Health-promoting role of dietary bioactive compounds through epigenetic modulations: a novel prophylactic and therapeutic approach

Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming

(2020) Dominic G. Roy et al.   Cell Metabolism

Curcumin induces re‑expression of BRCA1 and suppression of γ synuclein by modulating DNA promoter methylation in breast cancer cell lines

(2020) Nujoud Al‑Yousef et al.   ONCOLOGY REPORTS

Coenzyme Q10: Clinical Applications in Cardiovascular Diseases

(2020) Alma Martelli et al.   Antioxidants

EGCG Attenuates Renal Damage via Reversing Klotho Hypermethylation in Diabetic db/db Mice and HK-2 Cells

(2020) Xiu Hong Yang et al.   Oxidative Medicine and Cellular Longevity

Dietary Compounds as Epigenetic Modulating Agents in Cancer

(2019) Ángeles Carlos-Reyes et al.   Frontiers in Genetics

Histone H1, the forgotten histone

(2019) Kevin Brockers et al.   Epigenomics

Klotho recovery by genistein via promoter histone acetylation and DNA demethylation mitigates renal fibrosis in mice

(2019) Yanning Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

(2019) Julie Schulthess et al.   IMMUNITY

Quercetin based derivatives as sirtuin inhibitors

(2019) Vladimír Heger et al.   BIOMEDICINE & PHARMACOTHERAPY

Probiotic lactobacilli mediated changes in global epigenetic signatures of human intestinal epithelial cells during Escherichia coli challenge

(2019) Mohd Iqbal Bhat et al.   ANNALS OF MICROBIOLOGY

Genistein reverses isoproterenol-induced cardiac hypertrophy by regulating miR-451/TIMP2

(2019) Mailin Gan et al.   BIOMEDICINE & PHARMACOTHERAPY

Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms

(2019) Raphael J. F. Felizardo et al.   FASEB JOURNAL

Resveratrol up-regulates ATP2A3 gene expression in breast cancer cell lines through epigenetic mechanisms

(2019) Eduardo Izquierdo-Torres et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Potent antitumor activity of Laccaic acid and Phenethyl isothiocyanate combination in colorectal cancer via dual inhibition of DNA methyltransferase-1 and Histone deacetylase-1

(2019) Riya Gupta et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Berberine improves insulin resistance in adipocyte models by regulating the methylation of hypoxia-inducible factor-3α

(2019) Yuanli Wang et al.   BIOSCIENCE REPORTS

The effects and mechanisms of epigallocatechin-3-gallate on reversing multidrug resistance in cancer

(2019) Wenji Zhang et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation

(2018) Simona Bo et al.   ACTA DIABETOLOGICA

Resveratrol strongly enhances the retinoic acid-induced superoxide generating activity via up-regulation of gp91-phox gene expression in U937 cells

(2018) Hidehiko Kikuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The protective role of all-transretinoic acid (ATRA) against colorectal cancer development is achieved via increasing miR-3666 expression and decreasing E2F7 expression

(2018) Weihong Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

TET1-mediated hypomethylation activates oncogenic signaling in triple-negative breast cancer

(2018) Charly Ryan Good et al.   CANCER RESEARCH

DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice

(2018) Yue Guo et al.   CARCINOGENESIS

Coenzyme Q10: From bench to clinic in aging diseases, a translational review

(2018) Francisco M. Gutierrez-Mariscal et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer's disease

(2018) Fangfang Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation

(2018) Bidisha Paul et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Buffalo Milk Casein Derived Decapeptide (YQEPVLGPVR) Having Bifunctional Anti-inflammatory and Antioxidative Features Under Cellular Milieu

(2018) Kandukuri Sowmya et al.   International Journal of Peptide Research and Therapeutics

Fatty liver mediated by peroxisome proliferator-activated receptor-α DNA methylation can be reversed by a methylation inhibitor and curcumin

(2018) Yu Yuan Li et al.   Journal of Digestive Diseases

Riboflavin attenuates myocardial injury via LSD1-mediated crosstalk between phospholipid metabolism and histone methylation in mice with experimental myocardial infarction

(2018) Peng Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Metabolomics Analysis Reveals that Ethylene and Methyl Jasmonate Regulate Different Branch Pathways to Promote the Accumulation of Terpenoid Indole Alkaloids in Catharanthus roseus

(2018) Xiao-Ning Zhang et al.   JOURNAL OF NATURAL PRODUCTS

Modulation of dietary folate with age confers selective hepatocellular epigenetic imprints through DNA methylation

(2018) Rauf Ahmad Najar et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

α-Tocopherol influences glycaemic control and miR-9-3 DNA methylation in overweight and obese women under an energy-restricted diet: a randomized, double-blind, exploratory, controlled clinical trial

(2018) Rafaella Cristhine Pordeus Luna et al.   Nutrition & Metabolism

Counteraction of Oxidative Stress by Vitamin E Affects Epigenetic Regulation by Increasing Global Methylation and Gene Expression of MLH1 and DNMT1 Dose Dependently in Caco-2 Cells

(2018) Katja Zappe et al.   Oxidative Medicine and Cellular Longevity

Curcumin Modulates DNA Methyltransferase Functions in a Cellular Model of Diabetic Retinopathy

(2018) Andrea Maugeri et al.   Oxidative Medicine and Cellular Longevity

Dietary isoflavones, the modulator of breast carcinogenesis: Current landscape and future perspectives

(2018) Javed Iqbal et al.   Asian Pacific Journal of Tropical Medicine

S-allylcysteine suppresses ovarian cancer cell proliferation by DNA methylation through DNMT1

(2018) Yasi Xu et al.   Journal of Ovarian Research

Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer

(2018) Ding Peng et al.   Clinical Epigenetics

Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer

(2018) Xinqiang Wu et al.   Journal of Cancer

The Administration of Escherichia coli Nissle 1917 Ameliorates Development of DSS-Induced Colitis in Mice

(2018) Alba Rodríguez-Nogales et al.   Frontiers in Pharmacology

Coenzyme Q10 Supplementation in Aging and Disease

(2018) Juan D. Hernández-Camacho et al.   Frontiers in Physiology

Combinational Proanthocyanidins and Resveratrol Synergistically Inhibit Human Breast Cancer Cells and Impact Epigenetic–Mediating Machinery

(2018) Yifeng Gao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigallocatechin-3-gallate inhibited cancer stem cell-like properties by targeting hsa-mir-485-5p/RXRα in lung cancer

(2018) Pan Jiang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells

(2018) Christian Gerecke et al.   Oncotarget

Curcumin restores hepatic epigenetic changes in propylthiouracil(PTU) Induced hypothyroid male rats: A study on DNMTs, MBDs, GADD45a, C/EBP-β and PCNA

(2018) Suresh Kumar Bunker et al.   FOOD AND CHEMICAL TOXICOLOGY

The polyphenol quercetin induces cell death in leukemia by targeting epigenetic regulators of pro-apoptotic genes

(2018) Marisa Claudia Alvarez et al.   Clinical Epigenetics

Effects of SAHA and EGCG on Growth Potentiation of Triple-Negative Breast Cancer Cells

(2018) Kayla Lewis et al.   Cancers

Regulation of MicroRNAs by Natural Products and Bioactive Compounds Obtained From Common Medicinal Plants: Novel Strategy in Cancer Therapy

(2017) Sevgi Gezici et al.   Indian Journal of Pharmaceutical Education and Research

Genistein Protects Against Ox-LDL-Induced Inflammation Through MicroRNA-155/SOCS1-Mediated Repression of NF-ĸB Signaling Pathway in HUVECs

(2017) Huaping Zhang et al.   INFLAMMATION

Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway

(2017) Haiming Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Vitamin C down-regulate apo(a) expression via Tet2-dependent DNA demethylation in HepG2 cells

(2017) Kai Qu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells

(2017) Kendra Royston et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigallocatechin gallate reverses cTnI-low expression-induced age-related heart diastolic dysfunction through histone acetylation modification

