Age-Associated Resident Memory CD8 T Cells in the Central Nervous System Are Primed To Potentiate Inflammation after Ischemic Brain Injury

Understanding the Role of T Cells in CNS Homeostasis

(2016) Erik Ellwardt et al.   TRENDS IN IMMUNOLOGY

Keeping your senescent cells under control

(2016) Lars Zender et al.   Aging-US

CXCL9 Is Important for Recruiting Immune T Cells into the Brain and Inducing an Accumulation of the T Cells to the Areas of Tachyzoite Proliferation to Prevent Reactivation of Chronic Cerebral Infection with Toxoplasma gondii

(2015) Eri Ochiai et al.   AMERICAN JOURNAL OF PATHOLOGY

The blood-brain barrier in neuroimmunology: Tales of separation and assimilation

(2015) W.A. Banks   BRAIN BEHAVIOR AND IMMUNITY

Interaction of astrocytes and T cells in physiological and pathological conditions

(2015) Luokun Xie et al.   BRAIN RESEARCH

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

(2015) Elizabeth M. Steinert et al.   CELL

An integrative view on sex differences in brain tumors

(2015) Tao Sun et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tissue-Resident Memory T Cells and Fixed Immune Surveillance in Nonlymphoid Organs

(2015) Francis R. Carbone   JOURNAL OF IMMUNOLOGY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions

(2015) Judith Agudo et al.   NATURE BIOTECHNOLOGY

The emerging role of resident memory T cells in protective immunity and inflammatory disease

(2015) Chang Ook Park et al.   NATURE MEDICINE

Age- and location-related changes in microglial function

(2015) Rodney M. Ritzel et al.   NEUROBIOLOGY OF AGING

Attenuation of microglial RANTES by NEMO-binding domain peptide inhibits the infiltration of CD8+ T cells in the nigra of hemiparkinsonian monkey

(2015) A. Roy et al.   NEUROSCIENCE

Resident memory T cells in human health and disease

(2015) R. A. Clark   Science Translational Medicine

Sex-based differences in immune function and responses to vaccination

(2015) S. L. Klein et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Emerging concepts in tissue-resident T cells: lessons from humans

(2015) Joseph J.C. Thome et al.   TRENDS IN IMMUNOLOGY

Senescent cells: SASPected drivers of age-related pathologies

(2014) Yossi Ovadya et al.   BIOGERONTOLOGY

Spatial Map of Human T Cell Compartmentalization and Maintenance over Decades of Life

(2014) Joseph J.C. Thome et al.   CELL

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

Relapsing-Remitting Central Nervous System Autoimmunity Mediated by GFAP-Specific CD8 T Cells

(2014) K. Sasaki et al.   JOURNAL OF IMMUNOLOGY

Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model

(2014) Emily Mills Ko et al.   Journal of Neuroinflammation

Intravascular staining for discrimination of vascular and tissue leukocytes

(2014) Kristin G Anderson et al.   Nature Protocols

Age-specific transcriptional response to stroke

(2014) Matthias W. Sieber et al.   NEUROBIOLOGY OF AGING

Ageing combines CD4 T cell lymphopenia in secondary lymphoid organs and T cell accumulation in gut associated lymphoid tissue

(2014) Kim Martinet et al.   Immunity & Ageing

Characteristics of differentiated CD8+ and CD4+ T cells present in the human brain

(2013) Joost Smolders et al.   ACTA NEUROPATHOLOGICA

Immunosurveillance of senescent cells: the bright side of the senescence program

(2013) Adi Sagiv et al.   BIOGERONTOLOGY

Brain antigen-reactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire

(2013) Ali Radjavi et al.   BRAIN BEHAVIOR AND IMMUNITY

Differential effects of aging and sex on stroke induced inflammation across the lifespan

(2013) Bharti Manwani et al.   EXPERIMENTAL NEUROLOGY

How Do Immune Cells Support and Shape the Brain in Health, Disease, and Aging?

(2013) M. Schwartz et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-Derived CXCL10 Drives Accumulation of Antibody-Secreting Cells in the Central Nervous System during Viral Encephalomyelitis

(2013) T. W. Phares et al.   JOURNAL OF VIROLOGY

Dynamics of the meningeal CD4+ T-cell repertoire are defined by the cervical lymph nodes and facilitate cognitive task performance in mice

(2013) A Radjavi et al.   MOLECULAR PSYCHIATRY

Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

(2013) Marie Orre et al.   NEUROBIOLOGY OF AGING

CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging

(2013) K. Baruch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunosurveillance as a regulator of tissue homeostasis

(2013) Laura Senovilla et al.   TRENDS IN IMMUNOLOGY

Adoptive regulatory T-cell therapy protects against cerebral ischemia

(2012) Peiying Li et al.   ANNALS OF NEUROLOGY

Memory T Cell Subsets, Migration Patterns, and Tissue Residence

(2012) Scott N. Mueller et al.   Annual Review of Immunology

Sex influences immune responses to viruses, and efficacy of prophylaxis and treatments for viral diseases

(2012) Sabra L. Klein   BIOESSAYS

Chemokines in CNS injury and repair

(2012) Anne Jaerve et al.   CELL AND TISSUE RESEARCH

Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets

(2012) Taheri Sathaliyawala et al.   IMMUNITY

Sex affects immunity

(2012) Leesa M. Pennell et al.   JOURNAL OF AUTOIMMUNITY

Cutting Edge: Intravascular Staining Redefines Lung CD8 T Cell Responses

(2012) K. G. Anderson et al.   JOURNAL OF IMMUNOLOGY

Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues

(2012) K. A. Casey et al.   JOURNAL OF IMMUNOLOGY

The Molecular Signature of Tissue Resident Memory CD8 T Cells Isolated from the Brain

(2012) L. M. Wakim et al.   JOURNAL OF IMMUNOLOGY

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

(2012) David H Cribbs et al.   Journal of Neuroinflammation

Interactions between age, sex, and hormones in experimental ischemic stroke

(2012) Fudong Liu et al.   NEUROCHEMISTRY INTERNATIONAL

Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen

(2012) S. Ariotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation

(2012) L. K. Mackay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skin Effector Memory T Cells Do Not Recirculate and Provide Immune Protection in Alemtuzumab-Treated CTCL Patients

(2012) R. A. Clark et al.   Science Translational Medicine

T Cell Recruitment in the Brain during Normal Aging

(2012) Jickssa M. Gemechu et al.   Frontiers in Cellular Neuroscience

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

(2011) David R. Beers et al.   BRAIN

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype

(2011) Antero Salminen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue

(2011) C. N. Lumeng et al.   JOURNAL OF IMMUNOLOGY

Attenuated Inflammatory Response in Aged Mice Brains following Stroke

(2011) Matthias W. Sieber et al.   PLoS One

Neuroprotective activities of regulatory T cells

(2011) Howard E. Gendelman et al.   TRENDS IN MOLECULAR MEDICINE

Immunological Variation Between Inbred Laboratory Mouse Strains

(2011) R. S. Sellers et al.   VETERINARY PATHOLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

CXCR3 blockade inhibits T-cell migration into the CNS during EAE and prevents development of adoptively transferred, but not actively induced, disease

(2010) Romeo Sporici et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of learning and memory by meningeal immunity: a key role for IL-4

(2010) Noël C. Derecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke

(2010) Kristian P Doyle et al.   Journal of Neuroinflammation

Chronic Systemic Infection Exacerbates Ischemic Brain Damage via a CCL5 (Regulated on Activation, Normal T-Cell Expressed and Secreted)-Mediated Proinflammatory Response in Mice

(2010) A. Denes et al.   JOURNAL OF NEUROSCIENCE

Immune surveillance of the normal human CNS takes place in dependence of the locoregional blood-brain barrier configuration and is mainly performed by CD3+/CD8+ lymphocytes

(2010) Christian Loeffler et al.   NEUROPATHOLOGY

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence

(2010) L. M. Wakim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An antibody to IP-10 is a potent antagonist of cell migrationin vitroandin vivoand does not affect disease in several animal models of inflammation

(2009) Fergus R. Byrne et al.   AUTOIMMUNITY

Regulation of cytokine signaling and T-cell recruitment in the aging mouse brain in response to central inflammatory challenge

(2009) Yuan-Zhong Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

SASP reflects senescence

(2009) Andrew R J Young et al.   EMBO REPORTS

Chemokines and Chemokine Receptors: Standing at the Crossroads of Immunobiology and Neurobiology

(2009) Richard M. Ransohoff   IMMUNITY

Changes in Experimental Stroke Outcome across the Life Span

(2009) Fudong Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

De Novo Recruitment of Antigen-Experienced and Naive T Cells Contributes to the Long-Term Maintenance of Antiviral T Cell Populations in the Persistently Infected Central Nervous System

(2009) J. Zhao et al.   JOURNAL OF IMMUNOLOGY

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

(2009) Thomas Gebhardt et al.   NATURE IMMUNOLOGY

IP-10-Mediated T Cell Homing Promotes Cerebral Inflammation over Splenic Immunity to Malaria Infection

(2009) Catherine Q. Nie et al.   PLoS Pathogens

Sex Differences in Autoimmune Disease from a Pathological Perspective

(2008) DeLisa Fairweather et al.   AMERICAN JOURNAL OF PATHOLOGY

Lymphoid neogenesis and immune infiltration in aged liver

(2008) Pallavi Singh et al.   HEPATOLOGY

T Cells' Immunological Synapses Induce Polarization of Brain Astrocytes In Vivo and In Vitro: A Novel Astrocyte Response Mechanism to Cellular Injury

(2008) Carlos Barcia et al.   PLoS One

Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria

(2008) G. S. V. Campanella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA