Aging of the immune system: Focus on inflammation and vaccination

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Coordinated expansion of both memory T cells and NK cells in response to CMV infection in humans

(2016) Charles Bayard et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Obesity decreases B cell responses in young and elderly individuals

(2016) Daniela Frasca et al.   Obesity

Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomy

(2016) Manuela Zlamy et al.   Immunity & Ageing

Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors

(2015) Talibah U. Metcalf et al.   AGING CELL

Reduced naïve CD8+T-cell priming efficacy in elderly adults

(2015) Olivia Briceño et al.   AGING CELL

The stimulatory effect of the TLR4-mediated adjuvant glucopyranosyl lipid A is well preserved in old age

(2015) Birgit Weinberger et al.   BIOGERONTOLOGY

Inflammaging decreases adaptive and innate immune responses in mice and humans

(2015) Daniela Frasca et al.   BIOGERONTOLOGY

DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia

(2015) A. Bignon et al.   BLOOD

Modelling estimates of the burden of Respiratory Syncytial virus infection in adults and the elderly in the United Kingdom

(2015) Douglas M. Fleming et al.   BMC INFECTIOUS DISEASES

The Impact of Age on the Efficacy of 13-valent Pneumococcal Conjugate Vaccine in Elderly

(2015) Cornelis H. van Werkhoven et al.   CLINICAL INFECTIOUS DISEASES

Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8+T-cell proliferation by distinct pathways

(2015) Sian M. Henson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Aging affects B-cell antigen receptor repertoire diversity in primary and secondary lymphoid tissues

(2015) Hilla Tabibian-Keissar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures

(2015) Helder I. Nakaya et al.   IMMUNITY

Low Thymic Activity and Dendritic Cell Numbers Are Associated with the Immune Response to Primary Viral Infection in Elderly Humans

(2015) Axel Ronald Schulz et al.   JOURNAL OF IMMUNOLOGY

Paradoxical changes in innate immunity in aging: recent progress and new directions

(2015) Ruth R. Montgomery et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Narrowing of Human Influenza A Virus-Specific T Cell Receptor α and β Repertoires with Increasing Age

(2015) Anna Gil et al.   JOURNAL OF VIROLOGY

Responses of Dendritic Cells to TLR-4 Stimulation Are Maintained in the Elderly and Resist the Effects of CMV Infection Seen in the Young

(2015) Nicole Janssen et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults

(2015) Himal Lal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polysaccharide Conjugate Vaccine against Pneumococcal Pneumonia in Adults

(2015) Marc J.M. Bonten et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine

(2015) Daniela Frasca et al.   VACCINE

Aging, cytomegalovirus (CMV) and influenza vaccine responses

(2015) Daniela Frasca et al.   Human Vaccines & Immunotherapeutics

Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection

(2015) Justin M. Richner et al.   PLoS Pathogens

Blood Monocytes and Their Subsets: Established Features and Open Questions

(2015) Loems Ziegler-Heitbrock   Frontiers in Immunology

TCR-Signaling Events in Cellular Metabolism and Specialization

(2015) Danielle A. Chisolm et al.   Frontiers in Immunology

Cellular signalling pathways in immune aging and regeneration: Figure 1

(2014) Richard Aspinall et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

You Are What You Host: Microbiome Modulation of the Aging Process

(2014) Caroline Heintz et al.   CELL

Spatial Map of Human T Cell Compartmentalization and Maintenance over Decades of Life

(2014) Joseph J.C. Thome et al.   CELL

Downregulation of inhibitory SRC Homology 2 Domain-containing Phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly

(2014) Aurélie Le Page et al.   Cell Communication and Signaling

Cellular signaling in the aging immune system

(2014) Tamas Fulop et al.   CURRENT OPINION IN IMMUNOLOGY

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Plasma cell numbers decrease in bone marrow of old patients

(2014) Theresa Pritz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

(2014) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

High TNF-α levels in resting B cells negatively correlate with their response

(2014) Daniela Frasca et al.   EXPERIMENTAL GERONTOLOGY

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells

(2014) D. Frasca et al.   JOURNAL OF IMMUNOLOGY

Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling

(2014) O. V. Britanova et al.   JOURNAL OF IMMUNOLOGY

Enhancement of Adaptive Immunity by the Human Vaccine Adjuvant AS01 Depends on Activated Dendritic Cells

(2014) Arnaud M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

(2014) Alessio Lanna et al.   NATURE IMMUNOLOGY

Diversity and clonal selection in the human T-cell repertoire

(2014) Q. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

Obesity-induced chronic inflammation is associated with the reduced efficacy of influenza vaccine

(2014) Hye-Lim Park et al.   Human Vaccines & Immunotherapeutics

Autophagy is a critical regulator of memory CD8+ T cell formation

(2014) Daniel J Puleston et al.   eLife

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

(2013) E. Sapey et al.   BLOOD

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs

(2013) V. Beziat et al.   BLOOD

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

From “truly naïve” to “exhausted senescent” T cells: When markers predict functionality

(2013) Anis Larbi et al.   CYTOMETRY PART A

Differential activation of CD57-defined natural killer cell subsets during recall responses to vaccine antigens

(2013) Matthew J. White et al.   IMMUNOLOGY

Differential Impact of Age and Cytomegalovirus Infection on the    T Cell Compartment

(2013) A. Roux et al.   JOURNAL OF IMMUNOLOGY

Reduced Neutrophil Chemotaxis and Infiltration Contributes to Delayed Resolution of Cutaneous Wound Infection with Advanced Age

(2013) A. L. Brubaker et al.   JOURNAL OF IMMUNOLOGY

Age-Associated Increase of Low-Avidity Cytomegalovirus-Specific CD8+ T Cells That Re-Express CD45RA

(2013) S. J. Griffiths et al.   JOURNAL OF IMMUNOLOGY

Safety and Immunogenicity of an AS01-adjuvanted Varicella-zoster Virus Subunit Candidate Vaccine Against Herpes Zoster in Adults >=50 Years of Age

(2013) R. Chlibek et al.   JOURNAL OF INFECTIOUS DISEASES

Recall Responses to Tetanus and Diphtheria Vaccination Are Frequently Insufficient in Elderly Persons

(2013) Birgit Weinberger et al.   PLoS One

Lineage Structure of the Human Antibody Repertoire in Response to Influenza Vaccination

(2013) N. Jiang et al.   Science Translational Medicine

Cochrane re-arranged: Support for policies to vaccinate elderly people against influenza

(2013) Walter E.P. Beyer et al.   VACCINE

The path to an RSV vaccine

(2013) Christine A Shaw et al.   Current Opinion in Virology

Age-associated alterations in γδ T-cells are present predominantly in individuals infected with Cytomegalovirus

(2013) Kilian Wistuba-Hamprecht et al.   Immunity & Ageing

Effects of age on H1N1-specific serum IgG1 and IgG3 levels evaluated during the 2011–2012 influenza vaccine season

(2013) Daniela Frasca et al.   Immunity & Ageing

Exercise and the aging immune system

(2012) Richard J. Simpson et al.   AGEING RESEARCH REVIEWS

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

(2012) Anna C. Hearps et al.   AGING CELL

Free radicals and redox signalling in T-cells during chronic inflammation and ageing: Figure 1

(2012) Helen R. Griffiths et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Inflamm-ageing

(2012) Elisa Cevenini et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Unique biomarkers for B-cell function predict the serum response to pandemic H1N1 influenza vaccine

(2012) D. Frasca et al.   INTERNATIONAL IMMUNOLOGY

Lymphopenia-Driven Homeostatic Regulation of Naive T Cells in Elderly and Thymectomized Young Adults

(2012) D. Sauce et al.   JOURNAL OF IMMUNOLOGY

A Phase 1/2 Clinical Trial Evaluating Safety and Immunogenicity of a Varicella Zoster Glycoprotein E Subunit Vaccine Candidate in Young and Older Adults

(2012) Isabel Leroux-Roels et al.   JOURNAL OF INFECTIOUS DISEASES

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

Innate Immune Dysfunctions in Aged Mice Facilitate the Systemic Dissemination of Methicillin-Resistant S. aureus

(2012) Ching Wen Tseng et al.   PLoS One

Signaling pathways in aged T cells – A reflection of T cell differentiation, cell senescence and host environment

(2012) Jörg J. Goronzy et al.   SEMINARS IN IMMUNOLOGY

Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

(2012) Rafael Solana et al.   SEMINARS IN IMMUNOLOGY

The importance of pertussis in older adults: A growing case for reviewing vaccination strategy in the elderly

(2012) Iman Ridda et al.   VACCINE

The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines

(2012) Janet E. McElhaney et al.   VACCINE

Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination

(2012) Evelyna Derhovanessian et al.   VACCINE

AID Activity in B Cells Strongly Correlates with Polyclonal Antibody Affinity Maturation in-vivo Following Pandemic 2009-H1N1 Vaccination in Humans

(2012) Surender Khurana et al.   PLoS Pathogens

Ageing of the human metaorganism: the microbial counterpart

(2011) Elena Biagi et al.   AGE

Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages

(2011) Alexander Ademokun et al.   AGING CELL

Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly

(2011) Feng Qian et al.   AGING CELL

Immunoaging induced by hematopoietic stem cell aging

(2011) Jianwei Wang et al.   CURRENT OPINION IN IMMUNOLOGY

Decreased expression of DNAM-1 on NK cells from acute myeloid leukemia patients

(2011) Beatriz Sanchez-Correa et al.   IMMUNOLOGY AND CELL BIOLOGY

Human NK Cells Proliferate and Die In Vivo More Rapidly than T Cells in Healthy Young and Elderly Adults

(2011) C. T. Lutz et al.   JOURNAL OF IMMUNOLOGY

Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue

(2011) C. N. Lumeng et al.   JOURNAL OF IMMUNOLOGY

Reversible Senescence in Human CD4+CD45RA+CD27- Memory T Cells

(2011) D. Di Mitri et al.   JOURNAL OF IMMUNOLOGY

Immunosenescence of Human Natural Killer Cells

(2011) Inmaculada Gayoso et al.   Journal of Innate Immunity

Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis

(2011) Michael T Osterholm et al.   LANCET INFECTIOUS DISEASES

Expansion of a unique CD57+NKG2Chi natural killer cell subset during acute human cytomegalovirus infection

(2011) S. Lopez-Verges et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frailty is associated with impairment of vaccine-induced antibody response and increase in post-vaccination influenza infection in community-dwelling older adults

(2011) Xu Yao et al.   VACCINE

Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans

(2011) Xin Zhou et al.   VACCINE

Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity

(2010) Aishwarya Sridharan et al.   AGE

Cell resilience in species life spans: a link to inflammation?

(2010) Caleb E. Finch et al.   AGING CELL

Human NK cells display major phenotypic and functional changes over the life span

(2010) Magali Le Garff-Tavernier et al.   AGING CELL

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education

(2010) N. K. Bjorkstrom et al.   BLOOD

T Cell Homeostasis in Centenarians: From the Thymus to the Periphery

(2010) M. Pinti et al.   CURRENT PHARMACEUTICAL DESIGN

Flagellin as an Adjuvant: Cellular Mechanisms and Potential

(2010) S. B. Mizel et al.   JOURNAL OF IMMUNOLOGY

Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response

(2010) Alexander Panda et al.   JOURNAL OF IMMUNOLOGY

Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

(2010) Elena Biagi et al.   PLoS One

CD56 negative NK cells: origin, function, and role in chronic viral disease

(2010) Niklas K. Björkström et al.   TRENDS IN IMMUNOLOGY

Antibody response against heterogeneous circulating influenza virus strains elicited by MF59- and non-adjuvanted vaccines during seasons with good or partial matching between vaccine strain and clinical isolates

(2010) Filippo Ansaldi et al.   VACCINE

Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans

(2010) Daniela Frasca et al.   VACCINE

The ageing B cell population: Composition and function

(2009) Alexander Ademokun et al.   BIOGERONTOLOGY

Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood

(2009) Yu Jing et al.   HUMAN IMMUNOLOGY

Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype

(2009) Koji Ohashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence of premature immune aging in patients thymectomized during early childhood

(2009) Delphine Sauce et al.   JOURNAL OF CLINICAL INVESTIGATION

Randomized, Double‐Blind Controlled Phase 3 Trial Comparing the Immunogenicity of High‐Dose and Standard‐Dose Influenza Vaccine in Adults 65 Years of Age and Older

(2009) Ann R. Falsey et al.   JOURNAL OF INFECTIOUS DISEASES

A double-negative (IgD−CD27−) B cell population is increased in the peripheral blood of elderly people

(2009) Giuseppina Colonna-Romano et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

An evolutionary perspective on the mechanisms of immunosenescence

(2009) Daryl P. Shanley et al.   TRENDS IN IMMUNOLOGY

B-cell diversity decreases in old age and is correlated with poor health status

(2008) Kate L. Gibson et al.   AGING CELL

Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets

(2008) S. Kohler et al.   BLOOD

Age-Related Changes in Eosinophil Function in Human Subjects

(2008) Sameer K. Mathur et al.   CHEST

Intradermal Influenza Vaccine Administered Using a New Microinjection System Produces Superior Immunogenicity in Elderly Adults: A Randomized Controlled Trial

(2008) David Holland et al.   JOURNAL OF INFECTIOUS DISEASES

Neutrophils of Centenarians Show Function Levels Similar to Those of Young Adults

(2008) Patricia Alonso-Fernández et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

NK cells and cancer immunosurveillance

(2008) I Waldhauer et al.   ONCOGENE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY