The role of Eph receptors in cancer and how to target them: novel approaches in cancer treatment
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The role of Eph receptors in cancer and how to target them: novel approaches in cancer treatment
Authors
Keywords
-
Journal
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Volume -, Issue -, Pages 1-15
Publisher
Informa UK Limited
Online
2020-04-30
DOI
10.1080/13543784.2020.1762566
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The Small Molecule Ephrin Receptor Inhibitor, GLPG1790, Reduces Renewal Capabilities of Cancer Stem Cells, Showing Anti-Tumour Efficacy on Preclinical Glioblastoma Models
- (2019) Giovanni Gravina et al. Cancers
- Long noncoding RNA SNHG14 facilitates colorectal cancer metastasis through targeting EZH2-regulated EPHA7
- (2019) Wu Di et al. Cell Death & Disease
- Effects of EphB4 receptor expression on colorectal cancer cells, tumor growth, vascularization and composition
- (2018) Elif Kadife et al. ACTA ONCOLOGICA
- Tyrosine kinase activity of EphA2 promotes its S897 phosphorylation and glioblastoma cell proliferation
- (2018) Yuho Hamaoka et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Long noncoding RNA BC005927 upregulates EPHB4 and promotes gastric cancer metastasis under hypoxia
- (2018) Xiangqiang Liu et al. CANCER SCIENCE
- EphA3 maintains radioresistance in head and neck cancers through epithelial mesenchymal transition
- (2018) Song Hee Kim et al. CELLULAR SIGNALLING
- NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family
- (2018) Alix Tröster et al. ChemMedChem
- Design and synthesis of small molecule agonists of EphA2 receptor
- (2018) Aaron Petty et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- EphA3 Downregulation by Hypermethylation Associated with Lymph Node Metastasis and TNM Stage in Colorectal Cancer
- (2018) Yong Wang et al. DIGESTIVE DISEASES AND SCIENCES
- EphA8 is a Prognostic Factor for Oral Tongue Squamous Cell Carcinoma
- (2018) Lijun Liu et al. MEDICAL SCIENCE MONITOR
- Notch signaling promotes serrated neoplasia pathway in colorectal cancer through epigenetic modification of EPHB2 and EPHB4
- (2018) Haifeng Lian et al. Cancer Management and Research
- EZH2-mediated epigenetic suppression of EphB3 inhibits gastric cancer proliferation and metastasis by affecting E-cadherin and vimentin expression
- (2018) Kun Zhao et al. GENE
- S897 phosphorylation of EphA2 is indispensable for EphA2-dependent nasopharyngeal carcinoma cell invasion, metastasis and stem properties
- (2018) Jiao-Yang Li et al. CANCER LETTERS
- Targeting Eph/ephrin system in cancer therapy
- (2017) Alessio Lodola et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- EphA5 and EphA7 forward signaling enhances human hematopoietic stem and progenitor cell maintenance, migration, and adhesion via Rac1 activation
- (2017) Thao M. Nguyen et al. EXPERIMENTAL HEMATOLOGY
- Decreased expression of EphA5 is associated with Fuhrman nuclear grade and pathological tumour stage in ccRCC
- (2017) Xiaolin Wang et al. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
- Identification and characterization of Nanobodies targeting the EphA4 receptor
- (2017) Lies Schoonaert et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells
- (2017) Francesca Megiorni et al. Journal of Hematology & Oncology
- P2.06-001 A Study of MGCD516, a Receptor Tyrosine Kinase (RTK) Inhibitor, in Molecularly Selected Patients with NSCLC or Other Advanced Solid Tumors
- (2017) Theresa Werner et al. Journal of Thoracic Oncology
- Targeting receptor tyrosine kinase EphB4 in cancer therapy
- (2017) Yinnan Chen et al. SEMINARS IN CANCER BIOLOGY
- Ligand-dependent EphA7 signaling inhibits prostate tumor growth and progression
- (2017) Shibao Li et al. Cell Death & Disease
- Isoform expression patterns of EPHA10 protein mediate breast cancer progression by regulating the E-Cadherin and β-catenin complex
- (2017) Ye Li et al. Oncotarget
- Loss of the EPH receptor B6 contributes to colorectal cancer metastasis
- (2017) Silvia Mateo-Lozano et al. Scientific Reports
- High Expression of EphA4 Predicted Lesser Degree of Tumor Regression after Neoadjuvant Chemoradiotherapy in Rectal Cancer
- (2017) Ching-Yih Lin et al. Journal of Cancer
- A drug–drug interaction study of everolimus (an mTOR inhibitor) and JI-101, an orally active inhibitor of VEGF 2, PDGF, and EphB4 receptors, in patients with advanced urologic tumors.