(2017) Bo Pan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer

(2017) Laura M. Beaver et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A naturally occurring mixture of tocotrienols inhibits the growth of human prostate tumor, associated with epigenetic modifications of cyclin-dependent kinase inhibitors p21 and p27

(2017) Ying Huang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction

(2017) Chia-Ming Liu et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

The DNA methyltransferase family: a versatile toolkit for epigenetic regulation

(2017) Frank Lyko   NATURE REVIEWS GENETICS

Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals

(2017) Mohd Iqbal Bhat et al.   NUTRITION REVIEWS

Retinoic acid directs breast cancer cell state changes through regulation of TET2-PKCζ pathway

(2017) M-J Wu et al.   ONCOGENE

SIRT6: Novel Mechanisms and Links to Aging and Disease

(2017) Luisa Tasselli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Reversal of hypermethylation and reactivation of glutathione S-transferase pi 1 gene by curcumin in breast cancer cell line

(2017) Umesh Kumar et al.   TUMOR BIOLOGY

Use of potential dietary phytochemicals to target miRNA: Promising option for breast cancer prevention and treatment?

(2017) Md. Abu Sayeed et al.   Journal of Functional Foods

Soft-shelled turtle peptide modulates microRNA profile in human gastric cancer AGS cells

(2017) Yi‑Chen Wu et al.   Oncology Letters

Vitamin E Modifies High-Fat Diet-Induced Increase of DNA Strand Breaks, and Changes in Expression and DNA Methylation of Dnmt1 and MLH1 in C57BL/6J Male Mice

(2017) Marlene Remely et al.   Nutrients

Quercetin delays postovulatory aging of mouse oocytes by regulating SIRT expression and MPF activity

(2017) HaiYang Wang et al.   Oncotarget

Neuroprotective Functions for the Histone Deacetylase SIRT6

(2017) Shai Kaluski et al.   Cell Reports

Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens

(2017) Urban Alehagen et al.   PLoS One

Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers

(2017) Jung Eun Park et al.   Scientific Reports

Sulforaphane suppresses in vitro and in vivo lung tumorigenesis through downregulation of HDAC activity

(2016) Li-Li Jiang et al.   BIOMEDICINE & PHARMACOTHERAPY

Potential role of bioactive peptides in prevention and treatment of chronic diseases: a narrative review

(2016) Arrigo F G Cicero et al.   BRITISH JOURNAL OF PHARMACOLOGY

The epigenetic role of vitamin C in health and disease

(2016) Vladimir Camarena et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sodium Butyrate Upregulates miR-203 Expression to Exert Anti-Proliferation Effect on Colorectal Cancer Cells

(2016) Ruirui Han et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Berberine: New Insights from Pharmacological Aspects to Clinical Evidences in the Management of Metabolic Disorders

(2016) Cristiana Caliceti et al.   CURRENT MEDICINAL CHEMISTRY

Detection of long non-coding RNAs in human breastmilk extracellular vesicles: Implications for early child development

(2016) Oskar Karlsson et al.   Epigenetics

Milk: An epigenetic inducer of FoxP3 expression

(2016) Bodo C. Melnik et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Perinatal Dietary Choline Deficiency in Sows Influences Concentrations of Choline Metabolites, Fatty Acids, and Amino Acids in Milk throughout Lactation

(2016) Austin T Mudd et al.   JOURNAL OF NUTRITION

Differential neurogenic effects of casein-derived opioid peptides on neuronal stem cells: implications for redox-based epigenetic changes

(2016) Malav Trivedi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Vitamin D Enhances the Efficacy of Irinotecan through miR-627-Mediated Inhibition of Intratumoral Drug Metabolism

(2016) M. Sun et al.   MOLECULAR CANCER THERAPEUTICS

Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome

(2016) Alexey A. Soshnev et al.   MOLECULAR CELL

Curcumin and Health

(2016) Mario Pulido-Moran et al.   MOLECULES

Resveratrol affects DNA damage induced by ionizing radiation in human lymphocytes in vitro

(2016) Emiliano Basso et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?

