IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

(2009) Hyunkyung Jeong et al.   CELL

Phosphorylation of Threonine 3

(2009) Charity T. Aiken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice

(2009) Xiaofeng Gu et al.   NEURON

IKKα and IKKβ Regulation of DNA Damage-Induced Cleavage of Huntingtin

(2009) Ali Khoshnan et al.   PLoS One

Akt-dependent regulation of NF- B is controlled by mTOR and Raptor in association with IKK

(2008) H. C. Dan et al.   GENES & DEVELOPMENT

Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus

(2008) Simon C. Warby et al.   HUMAN MOLECULAR GENETICS

Proteasome activation as a novel antiaging strategy

(2008) Niki Chondrogianni et al.   IUBMB LIFE

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

(2008) Maria Björkqvist et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intrabodies Binding the Proline-Rich Domains of Mutant Huntingtin Increase Its Turnover and Reduce Neurotoxicity

(2008) A. L. Southwell et al.   JOURNAL OF NEUROSCIENCE

Characterization of the Human COP9 Signalosome Complex Using Affinity Purification and Mass Spectrometry

(2008) Lei Fang et al.   JOURNAL OF PROTEOME RESEARCH

Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

(2008) A. Tonoki et al.   MOLECULAR AND CELLULAR BIOLOGY

CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice

(2008) Barbara L. Apostol et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments

(2008) Simon C. Warby et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

(2008) Cong Zhang et al.   NATURE MEDICINE

Characterization of the proteasome interaction network using a QTAX-based tag-team strategy and protein interaction network analysis

(2008) C. Guerrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA