Ageing and recurrent episodes of neuroinflammation promote progressive experimental autoimmune encephalomyelitis in Biozzi ABH mice

Central nervous system inflammation across the age span

(2016) Amit Bar-Or et al.   CURRENT OPINION IN NEUROLOGY

Aging and multiple sclerosis

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Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline

(2016) Abbe H. Crawford et al.   Cell Reports

Aging and multiple sclerosis

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Thymic Involution Perturbs Negative Selection Leading to Autoreactive T Cells That Induce Chronic Inflammation

(2015) Brandon D. Coder et al.   JOURNAL OF IMMUNOLOGY

Age-related changes in spleen of Dark Agouti rats immunized for experimental autoimmune encephalomyelitis

(2015) Jasmina Djikić et al.   JOURNAL OF NEUROIMMUNOLOGY

Activation Status of Human Microglia Is Dependent on Lesion Formation Stage and Remyelination in Multiple Sclerosis

(2015) Laura A.N. Peferoen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-γ and alpha B-crystallin

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Mechanisms shaping the naïve T cell repertoire in the elderly — Thymic involution or peripheral homeostatic proliferation?

(2014) Qian Qi et al.   EXPERIMENTAL GERONTOLOGY

Priming of microglia in a DNA-repair deficient model of accelerated aging

(2014) Divya D.A. Raj et al.   NEUROBIOLOGY OF AGING

Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons

(2013) Shailender Singh et al.   ACTA NEUROPATHOLOGICA

Developmental maturation of innate immune cell function correlates with susceptibility to central nervous system autoimmunity

(2013) Deetje Hertzenberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination

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Novel pathogenic epitopes of myelin oligodendrocyte glycoprotein induce experimental autoimmune encephalomyelitis in C57BL/6 mice

(2013) Cecile Delarasse et al.   IMMUNOLOGY

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

(2013) Daphne YS Vogel et al.   Journal of Neuroinflammation

Alpha-B-Crystallin Induces an Immune-Regulatory and Antiviral Microglial Response in Preactive Multiple Sclerosis Lesions

(2013) Malika Bsibsi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

How Do Immune Cells Support and Shape the Brain in Health, Disease, and Aging?

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Disease-modifying treatments for progressive multiple sclerosis

(2013) Giancarlo Comi   Multiple Sclerosis Journal

Microglia during development and aging

(2013) G. Jean Harry   PHARMACOLOGY & THERAPEUTICS

Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation

(2013) Wai T. Wong   Frontiers in Cellular Neuroscience

Rejuvenation of Regeneration in the Aging Central Nervous System

(2012) Julia M. Ruckh et al.   Cell Stem Cell

In Vitro and In Vivo Models of Multiple Sclerosis

(2012) Baukje J. van der Star et al.   CNS & Neurological Disorders-Drug Targets

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

(2012) Jack van Horssen et al.   Journal of Neuroinflammation

Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis

(2012) M. Tutuncu et al.   Multiple Sclerosis Journal

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

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The Aging Brain and Neurodegenerative Diseases

(2011) Gary W. Duncan   CLINICS IN GERIATRIC MEDICINE

Age and disability accumulation in multiple sclerosis

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Practical guide to the induction of relapsing progressive experimental autoimmune encephalomyelitis in the Biozzi ABH mouse

(2011) Sarah Al-Izki et al.   Multiple Sclerosis and Related Disorders

Dysregulated neuronal–microglial cross-talk during aging, stress and inflammation

(2010) Heidi A. Jurgens et al.   EXPERIMENTAL NEUROLOGY

Animal Research: Reporting In Vivo Experiments: The ARRIVE Guidelines

(2010) Carol Kilkenny et al.   JOURNAL OF GENE MEDICINE

αB-Crystallin Is a Target for Adaptive Immune Responses and a Trigger of Innate Responses in Preactive Multiple Sclerosis Lesions

(2010) Johannes M. van Noort et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Remyelination capacity of the MS brain decreases with disease chronicity

(2009) T. Goldschmidt et al.   NEUROLOGY

An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss

(2008) David W. Hampton et al.   JOURNAL OF NEUROIMMUNOLOGY