(2016) Megan W. Bourassa et al.   NEUROSCIENCE LETTERS

Soy Isoflavone Genistein-Mediated Downregulation of miR-155 Contributes to the Anticancer Effects of Genistein

(2016) Columba de la Parra et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Non-coding RNAs as regulators in epigenetics

(2016) Jian-Wei Wei et al.   ONCOLOGY REPORTS

Resveratrol Enhances Autophagic Flux and Promotes Ox-LDL Degradation in HUVECs via Upregulation of SIRT1

(2016) Yanlin Zhang et al.   Oxidative Medicine and Cellular Longevity

Sirt1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic nephropathy rat

(2016) Liqun Ma et al.   PATHOLOGY RESEARCH AND PRACTICE

Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells

(2016) Sarandeep S.S. Boyanapalli et al.   PHARMACOLOGICAL RESEARCH

Resveratrol Protects against TNF-α-Induced Injury in Human Umbilical Endothelial Cells through Promoting Sirtuin-1-Induced Repression of NF-KB and p38 MAPK

(2016) Wei Pan et al.   PLoS One

Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine

(2016) Minmin Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of apoptosis-related miRNAs in resveratrol-induced breast cancer cell death

(2016) R Venkatadri et al.   Cell Death & Disease

Genistein inhibits A549 human lung cancer cell proliferation via miR-27a and MET signaling

(2016) Yang Yang et al.   Oncology Letters

Upregulation of miR-34a by diallyl disulfide suppresses invasion and induces apoptosis in SGC-7901 cells through inhibition of the PI3K/Akt signaling pathway

(2016) GUOJUN WANG et al.   Oncology Letters

Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells

(2016) Constanze Buhrmann et al.   Nutrients

Unraveling the Anticancer Effect of Curcumin and Resveratrol

(2016) Aline Pavan et al.   Nutrients

Quercetin, Inflammation and Immunity

(2016) Yao Li et al.   Nutrients

Ascorbic Acid Protects against Hypertension through Downregulation of ACE1 Gene Expression Mediated by Histone Deacetylation in Prenatal Inflammation-Induced Offspring

(2016) Jing Wang et al.   Scientific Reports

The healthy human microbiome

(2016) Jason Lloyd-Price et al.   Genome Medicine

Ellagitannins in Cancer Chemoprevention and Therapy

(2016) Tariq Ismail et al.   Toxins

Metabiotics: One Step ahead of Probiotics; an Insight into Mechanisms Involved in Anticancerous Effect in Colorectal Cancer

(2016) Mridul Sharma et al.   Frontiers in Microbiology

Milk: a postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation

(2016) Bodo C. Melnik et al.   Clinical and Translational Allergy

Human milk miRNAs primarily originate from the mammary gland resulting in unique miRNA profiles of fractionated milk

(2016) Mohammed Alsaweed et al.   Scientific Reports

Sulforaphane improves chemotherapy efficacy by targeting cancer stem cell-like properties via the miR-124/IL-6R/STAT3 axis

(2016) Xingxing Wang et al.   Scientific Reports

Exploring new ways of regulation by resveratrol involving miRNAs, with emphasis on inflammation

(2015) Norbert Latruffe et al.   Annals of the New York Academy of Sciences

Resveratrol, in its natural combination in whole grape, for health promotion and disease management

(2015) Chandra K. Singh et al.   Annals of the New York Academy of Sciences

Time - and Concentration - Dependent Effects of Resveratrol on miR 15a and miR16-1 Expression and Apoptosis in the CCRF-CEM Acute Lymphoblastic Leukemia Cell Line

(2015) Ako Azimi et al.   Asian Pacific Journal of Cancer Prevention

Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1

(2015) Yue Guo et al.   BIOCHEMICAL PHARMACOLOGY

Lifespan and healthspan extension by resveratrol

(2015) Khushwant S. Bhullar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MicroRNA-10a is reduced in breast cancer and regulated in part through retinoic acid

(2015) Sonja Khan et al.   BMC CANCER

Resveratrol elicits anti-colorectal cancer effect by activating miR-34c-KITLG in vitro and in vivo

