miRNA Signature in NAFLD: A Turning Point for a Non-Invasive Diagnosis

Down-regulation of microRNA-375 regulates adipokines and inhibits inflammatory cytokines by targeting AdipoR2 in non-alcoholic fatty liver disease

(2018) Lei Lei et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Fibrosis Severity as a Determinant of Cause-Specific Mortality in Patients With Advanced Nonalcoholic Fatty Liver Disease

(2018) Eduardo Vilar-Gomez et al.   GASTROENTEROLOGY

Expression of microRNA-155 in inflammatory cells modulates liver injury

(2018) Delia Blaya et al.   HEPATOLOGY

Genetic and Epigenetic Regulation in Nonalcoholic Fatty Liver Disease (NAFLD)

(2018) José Del Campo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional SNP in microRNA-491-5p binding site of MMP9 3′-UTR affects cancer susceptibility

(2018) Homeira Javadi Pirooz et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Gα 12 overexpression induced by miR-16 dysregulation contributes to liver fibrosis by promoting autophagy in hepatic stellate cells

(2018) Kyu Min Kim et al.   JOURNAL OF HEPATOLOGY

Integrated analysis of hepatic mRNA and miRNA profiles identified molecular networks and potential biomarkers of NAFLD

(2018) Mingzhe Zhu et al.   Scientific Reports

miRNAs in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis

(2018) Chang-Hai Liu et al.   JOURNAL OF HEPATOLOGY

Metabolic Circuit Involving Free Fatty Acids, microRNA 122, and Triglyceride Synthesis in Liver and Muscle Tissues

(2017) Chofit Chai et al.   GASTROENTEROLOGY

A Nutrigenomic Approach to Non-Alcoholic Fatty Liver Disease

(2017) Paola Dongiovanni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An Explorative Analysis for the Role of Serum miR-10b-3p Levels in Predicting Response to Sorafenib in Patients with Advanced Hepatocellular Carcinoma

(2017) Eileen L. Yoon et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Epigenetics in non-alcoholic fatty liver disease

(2017) Jooho Lee et al.   MOLECULAR ASPECTS OF MEDICINE

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice

(2017) Pedro M Rodrigues et al.   Cell Death & Disease

Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine

(2017) Chiranjib Chakraborty et al.   Molecular Therapy-Nucleic Acids

0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop

(2017) Caixia Xia et al.   Scientific Reports

MicroRNAs in obesity-associated disorders

(2016) Eugenio J. Abente et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Rhamnetin induces sensitization of hepatocellular carcinoma cells to a small molecular kinase inhibitor or chemotherapeutic agents

(2016) Hui Jia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Liver microRNAs: potential mediators and biomarkers for metabolic and cardiovascular disease?

(2016) Peter Willeit et al.   EUROPEAN HEART JOURNAL

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

A micro-RNA expression signature for human NAFLD progression

(2016) Yan Guo et al.   JOURNAL OF GASTROENTEROLOGY

Mopping up miRNA: An integrated HBV transcript disrupts liver homeostasis by sequestering miR-122

(2016) Joseph M. Luna et al.   JOURNAL OF HEPATOLOGY

MicroRNAs and liver disease

(2016) Motoyuki Otsuka et al.   JOURNAL OF HUMAN GENETICS

Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes

(2016) Regina Krattinger et al.   LIFE SCIENCES

Genetics of nonalcoholic fatty liver disease

(2016) Paola Dongiovanni et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

MiR-125a-5p decreases after long non-coding RNA HOTAIR knockdown to promote cancer cell apoptosis by releasing caspase 2

(2016) L Tang et al.   Cell Death & Disease

An artificial lncRNA targeting multiple miRNAs overcomes sorafenib resistance in hepatocellular carcinoma cells

(2016) Shuyao Tang et al.   Oncotarget

Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1α activation

(2016) Aditya Ambade et al.   Scientific Reports

MicroRNA-155 in the Heart: Figure.

