Counteracting roles of MHCI and CD8+ T cells in the peripheral and central nervous system of ALS SOD1G93A mice

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes

(2018) Okiru Komine et al.   CELL DEATH AND DIFFERENTIATION

Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications

(2018) Ruth Chia et al.   LANCET NEUROLOGY

The Emerging Role of the Major Histocompatibility Complex Class I in Amyotrophic Lateral Sclerosis

(2017) Gabriela Chiarotto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

(2017) Srikant Rangaraju et al.   Journal of Neuroinflammation

Immune Modulation in the Treatment of Amyotrophic Lateral Sclerosis: A Review of Clinical Trials

(2017) Syed I. Khalid et al.   Frontiers in Neurology

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

New Insights on the Mechanisms of Disease Course Variability in ALS from Mutant SOD1 Mouse Models

(2016) Giovanni Nardo et al.   BRAIN PATHOLOGY

Axonal degeneration, distal collateral branching and neuromuscular junction architecture alterations occur prior to symptom onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis

(2016) Jayden A. Clark et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Immune response in peripheral axons delays disease progression in SOD1G93A mice

(2016) Giovanni Nardo et al.   Journal of Neuroinflammation

The repair Schwann cell and its function in regenerating nerves

(2016) K. R. Jessen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis

(2016) SungWon Song et al.   NATURE MEDICINE

Enhanced Immune Response in Immunodeficient Mice Improves Peripheral Nerve Regeneration Following Axotomy

(2016) André L. Bombeiro et al.   Frontiers in Cellular Neuroscience

Major Histocompatibility Complex I Expression by Motor Neurons and Its Implication in Amyotrophic Lateral Sclerosis

(2016) Giovanni Nardo et al.   Frontiers in Neurology

Differences in protein quality control correlate with phenotype variability in 2 mouse models of familial amyotrophic lateral sclerosis

(2015) Marianna Marino et al.   NEUROBIOLOGY OF AGING

SOX10 Transactivates S100B to Suppress Schwann Cell Proliferation and to Promote Myelination

(2014) Sayaka Fujiwara et al.   PLoS One

Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinson’s and other brain diseases

(2014) Carolina Cebrián et al.   Frontiers in Neuroanatomy

The high molecular weight neurofilament subunit plays an essential role in axonal outgrowth and stabilization

(2014) S. Lee et al.   Biology Open

Rodent models of amyotrophic lateral sclerosis

(2013) Philip McGoldrick et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Axonal outgrowth is associated with increased ERK 1/2 activation but decreased caspase 3 linked cell death in Schwann cells after immediate nerve repair in rats

(2013) Yoshifumi Tsuda et al.   BMC NEUROSCIENCE

Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis

(2013) Giovanni Nardo et al.   BRAIN

Efficiently stimulated adult microglia cross-prime naive CD8+T cells injected in the brain

(2013) Ulrich Jarry et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis

(2013) Weihua Zhao et al.   Journal of Neuroimmune Pharmacology

Axonal Regeneration after Sciatic Nerve Lesion Is Delayed but Complete in GFAP- and Vimentin-Deficient Mice

(2013) Alexander Berg et al.   PLoS One

Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis

(2013) Kim A. Staats et al.   Frontiers in Cellular Neuroscience

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

Molecular Signatures of Amyotrophic Lateral Sclerosis Disease Progression in Hind and Forelimb Muscles of an SOD1G93A Mouse Model

(2012) Daniele Capitanio et al.   ANTIOXIDANTS & REDOX SIGNALING

Subcellular Knockout of Importin β1 Perturbs Axonal Retrograde Signaling

(2012) Rotem Ben-Tov Perry et al.   NEURON

Early Functional Deficit and Microglial Disturbances in a Mouse Model of Amyotrophic Lateral Sclerosis

(2012) Yannick Nicolas Gerber et al.   PLoS One

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

(2011) David R. Beers et al.   BRAIN

The Role of Immune and Inflammatory Mechanisms in ALS

(2011) P. A. McCombe et al.   CURRENT MOLECULAR MEDICINE

Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury

(2011) Andrew D Gaudet et al.   Journal of Neuroinflammation

Innate and adaptive immunity in amyotrophic lateral sclerosis: Evidence of complement activation

(2011) M. Sta et al.   NEUROBIOLOGY OF DISEASE

Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: Implication for protein aggregation and immune response

(2011) Caterina Bendotti et al.   PROGRESS IN NEUROBIOLOGY

Muscle atrophy induced by SOD1G93A expression does not involve the activation of caspase in the absence of denervation

(2011) Gabriella Dobrowolny et al.   Skeletal Muscle

Guidelines for preclinical animal research in ALS/MND: A consensus meeting

(2010) Albert C. Ludolph et al.   Amyotrophic Lateral Sclerosis

Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice

(2010) David R. Beers et al.   BRAIN BEHAVIOR AND IMMUNITY

Live imaging of amyotrophic lateral sclerosis pathogenesis: Disease onset is characterized by marked induction of GFAP in Schwann cells

(2009) A. Florence Keller et al.   GLIA

Classical Major Histocompatibility Complex Class I Molecules in Motoneurons: New Actors at the Neuromuscular Junction

(2009) S. Thams et al.   JOURNAL OF NEUROSCIENCE

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice

(2009) I. M. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gamma and alpha motor neurons distinguished by expression of transcription factor Err3

(2009) A. Friese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

(2009) Stanley H. Appel et al.   TRENDS IN IMMUNOLOGY

T cells in amyotrophic lateral sclerosis

(2008) T. Holmøy   EUROPEAN JOURNAL OF NEUROLOGY

Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis†

(2008) Cristina Cheroni et al.   HUMAN MOLECULAR GENETICS

The biology of CNS remyelination

(2008) Robin J. M. Franklin et al.   JOURNAL OF NEUROLOGY

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

(2008) D. R. Beers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS

(2008) I. M. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neonatal and adult microglia cross-present exogenous antigens

(2007) Celine Beauvillain et al.   GLIA