(2015) Shu Yang et al.   BMC CANCER

Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancer

(2015) Rishabh Kala et al.   BMC CANCER

3,3′-Diindolylmethane attenuates LPS-mediated acute liver failure by regulating miRNAs to target IRAK4 and suppress Toll-like receptor signalling

(2015) S Tomar et al.   BRITISH JOURNAL OF PHARMACOLOGY

All-trans retinoic acid induces p53-depenent apoptosis in human hepatocytes by activating p14 expression via promoter hypomethylation

(2015) Shin-Hee Heo et al.   CANCER LETTERS

The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: A review

(2015) F. Vahid et al.   GENE

What Do You Mean, “Epigenetic”?

(2015) Carrie Deans et al.   GENETICS

Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction

(2015) Xizhong Sui et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sulforaphane Alone and in Combination with Clofarabine Epigenetically Regulates the Expression of DNA Methylation-Silenced Tumour Suppressor Genes in Human Breast Cancer Cells

(2015) Katarzyna Lubecka-Pietruszewska et al.   Journal of Nutrigenetics and Nutrigenomics

Folic acid administration inhibits amyloid β-peptide accumulation in APP/PS1 transgenic mice

(2015) Wen Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis

(2015) Thomas K. Sin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion

(2015) V. Andrade-Oliveira et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases

(2015) Bodo C. Melnik   Journal of Translational Medicine

Bioactive Peptides in Milk and Dairy Products: A Review

(2015) Young Woo Park et al.   Korean Journal for Food Science of Animal Resources

The antibacterial properties of isothiocyanates

(2015) Virginie Dufour et al.   MICROBIOLOGY-SGM

Epigenetic reactivation of p21CIP1/WAF1 and KLOTHO by a combination of bioactive dietary supplements is partially ERα-dependent in ERα-negative human breast cancer cells

(2015) Sonam Sinha et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Aryl hydrocarbon receptor-microRNA-212/132 axis in human breast cancer suppresses metastasis by targeting SOX4

(2015) Hamza Hanieh   Molecular Cancer

Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells

(2015) Shien Hu et al.   Molecular Cancer

Comprehensive characterization of the effects of ellagic acid and urolithins on colorectal cancer and key-associated molecular hallmarks: MicroRNA cell specific induction ofCDKN1A(p21) as a common mechanism involved

(2015) Antonio González-Sarrías et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation

(2015) Ching-Hsia Hung et al.   MOLECULAR NUTRITION & FOOD RESEARCH

(−)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells

(2015) MUNAWWAR ALI KHAN et al.   ONCOLOGY REPORTS

Dendrosomal curcumin increases expression of the long non-coding RNA gene MEG3 via up-regulation of epi-miRs in hepatocellular cancer

(2015) Mina Zamani et al.   PHYTOMEDICINE

Systematic analysis of berberine-induced signaling pathway between miRNA clusters and mRNAs and identification of mir-99a∼125b cluster function by seed-targeting inhibitors in multiple myeloma cells

(2015) Maoxiao Feng et al.   RNA Biology

Green tea polyphenol EGCG suppresses osteosarcoma cell growth through upregulating miR-1

(2015) Kewei Zhu et al.   TUMOR BIOLOGY

Consumption of high-dose vitamin C (1250 mg per day) enhances functional and structural properties of serum lipoprotein to improve anti-oxidant, anti-atherosclerotic, and anti-aging effects via regulation of anti-inflammatory microRNA

(2015) Seong-Min Kim et al.   Food & Function

Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas

(2015) Shun-Fa Yang et al.   Oncotarget

The role of TORC1 in muscle development in Drosophila

(2015) Isabelle Hatfield et al.   Scientific Reports

Vitamins in Pancreatic Cancer: A Review of Underlying Mechanisms and Future Applications

(2015) Ashley H Davis-Yadley et al.   Advances in Nutrition

Genistein and Cancer: Current Status, Challenges, and Future Directions

(2015) Carmela Spagnuolo et al.   Advances in Nutrition

Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen Species

(2015) Piero Sestili et al.   Biomed Research International

Epigenetic reprogramming of melanoma cells by vitamin C treatment

(2015) Christopher B Gustafson et al.   Clinical Epigenetics

What Do You Mean, “Epigenetic”?

(2015) Carrie Deans et al.   GENETICS

Resveratrol Targets in Inflammation

(2015) Hiroyasu Inoue et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Breast Milk and Solid Food Shaping Intestinal Immunity

(2015) Sara M. Parigi et al.   Frontiers in Immunology

Natural Indoles, Indole-3-Carbinol (I3C) and 3,3’-Diindolylmethane (DIM), Attenuate Staphylococcal Enterotoxin B-Mediated Liver Injury by Downregulating miR-31 Expression and Promoting Caspase-2-Mediated Apoptosis

(2015) Philip B. Busbee et al.   PLoS One

Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway

(2015) Erli Zhang et al.   PLoS One

Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication

(2015) Tobias Forster et al.   Oncotarget

Ellagic Acid Inhibits VEGF/VEGFR2, PI3K/Akt and MAPK Signaling Cascades in the Hamster Cheek Pouch Carcinogenesis Model

(2014) Jaganathan Kowshik et al.   Anti-Cancer Agents in Medicinal Chemistry

Aberrant histone acetylation contributes to elevated interleukin-6 production in rheumatoid arthritis synovial fibroblasts

(2014) Takuma Tsuzuki Wada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Curcumin, a component of golden spice: From bedside to bench and back

(2014) Sahdeo Prasad et al.   BIOTECHNOLOGY ADVANCES

Genistein downregulates onco-miR-1260b and upregulates sFRP1 and Smad4 via demethylation and histone modification in prostate cancer cells

(2014) H Hirata et al.   BRITISH JOURNAL OF CANCER

Riboflavin (vitamin B2) and oxidative stress: a review

(2014) Marziyeh Ashoori et al.   BRITISH JOURNAL OF NUTRITION

Effect of vitamin E intake from food and supplement sources on plasma α- and γ-tocopherol concentrations in a healthy Irish adult population

(2014) Yang Zhao et al.   BRITISH JOURNAL OF NUTRITION

Requirement and Epigenetics Reprogramming of Nrf2 in Suppression of Tumor Promoter TPA-Induced Mouse Skin Cell Transformation by Sulforaphane

(2014) Z.-Y. Su et al.   Cancer Prevention Research

Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment

(2014) Tali Zitman-Gal et al.   Cardiovascular Diabetology

Berberine alters epigenetic modifications, disrupts microtubule network, and modulates HPV-18 E6–E7 oncoproteins by targeting p53 in cervical cancer cell HeLa: A mechanistic study including molecular docking

(2014) Santu Kumar Saha et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ascorbic acid: New role of an age-old micronutrient in the management of periodontal disease in older adults

(2014) Adel S Alagl et al.   Geriatrics & Gerontology International

Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition

(2014) MAHESH APPARI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Transcriptional Regulation of the Albumin Gene Depends on the Removal of Histone Methylation Marks by the FAD-Dependent Monoamine Oxidase Lysine-Specific Demethylase 1 in HepG2 Human Hepatocarcinoma Cells

(2014) Dandan Liu et al.   JOURNAL OF NUTRITION

Ellagic acid inhibits adipocyte differentiation through coactivator-associated arginine methyltransferase 1-mediated chromatin modification

(2014) Inhae Kang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Food-derived opioid peptides inhibit cysteine uptake with redox and epigenetic consequences

(2014) Malav S. Trivedi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?

(2014) Bodo C Melnik et al.   Journal of Translational Medicine

Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study

(2014) Vincenzo Libri et al.   LANCET

Mechanism of Action of Phenethylisothiocyanate and Other Reactive Oxygen Species-Inducing Anticancer Agents

(2014) I. Jutooru et al.   MOLECULAR AND CELLULAR BIOLOGY

Dual Promoter Usage as Regulatory Mechanism of let-7c Expression in Leukemic and Solid Tumors

(2014) Andrea Pelosi et al.   MOLECULAR CANCER RESEARCH

Epigenetic induction of tissue inhibitor of matrix metalloproteinase-3 by green tea polyphenols in breast cancer cells

