The Emerging Role of MicroRNAs in NAFLD: Highlight of MicroRNA-29a in Modulating Oxidative Stress, Inflammation, and Beyond

Are Liver Pericytes Just Precursors of Myofibroblasts in Hepatic Diseases? Insights from the Crosstalk between Perivascular and Inflammatory Cells in Liver Injury and Repair

(2020) Lindolfo da Silva Meirelles et al.   Cells

A-Kinase Anchoring Protein 1: Emerging Roles in Regulating Mitochondrial Form and Function in Health and Disease

(2020) Yujia Liu et al.   Cells

CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway

(2019) Yun Li et al.   JOURNAL OF LIPID RESEARCH

miR-148a regulates expression of the transferrin receptor 1 in hepatocellular carcinoma

(2019) Kamesh R. Babu et al.   Scientific Reports

MicroRNA-29a Disrupts DNMT3b to Ameliorate Diet-Induced Non-Alcoholic Steatohepatitis in Mice

(2019) Ya-Ling Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cardio-Metabolic Disorders in Non-Alcoholic Fatty Liver Disease

(2019) Hamza El Hadi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Associations of plasma CD36 and body fat distribution

(2019) Yeli Wang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Accumulation of free cholesterol and oxidized low-density lipoprotein is associated with portal inflammation and fibrosis in nonalcoholic fatty liver disease

(2019) Cheng-Maw Ho et al.   Journal of Inflammation-London

Skeletal muscle miR-34a/SIRT1:AMPK axis is activated in experimental and human non-alcoholic steatohepatitis

(2019) André L. Simão et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Brain involvement in non-alcoholic fatty liver disease (NAFLD): A systematic review

(2019) Rosa Lombardi et al.   DIGESTIVE AND LIVER DISEASE

miRNAs and NAFLD: from pathophysiology to therapy

(2019) Monika Gjorgjieva et al.   GUT

Antitumor activity of sevoflurane in HCC cell line is mediated by miR‐29a‐induced suppression of Dnmt3a

(2019) Guangming Song et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Reduction of miR-29a-3p induced cardiac ischemia reperfusion injury in mice via targeting Bax

(2019) Liang Zhang et al.   Experimental and Therapeutic Medicine

ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy

(2019) Yuan Tian et al.   Nature Communications

Mitochondria and Inflammation: Cell Death Heats Up

(2019) Esmee Vringer et al.   Frontiers in Cell and Developmental Biology

Molecular insights into the role of mitochondria in non-alcoholic fatty liver disease

(2019) Jin Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

miR-21 promotes non-small cell lung cancer cells growth by regulating fatty acid metabolism

(2019) Kewei Ni et al.   Cancer Cell International

High Blood miR-802 Is Associated With Poor Prognosis in HCC Patients by Regulating DNA Damage Response 1 (REDD1)-Mediated Function of T Cells

(2019) Chao Jiang et al.   ONCOLOGY RESEARCH

The miRFIB-Score: A Serological miRNA-Based Scoring Algorithm for the Diagnosis of Significant Liver Fibrosis

(2019) Lambrecht et al.   Cells

MicroRNA-29a Counteracts Glucocorticoid Induction of Bone Loss through Repressing TNFSF13b Modulation of Osteoclastogenesis

(2019) Re-Wen Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of MicroRNAs in Parkinson’s Disease

(2019) Suh Yee Goh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial plasticity in cell fate regulation

(2019) Amir Bahat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating miRNAs as Biomarkers of Obesity and Obesity-Associated Comorbidities in Children and Adolescents: A Systematic Review

(2019) Maddi Oses et al.   Nutrients

MicroRNA-29a Suppresses CD36 to Ameliorate High Fat Diet-Induced Steatohepatitis and Liver Fibrosis in Mice

(2019) Hung-Yu Lin et al.   Cells

The Non-Canonical Aspects of MicroRNAs: Many Roads to Gene Regulation

(2019) Christiaan J. Stavast et al.   Cells

Mitochondrial Dysfunction in the Transition from NASH to HCC

(2019) Mélissa Léveillé et al.   Metabolites

Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses

(2019) Yiliang Chen et al.   CIRCULATION RESEARCH

2, 2′, 4, 4′-tetrabromodiphenyl ether (BDE-47) induces mitochondrial dysfunction and related liver injury via eliciting miR-34a-5p-mediated mitophagy impairment

(2019) Feng Chen et al.   ENVIRONMENTAL POLLUTION

microRNA-29a regulates liver tumor-initiating cells expansion via Bcl-2 pathway

(2019) Shaohua Song et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial double‐stranded RNA in exosome promotes interleukin‐17 production through toll‐like receptor 3 in alcoholic liver injury

(2019) Jun‐Hee Lee et al.   HEPATOLOGY

MicroRNAs Involved in Metastasis of Hepatocellular Carcinoma: Target Candidates, Functionality and Efficacy in Animal Models and Prognostic Relevance

(2019) ULRICH H. WEIDLE et al.   Cancer Genomics & Proteomics

MicroRNA-29a mitigation of toll-like receptor 2 and 4 signaling and alleviation of obstructive jaundice-induced fibrosis in mice

(2018) Yen-Cheng Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A circulating microRNA signature as noninvasive diagnostic and prognostic biomarkers for nonalcoholic steatohepatitis

(2018) Jie Liu et al.   BMC GENOMICS

MiR-29a suppresses cell proliferation by targeting SIRT1 in hepatocellular carcinoma

(2018) Yongyu Zhang et al.   Cancer Biomarkers

MicroRNA-34a-5p inhibits liver fibrosis by regulating TGF-β1/Smad3 pathway in hepatic stellate cells

(2018) Xiaofei Li et al.   CELL BIOLOGY INTERNATIONAL

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

(2018) David Højland Ipsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Evolutionary consequences of epigenetic inheritance

(2018) Martin I. Lind et al.   HEREDITY

The Role of miR-29a in the Regulation, Function, and Signaling of Liver Fibrosis

(2018) Ying-Hsien Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease

(2018) Cynthia Lebeaupin et al.   JOURNAL OF HEPATOLOGY

Plasma MicroRNA-21, 26a, and 29a-3p as Predictive Markers for Treatment Response Following Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma

(2018) Soon Sun Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Development and validation of serum exosomal microRNAs as diagnostic and prognostic biomarkers for hepatocellular carcinoma

(2018) Xiaofeng Xue et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

(2018) Ashish Dhir et al.   NATURE

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Upregulation of miR-181a impairs lipid metabolism by targeting PPARα expression in nonalcoholic fatty liver disease

(2018) Ruixian Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dietary Lipids Differentially Shape NASH Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages

(2018) Brett McGettigan et al.   HEPATOLOGY

miRNA Signature in NAFLD: A Turning Point for a Non-Invasive Diagnosis

(2018) Paola Dongiovanni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amelioration of hepatic steatosis is associated with modulation of gut microbiota and suppression of hepatic miR-34a in Gynostemma pentaphylla (Thunb.) Makino treated mice

(2018) Ning Jia et al.   Nutrition & Metabolism

Suppression of SUN2 by DNA methylation is associated with HSCs activation and hepatic fibrosis

(2018) Xin Chen et al.   Cell Death & Disease

High Fat Diet-Induced miR-122 Regulates Lipid Metabolism and Fat Deposition in Genetically Improved Farmed Tilapia (GIFT, Oreochromis niloticus) Liver

(2018) Jun Qiang et al.   Frontiers in Physiology

MicroRNA-29a mitigation of endoplasmic reticulum and autophagy aberrance counteracts in obstructive jaundice-induced fibrosis in mice

(2017) Ying-Hsien Huang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

MicroRNA-29a Alleviates Bile Duct Ligation Exacerbation of Hepatic Fibrosis in Mice through Epigenetic Control of Methyltransferases

(2017) Ya-Ling Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Combined low miRNA-29s is an independent risk factor in predicting prognosis of patients with hepatocellular carcinoma after hepatectomy

(2017) Zhen Zhang et al.   MEDICINE

Leptin reduces microRNA-122 level in hepatic stellate cells in vitro and in vivo

(2017) Xuguang Zhai et al.   MOLECULAR IMMUNOLOGY

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Mitochondrial Adaptation in Nonalcoholic Fatty Liver Disease: Novel Mechanisms and Treatment Strategies

(2017) Nishanth E. Sunny et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

MicroRNA-29a induces loss of 5-hydroxymethylcytosine and promotes metastasis of hepatocellular carcinoma through a TET–SOCS1–MMP9 signaling axis

(2017) Qing Chen et al.   Cell Death & Disease

Low levels of circulating microRNA-26a/29a as poor prognostic markers in patients with hepatocellular carcinoma who underwent curative treatment

(2017) Hyo Jung Cho et al.   Clinics and Research in Hepatology and Gastroenterology

Upregulation of miR-181a impairs hepatic glucose and lipid homeostasis

(2017) Xiliang Du et al.   Oncotarget

Genetic Dissection of the Impact of miR-33a and miR-33b during the Progression of Atherosclerosis

(2017) Nathan L. Price et al.   Cell Reports

New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease

(2017) Mireia López-Riera et al.   Frontiers in Pharmacology

Blood-derived macrophages prone to accumulate lysosomal lipids trigger oxLDL-dependent murine hepatic inflammation

(2017) Tom Houben et al.   Scientific Reports

MicroRNAs in metabolism

(2016) S. Vienberg et al.   Acta Physiologica

The Relationship of Plasma miR-29a and Oxidized Low Density Lipoprotein with Atherosclerosis

(2016) Yu-Qing Huang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice

(2016) Camella G. Wilson et al.   ENDOCRINOLOGY

Stress-activatedmiR-21/miR-21*in hepatocytes promotes lipid and glucose metabolic disorders associated with high-fat diet consumption

(2016) Nicolas Calo et al.   GUT

Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood

(2016) Akiko Eguchi et al.   HEPATOLOGY

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

MiR-29a Assists in Preventing the Activation of Human Stellate Cells and Promotes Recovery From Liver Fibrosis in Mice

(2016) Yoshinari Matsumoto et al.   MOLECULAR THERAPY

MicroRNAs activate gene transcription epigenetically as an enhancer trigger

(2016) Min Xiao et al.   RNA Biology

Disease-specific miR-34a as diagnostic marker of non-alcoholic steatohepatitis in a Chinese population

(2016) Xiao-Lin Liu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Serum microRNA profiles as prognostic biomarkers for HBV-positive hepatocellular carcinoma

(2016) Hao-Tu Zhu et al.   Oncotarget

Protective effects of miR-29a on diabetic glomerular dysfunction by modulation of DKK1/Wnt/β-catenin signaling

(2016) Yung-Chien Hsu et al.   Scientific Reports

Underexpression of CACNA1C Caused by Overexpression of microRNA-29a Underlies the Pathogenesis of Atrial Fibrillation

(2016) Yujie Zhao et al.   MEDICAL SCIENCE MONITOR

Circulating miR-21 and miR-29a as Markers of Disease Severity and Etiology in Cholestatic Pediatric Liver Disease

(2016) Imeke Goldschmidt et al.   Journal of Clinical Medicine

Therapeutic Inhibition of miR-33 Promotes Fatty Acid Oxidation but Does Not Ameliorate Metabolic Dysfunction in Diet-Induced ObesitySignificance

(2015) Denuja Karunakaran et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression

(2015) Xavier Loyer et al.   GUT

Nonalcoholic Fatty Liver Disease

(2015) Mary E. Rinella   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Glucose fluctuation increased hepatocyte apoptosis under lipotoxicity and the involvement of mitochondrial permeability transition opening

(2015) Xueyao Yin et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

MicroRNA-29a Is a Candidate Biomarker for Alzheimer’s Disease in Cell-Free Cerebrospinal Fluid

(2015) Mareike Müller et al.   MOLECULAR NEUROBIOLOGY

Performance of Serum microRNAs -122, -192 and -21 as Biomarkers in Patients with Non-Alcoholic Steatohepatitis

(2015) Philip P. Becker et al.   PLoS One

Systemic Delivery of scAAV8-Encoded MiR-29a Ameliorates Hepatic Fibrosis in Carbon Tetrachloride-Treated Mice

(2015) Matthew K. Knabel et al.   PLoS One

BRD4 is a novel therapeutic target for liver fibrosis

(2015) Ning Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease

(2015) Neal L. Millar et al.   Nature Communications

Effect of miR-34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease

(2015) Jiexia Ding et al.   Scientific Reports

Activation of Mir-29a in Activated Hepatic Stellate Cells Modulates Its Profibrogenic Phenotype through Inhibition of Histone Deacetylases 4

(2015) Ying-Hsien Huang et al.   PLoS One

Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis

(2014) Carlos J Pirola et al.   GUT

A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver

(2014) Aras N. Mattis et al.   HEPATOLOGY

Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice

(2014) Pedro Elias Marques et al.   HEPATOLOGY

Dynamics of T-cell IFN-  and miR-29a expression during active pulmonary tuberculosis

(2014) A. Afum-Adjei Awuah et al.   INTERNATIONAL IMMUNOLOGY

TGF-β/Smad signaling during hepatic fibro-carcinogenesis (Review)

(2014) KATSUNORI YOSHIDA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in hepatocellular carcinogenesis

(2014) XIAO-RAN LONG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Serum microRNA-29 levels correlate with disease progression in patients with chronic hepatitis B virus infection

