Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion

Correlative cryo-electron microscopy reveals the structure of TNTs in neuronal cells

(2019) Anna Sartori-Rupp et al.   Nature Communications

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

(2019) Israel Hernandez et al.   Science Translational Medicine

Bioelectrical coupling in multicellular domains regulated by gap junctions: A conceptual approach

(2018) Javier Cervera et al.   BIOELECTROCHEMISTRY

Stereotyped Synaptic Connectivity Is Restored during Circuit Repair in the Adult Mammalian Retina

(2018) Corinne Beier et al.   CURRENT BIOLOGY

Exosomes and extracellular vesicles: the path forward

(2018) Philip D. Stahl et al.   Essays in Biochemistry

Tunneling Nanotubes as a Novel Route of Cell-to-Cell Spread of Herpesviruses

(2018) Mirosława Panasiuk et al.   JOURNAL OF VIROLOGY

Intercellular transfer of mitochondria rescues virus-induced cell death but facilitates cell-to-cell spreading of porcine reproductive and respiratory syndrome virus

(2018) Rui Guo et al.   VIROLOGY

Tunneling Nanotubes: Intimate Communication between Myeloid Cells

(2018) Maeva Dupont et al.   Frontiers in Immunology

Huntington's disease: a clinical review

(2017) P. McColgan et al.   EUROPEAN JOURNAL OF NEUROLOGY

Mutant Huntingtin Inhibits αB-Crystallin Expression and Impairs Exosome Secretion from Astrocytes

(2017) Yan Hong et al.   JOURNAL OF NEUROSCIENCE

Pseudorabies Virus US3-Induced Tunneling Nanotubes Contain Stabilized Microtubules, Interact with Neighboring Cells via Cadherins, and Allow Intercellular Molecular Communication

(2017) Robert J. J. Jansens et al.   JOURNAL OF VIROLOGY

Influenza virus exploits tunneling nanotubes for cell-to-cell spread

(2017) Amrita Kumar et al.   Scientific Reports

Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy

(2017) Marie-Luce Vignais et al.   Stem Cells International

Tunneling Nanotubes and Gap Junctions–Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions

(2017) Jennifer Ariazi et al.   Frontiers in Molecular Neuroscience

Human-to-mouse prion-like propagation of mutant huntingtin protein

(2016) Iksoo Jeon et al.   ACTA NEUROPATHOLOGICA

Communication of Ca2+ signals via tunneling membrane nanotubes is mediated by transmission of inositol trisphosphate through gap junctions

(2016) Jeffrey T. Lock et al.   CELL CALCIUM

Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages

(2016) Michihiro Hashimoto et al.   JOURNAL OF IMMUNOLOGY

Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases

(2016) Saida Abounit et al.   Prion

RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum

(2016) N. Shahani et al.   Science Signaling

Rab8a/Rab11a regulate intercellular communications between neural cells via tunneling nanotubes

(2016) Hui Zhu et al.   Cell Death & Disease

Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells

(2016) Snider Desir et al.   Oncotarget

RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum

(2016) N. Shahani et al.   Science Signaling

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

(2016) Meryem Tardivel et al.   Acta Neuropathologica Communications

Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes

(2016) Elise Delage et al.   Scientific Reports

B-cell precursor acute lymphoblastic leukemia cells use tunneling nanotubes to orchestrate their microenvironment

(2015) R. Polak et al.   BLOOD

Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells

(2015) X Wang et al.   CELL DEATH AND DIFFERENTIATION

Intercellular transfer of transferrin receptor by a contact-, Rab8-dependent mechanism involving tunneling nanotubes

(2015) Anne Burtey et al.   FASEB JOURNAL

Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado–Joseph disease

(2015) Joana Duarte-Neves et al.   HUMAN MOLECULAR GENETICS

Nanotubes Connect CD4+T Cells to Airway Smooth Muscle Cells: Novel Mechanism of T Cell Survival

(2015) Saba Al Heialy et al.   JOURNAL OF IMMUNOLOGY

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease

(2015) Supriya Swarnkar et al.   NEUROBIOLOGY OF DISEASE

Transcellular spreading of huntingtin aggregates in theDrosophilabrain

(2015) Daniel T. Babcock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant huntingtin is present in neuronal grafts in huntington disease patients

(2014) Francesca Cicchetti et al.   ANNALS OF NEUROLOGY

Cutting Edge: Membrane Nanotubes In Vivo: A Feature of MHC Class II + Cells in the Mouse Cornea

(2014) Holly R. Chinnery et al.   JOURNAL OF IMMUNOLOGY

Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons

(2014) Eline Pecho-Vrieseling et al.   NATURE NEUROSCIENCE

Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease

(2014) W. M. Pryor et al.   Science Signaling

Exo70 Generates Membrane Curvature for Morphogenesis and Cell Migration

(2013) Yuting Zhao et al.   DEVELOPMENTAL CELL

A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration

(2013) Boxun Lu et al.   FASEB JOURNAL

Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes

(2013) M. Costanzo et al.   JOURNAL OF CELL SCIENCE

Myo10 is a key regulator of TNT formation in neuronal cells

(2013) K. Gousset et al.   JOURNAL OF CELL SCIENCE

Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia

(2013) Marcus Bischoff et al.   NATURE CELL BIOLOGY

Attenuation of Rhes Activity Significantly Delays the Appearance of Behavioral Symptoms in a Mouse Model of Huntington's Disease

(2013) Brandon A. Baiamonte et al.   PLoS One

Golgi Protein ACBD3 Mediates Neurotoxicity Associated with Huntington’s Disease

(2013) Juan I. Sbodio et al.   Cell Reports

SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation

(2013) Jacqueline Gire O’Rourke et al.   Cell Reports

Exo70 Stimulates the Arp2/3 Complex for Lamellipodia Formation and Directional Cell Migration

(2012) Jianglan Liu et al.   CURRENT BIOLOGY

Tunneling nanotubes enable intercellular transfer of MHC class I molecules

(2012) Christian Schiller et al.   HUMAN IMMUNOLOGY

Tunneling nanotubes, an emerging intercellular communication route in development

(2012) Hans-Hermann Gerdes et al.   MECHANISMS OF DEVELOPMENT

Multi-Level Communication of Human Retinal Pigment Epithelial Cells via Tunneling Nanotubes

(2012) Dierk Wittig et al.   PLoS One

Tunneling Nanotubes Provide a Unique Conduit for Intercellular Transfer of Cellular Contents in Human Malignant Pleural Mesothelioma

(2012) Emil Lou et al.   PLoS One

Active Generation and Propagation of Ca2+ Signals within Tunneling Membrane Nanotubes

(2011) Ian F. Smith et al.   BIOPHYSICAL JOURNAL

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA–induced dyskinesia

(2011) Srinivasa Subramaniam et al.   NATURE NEUROSCIENCE

Intercellular Bridges in Vertebrate Gastrulation

(2011) Luca Caneparo et al.   PLoS One

Decreased Striatal RGS2 Expression Is Neuroprotective in Huntington's Disease (HD) and Exemplifies a Compensatory Aspect of HD-Induced Gene Regulation

(2011) Tamara Seredenina et al.   PLoS One

Mechanisms, regulation and consequences of protein SUMOylation

(2010) Kevin A. Wilkinson et al.   BIOCHEMICAL JOURNAL

Dynamic imaging of mammalian neural tube closure

(2010) Christina Pyrgaki et al.   DEVELOPMENTAL BIOLOGY

Rhes, a Physiologic Regulator of Sumoylation, Enhances Cross-sumoylation between the Basic Sumoylation Enzymes E1 and Ubc9

(2010) Srinivasa Subramaniam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntington’s Disease is a disorder of the corpus striatum: Focus on Rhes (Ras homologue enriched in the striatum)

(2010) Srinivasa Subramaniam et al.   NEUROPHARMACOLOGY

Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channels

(2010) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex

(2009) Koji Hase et al.   NATURE CELL BIOLOGY

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration

(2009) F. Cicchetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity

(2009) S. Subramaniam et al.   SCIENCE

Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

(2008) Sandro Alves et al.   HUMAN MOLECULAR GENETICS

Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission

(2008) Stefanie Sowinski et al.   NATURE CELL BIOLOGY