Transcription, Epigenetics and Ameliorative Strategies in Huntington’s Disease: a Genome-Wide Perspective

Study of cholesterol metabolism in Huntington′s disease

(2014) Valerio Leoni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The panorama of miRNA-mediated mechanisms in mammalian cells

(2014) Anna Stroynowska-Czerwinska et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Decoding transcriptional repressor complexes in the adult central nervous system

(2014) Megumi Adachi et al.   NEUROPHARMACOLOGY

Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca2+ signaling in Huntington’s disease

(2013) Junghee Lee et al.   ACTA NEUROPATHOLOGICA

FOXP1mutations cause intellectual disability and a recognizable phenotype

(2013) Anna K. Le Fevre et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Reconciling differential gene expression data with molecular interaction networks

(2013) Christopher L. Poirel et al.   BIOINFORMATICS

Longitudinal transcriptomic dysregulation in the peripheral blood of transgenic Huntington’s disease monkeys

(2013) Jannet Kocerha et al.   BMC NEUROSCIENCE

Lysine Acetyltransferases CBP and p300 as Therapeutic Targets in Cognitive and Neurodegenerative Disorders

(2013) Luis Valor et al.   CURRENT PHARMACEUTICAL DESIGN

A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration

(2013) Boxun Lu et al.   FASEB JOURNAL

Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age

(2013) Amanda G. Mason et al.   HUMAN MOLECULAR GENETICS

Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease

(2013) Fabiola M. Ribeiro et al.   HUMAN MOLECULAR GENETICS

Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease

(2013) Fengli Wang et al.   HUMAN MOLECULAR GENETICS

Dominant effects of the Huntington's disease HTT CAG repeat length are captured in gene-expression data sets by a continuous analysis mathematical modeling strategy

(2013) Jong-Min Lee et al.   HUMAN MOLECULAR GENETICS

ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (ARFGEF2): A New Potential Biomarker in Huntington's Disease

(2013) L Lovrecic et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Specific Acetylation of p53 by HDAC Inhibition Prevents DNA Damage-Induced Apoptosis in Neurons

(2013) C. Brochier et al.   JOURNAL OF NEUROSCIENCE

Genomic Landscape of Transcriptional and Epigenetic Dysregulation in Early Onset Polyglutamine Disease

(2013) L. M. Valor et al.   JOURNAL OF NEUROSCIENCE

Gene expression profile in fibroblasts of Huntington's disease patients and controls

(2013) Eleonora Marchina et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Histone H3 lysine methylation in cognition and intellectual disability disorders

(2013) S. Parkel et al.   LEARNING & MEMORY

Association of heat-shock proteins in various neurodegenerative disorders: is it a master key to open the therapeutic door?

(2013) Subhankar Paul et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

What's wrong with epigenetics in Huntington's disease?

(2013) Luis M. Valor et al.   NEUROPHARMACOLOGY

MicroRNA-22 (miR-22) Overexpression Is Neuroprotective via General Anti-Apoptotic Effects and May also Target Specific Huntington’s Disease-Related Mechanisms

(2013) Ana Jovicic et al.   PLoS One

Systemic Delivery of Recombinant Brain Derived Neurotrophic Factor (BDNF) in the R6/2 Mouse Model of Huntington’s Disease

(2013) Carmela Giampà et al.   PLoS One

HDAC4 Does Not Act as a Protein Deacetylase in the Postnatal Murine Brain In Vivo

(2013) Michal Mielcarek et al.   PLoS One

Extensive changes in DNA methylation are associated with expression of mutant huntingtin

(2013) C. W. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting H3K4 trimethylation in Huntington disease

(2013) M. Vashishtha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes

(2013) Jérémie Charbord et al.   STEM CELLS

The involvement of microRNAs in neurodegenerative diseases

(2013) Simona Maciotta et al.   Frontiers in Cellular Neuroscience

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

(2013) Baoxu Pang et al.   Nature Communications

Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress

(2013) Julia Leitman et al.   Nature Communications

HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration

(2013) Michal Mielcarek et al.   PLOS BIOLOGY

Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum

(2012) Richard Grondin et al.   BRAIN

Comparative analyses of Purkinje cell gene expression profiles reveal shared molecular abnormalities in models of different polyglutamine diseases

(2012) Bernd Friedrich et al.   BRAIN RESEARCH

HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory

(2012) Richard Sando et al.   CELL

ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease

(2012) J Lee et al.   CELL DEATH AND DIFFERENTIATION

Axon degeneration in Parkinson's disease

(2012) Robert E. Burke et al.   EXPERIMENTAL NEUROLOGY

Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells

(2012) Maxime Feyeux et al.   HUMAN MOLECULAR GENETICS

Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease

(2012) Bin Tang et al.   HUMAN MOLECULAR GENETICS

Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin

(2012) Jing Jin et al.   JOURNAL OF NEUROCHEMISTRY

Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington's disease

(2012) Chiara Soldati et al.   JOURNAL OF NEUROCHEMISTRY

Common Transcriptional Signatures in Brain Tissue from Patients with HIV-Associated Neurocognitive Disorders, Alzheimer’s Disease, and Multiple Sclerosis

