Life and death of circulating cell-free DNA

Circulating Tumor DNA: Measurement and Clinical Utility

(2018) Joshua Donaldson et al.   Annual Review of Medicine

Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth

(2018) Yi Yang et al.   CELL RESEARCH

The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer Patients

(2018) Oliver A. Zill et al.   CLINICAL CANCER RESEARCH

Plasma total cell-free DNA (cfDNA) is a surrogate biomarker for tumour burden and a prognostic biomarker for survival in metastatic melanoma patients

(2018) S. Valpione et al.   EUROPEAN JOURNAL OF CANCER

Cell-free DNA: the role in pathophysiology and as a biomarker in kidney diseases

(2018) Peter Celec et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Circulating Tumor DNA Analysis in Patients With Cancer: American Society of Clinical Oncology and College of American Pathologists Joint Review

(2018) Jason D. Merker et al.   JOURNAL OF CLINICAL ONCOLOGY

Standards and Guidelines for Validating Next-Generation Sequencing Bioinformatics Pipelines

(2018) Somak Roy et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Extracellular vesicles compartment in liquid biopsies: Clinical application

(2018) Noemi Garcia-Romero et al.   MOLECULAR ASPECTS OF MEDICINE

Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer

(2018) Seung Tae Kim et al.   NATURE MEDICINE

Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C

(2018) Björn Ingelsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection and localization of surgically resectable cancers with a multi-analyte blood test

(2018) Joshua D. Cohen et al.   SCIENCE

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

(2018) Daniel Torralba et al.   Nature Communications

ctDNA and CTCs in Liquid Biopsy – Current Status and Where We Need to Progress

(2018) Martin H.D. Neumann et al.   Computational and Structural Biotechnology Journal

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

(2018) Gillian Dunphy et al.   MOLECULAR CELL

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Circulating tumor DNA in patients with colorectal adenomas: assessment of detectability and genetic heterogeneity

(2018) Ni Ni Moe Myint et al.   Cell Death & Disease

Current and future perspectives of liquid biopsies in genomics-driven oncology

(2018) Ellen Heitzer et al.   NATURE REVIEWS GENETICS

Application of Cell-free DNA Analysis to Cancer Treatment

(2018) Ryan B. Corcoran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhanced detection of circulating tumor DNA by fragment size analysis

(2018) Florent Mouliere et al.   Science Translational Medicine

Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

(2018) Joshua Moss et al.   Nature Communications

Neutrophils, G-CSF and their contribution to breast cancer metastasis

(2017) Kellie A. Mouchemore et al.   FEBS Journal

Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling

(2017) Meng Michelle Xu et al.   IMMUNITY

Molecular Analysis of Circulating Cell-Free DNA from Lung Cancer Patients in Routine Laboratory Practice

(2017) Stephan Bartels et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Circulating Tumor DNA Reflects Tumor Metabolism Rather Than Tumor Burden in Chemotherapy-Naive Patients with Advanced Non–Small Cell Lung Cancer:18F-FDG PET/CT Study

(2017) Silvia Morbelli et al.   JOURNAL OF NUCLEAR MEDICINE

Kinetics of Plasma Cell-Free DNA and Creatine Kinase in a Canine Model of Tissue Injury

(2017) I.J. Wilson et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Quantitative cell-free circulating EGFR mutation concentration is correlated with tumor burden in advanced NSCLC patients

(2017) Yan-juan Zhu et al.   LUNG CANCER

Integrating liquid biopsies into the management of cancer

(2017) Giulia Siravegna et al.   Nature Reviews Clinical Oncology

New evidence that a large proportion of human blood plasma cell-free DNA is localized in exosomes

(2017) M. Rohan Fernando et al.   PLoS One

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current approaches for avoiding the limitations of circulating tumor cells detection methods—implications for diagnosis and treatment of patients with solid tumors

(2017) Artur Kowalik et al.   Translational Research

Cell-free mitochondrial DNA copy number variation in head and neck squamous cell carcinoma: A study of non-invasive biomarker from Northeast India

(2017) Manish Kumar et al.   TUMOR BIOLOGY

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

(2017) Akiko Takahashi et al.   Nature Communications

Characterization of the release and biological significance of cell-free DNA from breast cancer cell lines

(2017) Wei Wang et al.   Oncotarget

The regulation of pre-metastatic niche formation by neutrophils

(2017) Jadwiga Jablonska et al.   Oncotarget

Facile single-stranded DNA sequencing of human plasma DNA via thermostable group II intron reverse transcriptase template switching

(2017) Douglas C. Wu et al.   Scientific Reports

Effectiveness of and overdiagnosis from mammography screening in the Netherlands: population based study

(2017) Philippe Autier et al.   BMJ-British Medical Journal

Quantification of transplant-derived circulating cell-free DNA in absence of a donor genotype

(2017) Eilon Sharon et al.   PLoS Computational Biology

Effectiveness of and overdiagnosis from mammography screening in the Netherlands: population based study

(2017) Philippe Autier et al.   BMJ-British Medical Journal

Circulating nucleosomes as new blood-based biomarkers for detection of colorectal cancer

(2017) Jean-François Rahier et al.   Clinical Epigenetics

From Erythroblasts to Mature Red Blood Cells: Organelle Clearance in Mammals

(2017) Martina Moras et al.   Frontiers in Physiology

Clinical Relevance of Circulating, Cell-Free and Exosomal microRNAs in Plasma and Serum of Breast Cancer Patients

(2017) Heidi Schwarzenbach   Oncology Research and Treatment

Adipocytes and Macrophages Interplay in the Orchestration of Tumor Microenvironment: New Implications in Cancer Progression

(2017) Luís Henrique Corrêa et al.   Frontiers in Immunology

The applications of liquid biopsy in resistance surveillance of anaplastic lymphoma kinase inhibitor

(2017) Yating Chen et al.   Cancer Management and Research

Circulating Nucleosomes and Nucleosome Modifications as Biomarkers in Cancer

(2017) Peter McAnena et al.   Cancers

Overdiagnosis of breast cancer in population screening: does it make breast screening worthless?

(2017) Houssami Nehmat et al.   Cancer Biology & Medicine

Cell-Free DNA Provides a Good Representation of the Tumor Genome Despite Its Biased Fragmentation Patterns

(2017) Xiangyuan Ma et al.   PLoS One

Statistical analysis of mutant allele frequency level of circulating cell-free DNA and blood cells in healthy individuals

(2017) Ligang Xia et al.   Scientific Reports

cfDNA correlates with endothelial damage after cardiac surgery with prolonged cardiopulmonary bypass and amplifies NETosis in an intracellular TLR9-independent manner

(2017) Adnana Paunel-Görgülü et al.   Scientific Reports

Cell-Free DNA Kinetics in a Pre-Clinical Model of Head and Neck Cancer

(2017) Nidal Muhanna et al.   Scientific Reports

Tracing the tissue of origin of plasma DNA-feasibility and implications

(2016) Yuk Ming Dennis Lo et al.   Annals of the New York Academy of Sciences

Characterization of the cell-free DNA released by cultured cancer cells

(2016) Abel Jacobus Bronkhorst et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Origins, structures, and functions of circulating DNA in oncology

(2016) A. R. Thierry et al.   CANCER AND METASTASIS REVIEWS

Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress

(2016) Samer Tohme et al.   CANCER RESEARCH

Factor H uptake regulates intracellular C3 activation during apoptosis and decreases the inflammatory potential of nucleosomes

(2016) M Martin et al.   CELL DEATH AND DIFFERENTIATION

Cell-free DNA in maternal plasma and serum: A comparison of quantity, quality and tissue origin using genomic and epigenomic approaches

(2016) Felix C.K. Wong et al.   CLINICAL BIOCHEMISTRY

Circulating Tumor DNA as a Cancer Biomarker: Fact or Fiction?

(2016) F. Leung et al.   CLINICAL CHEMISTRY

Propagation of thrombosis by neutrophils and extracellular nucleosome networks

(2016) Susanne Pfeiler et al.   HAEMATOLOGICA

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

(2016) Eileen E. Parkes et al.   JNCI-Journal of the National Cancer Institute

Cell-free DNA (cfDNA): Clinical Significance and Utility in Cancer Shaped By Emerging Technologies

(2016) S. Volik et al.   MOLECULAR CANCER RESEARCH

Inferring expressed genes by whole-genome sequencing of plasma DNA

(2016) Peter Ulz et al.   NATURE GENETICS

Neutrophil extracellular traps: protagonists of cancer progression?

(2016) L Erpenbeck et al.   ONCOGENE

Identification of tissue-specific cell death using methylation patterns of circulating DNA

(2016) Roni Lehmann-Werman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-free DNA as a diagnostic marker for cancer: current insights

(2016) Samanta Salvi et al.   OncoTargets and Therapy

Extracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation

(2016) Gerben Marsman et al.   Cell Death & Disease

Barriers to horizontal cell transformation by extracellular vesicles containing oncogenic H-ras

(2016) Tae Hoon Lee et al.   Oncotarget

Cell-free DNA and next-generation sequencing in the service of personalized medicine for lung cancer

(2016) Catherine W. Bennett et al.   Oncotarget

Fragment Length of Circulating Tumor DNA

(2016) Hunter R. Underhill et al.   PLoS Genetics

Propagation of thrombosis by neutrophils and extracellular nucleosome networks

(2016) Susanne Pfeiler et al.   HAEMATOLOGICA

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

(2016) Eileen E. Parkes et al.   JNCI-Journal of the National Cancer Institute

Intercellular Interactions as Regulators of NETosis

(2016) Nayef M. Kazzaz et al.   Frontiers in Immunology

The Selective Estrogen Receptor Modulator Raloxifene Inhibits Neutrophil Extracellular Trap Formation

(2016) Roxana Flores et al.   Frontiers in Immunology

NETosis in Cancer – Platelet–Neutrophil Crosstalk Promotes Tumor-Associated Pathology

(2016) Anna-Karin Olsson et al.   Frontiers in Immunology

New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation

(2016) Hang Yang et al.   Frontiers in Immunology

Priming of neutrophils toward NETosis promotes tumor growth

(2016) Mélanie Demers et al.   OncoImmunology

Circulating biomarkers to monitor cancer progression and treatment

(2016) Suthee Rapisuwon et al.   Computational and Structural Biotechnology Journal

Very Short Mitochondrial DNA Fragments and Heteroplasmy in Human Plasma

(2016) Ruoyu Zhang et al.   Scientific Reports

Non-random fragmentation patterns in circulating cell-free DNA reflect epigenetic regulation

(2015) Maxim Ivanov et al.   BMC GENOMICS

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

(2015) Anetta Härtlova et al.   IMMUNITY

Circulating nucleic acids damage DNA of healthy cells by integrating into their genomes

(2015) Indraneel Mittra et al.   JOURNAL OF BIOSCIENCES

Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients

(2015) Peiyong Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of the Proinflammatory and Procoagulant Properties of Nuclear, Mitochondrial, and Bacterial DNA

(2015) Vinai C. Bhagirath et al.   SHOCK

Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide

(2015) Ross Corriden et al.   Nature Communications

Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer

(2015) Muhammed Murtaza et al.   Nature Communications

Neutrophil Extracellular Trap Mitochondrial DNA and Its Autoantibody in Systemic Lupus Erythematosus and a Proof-of-Concept Trial of Metformin

(2015) Haiting Wang et al.   Arthritis & Rheumatology

Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps

(2015) Kiyoshi Itagaki et al.   PLoS One

Cell Free DNA of Tumor Origin Induces a ‘Metastatic’ Expression Profile in HT-29 Cancer Cell Line

(2015) István Fűri et al.   PLoS One

Circulating Mitochondrial DNA Level, a Noninvasive Biomarker for the Early Detection of Gastric Cancer

(2014) J. Fernandes et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Mesenchymal stem cells rescue injured endothelial cells in an in vitro ischemia–reperfusion model via tunneling nanotube like structure-mediated mitochondrial transfer

(2014) Kaiming Liu et al.   MICROVASCULAR RESEARCH

Direct Quantification of Cell-Free, Circulating DNA from Unpurified Plasma

(2014) Sarah Breitbach et al.   PLoS One

Inflammation-driven carcinogenesis is mediated through STING

(2014) Jeonghyun Ahn et al.   Nature Communications

High-Resolution Profiling of Fetal DNA Clearance from Maternal Plasma by Massively Parallel Sequencing

(2013) S. C. Y. Yu et al.   CLINICAL CHEMISTRY

Liquid biopsy: monitoring cancer-genetics in the blood

(2013) Emily Crowley et al.   Nature Reviews Clinical Oncology

Extracellular vesicle-mediated transfer of donor genomic DNA to recipient cells is a novel mechanism for genetic influence between cells

(2013) Jin Cai et al.   Journal of Molecular Cell Biology

Cooperation of Factor VII-Activating Protease and Serum DNase I in the Release of Nucleosomes From Necrotic Cells

(2013) Femke Stephan et al.   Arthritis & Rheumatology

Circulating Histones Are Mediators of Trauma-associated Lung Injury

(2012) Simon T. Abrams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Modeling nuclear molecule release duringin vitrocell death

(2012) Christian Beyer et al.   AUTOIMMUNITY

The importance of examining the proportion of circulating DNA originating from tumor, microenvironment and normal cells in colorectal cancer patients

(2012) Florent Mouliere et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death

(2012) Christian Beyer et al.   Innate Immunity

Mechanism of Release and Fate of Excised Oligonucleotides during Nucleotide Excision Repair

(2012) Michael G. Kemp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

(2012) Mohammad Naimul Islam et al.   NATURE MEDICINE

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Total serum DNA and DNA integrity: diagnostic value in patients with hepatitis B virus-related hepatocellular carcinoma

(2012) Hui Chen et al.   PATHOLOGY

Cancer Progression Mediated by Horizontal Gene Transfer in an In Vivo Model

(2012) Catalina Trejo-Becerril et al.   PLoS One

Circulating Cell-Free DNA: A Promising Marker of Pathologic Tumor Response in Rectal Cancer Patients Receiving Preoperative Chemoradiotherapy

(2011) Marco Agostini et al.   ANNALS OF SURGICAL ONCOLOGY

Origin, translocation and destination of extracellular occurring DNA — A new paradigm in genetic behaviour

(2011) Dimetrie L. Peters et al.   CLINICA CHIMICA ACTA

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Breast cancer chemotherapy induces the release of cell-free DNA, a novel procoagulant stimulus

(2011) L. L. SWYSTUN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Origin and quantification of circulating DNA in mice with human colorectal cancer xenografts

(2010) Alain R. Thierry et al.   NUCLEIC ACIDS RESEARCH

Deoxyribonuclease Activity and Circulating DNA Concentration in Blood Plasma of Patients with Prostate Tumors

(2009) Anna V. Cherepanova et al.   Annals of the New York Academy of Sciences

Clinical Relevance of Circulating Nucleosomes in Cancer

(2009) Stefan Holdenrieder et al.   Annals of the New York Academy of Sciences

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

(2009) Michele Guescini et al.   JOURNAL OF NEURAL TRANSMISSION

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Prediction of Clear Cell Renal Cell Carcinoma by Integrity of Cell-free DNA in Serum

(2009) Feng Gang et al.   UROLOGY

Quantification of circulating cell-free DNA in the plasma of cancer patients during radiation therapy

(2008) Chao Cheng et al.   CANCER SCIENCE

Circulating mutant DNA to assess tumor dynamics

(2008) Frank Diehl et al.   NATURE MEDICINE