(2015) Katey J. Rayner   CIRCULATION

MicroRNA-34 Family and Its Role in Cardiovascular Disease

(2015) Na Li et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

(2015) Amedeo Lonardo et al.   DIGESTIVE AND LIVER DISEASE

Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States

(2015) Robert J. Wong et al.   GASTROENTEROLOGY

Serum microRNAs explain discordance of non-alcoholic fatty liver disease in monozygotic and dizygotic twins: a prospective study

(2015) Amir Zarrinpar et al.   GUT

MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway

(2015) Heng Wu et al.   GUT

Downregulation of microRNA-451 in non-alcoholic steatohepatitis inhibits fatty acid-induced proinflammatory cytokine production through the AMPK/AKT pathway

(2015) Wonhee Hur et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Suppressive effects of microRNA-16 on the proliferation, invasion and metastasis of hepatocellular carcinoma cells

(2015) WEI-LU WU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis

(2015) AKIKO KATSURA et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Nonalcoholic Fatty Liver Disease

(2015) Mary E. Rinella   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

(2015) Guohua Lou et al.   Journal of Hematology & Oncology

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

miR-494 promotes cell proliferation, migration and invasion, and increased sorafenib resistance in hepatocellular carcinoma by targeting PTEN

(2015) KAI LIU et al.   ONCOLOGY REPORTS

Performance of Serum microRNAs -122, -192 and -21 as Biomarkers in Patients with Non-Alcoholic Steatohepatitis

(2015) Philip P. Becker et al.   PLoS One

Overview of MicroRNA Biology

(2015) Ashley Mohr et al.   SEMINARS IN LIVER DISEASE

MicroRNA-155 deficiency attenuates ischemia-reperfusion injury after liver transplantation in mice

(2015) Bo Tang et al.   TRANSPLANT INTERNATIONAL

miR-122 negatively correlates with liver fibrosis as detected by histology and FibroScan

(2015) Tünde Halász   WORLD JOURNAL OF GASTROENTEROLOGY

Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease

(2015) W Shan et al.   Cell Death & Disease

A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism

(2015) Yang Xu et al.   Nature Communications

MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway

(2015) Changjun He et al.   Oncotarget

Effect of miR-34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease

(2015) Jiexia Ding et al.   Scientific Reports

Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells

(2015) Mar Coll et al.   Scientific Reports

Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis

(2015) Paola Dongiovanni et al.   Biomed Research International

MicroRNA-34a Promotes Hepatic Stellate Cell Activation via Targeting ACSL1

(2015) Gangli Yan et al.   MEDICAL SCIENCE MONITOR

Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function

(2015) Jian Zhang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury

(2015) Mitchell McGill et al.   Journal of Clinical Medicine

MicroRNAs in Nonalcoholic Fatty Liver Disease

(2015) György Baffy   Journal of Clinical Medicine

MicroRNA Expression Relating to Dietary-Induced Liver Steatosis and NASH

(2015) Aida Zarfeshani et al.   Journal of Clinical Medicine

MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis

(2015) Timea Csak et al.   PLoS One

The microRNA-15 family inhibits the TGFβ-pathway in the heart

(2014) Anke J. Tijsen et al.   CARDIOVASCULAR RESEARCH

Aberrant Hepatic MicroRNA Expression in Nonalcoholic Fatty Liver Disease

(2014) Yue Ying Feng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis

(2014) Carlos J Pirola et al.   GUT

Circulating RNA Molecules as Biomarkers in Liver Disease

(2014) Liviu Enache et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

microRNA-34a and microRNA-34c promote the activation of human hepatic stellate cells by targeting peroxisome proliferator-activated receptor γ

(2014) XIAOFEI LI et al.   Molecular Medicine Reports

Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons

(2014) Belinda J. Goldie et al.   NUCLEIC ACIDS RESEARCH

A Pilot Study of Serum MicroRNAs Panel as Potential Biomarkers for Diagnosis of Nonalcoholic Fatty Liver Disease

(2014) Youwen Tan et al.   PLoS One

MiR-21 Simultaneously Regulates ERK1 Signaling in HSC Activation and Hepatocyte EMT in Hepatic Fibrosis

(2014) Juan Zhao et al.   PLoS One

Hepatocellular carcinoma in nonalcoholic fatty liver: Role of environmental and genetic factors

(2014) Paola Dongiovanni   WORLD JOURNAL OF GASTROENTEROLOGY

MicroRNAs as controlled systems and controllers in non-alcoholic fatty liver disease

(2014) Nadia Panera   WORLD JOURNAL OF GASTROENTEROLOGY

MicroRNAs in Nonalcoholic Fatty Liver Disease: Novel Biomarkers and Prognostic Tools during the Transition from Steatosis to Hepatocarcinoma

(2014) Manuele Gori et al.   Biomed Research International

Mir-34: A New Weapon Against Cancer?

(2014) Gabriella Misso et al.   Molecular Therapy-Nucleic Acids

Progress and challenge of microRNA research in immunity

(2014) Hyang-Mi Lee et al.   Frontiers in Genetics

MicroRNA-21 activates hepatic stellate cells via PTEN/Akt signaling

(2013) Jun Wei et al.   BIOMEDICINE & PHARMACOTHERAPY

Profibrotic effect of miR-33a with Akt activation in hepatic stellate cells

(2013) Zhuo-Jian Li et al.   CELLULAR SIGNALLING

Associations between circulating microRNAs (miR-21, miR-34a, miR-122 and miR-451) and non-alcoholic fatty liver

(2013) Hiroya Yamada et al.   CLINICA CHIMICA ACTA

Comparison of serum exosome isolation methods for microRNA profiling

(2013) Kadri Rekker et al.   CLINICAL BIOCHEMISTRY

MicroRNA miR-122 as a Therapeutic Target for Oligonucleotides and Small Molecules

(2013) M. Thomas et al.   CURRENT MEDICINAL CHEMISTRY

Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice

(2013) Kengo Tomita et al.   HEPATOLOGY

Circulating microRNA 122 in the methionine and choline-deficient mouse model of non-alcoholic steatohepatitis

(2013) John D. Clarke et al.   JOURNAL OF APPLIED TOXICOLOGY

The role of microRNAs in hepatocarcinogenesis: current knowledge and future prospects

(2013) Motoyuki Otsuka et al.   JOURNAL OF GASTROENTEROLOGY

Expression of genes for microRNA-processing enzymes is altered in advanced non-alcoholic fatty liver disease

(2013) Haveesh Sharma et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

MicroRNA-155 controls Toll-like receptor 3- and hepatitis C virus-induced immune responses in the liver

(2013) M. Jiang et al.   JOURNAL OF VIRAL HEPATITIS

MicroRNAs in liver disease

(2013) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

Treatment of HCV Infection by Targeting MicroRNA

(2013) Harry L.A. Janssen et al.   NEW ENGLAND JOURNAL OF MEDICINE

microRNA-122 Dependent Binding of Ago2 Protein to Hepatitis C Virus RNA Is Associated with Enhanced RNA Stability and Translation Stimulation

(2013) K. Dominik Conrad et al.   PLoS One

MicroRNA-21 Knockout Improve the Survival Rate in DSS Induced Fatal Colitis through Protecting against Inflammation and Tissue Injury

(2013) Chenzhang Shi et al.   PLoS One

Alcohol Facilitates HCV RNA Replication Via Up-Regulation of miR-122 Expression and Inhibition of Cyclin G1 in Human Hepatoma Cells

(2012) Wei Hou et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Epigenetic Regulation of miR-34a Expression in Alcoholic Liver Injury

(2012) Fanyin Meng et al.   AMERICAN JOURNAL OF PATHOLOGY

Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types

(2012) Jasenka Guduric-Fuchs et al.   BMC GENOMICS

MicroRNAs

(2012) Jennifer Sacco et al.   CURRENT OPINION IN LIPIDOLOGY

miR-375 Inhibits Autophagy and Reduces Viability of Hepatocellular Carcinoma Cells Under Hypoxic Conditions

