Role of MicroRNAs in Parkinson’s Disease

The microRNAs let-7 and miR-9 down-regulate the axon-guidance genes NTN1 and DCC during peripheral nerve regeneration

(2019) Xinghui Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-26 Induces Apoptosis and Inhibits Autophagy in Non-small Cell Lung Cancer Cells by Suppressing TGF-β1-JNK Signaling Pathway

(2019) Yi He et al.   Frontiers in Pharmacology

Emerging therapies in Parkinson disease — repurposed drugs and new approaches

(2019) Ahmad Elkouzi et al.   Nature Reviews Neurology

Parkinson's Disease and Parkinsonism

(2019) Michael T Hayes   AMERICAN JOURNAL OF MEDICINE

The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathway

(2019) Shun Xu et al.   AGING CELL

Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson’s disease

(2019) Penelope J. Hallett et al.   Journal of Neuroinflammation

MicroRNA expression patterns in human anterior cingulate and motor cortex: A study of dementia with Lewy bodies cases and controls

(2018) Peter T. Nelson et al.   BRAIN RESEARCH

LRRK2 and mitochondria: Recent advances and current views

(2018) Alpana Singh et al.   BRAIN RESEARCH

Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients

(2018) Shuai Jiang et al.   Cell Metabolism

Progression Rate Associated Peripheral Blood Biomarkers of Parkinson’s Disease

(2018) Yanxia Fan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Parkinson’s disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1/Th2/T17 and Treg in drug-naïve and drug-treated patients

(2018) Natasa Kustrimovic et al.   Journal of Neuroinflammation

Notch1 primes CD4 T cells for T helper type I differentiation through its early effects on miR-29

(2018) Karthik Chandiran et al.   MOLECULAR IMMUNOLOGY

Identification of altered microRNAs in serum of a mouse model of Parkinson’s disease

(2018) Hector Rosas-Hernandez et al.   NEUROSCIENCE LETTERS

Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease

(2018) Diego Grassi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

(2018) Guoliang Lyu et al.   Nature Communications

miR-30 Family: A Promising Regulator in Development and Disease

(2018) Ling Mao et al.   Biomed Research International

Identification of aberrant circulating miRNAs in Parkinson's disease plasma samples

(2018) Lei Chen et al.   Brain and Behavior

On Cell Loss and Selective Vulnerability of Neuronal Populations in Parkinson's Disease

(2018) Nicolas Giguère et al.   Frontiers in Neurology

Signature of Aberrantly Expressed microRNAs in the Striatum of Rotenone-Induced Parkinsonian Rats

(2018) Camila Hillesheim Horst et al.   NEUROCHEMICAL RESEARCH

Lin28 Signaling Supports Mammalian PNS and CNS Axon Regeneration

(2018) Xue-Wei Wang et al.   Cell Reports

ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep

(2018) Ketty Sinigaglia et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Let-7d microRNA Attenuates 6-OHDA-Induced Injury by Targeting Caspase-3 in MN9D Cells

(2017) Li Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Plasma and White Blood Cells Show Different miRNA Expression Profiles in Parkinson’s Disease

(2017) Christine Schwienbacher et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

MicroRNA biomarkers of Parkinson’s disease in serum exosome-like microvesicles

(2017) Xiang-Yang Cao et al.   NEUROSCIENCE LETTERS

MicroRNAs: Roles in Regulating Neuroinflammation

(2017) Andrew D. Gaudet et al.   NEUROSCIENTIST

MiR-26 enhances chemosensitivity and promotes apoptosis of hepatocellular carcinoma cells through inhibiting autophagy

(2017) Fangfang Jin et al.   Cell Death & Disease

MicroRNA-29b alleviates oxygen and glucose deprivation/reperfusion-induced injury via inhibition of the p53‑dependent apoptosis pathway in N2a neuroblastoma cells

(2017) Lei Cao et al.   Experimental and Therapeutic Medicine

MicroRNA-30e regulates neuroinflammation in MPTP model of Parkinson’s disease by targeting Nlrp3

(2017) Dongsheng Li et al.   Human Cell

About miRNAs, miRNA seeds, target genes and target pathways

(2017) Tim Kehl et al.   Oncotarget

Circulating brain-enriched microRNAs as novel biomarkers for detection and differentiation of neurodegenerative diseases

(2017) Kira S. Sheinerman et al.   Alzheimers Research & Therapy

Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells

(2017) Alexandria C Wells et al.   eLife

Modulation of Alpha-synuclein Expression and Associated Effects by MicroRNA Let-7 in Transgenic C. elegans

(2017) Shamsuzzama et al.   Frontiers in Molecular Neuroscience

Downregulation of blood serum microRNA 29 family in patients with Parkinson’s disease

(2017) Xiaochen Bai et al.   Scientific Reports

Hydrogen sulfide protects against TNF-α induced neuronal cell apoptosis through miR-485-5p/TRADD signaling