(2014) Gauri Deb et al.   MOLECULAR CARCINOGENESIS

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

Curcumin-mediated decrease in the expression of nucleolar organizer regions in cervical cancer (HeLa) cells

(2014) Anna Lewinska et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Histone Deacetylase Inhibitors Sensitize Lung Cancer Cells to Hyperthermia: Involvement of Ku70/SirT-1 in Thermo-Protection

(2014) Mohamed K. Hassan et al.   PLoS One

Histone Acetyltransferase p300 Mediates Histone Acetylation of PS1 and BACE1 in a Cellular Model of Alzheimer's Disease

(2014) Xi Lu et al.   PLoS One

Diallyl Disulfide Suppresses SRC/Ras/ERK Signaling-Mediated Proliferation and Metastasis in Human Breast Cancer by Up-Regulating miR-34a

(2014) Xiangsheng Xiao et al.   PLoS One

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenomic regulation of host–microbiota interactions

(2014) Theresa Alenghat et al.   TRENDS IN IMMUNOLOGY

Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells

(2014) X Zhou et al.   Cell Death & Disease

A Gnotobiotic Mouse Model Demonstrates That Dietary Fiber Protects against Colorectal Tumorigenesis in a Microbiota- and Butyrate-Dependent Manner

(2014) D. R. Donohoe et al.   Cancer Discovery

Epigenetic Modifications of Nrf2 by 3,3′-diindolylmethane In Vitro in TRAMP C1 Cell Line and In Vivo TRAMP Prostate Tumors

(2013) Tien-Yuan Wu et al.   AAPS Journal

Oncogenic MicroRNA-27a is a Target for Genistein in Ovarian Cancer Cells

(2013) Linlin Xu et al.   Anti-Cancer Agents in Medicinal Chemistry

Integrating DNA methylation dynamics into a framework for understanding epigenetic codes

(2013) Keith E. Szulwach et al.   BIOESSAYS

Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22

(2013) Hailin Tang et al.   CANCER LETTERS

MiR-21 suppresses the anticancer activities of curcumin by targeting PTEN gene in human non-small cell lung cancer A549 cells

(2013) W. Zhang et al.   Clinical & Translational Oncology

Technologies for Extraction and Production of Bioactive Compounds to be Used as Nutraceuticals and Food Ingredients: An Overview

(2013) G. Joana Gil-Chávez et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Epigenetic impact of dietary isothiocyanates in cancer chemoprevention

(2013) Clarissa Gerhauser   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates

(2013) Praveen Rajendran et al.   Epigenetics

Comparative evaluation of cow β-casein variants (A1/A2) consumption on Th2-mediated inflammatory response in mouse gut

(2013) Mohammad Raies Ul Haq et al.   EUROPEAN JOURNAL OF NUTRITION

MicroRNA-627 Mediates the Epigenetic Mechanisms of Vitamin D to Suppress Proliferation of Human Colorectal Cancer Cells and Growth of Xenograft Tumors in Mice

(2013) Sathish K.R. Padi et al.   GASTROENTEROLOGY

Expression of DNA Methyltransferases in Breast Cancer Patients and to Analyze the Effect of Natural Compounds on DNA Methyltransferases and Associated Proteins

(2013) Sameer Mirza et al.   Journal of Breast Cancer

Long interspersed nucleotide element-1 hypomethylation in folate-deficient mouse embryonic stem cells

(2013) Shaoyan Chang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Betaine attenuates hepatic steatosis by reducing methylation of the MTTP promoter and elevating genomic methylation in mice fed a high-fat diet

(2013) Li-jun Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol ameliorates subacute intestinal ischemia-reperfusion injury

(2013) WenPeng Dong et al.   JOURNAL OF SURGICAL RESEARCH

Role of commensal and probiotic bacteria in human health: a focus on inflammatory bowel disease

(2013) Rebeca Martín et al.   Microbial Cell Factories

DNA methylation of theMAPTgene in Parkinson's disease cohorts and modulation by vitamin EIn Vitro