(2012) Alejandra Borjabad et al.   Journal of Neuroimmune Pharmacology

Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases

(2012) Rajnish K. Chaturvedi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Epigenetic mechanisms in neurological disease

(2012) Mira Jakovcevski et al.   NATURE MEDICINE

Gene expression analysis on a single cell level in Purkinje cells of Huntington's disease transgenic mice

(2012) Philipp Euler et al.   NEUROSCIENCE LETTERS

Genome-Wide Histone Acetylation Is Altered in a Transgenic Mouse Model of Huntington's Disease

(2012) Karen N. McFarland et al.   PLoS One

Developmental Alterations in Motor Coordination and Medium Spiny Neuron Markers in Mice Lacking PGC-1α

(2012) Elizabeth K. Lucas et al.   PLoS One

A Pathogenic Mechanism in Huntington's Disease Involves Small CAG-Repeated RNAs with Neurotoxic Activity

(2012) Mónica Bañez-Coronel et al.   PLoS Genetics

Genome wide gene expression regulation by HIP1 Protein Interactor, HIPPI: Prediction and validation

(2011) Moumita Datta et al.   BMC GENOMICS

Dysregulation of upstream binding factor-1 acetylation at K352 is linked to impaired ribosomal DNA transcription in Huntington's disease

(2011) J Lee et al.   CELL DEATH AND DIFFERENTIATION

CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement

(2011) Jose P Lopez-Atalaya et al.   EMBO JOURNAL

Protein aggregates in Huntington's disease

(2011) Montserrat Arrasate et al.   EXPERIMENTAL NEUROLOGY

Using non-coding small RNAs to develop therapies for Huntington's disease

(2011) Y Zhang et al.   GENE THERAPY

Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter

(2011) Elodie Martin et al.   HUMAN MOLECULAR GENETICS

Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative

(2011) Elisa Fossale et al.   HUMAN MOLECULAR GENETICS

HD CAG-correlated gene expression changes support a simple dominant gain of function

(2011) Jessie C. Jacobsen et al.   HUMAN MOLECULAR GENETICS

Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease

(2011) Philip Michael Gaughwin et al.   HUMAN MOLECULAR GENETICS

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

(2011) John Labbadia et al.   JOURNAL OF CLINICAL INVESTIGATION

Modifications of p53 and the DNA Damage Response in Cells Expressing Mutant Form of the Protein Huntingtin

(2011) Jennifer L. Illuzzi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mithramycin Is a Gene-Selective Sp1 Inhibitor That Identifies a Biological Intersection between Cancer and Neurodegeneration

(2011) S. F. Sleiman et al.   JOURNAL OF NEUROSCIENCE

Suppression of aggregate formation of mutant huntingtin potentiates CREB-binding protein sequestration and apoptotic cell death

(2011) Yong-Joon Choi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Rational Design of Therapeutic siRNAs: Minimizing Off-targeting Potential to Improve the Safety of RNAi Therapy for Huntington's Disease

(2011) Ryan L Boudreau et al.   MOLECULAR THERAPY

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

(2011) Mali Jiang et al.   NATURE MEDICINE

Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain

(2011) Alexandre Kuhn et al.   NATURE METHODS

Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease

(2011) Bin Tang et al.   NEUROBIOLOGY OF DISEASE

What have we learned from gene expression profiles in Huntington's disease?

(2011) Tamara Seredenina et al.   NEUROBIOLOGY OF DISEASE

Protective action of mithramycin against neurodegeneration and impairment of synaptic plasticity in the hippocampal CA1 area after transient global ischemia

(2011) Nobuhiro Osada et al.   NEUROCHEMISTRY INTERNATIONAL

Huntington's disease: new aspects on phenotype and genotype

(2011) Huifang Shang et al.   PARKINSONISM & RELATED DISORDERS

Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse

(2011) Y. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of CREB signaling in Alzheimer’s disease and other cognitive disorders

(2011) Carlos A. Saura et al.   REVIEWS IN THE NEUROSCIENCES

Emerging roles for cholesterol in Huntington's disease

(2011) Marta Valenza et al.   TRENDS IN NEUROSCIENCES

The impact of acetylation and deacetylation on the p53 pathway

(2011) Christopher L. Brooks et al.   Protein & Cell

Altered microRNAs in STHdhQ111/HdhQ111 cells: miR-146a targets TBP

(2010) Mithun Sinha et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A novel approach to investigate tissue-specific trinucleotide repeat instability

(2010) Jong-Min Lee et al.   BMC Systems Biology

Ultrastructural and transcriptional profiling of neuropathological misregulation of CREB function

(2010) L M Valor et al.   CELL DEATH AND DIFFERENTIATION

Induction of Molecular Chaperones as a Therapeutic Strategy for the Polyglutamine Diseases

(2010) Yoshitaka Nagai et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Mutant huntingtin-impaired degradation of β-catenin causes neurotoxicity in Huntington's disease

(2010) Juliette D Godin et al.   EMBO JOURNAL

Altered microRNA regulation in Huntington's disease models

(2010) Soon-Tae Lee et al.   EXPERIMENTAL NEUROLOGY

Hippocampal gene profiling: Toward a systems biology of the hippocampus

(2010) Luis M. Valor et al.   HIPPOCAMPUS

In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons

(2010) Elizabeth A. Thomas et al.   HUMAN MOLECULAR GENETICS

The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus

(2010) Edoardo Marcora et al.   HUMAN MOLECULAR GENETICS

Mutant Huntingtin Alters Cell Fate in Response to Microtubule Depolymerization via the GEF-H1-RhoA-ERK Pathway

(2010) Hemant Varma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Gene Expression Profiling in Yeast Implicates Translational Dysfunction in Mutant Huntingtin Toxicity

(2010) Eran Tauber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington’s disease

(2010) Chiara Soldati et al.   JOURNAL OF NEUROCHEMISTRY

Decreased Lin7b Expression in Layer 5 Pyramidal Neurons May Contribute to Impaired Corticostriatal Connectivity in Huntington Disease

(2010) Birgit Zucker et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Environmental Enrichment Reduces Neuronal Intranuclear Inclusion Load But Has No Effect on Messenger RNA Expression in a Mouse Model of Huntington Disease

(2010) Caroline L. Benn et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

BDNF Overexpression in the Forebrain Rescues Huntington's Disease Phenotypes in YAC128 Mice

(2010) Y. Xie et al.   JOURNAL OF NEUROSCIENCE

3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington’s Disease: Past, Present and Future

(2010) Isaac Túnez et al.   MOLECULES

The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease

(2010) Noel J. Buckley et al.   NEUROBIOLOGY OF DISEASE

A myriad of miRNA variants in control and Huntington’s disease brain regions detected by massively parallel sequencing

(2010) Eulàlia Martí et al.   NUCLEIC ACIDS RESEARCH

Human accelerated region 1 noncoding RNA is repressed by REST in Huntington's disease

(2010) Rory Johnson et al.   PHYSIOLOGICAL GENOMICS

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Inhibition of the Striatal Specific Phosphodiesterase PDE10A Ameliorates Striatal and Cortical Pathology in R6/2 Mouse Model of Huntington's Disease

(2010) Carmela Giampà et al.   PLoS One

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

(2010) Ruth Luthi-Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

Targeting the correct HDAC(s) to treat cognitive disorders

(2010) André Fischer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sustained effects of nonallele-specificHuntingtinsilencing

(2009) Valérie Drouet et al.   ANNALS OF NEUROLOGY

ATF3 plays a protective role against toxicity by N-terminal fragment of mutant huntingtin in stable PC12 cell line

(2009) Yideng Liang et al.   BRAIN RESEARCH

Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

(2009) Hyunkyung Jeong et al.   CELL

Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors

(2009) M Futter et al.   JOURNAL OF MEDICAL GENETICS

The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease

(2009) A. N. Packer et al.   JOURNAL OF NEUROSCIENCE

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

(2009) Rocio G Urdinguio et al.   LANCET NEUROLOGY

Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice

(2009) Ryan L Boudreau et al.   MOLECULAR THERAPY

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease

(2009) Yun-Sik Choi et al.   NEUROBIOLOGY OF DISEASE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts

(2008) Hua Zhang et al.   BMC NEUROSCIENCE

Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor

(2008) Tomoyuki Yamanaka et al.   EMBO JOURNAL

Monoallele deletion of CBP leads to pericentromeric heterochromatin condensation through ESET expression and histone H3 (K9) methylation

(2008) Junghee Lee et al.   HUMAN MOLECULAR GENETICS

Protective role of Engrailed in a Drosophila model of Huntington's disease

(2008) Bruno Mugat et al.   HUMAN MOLECULAR GENETICS

Huntingtin Modulates Transcription, Occupies Gene Promoters In Vivo, and Binds Directly to DNA in a Polyglutamine-Dependent Manner

(2008) C. L. Benn et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of Gene Expression in Primary Neuron Models of Huntington's Disease Shows That Polyglutamine-Related Effects on the Striatal Transcriptome May Not Be Dependent on Brain Circuitry

(2008) H. Runne et al.   JOURNAL OF NEUROSCIENCE

Expanded CAG repeats in the murine Huntington's disease gene increases neuronal differentiation of embryonic and neural stem cells

(2008) Matthew T. Lorincz et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease

(2008) Zena DeMarch et al.   NEUROBIOLOGY OF DISEASE

Target Identification for CNS Diseases by Transcriptional Profiling

(2008) C Anthony Altar et al.   NEUROPSYCHOPHARMACOLOGY

The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

(2008) E. A. Thomas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington’s disease

(2007) A. Hodges et al.   GENES BRAIN AND BEHAVIOR

Gene–environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington’s disease transgenic mice

(2007) Jess Nithianantharajah et al.   NEUROBIOLOGY OF DISEASE

A microRNA-based gene dysregulation pathway in Huntington's disease

(2007) Rory Johnson et al.   NEUROBIOLOGY OF DISEASE