Suppression of SUN2 by DNA methylation is associated with HSCs activation and hepatic fibrosis

Endothelial Notch activation reshapes the angiocrine of sinusoidal endothelia to aggravate liver fibrosis and blunt regeneration in mice

(2018) Juan-Li Duan et al.   HEPATOLOGY

Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2

(2018) Tian Lan et al.   HEPATOLOGY

Propranolol prevents liver cirrhosis by inhibiting hepatic stellate cell activation mediated by the PDGFR/Akt pathway

(2018) Qian Ding et al.   HUMAN PATHOLOGY

Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver

(2017) Jie Wei et al.   PLANT FOODS FOR HUMAN NUTRITION

Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis

(2017) Yuting Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

MiR-130a-3p attenuates activation and induces apoptosis of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2

(2017) Yang Wang et al.   Cell Death & Disease

Forkhead box A3 attenuated the progression of fibrosis in a rat model of biliary atresia

(2017) Rui Dong et al.   Cell Death & Disease

Decitabine and 5-azacitidine both alleviate LPS induced ARDS through anti-inflammatory/antioxidant activity and protection of glycocalyx and inhibition of MAPK pathways in mice

(2016) Xiao Huang et al.   BIOMEDICINE & PHARMACOTHERAPY

Hepatic stellate cell transdifferentiation involves genome-wide remodeling of the DNA methylation landscape

(2016) Agata Page et al.   JOURNAL OF HEPATOLOGY

Species-wide patterns of DNA methylation variation inQuercus lobataand their association with climate gradients

(2016) Paul F. Gugger et al.   MOLECULAR ECOLOGY

Transmembrane protein 88 attenuates liver fibrosis by promoting apoptosis and reversion of activated hepatic stellate cells

(2016) Shuang-Peng Cai et al.   MOLECULAR IMMUNOLOGY

Global loss of a nuclear lamina component, lamin A/C, and LINC complex components SUN1, SUN2, and nesprin-2 in breast cancer

(2015) Ayaka Matsumoto et al.   Cancer Medicine

Downregulation of SUN2, a novel tumor suppressor, mediates miR-221/222-induced malignancy in central nervous system embryonal tumors

(2014) Tsung-Han Hsieh et al.   CARCINOGENESIS

Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells

(2014) Sergio Valente et al.   JOURNAL OF MEDICINAL CHEMISTRY

Origin of myofibroblasts in the fibrotic liver in mice

(2014) K. Iwaisako et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Induction of Apoptosis and Senescence by the DNA Methyltransferase Inhibitors 5-Azacytidine and 5-Aza-2'-Deoxycytidine in Solid Tumor Cells

(2013) S. Venturelli et al.   MOLECULAR CANCER THERAPEUTICS

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

Global analysis of DNA methylation in early-stage liver fibrosis

(2012) Yoko Komatsu et al.   BMC Medical Genomics

Inner Nuclear Envelope Proteins SUN1 and SUN2 Play a Prominent Role in the DNA Damage Response

(2012) Kai Lei et al.   CURRENT BIOLOGY

The myofibroblast matrix: implications for tissue repair and fibrosis

(2012) Franco Klingberg et al.   JOURNAL OF PATHOLOGY

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib

(2011) Yuqing Liu et al.   JOURNAL OF HEPATOLOGY

AKT signaling pathway activated by HIN-1 methylation in non-small cell lung cancer

(2011) Yuanzi Yu et al.   TUMOR BIOLOGY

Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer

(2010) Diego F. Calvisi et al.   JOURNAL OF HEPATOLOGY

Smad2 Protects against TGF- /Smad3-Mediated Renal Fibrosis

(2010) X. M. Meng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A perinuclear actin cap regulates nuclear shape

(2009) Shyam B. Khatau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY