Mechanism of Action of Phenethylisothiocyanate and Other Reactive Oxygen Species-Inducing Anticancer Agents

The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis

(2013) Giuliana D. Noratto et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells

(2012) Gayathri Chadalapaka et al.   CARCINOGENESIS

HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer

(2012) K Kim et al.   ONCOGENE

Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors

(2011) Sudhakar Chintharlapalli et al.   BMC CANCER

Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

(2011) Heather M. O'Hagan et al.   CANCER CELL

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Pharmacologic Doses of Ascorbic Acid Repress Specificity Protein (Sp) Transcription Factors and Sp-Regulated Genes in Colon Cancer Cells

(2011) Satya S. Pathi et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer

(2011) K Kim et al.   ONCOGENE

Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3

(2010) Su-Hyeong Kim et al.   CARCINOGENESIS

Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth

(2010) Indira Jutooru et al.   EXPERIMENTAL CELL RESEARCH

Tumorigenicity of the miR-17-92 cluster distilled

(2010) G. van Haaften et al.   GENES & DEVELOPMENT

Benzyl Isothiocyanate (BITC) Inhibits Migration and Invasion of Human Colon Cancer HT29 Cells by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase Plasminogen (uPA) through PKC and MAPK Signaling Pathway

(2010) Kuang-Chi Lai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Phenethyl Isothiocyanate Inhibits Oxidative Phosphorylation to Trigger Reactive Oxygen Species-mediated Death of Human Prostate Cancer Cells

(2010) Dong Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of NFκB and Pancreatic Cancer Cell and Tumor Growth by Curcumin Is Dependent on Specificity Protein Down-regulation

(2010) Indira Jutooru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GT-094, a NO-NSAID, Inhibits Colon Cancer Cell Growth by Activation of a Reactive Oxygen Species-MicroRNA-27a: ZBTB10-Specificity Protein Pathway

(2010) S. S. Pathi et al.   MOLECULAR CANCER RESEARCH

Drugs that Target Specificity Proteins Downregulate Epidermal Growth Factor Receptor in Bladder Cancer Cells

(2010) Gayathri Chadalapaka et al.   MOLECULAR CANCER RESEARCH

Methyl 2-Cyano-3,12-dioxooleana-1,9-dien-28-oate Decreases Specificity Protein Transcription Factors and Inhibits Pancreatic Tumor Growth: Role of MicroRNA-27a

(2010) I. Jutooru et al.   MOLECULAR PHARMACOLOGY

Differential Response of Normal (PrEC) and Cancerous Human Prostate Cells (PC-3) to Phenethyl Isothiocyanate-Mediated Changes in Expression of Antioxidant Defense Genes

(2010) Anna A. Powolny et al.   PHARMACEUTICAL RESEARCH

Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells

(2009) Ravi P. Sahu et al.   CARCINOGENESIS

The Role of STAT-3 in the Induction of Apoptosis in Pancreatic Cancer Cells by Benzyl Isothiocyanate

(2009) R. P. Sahu et al.   JNCI-Journal of the National Cancer Institute

Attacking cancer at its foundation

(2009) Nicholas Lydon   NATURE MEDICINE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Sp1, a New Biomarker That Identifies a Subset of Aggressive Pancreatic Ductal Adenocarcinoma

(2008) N. Y. Jiang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Curcumin Decreases Specificity Protein Expression in Bladder Cancer Cells

(2008) G. Chadalapaka et al.   CANCER RESEARCH

Sulforaphane targets pancreatic tumour-initiating cells by NF- B-induced antiapoptotic signalling

(2008) G Kallifatidis et al.   GUT