Origins, structures, and functions of circulating DNA in oncology

Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress

(2016) Samer Tohme et al.   CANCER RESEARCH

Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin

(2016) Matthew W. Snyder et al.   CELL

Diagnostic and prognostic potential of circulating cell-free genomic and mitochondrial DNA fragments in clear cell renal cell carcinoma patients

(2016) Hongbiao Lu et al.   CLINICA CHIMICA ACTA

Circulating DNA as a Strong Multimarker Prognostic Tool for Metastatic Colorectal Cancer Patient Management Care

(2016) S. El Messaoudi et al.   CLINICAL CANCER RESEARCH

Decreased Circulating mtDNA Levels in Professional Male Volleyball Players

(2016) Milena Nasi et al.   International Journal of Sports Physiology and Performance

Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment

(2016) Jaehong Kim et al.   MEDIATORS OF INFLAMMATION

Identification of tissue-specific cell death using methylation patterns of circulating DNA

(2016) Roni Lehmann-Werman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Level of blood cell-free circulating mitochondrial DNA as a novel biomarker of acute myocardial ischemia

(2015) N. P. Sudakov et al.   BIOCHEMISTRY-MOSCOW

The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer

(2015) B A Boone et al.   CANCER GENE THERAPY

Extracellular DNA: A Bridge to Cancer

(2015) M. C. Hawes et al.   CANCER RESEARCH

Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats

(2015) Cameron G. McCarthy et al.   CARDIOVASCULAR RESEARCH

Circulating mitochondrial DNA in serum of patients with granulomatosis with polyangiitis

(2015) M. P. Surmiak et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Altered circulating mitochondrial DNA and increased inflammation in patients with diabetic retinopathy

(2015) Afshan N. Malik et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Circulating nucleic acids damage DNA of healthy cells by integrating into their genomes

(2015) Indraneel Mittra et al.   JOURNAL OF BIOSCIENCES

Cell-free DNA screening and sex chromosome aneuploidies

(2015) Michael T. Mennuti et al.   PRENATAL DIAGNOSIS

Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients

(2015) Peiyong Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer

(2015) Isaac Garcia-Murillas et al.   Science Translational Medicine

Noninvasive Antenatal Determination of Fetal Blood Group Using Next-Generation Sequencing

(2015) Klaus Rieneck et al.   Cold Spring Harbor Perspectives in Medicine

Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps

(2015) Kiyoshi Itagaki et al.   PLoS One

Mutations in circulating mitochondrial DNA: Cassandra of oral cancer?

(2015) Eugene S. Kandel   Oncotarget

Circulating tumor-derived mutant mitochondrial DNA: a predictive biomarker of clinical prognosis in human squamous cell carcinoma.

(2015) Katsuhiro Uzawa et al.   Oncotarget

Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages

(2014) Giuseppina Turturici et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Proinflammatory role of neutrophil extracellular traps in abdominal sepsis

(2014) Lingtao Luo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Circulating Tumor DNA as a Liquid Biopsy for Cancer

(2014) E. Heitzer et al.   CLINICAL CHEMISTRY

Neutrophils release extracellular DNA traps in response to exercise

(2014) Thomas Beiter et al.   JOURNAL OF APPLIED PHYSIOLOGY

Non-invasive pre-implantation genetic diagnosis of X-linked disorders

(2014) Said Assou et al.   MEDICAL HYPOTHESES

Multi-marker analysis of circulating cell-free DNA toward personalized medicine for colorectal cancer

(2014) Florent Mouliere et al.   Molecular Oncology

Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA

(2014) Alain R Thierry et al.   NATURE MEDICINE

Circulatory Mitochondrial DNA Is a Pro-Inflammatory Agent in Maintenance Hemodialysis Patients

(2014) Hongdi Cao et al.   PLoS One

Size-based molecular diagnostics using plasma DNA for noninvasive prenatal testing

(2014) S. C. Y. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative and stoichiometric analysis of the microRNA content of exosomes

(2014) J. R. Chevillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

(2014) C. Bettegowda et al.   Science Translational Medicine

Circulating miR-210 as a Novel Hypoxia Marker in Pancreatic Cancer

(2014) Allen S. Ho et al.   Translational Oncology

Circulating Cell-Free DNA from Colorectal Cancer Patients May Reveal High KRAS or BRAF Mutation Load

(2014) Florent Mouliere et al.   Translational Oncology

Extracellular vesicles shed by glioma cells: pathogenic role and clinical value

(2014) Dimitry A. Chistiakov et al.   TUMOR BIOLOGY

Circulating free mitochondrial DNA concentration and its association with erlotinib treatment in patients with adenocarcinoma of the lung

(2014) CHU-YUN HUANG et al.   Oncology Letters

Eosinophils and Cancer

(2014) B. P. Davis et al.   Cancer Immunology Research

Extracellular Vesicles: Potential Roles in Regenerative Medicine

(2014) Olivier G. De Jong et al.   Frontiers in Immunology

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression

(2013) Inbal Mishalian et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Monitoring tumor-derived cell-free DNA in patients with solid tumors: Clinical perspectives and research opportunities

(2013) Angela Esposito et al.   CANCER TREATMENT REVIEWS

Circulating cell free DNA: Preanalytical considerations

(2013) Safia El Messaoudi et al.   CLINICA CHIMICA ACTA

High-Resolution Profiling of Fetal DNA Clearance from Maternal Plasma by Massively Parallel Sequencing

(2013) S. C. Y. Yu et al.   CLINICAL CHEMISTRY

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

(2013) Jonathan Cools-Lartigue et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

(2013) Muhammed Murtaza et al.   NATURE

Liquid biopsy: monitoring cancer-genetics in the blood

(2013) Emily Crowley et al.   Nature Reviews Clinical Oncology

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

(2013) Sarah-Jane Dawson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophil extracellular traps as a new paradigm in innate immunity: friend or foe?

(2013) Paul R. Cooper et al.   PERIODONTOLOGY 2000

Circulating Mitochondrial DNA as Biomarker Linking Environmental Chemical Exposure to Early Preclinical Lesions Elevation of mtDNA in Human Serum after Exposure to Carcinogenic Halo-Alkane-Based Pesticides

(2013) Lygia T. Budnik et al.   PLoS One

Trans-Kingdom Horizontal DNA Transfer from Bacteria to Yeast Is Highly Plastic Due to Natural Polymorphisms in Auxiliary Nonessential Recipient Genes

(2013) Kazuki Moriguchi et al.   PLoS One

Nucleic Acid Scavenging Polymers Inhibit Extracellular DNA-Mediated Innate Immune Activation without Inhibiting Anti-Viral Responses

(2013) Eda K. Holl et al.   PLoS One

Molecular mechanisms regulating NETosis in infection and disease

(2013) Nora Branzk et al.   Seminars in Immunopathology

A proposed role for neutrophil extracellular traps in cancer immunoediting

(2013) Sivan Berger-Achituv et al.   Frontiers in Immunology

Neutrophil extracellular traps

(2013) Mélanie Demers et al.   OncoImmunology

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

Neutrophils Promote Liver Metastasis via Mac-1–Mediated Interactions with Circulating Tumor Cells

(2012) Jonathan D. Spicer et al.   CANCER RESEARCH

Tumor-associated neutrophils: friend or foe?

(2012) Z. G. Fridlender et al.   CARCINOGENESIS

Quantitative Cell-Free DNA, KRAS, and BRAF Mutations in Plasma from Patients with Metastatic Colorectal Cancer during Treatment with Cetuximab and Irinotecan

(2012) K.-L. G. Spindler et al.   CLINICAL CANCER RESEARCH

The origin and properties of extracellular DNA: From PAMP to DAMP

(2012) David S. Pisetsky   CLINICAL IMMUNOLOGY

Eosinophil extracellular DNA traps: molecular mechanisms and potential roles in disease

(2012) Shida Yousefi et al.   CURRENT OPINION IN IMMUNOLOGY

Oncosis: An important non-apoptotic mode of cell death

(2012) Priya Weerasinghe et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The importance of examining the proportion of circulating DNA originating from tumor, microenvironment and normal cells in colorectal cancer patients

(2012) Florent Mouliere et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Cell-free and cell-bound circulating nucleic acid complexes: mechanisms of generation, concentration and content

(2012) Elena Y Rykova et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Transformation of non-tumor host cells during tumor progression: theories and evidence

(2012) Dolores C García-Olmo et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Continuous adaptation through genetic communication – a putative role for cell-free DNA

(2012) Dimetrie L Peters et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Circulating nucleic acids and evolution

(2012) Philippe Anker et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers

(2012) C. D'Souza-Schorey et al.   GENES & DEVELOPMENT

Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

(2012) Y. Lee et al.   HUMAN MOLECULAR GENETICS

Nucleic acids in circulation: Are they harmful to the host?

(2012) Indraneel Mittra et al.   JOURNAL OF BIOSCIENCES

Neutrophil extracellular traps: Is immunity the second function of chromatin?

(2012) Volker Brinkmann et al.   JOURNAL OF CELL BIOLOGY

TLR9 Provokes Inflammation in Response to Fetal DNA: Mechanism for Fetal Loss in Preterm Birth and Preeclampsia

(2012) A. Scharfe-Nugent et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Circulating cell-free mitochondrial DNA as a novel cancer biomarker: opportunities and challenges

(2012) Man Yu   Mitochondrial DNA

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

(2012) Sandra Misale et al.   NATURE

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

(2012) Luis A. Diaz Jr et al.   NATURE

Cancer Progression Mediated by Horizontal Gene Transfer in an In Vivo Model

(2012) Catalina Trejo-Becerril et al.   PLoS One

Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity

(2011) Takumi Kawasaki et al.   IMMUNOLOGICAL REVIEWS

Generation, function and diagnostic value of mitochondrial DNA copy number alterations in human cancers

(2011) Man Yu   LIFE SCIENCES

High Fragmentation Characterizes Tumour-Derived Circulating DNA

(2011) Florent Mouliere et al.   PLoS One

Nucleic acid-binding polymers as anti-inflammatory agents

(2011) J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The blood nucleome in the pathogenesis of SLE

(2010) David S. Pisetsky et al.   AUTOIMMUNITY REVIEWS

Inhibition of metastasis development by daily administration of ultralow doses of RNase A and DNase I

(2010) Olga Patutina et al.   BIOCHIMIE

The proportion of tumour cells is an independent predictor for survival in colorectal cancer patients

(2010) N P West et al.   BRITISH JOURNAL OF CANCER

Cell-Free Nucleic Acids Circulating in the Plasma of Colorectal Cancer Patients Induce the Oncogenic Transformation of Susceptible Cultured Cells

(2010) D. C. Garcia-Olmo et al.   CANCER RESEARCH

The virtosome-a novel cytosolic informative entity and intercellular messenger

(2010) Peter B. Gahan et al.   CELL BIOCHEMISTRY AND FUNCTION

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Origin and quantification of circulating DNA in mice with human colorectal cancer xenografts

(2010) Alain R. Thierry et al.   NUCLEIC ACIDS RESEARCH

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE

(2010) Qin Zhang et al.   SHOCK

Circulating mitochondrial DNA in serum: A universal diagnostic biomarker for patients with urological malignancies

(2010) Jörg Ellinger et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Circulating Nucleic Acids in Plasma and Serum

(2009) Peter B. Gahan et al.   Annals of the New York Academy of Sciences

Metabolic DNA as the Origin of Spontaneously Released DNA?

(2009) Peter B. Gahan et al.   Annals of the New York Academy of Sciences

Is the role of circulating DNA as a biomarker of cancer being prematurely overrated?

(2009) Maniesh van der Vaart et al.   CLINICAL BIOCHEMISTRY

Clinical use of circulating nucleosomes

(2009) Stefan Holdenrieder et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Systemic inflammation increases cancer cell adhesion to hepatic sinusoids by neutrophil mediated mechanisms

(2009) Braedon McDonald et al.   INTERNATIONAL JOURNAL OF CANCER

DNase 1 activity in patients with systemic lupus erythematosus: relationship with epidemiological, clinical, immunological and therapeutical features

(2009) F Martinez-Valle et al.   LUPUS

Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors

(2009) Corina Kohler et al.   Molecular Cancer

A new perspective on Darwin’s Pangenesis

(2008) Yongsheng Liu   BIOLOGICAL REVIEWS

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE

Circulating mutant DNA to assess tumor dynamics

(2008) Frank Diehl et al.   NATURE MEDICINE