(2014) Chong Huang et al.   Journal of Digestive Diseases

microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis

(2014) Timea Csak et al.   LIVER INTERNATIONAL

miR-181c Regulates the Mitochondrial Genome, Bioenergetics, and Propensity for Heart Failure In Vivo

(2014) Samarjit Das et al.   PLoS One

MicroRNA-29a protects against acute liver injury in a mouse model of obstructive jaundice via inhibition of the extrinsic apoptosis pathway

(2013) Mao-Meng Tiao et al.   APOPTOSIS

Associations between circulating microRNAs (miR-21, miR-34a, miR-122 and miR-451) and non-alcoholic fatty liver

(2013) Hiroya Yamada et al.   CLINICA CHIMICA ACTA

Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia

(2013) Yi-Bing Ouyang et al.   GLIA

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease

(2013) Karima Begriche et al.   HEPATOLOGY

Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice

(2013) Kengo Tomita et al.   HEPATOLOGY

Epigenetic histone methylation regulates transforming growth factor β-1 expression following bile duct ligation in rats

(2013) Shyr-Ming Sheen-Chen et al.   JOURNAL OF GASTROENTEROLOGY

Regulation of NF-B-Induced Inflammatory Signaling by Lipid Peroxidation-Derived Aldehydes

(2013) Umesh C. S. Yadav et al.   Oxidative Medicine and Cellular Longevity

Class II HDAC Inhibition Hampers Hepatic Stellate Cell Activation by Induction of MicroRNA-29

(2013) Inge Mannaerts et al.   PLoS One

A new role for microRNAs, as ligands of Toll-like receptors

(2013) Muller Fabbri et al.   RNA Biology

MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice

(2013) Takahiro Horie et al.   Nature Communications

Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice

(2012) Jorge Joven et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Role of Lipids in VDAC Oligomerization

(2012) Viktoria Betaneli et al.   BIOPHYSICAL JOURNAL

Role of mitochondria in nonalcoholic fatty liver disease-from origin to propagation

(2012) Ignazio Grattagliano et al.   CLINICAL BIOCHEMISTRY

MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis

(2012) Tomohiro Ogawa et al.   GUT

Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation

(2012) Maria Jesus Perugorria et al.   HEPATOLOGY

microRNA-29a suppresses cell proliferation by targeting SPARC in hepatocellular carcinoma

(2012) XU-CHAO ZHU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury

(2012) Alison J. Kriegel et al.   PHYSIOLOGICAL GENOMICS

Identification of Novel Targets for miR-29a Using miRNA Proteomics

(2012) Rhishikesh Bargaje et al.   PLoS One

MicroRNA-29a-5p Is a Novel Predictor for Early Recurrence of Hepatitis B Virus-Related Hepatocellular Carcinoma after Surgical Resection

(2012) Hai-Tao Zhu et al.   PLoS One

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet

(2012) Volodymyr P. Tryndyak et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Selective MicroRNA Suppression in Human Thoracic Aneurysms

(2011) Jeffrey A. Jones et al.   Circulation-Cardiovascular Genetics

Positive regulation of hepatic miR-122 expression by HNF4α

(2011) Zhen-Ya Li et al.   JOURNAL OF HEPATOLOGY

Upregulated MicroRNA-29a by Hepatitis B Virus X Protein Enhances Hepatoma Cell Migration by Targeting PTEN in Cell Culture Model

(2011) Guangyao Kong et al.   PLoS One

Circulating MicroRNAs in Patients with Chronic Hepatitis C and Non-Alcoholic Fatty Liver Disease

(2011) Silvia Cermelli et al.   PLoS One

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling

(2011) A. Davalos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis

(2010) Christoph Roderburg et al.   HEPATOLOGY

Circulating miR-29a levels in patients with scleroderma spectrum disorder

(2010) Yoshio Kawashita et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model

(2010) R. Scott Rector et al.   JOURNAL OF HEPATOLOGY

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

MiR-33 Contributes to the Regulation of Cholesterol Homeostasis

(2010) K. J. Rayner et al.   SCIENCE

New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites

(2009) I. Lee et al.   GENOME RESEARCH

Effects of MicroRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma

(2009) Yujuan Xiong et al.   HEPATOLOGY

Controlling metabolism and cell death: At the heart of mitochondrial calcium signalling

(2009) Marta Murgia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial functionin vivo

(2008) Sudheer K. Mantena et al.   BIOCHEMICAL JOURNAL

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

(2007) Jie Zhou et al.   GASTROENTEROLOGY