sclerosis

(2014) Tomas Kalincik et al.   Multiple Sclerosis Journal

Comparing clinical features of young onset, middle onset and late onset Parkinson's disease

(2014) Raja Mehanna et al.   PARKINSONISM & RELATED DISORDERS

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

Interleukin-17 inhibits Adult Hippocampal Neurogenesis

(2014) Qiang Liu et al.   Scientific Reports

Traumatic brain injury causes selective, CD74-dependent peripheral lymphocyte activation that exacerbates neurodegeneration

(2014) Richard P Tobin et al.   Acta Neuropathologica Communications

Characteristics of differentiated CD8+ and CD4+ T cells present in the human brain

(2013) Joost Smolders et al.   ACTA NEUROPATHOLOGICA

Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection

(2013) Hiramani Dhungana et al.   AGING CELL

In senescence, age-associated B cells secrete TNFα and inhibit survival of B-cell precursors*

(2013) Michelle Ratliff et al.   AGING CELL

Inflammation and white matter degeneration persist for years after a single traumatic brain injury

(2013) Victoria E. Johnson et al.   BRAIN

Brain antigen-reactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire

(2013) Ali Radjavi et al.   BRAIN BEHAVIOR AND IMMUNITY

T helper-17 activation dominates the immunologic milieu of both amyotrophic lateral sclerosis and progressive multiple sclerosis

(2013) Marina Saresella et al.   CLINICAL IMMUNOLOGY

Differential effects of aging and sex on stroke induced inflammation across the lifespan

(2013) Bharti Manwani et al.   EXPERIMENTAL NEUROLOGY

Impaired inhibitory function of circulating CD4+CD25+ regulatory T cells in alopecia areata

(2013) Bong Seok Shin et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Dopamine Receptor D3 Expressed on CD4+ T Cells Favors Neurodegeneration of Dopaminergic Neurons during Parkinson's Disease

(2013) H. Gonzalez et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Central Memory CD8 T Cells in Aged Mice Are Virtual Memory Cells

(2013) B.-C. Chiu et al.   JOURNAL OF IMMUNOLOGY

IFN-  Production by Amyloid  -Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease

(2013) T. C. Browne et al.   JOURNAL OF IMMUNOLOGY

GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxicated mice

(2013) Lisa M. Kosloski et al.   JOURNAL OF NEUROIMMUNOLOGY

Autonomic Dysreflexia Causes Chronic Immune Suppression after Spinal Cord Injury

(2013) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

The influence of age and gender on motor and non-motor features of early Parkinson's disease: Initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort

(2013) Konrad Szewczyk-Krolikowski et al.   PARKINSONISM & RELATED DISORDERS

Th17 Cell-Mediated Neuroinflammation Is Involved in Neurodegeneration of Aβ1-42-Induced Alzheimer’s Disease Model Rats

(2013) Jun Zhang et al.   PLoS One

CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging

(2013) K. Baruch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and Adaptive Immunity in Parkinson's Disease

(2013) R. L. Mosley et al.   Cold Spring Harbor Perspectives in Medicine

The Genetics of Alzheimer Disease

(2013) R. E. Tanzi   Cold Spring Harbor Perspectives in Medicine

A single administration of human umbilical cord blood T cells produces long-lasting effects in the aging hippocampus

(2012) Md Shahaduzzaman et al.   AGE

Evidence of Intrathecal Immunoglobulin Synthesis in Stroke

(2012) Harald Prüss et al.   ARCHIVES OF NEUROLOGY

Brain-Immune Interactions and Ischemic Stroke

(2012) Costantino Iadecola   ARCHIVES OF NEUROLOGY

Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke

(2012) M. Gelderblom et al.   BLOOD

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival

(2012) Jenny S. Henkel et al.   EMBO Molecular Medicine

Improved regeneration after spinal cord injury in mice lacking functional T- and B-lymphocytes

(2012) Bin Wu et al.   EXPERIMENTAL NEUROLOGY

CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s Disease

(2012) Jessica A. Hutter Saunders et al.   Journal of Neuroimmune Pharmacology

Reduced T helper and B lymphocytes in Parkinson's disease

(2012) Claire H. Stevens et al.   JOURNAL OF NEUROIMMUNOLOGY

Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease

(2012) David Tweedie et al.   Journal of Neuroinflammation

Challenging the Role of Adaptive Immunity in Neurotrauma: Rag1−/− Mice Lacking Mature B and T Cells Do Not Show Neuroprotection after Closed Head Injury

(2012) Sebastian Weckbach et al.   JOURNAL OF NEUROTRAUMA

Multiple Sclerosis Risk Variant HLA-DRB1*1501 Associates with High Expression of DRB1 Gene in Different Human Populations

(2012) Antonio Alcina et al.   PLoS One

Glycans in Sera of Amyotrophic Lateral Sclerosis Patients and Their Role in Killing Neuronal Cells

(2012) Meital Edri-Brami et al.   PLoS One

Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord injury

(2012) H Ishii et al.   Cell Death & Disease

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

(2011) Y. Hao et al.   BLOOD

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

(2011) Arthur Liesz et al.   BRAIN

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

(2011) David R. Beers et al.   BRAIN

Functional recovery in aging mice after experimental stroke

(2011) Bharti Manwani et al.   BRAIN BEHAVIOR AND IMMUNITY

Non-Resolving Aspects of Acute Inflammation after Spinal Cord Injury (SCI): Indices and Resolution Plateau

(2011) Harald Prüss et al.   BRAIN PATHOLOGY

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

(2011) Cris S Constantinescu et al.   BRITISH JOURNAL OF PHARMACOLOGY

FTD and ALS: A Tale of Two Diseases

(2011) R. Ferrari et al.   Current Alzheimer Research

A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis

(2011) A. Acevedo-Arozena et al.   Disease Models & Mechanisms

Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice

(2011) Megan J. Smithey et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Effects of aging on blood brain barrier and matrix metalloproteases following controlled cortical impact in mice

(2011) Phil Lee et al.   EXPERIMENTAL NEUROLOGY

Effects of peripheral lymphocyte subpopulations and the clinical correlation with Parkinson's disease

(2011) Fumitoshi Niwa et al.   Geriatrics & Gerontology International

An Alzheimer's disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction

(2011) Maya K. Desai et al.   GLIA

The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study

(2011) Julie Phukan et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neurite outgrowth is differentially impacted by distinct immune cell subsets

(2011) Madeline Pool et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Age at onset as a determinant of presenting phenotype and initial relapse recovery in multiple sclerosis

(2011) M Cossburn et al.   Multiple Sclerosis Journal

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability

(2011) Christoph W. Blau et al.   NEUROBIOLOGY OF AGING

Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions

(2011) B. D. Rudd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoimmune Responses to the Brain After Stroke Are Associated With Worse Outcome

(2011) Kyra J. Becker et al.   STROKE

Mouse Model of Middle Cerebral Artery Occlusion

(2011) Terrance Chiang et al.   Jove-Journal of Visualized Experiments

Parkinson's disease and immunological abnormalities: increase of HLA-DR expression on monocytes in cerebrospinal fluid and of CD45RO+ T cells in peripheral blood

(2010) U. Fiszer et al.   ACTA NEUROLOGICA SCANDINAVICA

Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation

(2010) C. Kleinschnitz et al.   BLOOD

Relationships between age and late progression of Parkinson's disease: a clinico-pathological study

(2010) P. A. Kempster et al.   BRAIN

Activation of mixed glia by Aβ-specific Th1 and Th17 cells and its regulation by Th2 cells

(2010) K. McQuillan et al.   BRAIN BEHAVIOR AND IMMUNITY

Myelin antigen reactive T cells in cerebrovascular diseases

(2010) W. Z. WANG et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Overview of the immune response

(2010) David D. Chaplin   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulation of learning and memory by meningeal immunity: a key role for IL-4

(2010) Noël C. Derecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T Cells Attenuate Th17 Cell-Mediated Nigrostriatal Dopaminergic Neurodegeneration in a Model of Parkinson’s Disease

(2010) Ashley D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

A Placebo-Controlled Trial of Oral Cladribine for Relapsing Multiple Sclerosis

(2010) Gavin Giovannoni et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional and Pathogenic Differences of Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis

(2010) Helena S. Domingues et al.   PLoS One

Regulation of cytokine signaling and T-cell recruitment in the aging mouse brain in response to central inflammatory challenge

(2009) Yuan-Zhong Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Brain dendritic cells in ischemic stroke: Time course, activation state, and origin

(2009) Jennifer C. Felger et al.   BRAIN BEHAVIOR AND IMMUNITY

Incidence and lifetime risk of motor neuron disease in the United Kingdom: a population-based study

(2009) A. Alonso et al.   EUROPEAN JOURNAL OF NEUROLOGY

Adaptive peripheral immune response increases proliferation of neural precursor cells in the adult hippocampus

(2009) Susanne A. Wolf et al.   FASEB JOURNAL

B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice

(2009) Daniel P. Ankeny et al.   JOURNAL OF CLINICAL INVESTIGATION

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

(2009) A. Jager et al.   JOURNAL OF IMMUNOLOGY

Nitrated  -Synuclein-Induced Alterations in Microglial Immunity Are Regulated by CD4+ T Cell Subsets

(2009) A. D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

CD4-Positive T Lymphocytes Provide a Neuroimmunological Link in the Control of Adult Hippocampal Neurogenesis

(2009) S. A. Wolf et al.   JOURNAL OF IMMUNOLOGY

Development of ALS-like disease in SOD-1 mice deficient of B lymphocytes

(2009) Shulamit Naor et al.   JOURNAL OF NEUROLOGY

Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury

(2009) Ann C. McKee et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Reproductive age-related changes in the blood brain barrier: Expression of IgG and tight junction proteins

(2009) Shameena Bake et al.   MICROVASCULAR RESEARCH

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

Aβ-specific Th2 cells provide cognitive and pathological benefits to Alzheimer's mice without infiltrating the CNS

(2009) Chuanhai Cao et al.   NEUROBIOLOGY OF DISEASE

B-cell diversity decreases in old age and is correlated with poor health status

(2008) Kate L. Gibson et al.   AGING CELL

Amyloid Plaque and Neurofibrillary Tangle Pathology in a Regulatable Mouse Model of Alzheimer's Disease

(2008) Jennifer B. Paulson et al.   AMERICAN JOURNAL OF PATHOLOGY

Adaptive immunity affects learning behavior in mice

(2008) Anna Brynskikh et al.   BRAIN BEHAVIOR AND IMMUNITY

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

(2008) Vanessa Brochard et al.   JOURNAL OF CLINICAL INVESTIGATION

Alemtuzumab vs. Interferon Beta-1a in Early Multiple Sclerosis

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons

(2008) Eric J. Benner et al.   PLoS One

Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice

(2008) Rebecca Banerjee et al.   PLoS One

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

(2008) D. R. Beers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS

(2008) I. M. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stroke Outcome in Those Over 80

(2008) Gustavo Saposnik et al.   STROKE

Genetic epidemiology: the use of old and new tools for multiple sclerosis

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