(2016) Zhiqiang Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serum miR-221 serves as a biomarker for Parkinson's disease

(2016) Wenbin Ma et al.   CELL BIOCHEMISTRY AND FUNCTION

MicroRNAs in Cerebrospinal Fluid as Potential Biomarkers for Parkinson’s Disease and Multiple System Atrophy

(2016) Tainá M. Marques et al.   MOLECULAR NEUROBIOLOGY

Alterations of miRNAs reveal a dysregulated molecular regulatory network in Parkinson’s disease striatum

(2016) Venugopalan D. Nair et al.   NEUROSCIENCE LETTERS

MiR-26 down-regulates TNF-α/NF-κB signalling and IL-6 expression by silencing HMGA1 and MALT1

(2016) Chyi-Ying A. Chen et al.   NUCLEIC ACIDS RESEARCH

Parkinson's disease: SNCA-, PARK2-, and LRRK2- targeting microRNAs elevated in cingulate gyrus

(2016) Roman Tatura et al.   PARKINSONISM & RELATED DISORDERS

Low BDNF is associated with cognitive impairments in patients with Parkinson’s disease

(2016) Yu Wang et al.   PARKINSONISM & RELATED DISORDERS

Identification of a panel of five serum miRNAs as a biomarker for Parkinson's disease

(2016) Haixia Ding et al.   PARKINSONISM & RELATED DISORDERS

MiR-485-3p and miR-485-5p suppress breast cancer cell metastasis by inhibiting PGC-1α expression

(2016) C Lou et al.   Cell Death & Disease

MicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian

(2016) Mingshu Mo et al.   Oncotarget

microRNA Profiles in Parkinson's Disease Prefrontal Cortex

(2016) Andrew G. Hoss et al.   Frontiers in Aging Neuroscience

A panel of four decreased serum microRNAs as a novel biomarker for early Parkinson’s disease

(2015) Hui Dong et al.   BIOMARKERS

Midbrain dopamine neurons in Parkinson׳s disease exhibit a dysregulated miRNA and target-gene network

(2015) Christine E. Briggs et al.   BRAIN RESEARCH

Current Update on Synopsis of miRNA Dysregulation in Neurological Disorders

(2015) Mohammad Kamal et al.   CNS & Neurological Disorders-Drug Targets

miR-98 and let-7g* Protect the Blood-Brain Barrier Under Neuroinflammatory Conditions

(2015) Slava Rom et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids

(2015) Xianghui Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Let-7 microRNAs Regenerate Peripheral Nerve Regeneration by Targeting Nerve Growth Factor

(2015) Shiying Li et al.   MOLECULAR THERAPY

Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice

(2015) Aikaterini S. Papadopoulou et al.   NEUROBIOLOGY OF DISEASE

Overexpression of blood microRNAs 103a, 30b, and 29a in L-dopa-treated patients with PD

(2015) A. Serafin et al.   NEUROLOGY

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model

(2015) Yan Kong et al.   PLoS One

miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement

(2015) Qin-Hua Gu et al.   Nature Communications

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

(2015) YaXing Gui et al.   Oncotarget

Matrix Metalloproteinase-14 Both Sheds Cell Surface Neuronal Glial Antigen 2 (NG2) Proteoglycan on Macrophages and Governs the Response to Peripheral Nerve Injury

(2014) Tasuku Nishihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells

(2014) Antoine Marcais et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MiRNA Profile in the Substantia Nigra of Parkinson’s Disease and Healthy Subjects

(2014) Lucía F. Cardo et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Identification of blood serum micro-RNAs associated with idiopathic andLRRK2Parkinson's disease

(2014) Teresa Botta-Orfila et al.   JOURNAL OF NEUROSCIENCE RESEARCH

MicroRNA-26b suppresses the NF-κB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3

(2014) Na Zhao et al.   Molecular Cancer

Gene and MicroRNA Transcriptome Analysis of Parkinson's Related LRRK2 Mouse Models

(2014) Véronique Dorval et al.   PLoS One

Profiles of Extracellular miRNA in Cerebrospinal Fluid and Serum from Patients with Alzheimer's and Parkinson's Diseases Correlate with Disease Status and Features of Pathology

(2014) Kasandra Burgos et al.   PLoS One

Brain-specific knockdown of miR-29 results in neuronal cell death and ataxia in mice

(2014) Reema Roshan et al.   RNA

An emerging role for the miR-26 family in cardiovascular disease

(2014) Basak Icli et al.   TRENDS IN CARDIOVASCULAR MEDICINE

miRNA dysregulation in cancer: towards a mechanistic understanding

(2014) Jayanth Kumar Palanichamy et al.   Frontiers in Genetics

miR-29 Represses the Activities of DNA Methyltransferases and DNA Demethylases

(2013) Sumiyo Morita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA let-7c Regulates Macrophage Polarization

