Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

Th17 cell development: from the cradle to the grave

(2013) Luis A. Zúñiga et al.   IMMUNOLOGICAL REVIEWS

Role of the Gut Microbiota in the Development and Function of Lymphoid Cells

(2013) N. Kamada et al.   JOURNAL OF IMMUNOLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

The role of the gut microbiota in nutrition and health

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Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells

(2011) Ulf H Beier et al.   CURRENT OPINION IN IMMUNOLOGY

Microbiota in autoimmunity and tolerance

(2011) Koji Atarashi et al.   CURRENT OPINION IN IMMUNOLOGY

Enteric pathogen exploitation of the microbiota-generated nutrient environment of the gut

(2011) Kristie M Keeney et al.   CURRENT OPINION IN MICROBIOLOGY

Mechanisms controlling Th17 cytokine expression and host defense

(2011) Jeremy P. McAleer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Are Th17 cells in the gut pathogenic or protective?

(2011) A Symons et al.   Mucosal Immunology

Key questions to guide a better understanding of host–commensal microbiota interactions in intestinal inflammation

(2011) R B Sartor   Mucosal Immunology

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor

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Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea

(2010) Henry J. Binder   Annual Review of Physiology

S6K1 is acetylated at lysine 516 in response to growth factor stimulation

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Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

TGF-  Enhances Effector Th1 Cell Activation but Promotes Self-Regulation via IL-10

(2010) D. J. Huss et al.   JOURNAL OF IMMUNOLOGY

Segmented filamentous bacteria take the stage

(2010) I I Ivanov et al.   Mucosal Immunology

IL-10 production by CD4+ effector T cells: a mechanism for self-regulation

(2010) D Jankovic et al.   Mucosal Immunology

Inhibition of Effector Function but Not T Cell Activation and Increase in FoxP3 Expression in T Cells Differentiated in the Presence of PP14

(2010) Zohar Ochanuna et al.   PLoS One

Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?

(2010) Y. K. Lee et al.   SCIENCE

Involvement of T helper type 17 and regulatory T cell activity inCitrobacter rodentiuminvasion and inflammatory damage

(2009) E. L. Symonds et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen Dose

(2009) Margarida Saraiva et al.   IMMUNITY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Histone acetyltransferases interact with and acetylate p70 ribosomal S6 kinases in vitro and in vivo

(2009) T.R. Fenton et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa

(2009) S A Khader et al.   Mucosal Immunology

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways

(2009) Michiko Aoyama et al.   NUTRITION

The role of histone deacetylases in asthma and allergic diseases

(2008) Pankaj Bhavsar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells

(2008) Sokol Haxhinasto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation

(2008) Lai Wei et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY