A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice

Cutting Edge: The Aging Immune System Reveals the Biological Impact of Direct Antigen Presentation on CD8 T Cell Responses

(2017) Jennifer L. Uhrlaub et al.   JOURNAL OF IMMUNOLOGY

T Cell Receptor Cross-Reactivity between Similar Foreign and Self Peptides Influences Naive Cell Population Size and Autoimmunity

(2015) Ryan W. Nelson et al.   IMMUNITY

Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection

(2015) Justin M. Richner et al.   PLoS Pathogens

Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged mice

(2015) Neha R Deshpande et al.   eLife

Revisiting Thymic Positive Selection and the Mature T Cell Repertoire for Antigen

(2014) Nienke Vrisekoop et al.   IMMUNITY

West Nile Virus-Specific CD4 T Cells Exhibit Direct Antiviral Cytokine Secretion and Cytotoxicity and Are Sufficient for Antiviral Protection

(2014) J. D. Brien et al.   JOURNAL OF IMMUNOLOGY

Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC

(2014) Stephen P Persaud et al.   NATURE IMMUNOLOGY

Ageing combines CD4 T cell lymphopenia in secondary lymphoid organs and T cell accumulation in gut associated lymphoid tissue

(2014) Kim Martinet et al.   Immunity & Ageing

Impact of aging on antigen presentation cell function of dendritic cells

(2013) Christine Wong et al.   CURRENT OPINION IN IMMUNOLOGY

T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens

(2013) Judith N. Mandl et al.   IMMUNITY

Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium

(2012) Gang Li et al.   AGING CELL

Defective CD8 T Cell Responses in Aged Mice Are Due to Quantitative and Qualitative Changes in Virus-Specific Precursors

(2012) V. Decman et al.   JOURNAL OF IMMUNOLOGY

Lifelong Persistent Viral Infection Alters the Naive T Cell Pool, Impairing CD8 T Cell Immunity in Late Life

(2012) M. J. Smithey et al.   JOURNAL OF IMMUNOLOGY

Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice

(2011) Megan J. Smithey et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Repeated In Vivo Stimulation of T and B Cell Responses in Old Mice Generates Protective Immunity against Lethal West Nile Virus Encephalitis

(2011) Jennifer L. Uhrlaub et al.   JOURNAL OF IMMUNOLOGY

Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions

(2011) B. D. Rudd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity of the CD8+ T Cell Repertoire Elicited against an Immunodominant Epitope Does Not Depend on the Context of Infection

(2010) B. D. Rudd et al.   JOURNAL OF IMMUNOLOGY

Effects of aging on T cell function

(2009) Laura Haynes et al.   CURRENT OPINION IN IMMUNOLOGY

Key role of T cell defects in age-related vulnerability to West Nile virus

(2009) James D. Brien et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selective Priming and Expansion of Antigen-Specific Foxp3-CD4+ T Cells during Listeria monocytogenes Infection

(2009) J. M. Ertelt et al.   JOURNAL OF IMMUNOLOGY

T-cell immunosenescence: lessons learned from mouse models of aging

(2009) Alexander C. Maue et al.   TRENDS IN IMMUNOLOGY

Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus

(2008) Eric J. Yager et al.   JOURNAL OF EXPERIMENTAL MEDICINE