Bioactive DNA from extracellular vesicles and particles

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Isolation and mutational assessment of pancreatic cancer extracellular vesicles using a microfluidic platform

(2020) Nabiollah Kamyabi et al.   BIOMEDICAL MICRODEVICES

The function and clinical application of extracellular vesicles in innate immune regulation

(2020) Xiaoxue Zhou et al.   Cellular & Molecular Immunology

Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease

(2020) Anna Picca et al.   Journal of Clinical Medicine

Mechanisms of mitochondrial DNA escape and its relationship with different metabolic diseases

(2020) Perla Pérez-Treviño et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Flow Cytometric Analysis of Nanoscale Biological Particles and Organelles

(2019) Hong Lian et al.   Annual Review of Analytical Chemistry

Life and death of circulating cell-free DNA

(2019) Anatoli Kustanovich et al.   CANCER BIOLOGY & THERAPY

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Exosome-Mediated Metastasis: Communication from a Distance

(2019) Inbal Wortzel et al.   DEVELOPMENTAL CELL

Transfer of Functional Cargo in Exomeres

(2019) Qin Zhang et al.   Cell Reports

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

Detection of cell-free, exosomal and whole blood mitochondrial DNA copy number in plasma or whole blood of patients with serous epithelial ovarian cancer

(2019) Judit Szilvia Keserű et al.   JOURNAL OF BIOTECHNOLOGY

ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA enriched extracellular vesicles

(2019) Wonhyo Seo et al.   JOURNAL OF HEPATOLOGY

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Radiation-Induced Bystander Effect is Mediated by Mitochondrial DNA in Exosome-Like Vesicles

(2019) Kentaro Ariyoshi et al.   Scientific Reports

Mapping Subpopulations of Cancer Cell-Derived Extracellular Vesicles and Particles by Nano-Flow Cytometry

(2019) Dongsic Choi et al.   ACS Nano

Challenges in Exosome Isolation and Analysis in Health and Disease

(2019) Nils Ludwig et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HPV DNA Associates With Breast Cancer Malignancy and It Is Transferred to Breast Cancer Stromal Cells by Extracellular Vesicles

(2019) Sabrina De Carolis et al.   Frontiers in Oncology

Double-Stranded DNA in Exosomes of Malignant Pleural Effusions as a Novel DNA Source for EGFR Mutation Detection in Lung Adenocarcinoma

(2019) Xueling Qu et al.   Frontiers in Oncology

DNA analysis of low- and high-density fractions defines heterogeneous subpopulations of small extracellular vesicles based on their DNA cargo and topology

(2019) Elisa Lázaro-Ibáñez et al.   Journal of Extracellular Vesicles

Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature

(2019) Kenneth W. Witwer et al.   Journal of Extracellular Vesicles

Liquid biopsies using pleural effusion-derived exosomal DNA in advanced lung adenocarcinoma

(2019) Zhengbo Song et al.   Translational Lung Cancer Research

Beyond tumor mutational burden: potential and limitations in using exosomes to predict response to immunotherapy

(2019) Jennifer Crow et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Detection and Quantification of eDNA-Associated Bacterial Membrane Vesicles by Flow Cytometry

(2019) Valentina Puca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumor-derived extracellular vesicles: molecular parcels that enable regulation of the immune response in cancer

(2019) Colin Sheehan et al.   JOURNAL OF CELL SCIENCE

Mechanisms of nuclear content loading to exosomes

(2019) Akira Yokoi et al.   Science Advances

Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop

(2019) Ashley E. Russell et al.   Journal of Extracellular Vesicles

New Sensors for Extracellular Vesicles: Insights on Constituent and Associated Biomarkers

(2019) Carine Z. J. Lim et al.   ACS Sensors

Inhibiting extracellular vesicles formation and release: a review of EV inhibitors

(2019) Mariadelva Catalano et al.   Journal of Extracellular Vesicles

Extracellular Vesicles in Oncology: Progress and Pitfalls in the Methods of Isolation and Analysis

(2018) Donatella Lucchetti et al.   Biotechnology Journal

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biogenesis and function of extracellular vesicles in cancer

(2018) Maarten P. Bebelman et al.   PHARMACOLOGY & THERAPEUTICS

Molecular interactions at the surface of extracellular vesicles

(2018) Edit I. Buzás et al.   Seminars in Immunopathology

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

(2018) Daniel Torralba et al.   Nature Communications

Extracellular Vesicles in Oncology: Progress and Pitfalls in the Methods of Isolation and Analysis

(2018) Donatella Lucchetti et al.   Biotechnology Journal

Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs

(2018) Julie M. Diamond et al.   Cancer Immunology Research

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

(2018) Eduard Willms et al.   Frontiers in Immunology

Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris

(2018) Sarah Caruso et al.   Frontiers in Immunology

Exosomes Play Roles in Sequential Processes of Tumor Metastasis

(2018) Keyu Li et al.   INTERNATIONAL JOURNAL OF CANCER

Extracellular vesicles are increased in the serum of children with autism spectrum disorder, contain mitochondrial DNA, and stimulate human microglia to secrete IL-1β

(2018) Irene Tsilioni et al.   Journal of Neuroinflammation

Nanoscale extracellular vesicle-derived DNA is superior to circulating cell-free DNA for mutation detection in early-stage non-small-cell lung cancer

(2018) Y Wan et al.   ANNALS OF ONCOLOGY

Measurement of Plasma Cell-Free Mitochondrial Tumor DNA Improves Detection of Glioblastoma in Patient-Derived Orthotopic Xenograft Models

(2018) Richard Mair et al.   CANCER RESEARCH

Circulating Nucleic Acids Are Associated With Outcomes of Patients With Pancreatic Cancer

(2018) Vincent Bernard et al.   GASTROENTEROLOGY

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles

(2018) Mohashin Pathan et al.   NUCLEIC ACIDS RESEARCH

Exosomes isolated from cancer patients’ sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells

(2017) Mohamed Abdouh et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity

(2017) Yuichi Kitai et al.   JOURNAL OF IMMUNOLOGY

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

(2017) Liudmila Andreeva et al.   NATURE

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biological Functions and Current Advances in Isolation and Detection Strategies for Exosome Nanovesicles

(2017) Kseniia Boriachek et al.   Small

Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

(2017) Xavier Sisquella et al.   Nature Communications

Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA

(2017) Andrea Németh et al.   Scientific Reports

Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview

(2017) Vidal Delgado-Rizo et al.   Frontiers in Immunology

Bacterial membrane vesicles transport their DNA cargo into host cells

(2017) Natalie J. Bitto et al.   Scientific Reports

Recent advances of exosomes in immune modulation and autoimmune diseases

(2016) Lina Tan et al.   AUTOIMMUNITY

Role of extracellular vesicles in autoimmune diseases

(2016) Delphine Turpin et al.   AUTOIMMUNITY REVIEWS

Origins, structures, and functions of circulating DNA in oncology

(2016) A. R. Thierry et al.   CANCER AND METASTASIS REVIEWS

Mitochondrial DNA sensing by STING signaling participates in inflammation, cancer and beyond

(2016) Song Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

(2016) Simone Caielli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ExoCarta: A Web-Based Compendium of Exosomal Cargo

(2016) Shivakumar Keerthikumar et al.   JOURNAL OF MOLECULAR BIOLOGY

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA sequences within glioma-derived extracellular vesicles can cross the intact blood-brain barrier and be detected in peripheral blood of patients

(2016) Noemí García-Romero et al.   Oncotarget

Cells release subpopulations of exosomes with distinct molecular and biological properties

(2016) Eduard Willms et al.   Scientific Reports

Extracellular DNA: A Bridge to Cancer

(2015) M. C. Hawes et al.   CANCER RESEARCH

SRYgene transferred by extracellular vesicles accelerates atherosclerosis by promotion of leucocyte adherence to endothelial cells

(2015) Jin Cai et al.   CLINICAL SCIENCE

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

(2015) Valentina R. Minciacchi et al.   Oncotarget

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with MutatedKRASandp53DNA in the Serum Exosomes of Patients with Pancreatic Cancer

(2014) Christoph Kahlert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging role of extracellular vesicles in inflammatory diseases

(2014) Edit I. Buzas et al.   Nature Reviews Rheumatology

Different gDNA content in the subpopulations of prostate cancer extracellular vesicles: Apoptotic bodies, microvesicles, and exosomes

(2014) Elisa Lázaro-Ibáñez et al.   PROSTATE

Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

(2013) Nadine Gehrke et al.   IMMUNITY

Extracellular vesicle-mediated transfer of donor genomic DNA to recipient cells is a novel mechanism for genetic influence between cells

(2013) Jin Cai et al.   Journal of Molecular Cell Biology

Plasma membrane associated transcription of cytoplasmic DNA

(2012) J. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

(2011) Leonora Balaj et al.   Nature Communications

Microparticles as a source of extracellular DNA

(2010) David S. Pisetsky et al.   IMMUNOLOGIC RESEARCH

Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease

(2010) Kevin C. Miranda et al.   KIDNEY INTERNATIONAL

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

(2009) Michele Guescini et al.   JOURNAL OF NEURAL TRANSMISSION