(2013) Kirsten G. Coupland et al.   MOVEMENT DISORDERS

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Sulforaphane: translational research from laboratory bench to clinic

(2013) Christine A Houghton et al.   NUTRITION REVIEWS

MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine

(2013) Y Xiang et al.   ONCOGENE

Natural indoles, indole-3-carbinol and 3,3′-diindolymethane, inhibit T cell activation by staphylococcal enterotoxin B through epigenetic regulation involving HDAC expression

(2013) Philip B. Busbee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The enhanced apoptosis and antiproliferative response to combined treatment with valproate and nicotinamide in MCF-7 breast cancer cells

(2013) Hanieh Jafary et al.   TUMOR BIOLOGY

WITHDRAWN: Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1

(2012) Mayada Achour et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

S-adenosyl-L-homocysteine hydrolase and methylation disorders: Yeast as a model system

(2012) Oksana Tehlivets et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Epigenetic imprinting by commensal probiotics inhibits the IL-23/IL-17 axis in an in vitro model of the intestinal mucosal immune system

(2012) Darab Ghadimi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation

(2012) Olivia S. Anderson et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs

(2012) S Das et al.   ONCOGENE

Loss of Let-7 Up-Regulates EZH2 in Prostate Cancer Consistent with the Acquisition of Cancer Stem Cell Signatures That Are Attenuated by BR-DIM

(2012) Dejuan Kong et al.   PLoS One

A focus on the preclinical development and clinical status of the histone deacetylase inhibitor, romidepsin (depsipeptide, Istodax®)

(2012) Simon J Harrison et al.   Epigenomics

TET1 Suppresses Cancer Invasion by Activating the Tissue Inhibitors of Metalloproteinases

(2012) Chih-Hung Hsu et al.   Cell Reports

The epigenetic effects of butyrate: potential therapeutic implications for clinical practice

(2012) Roberto Berni Canani et al.   Clinical Epigenetics

Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells

(2011) C. N. Marconett et al.   CARCINOGENESIS

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Vitamins C and E: Beneficial effects from a mechanistic perspective

(2011) Maret G. Traber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epigenetic changes induced by curcumin and other natural compounds

(2011) Simone Reuter et al.   Genes and Nutrition

The Epigenotype

(2011) C. H. Waddington   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Food Protein-Derived Bioactive Peptides: Production, Processing, and Potential Health Benefits

(2011) Chibuike C. Udenigwe et al.   JOURNAL OF FOOD SCIENCE

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

MicroRNA: Biogenesis, Function and Role in Cancer

(2010) Leigh-Ann MacFarlane et al.   CURRENT GENOMICS

Isolation of antioxidant catechins from green tea and its decaffeination

(2010) Jun-Jie Dong et al.   FOOD AND BIOPRODUCTS PROCESSING

Berberine reduces methylation of theMTTPpromoter and alleviates fatty liver induced by a high-fat diet in rats

(2010) XinXia Chang et al.   JOURNAL OF LIPID RESEARCH

Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin

(2010) Jung-Mi Yun et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Anticolon Cancer Activity of Largazole, a Marine-Derived Tunable Histone Deacetylase Inhibitor

(2010) Y. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cytotoxicity of berberine on human cervical carcinoma HeLa cells through mitochondria, death receptor and MAPK pathways, and in-silico drug-target prediction

(2010) Binan Lu et al.   TOXICOLOGY IN VITRO

Assessment of the effect of betaine on p16 and c-mycDNA methylation and mRNA expression in a chemical induced rat liver cancer model

(2009) Yan-ping Du et al.   BMC CANCER

Biological properties of garlic and garlic-derived organosulfur compounds

(2009) Małgorzata Iciek et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds

(2009) Hui Nian et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Berberine Inhibits Metastasis of Nasopharyngeal Carcinoma 5-8F Cells by Targeting Rho Kinase-mediated Ezrin Phosphorylation at Threonine 567

(2009) Faqing Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genistein inhibits growth of human uveal melanoma cells and affects microRNA-27a and target gene expression

(2009) Wang   ONCOLOGY REPORTS