(2012) Ying Chang et al.   GASTROENTEROLOGY

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis

(2012) Tomohiro Ogawa et al.   GUT

Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases

(2012) Shashi Bala et al.   HEPATOLOGY

Ethanol facilitates hepatitis C virus replication via up-regulation of GW182 and heat shock protein 90 in human hepatoma cells

(2012) Terence N. Bukong et al.   HEPATOLOGY

Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

(2012) Y. Lee et al.   HUMAN MOLECULAR GENETICS

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver

(2012) Shu-hao Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis

(2012) Wei-Chih Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease

(2012) Rui E. Castro et al.   JOURNAL OF HEPATOLOGY

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor  -Klotho

(2012) T. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PNPLA3, the triacylglycerol synthesis/hydrolysis/storage dilemma, and nonalcoholic fatty liver disease

(2012) Silvia Sookoian   WORLD JOURNAL OF GASTROENTEROLOGY

The Role of MicroRNAs in Cholesterol Efflux and Hepatic Lipid Metabolism

(2011) Kathryn J. Moore et al.   Annual Review of Nutrition

Genetics and epigenetics in the fibrogenic evolution of chronic liver diseases

(2011) Vincent Zimmer et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

MicroRNA Regulation of Intestinal Epithelial Tight Junction Permeability

(2011) Dongmei Ye et al.   GASTROENTEROLOGY

A Feedback Loop Between the Liver-Enriched Transcription Factor Network and Mir-122 Controls Hepatocyte Differentiation

(2011) Ilaria Laudadio et al.   GASTROENTEROLOGY

Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1-modulated P53 activity

(2011) Saifeng Wang et al.   HEPATOLOGY

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides

(2011) Katey J. Rayner et al.   NATURE

miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components

(2011) Ashley P. E. Roberts et al.   NUCLEIC ACIDS RESEARCH

Characterization of extracellular circulating microRNA

(2011) Andrey Turchinovich et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo

(2011) X-X He et al.   ONCOGENE

Circulating MicroRNAs in Patients with Chronic Hepatitis C and Non-Alcoholic Fatty Liver Disease

(2011) Silvia Cermelli et al.   PLoS One

MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR

(2011) Y.-P. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling

(2011) A. Davalos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Differential expression of miRNAs in the visceral adipose tissue of patients with non-alcoholic fatty liver disease

(2010) M. Estep et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties

(2010) Angela M. Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Genetic Covariance Between γ-Glutamyl Transpeptidase and Fatty Liver Risk Factors: Role of β2-Adrenergic Receptor Genetic Variation in Twins

(2010) Rohit Loomba et al.   GASTROENTEROLOGY

MicroRNAs control hepatocyte proliferation during liver regeneration

(2010) Guisheng Song et al.   HEPATOLOGY

A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma

(2010) Yan Xu et al.   INTERNATIONAL JOURNAL OF CANCER

Up-regulation of MicroRNA-155 in Macrophages Contributes to Increased Tumor Necrosis Factor α (TNFα) Production via Increased mRNA Half-life in Alcoholic Liver Disease

(2010) Shashi Bala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line

(2010) Keiichi Ohshima et al.   PLoS One

MiR-33 Contributes to the Regulation of Cholesterol Homeostasis

(2010) K. J. Rayner et al.   SCIENCE

miR-15a and miR-16-1 in cancer: discovery, function and future perspectives

(2009) R I Aqeilan et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA-221 Targets Bmf in Hepatocellular Carcinoma and Correlates with Tumor Multifocality

(2009) L. Gramantieri et al.   CLINICAL CANCER RESEARCH

Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways

(2009) Can-Jie Guo et al.   FEBS Journal

Heritability of Nonalcoholic Fatty Liver Disease

(2009) Jeffrey B. Schwimmer et al.   GASTROENTEROLOGY

miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: An essential role for apoptosis

(2009) Can-Jie Guo et al.   JOURNAL OF HEPATOLOGY

miR-221 overexpression contributes to liver tumorigenesis

(2009) P. Pineau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression

(2008) Onpan Cheung et al.   HEPATOLOGY

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE