Peripheral proinflammatory Th1/Th17 immune cell shift is linked to disease severity in amyotrophic lateral sclerosis

ROCK-ALS: Protocol for a Randomized, Placebo-Controlled, Double-Blind Phase IIa Trial of Safety, Tolerability and Efficacy of the Rho Kinase (ROCK) Inhibitor Fasudil in Amyotrophic Lateral Sclerosis

(2019) Paul Lingor et al.   Frontiers in Neurology

Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial

(2018) Albert C Ludolph et al.   LANCET NEUROLOGY

Inflammation, Immunity, and ALS, Part II: Immune-modulating therapies

(2018) Marlena Wosiski-Kuhn et al.   MUSCLE & NERVE

Inflammation, Immunity and ALS: Etiology and Pathology

(2018) Miles Lyon et al.   MUSCLE & NERVE

A novel ligand on astrocytes interacts with natural cytotoxicity receptor NKp44 regulating immune response mediated by NK cells

(2018) Kelly E. Bowen et al.   PLoS One

Repeated Intrathecal Mesenchymal Stem Cells for Amyotrophic Lateral Sclerosis

(2018) Ki-Wook Oh et al.   ANNALS OF NEUROLOGY

Neuroinflammatory mechanisms in amyotrophic lateral sclerosis pathogenesis

(2018) Jason R. Thonhoff et al.   CURRENT OPINION IN NEUROLOGY

Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

(2017) Koji Abe et al.   LANCET NEUROLOGY

Comprehensive immune profiling reveals substantial immune system alterations in a subset of patients with amyotrophic lateral sclerosis

(2017) Michael P. Gustafson et al.   PLoS One

ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment?

(2017) Dmitry Petrov et al.   Frontiers in Aging Neuroscience

Correlation of Peripheral Immunity With Rapid Amyotrophic Lateral Sclerosis Progression

(2017) Benjamin J. Murdock et al.   JAMA Neurology

Evaluating the levels of CSF and serum factors in ALS

(2017) Jie Guo et al.   Brain and Behavior

Rho Kinase Inhibition with Fasudil in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis—Symptomatic Treatment Potential after Disease Onset

(2017) René Günther et al.   Frontiers in Pharmacology

Peripheral monocytes are functionally altered and invade the CNS in ALS patients

(2016) Lisa Zondler et al.   ACTA NEUROPATHOLOGICA

Human CD56brightNK Cells: An Update

(2016) Tatiana Michel et al.   JOURNAL OF IMMUNOLOGY

Th17 Cell Response inSOD1G93AMice following Motor Nerve Injury

(2016) Allen Ni et al.   MEDIATORS OF INFLAMMATION

Elevated Levels of IFN-γ in CSF and Serum of Patients with Amyotrophic Lateral Sclerosis

(2015) Juan Liu et al.   PLoS One

The immunomodulatory effects of human mesenchymal stem cells on peripheral blood mononuclear cells in ALS patients

(2014) Min-Soo Kwon et al.   JOURNAL OF NEUROCHEMISTRY

Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis

(2014) Paola Italiani et al.   Journal of Neuroinflammation

Evidence for peripheral immune activation in amyotrophic lateral sclerosis

(2014) Xueping Chen et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

T helper-17 activation dominates the immunologic milieu of both amyotrophic lateral sclerosis and progressive multiple sclerosis

(2013) Marina Saresella et al.   CLINICAL IMMUNOLOGY

Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis

(2013) Lars Tönges et al.   GLIA

Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis

(2013) Weihua Zhao et al.   Journal of Neuroimmune Pharmacology

Biomarker-Based Predictive Models for Prognosis in Amyotrophic Lateral Sclerosis

(2013) Xiaowei William Su et al.   JAMA Neurology

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival

(2012) Jenny S. Henkel et al.   EMBO Molecular Medicine

Elevated levels of IFNγ and LIGHT in the spinal cord of patients with sporadic amyotrophic lateral sclerosis

(2012) J. Aebischer et al.   EUROPEAN JOURNAL OF NEUROLOGY

Regulation of microglia development and homeostasis

(2012) Melanie Greter et al.   GLIA

Cytotoxicity of CD56bright NK Cells towards Autologous Activated CD4+ T Cells Is Mediated through NKG2D, LFA-1 and TRAIL and Dampened via CD94/NKG2A

(2012) Natasja Nielsen et al.   PLoS One

Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis

(2012) Johannes Brettschneider et al.   PLoS One

Alterations of T cell subsets in ALS: a systemic immune activation?

(2011) M. Rentzos et al.   ACTA NEUROLOGICA SCANDINAVICA

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

(2011) David R. Beers et al.   BRAIN

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

Innate and adaptive immunity in amyotrophic lateral sclerosis: Evidence of complement activation

(2011) M. Sta et al.   NEUROBIOLOGY OF DISEASE

Interleukin-17 and interleukin-23 are elevated in serum and cerebrospinal fluid of patients with ALS: a reflection of Th17 cells activation?

(2010) M. Rentzos et al.   ACTA NEUROLOGICA SCANDINAVICA

Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice

(2010) David R. Beers et al.   BRAIN BEHAVIOR AND IMMUNITY

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients

(2010) Milan Fiala et al.   Journal of Neuroinflammation

Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells

(2009) Cedric Auffray et al.   Annual Review of Immunology

Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process

(2009) Stefania Mantovani et al.   JOURNAL OF NEUROIMMUNOLOGY

Human natural killer cells

(2008) M. A. Caligiuri   BLOOD

TNF and sTNFR1/2 plasma levels in ALS patients

(2008) Cristina Cereda et al.   JOURNAL OF NEUROIMMUNOLOGY