(2013) S. Banerjee et al.   JOURNAL OF IMMUNOLOGY

Profile of microRNAs in the plasma of Parkinson’s disease patients and healthy controls

(2013) Lucía F. Cardo et al.   JOURNAL OF NEUROLOGY

MiR-26b, Upregulated in Alzheimer's Disease, Activates Cell Cycle Entry, Tau-Phosphorylation, and Apoptosis in Postmitotic Neurons

(2013) S. Absalon et al.   JOURNAL OF NEUROSCIENCE

Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases

(2013) Anika Langenfurth et al.   JOURNAL OF NEUROSCIENCE RESEARCH

MicroRNA profiling and the role of microRNA-132 in neurodegeneration using a rat model

(2013) Gina Lungu et al.   NEUROSCIENCE LETTERS

Iron-Responsive miR-485-3p Regulates Cellular Iron Homeostasis by Targeting Ferroportin

(2013) Carolyn Sangokoya et al.   PLoS Genetics

Small RNA sequencing-microarray analyses in Parkinson leukocytes reveal deep brain stimulation-induced splicing changes that classify brain region transcriptomes

(2013) Lilach Soreq et al.   Frontiers in Molecular Neuroscience

RISC in PD: the impact of microRNAs in Parkinson's disease cellular and molecular pathogenesis

(2013) Sabrina M. Heman-Ackah et al.   Frontiers in Molecular Neuroscience

miR-29ab1 Deficiency Identifies a Negative Feedback Loop Controlling Th1 Bias That Is Dysregulated in Multiple Sclerosis

(2012) K. M. Smith et al.   JOURNAL OF IMMUNOLOGY

Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells

(2012) Moussa Benhamed et al.   NATURE CELL BIOLOGY

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury

(2012) Alison J. Kriegel et al.   PHYSIOLOGICAL GENOMICS

Analysis of the host microRNA response toSalmonellauncovers the control of major cytokines by thelet-7family

(2011) Leon N Schulte et al.   EMBO JOURNAL

HOCTAR database: A unique resource for microRNA target prediction

(2011) Vincenzo Alessandro Gennarino et al.   GENE

miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis

(2011) A. J. Kole et al.   GENES & DEVELOPMENT

Let-7/miR-98 regulate Fas and Fas-mediated apoptosis

(2011) S Wang et al.   GENES AND IMMUNITY

MicroRNA-29 Regulates T-Box Transcription Factors and Interferon-γ Production in Helper T Cells

(2011) David F. Steiner et al.   IMMUNITY

Nonmotor Symptoms in Parkinson's Disease

(2011) Mark Stacy   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Identification of blood microRNAs associated to Parkinsońs disease

(2011) Regina Margis et al.   JOURNAL OF BIOTECHNOLOGY

Extracellular microRNA: A new source of biomarkers

(2011) Alton Etheridge et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Convergence of miRNA Expression Profiling, α-Synuclein Interacton and GWAS in Parkinson's Disease

(2011) Madalena Martins et al.   PLoS One

MicroRNA regulation of homeostatic synaptic plasticity

(2011) J. E. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current approaches to the treatment of Parkinson’s disease

(2011) Joseph Jankovic   Neuropsychiatric Disease and Treatment

Degradation of Soluble and Fibrillar Amyloid β-Protein by Matrix Metalloproteinase (MT1-MMP)in Vitro

(2010) Mei-Chen Liao et al.   BIOCHEMISTRY

Global microRNA Expression Profiling of Caenorhabditis elegans Parkinson's Disease Models

(2010) Suvi Asikainen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

MicroRNA Functions in Stress Responses

(2010) Anthony K.L. Leung et al.   MOLECULAR CELL

Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

(2010) Stephan Gehrke et al.   NATURE

Reduced expression of peroxisome-proliferator activated receptor gamma coactivator-1α enhances α-synuclein oligomerization and down regulates AKT/GSK3β signaling pathway in human neuronal cells that inducibly express α-synuclein

(2010) Abdul Shukkur Ebrahim et al.   NEUROSCIENCE LETTERS

miR-29 and miR-30 regulate B-Myb expression during cellular senescence

(2010) I. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo

(2009) J. T. Huse et al.   GENES & DEVELOPMENT

A critical evaluation of the Braak staging scheme for Parkinson's disease

(2008) Robert E. Burke et al.   ANNALS OF NEUROLOGY

A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex

(2008) Nikolaos Mellios et al.   HUMAN MOLECULAR GENETICS

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

(2008) Vanessa Brochard et al.   JOURNAL OF CLINICAL INVESTIGATION

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The let-7 family of microRNAs

(2008) Sarah Roush et al.   TRENDS IN CELL BIOLOGY