- (2017) N. Agarwal et al. JOURNAL OF CLINICAL ONCOLOGY
- MicroRNA-448 suppresses osteosarcoma cell proliferation and invasion through targeting EPHA7
- (2017) Xiangkun Wu et al. PLoS One
- A role of the SAM domain in EphA2 receptor activation
- (2017) Xiaojun Shi et al. Scientific Reports
- EphA2 is a key effector of the MEK/ERK/RSK pathway regulating glioblastoma cell proliferation
- (2016) Yuho Hamaoka et al. CELLULAR SIGNALLING
- Dysregulation of EGFR Pathway in EphA2 Cell Subpopulation Significantly Associates with Poor Prognosis in Colorectal Cancer
- (2016) Mariangela De Robertis et al. CLINICAL CANCER RESEARCH
- EphB3 Stimulates Cell Migration and Metastasis in a Kinase-dependent Manner through Vav2-Rho GTPase Axis in Papillary Thyroid Cancer
- (2016) Jing-Jing Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- EphA1 activation promotes the homing of endothelial progenitor cells to hepatocellular carcinoma for tumor neovascularization through the SDF-1/CXCR4 signaling pathway
- (2016) Yi Wang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study
- (2016) Ronan T. Swords et al. LEUKEMIA RESEARCH
- Knockdown of ephrin receptor A7 suppresses the proliferation and metastasis of A549 human lung cancer cells
- (2016) RONGHUI LI et al. Molecular Medicine Reports
- Mechanisms of ephrin–Eph signalling in development, physiology and disease
- (2016) Artur Kania et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- EPHA3 regulates the multidrug resistance of small cell lung cancer via the PI3K/BMX/STAT3 signaling pathway
- (2016) Juan Peng et al. TUMOR BIOLOGY
- EphA4-mediated signaling regulates the aggressive phenotype of irradiation survivor colorectal cancer cells
- (2016) Priscila Guimarães de Marcondes et al. TUMOR BIOLOGY
- EphA5 protein, a potential marker for distinguishing histological grade and prognosis in ovarian serous carcinoma
- (2016) Xiao Chen et al. Journal of Ovarian Research
- EphA8 is a prognostic marker for epithelial ovarian cancer
- (2016) Xiaoqin Liu et al. Oncotarget
- EphB6 overexpression and Apc mutation together promote colorectal cancer
- (2016) Dan Xu et al. Oncotarget
- EPH/ephrin profile and EPHB2 expression predicts patient survival in breast cancer
- (2016) Anna-Maria Husa et al. Oncotarget
- The intrinsically kinase-inactive EPHB6 receptor predisposes cancer cells to DR5-induced apoptosis by promoting mitochondrial fragmentation
- (2016) Amr M. El Zawily et al. Oncotarget
- Low EphA7 Expression Correlated with Lymph Node Metastasis and Poor Prognosis of Patients with Esophageal Squamous Cell Carcinoma
- (2015) Yu-Qin Bai et al. ACTA HISTOCHEMICA ET CYTOCHEMICA
- Downregulation of EphA5 by promoter methylation in human prostate cancer
- (2015) Shibao Li et al. BMC CANCER
- The tumour-promoting receptor tyrosine kinase, EphB4, regulates expression of Integrin-β8 in prostate cancer cells
- (2015) Inga Mertens-Walker et al. BMC CANCER
- Effect of EphA7 Silencing on Proliferation, Invasion and Apoptosis in Human Laryngeal Cancer Cell Lines Hep-2 and AMC-HN-8
- (2015) Cheng Xiang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph–ephrin system
- (2015) Riccardo Castelli et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- A pilot study of JI-101, an inhibitor of VEGFR-2, PDGFR-β, and EphB4 receptors, in combination with everolimus and as a single agent in an ovarian cancer expansion cohort
- (2015) Theresa L. Werner et al. INVESTIGATIONAL NEW DRUGS
- Receptor Tyrosine Kinase EphA5 Is a Functional Molecular Target in Human Lung Cancer
- (2015) Fernanda I. Staquicini et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- EphB1 Suppression in Acute Myelogenous Leukemia: Regulating the DNA Damage Control System
- (2015) K. R. Kampen et al. MOLECULAR CANCER RESEARCH
- Screening for tumor suppressors: Loss of ephrin receptor A2 cooperates with oncogenicKRasin promoting lung adenocarcinoma
- (2015) Narayana Yeddula et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- EphA6 promotes angiogenesis and prostate cancer metastasis and is associated with human prostate cancer progression
- (2015) Shibao Li et al. Oncotarget
- Inhibition of Eph receptor A4 by 2,5-dimethylpyrrolyl benzoic acid suppresses human pancreatic cancer growing orthotopically in nude mice
- (2015) Hironobu Takano et al. Oncotarget
- Significant blockade of multiple receptor tyrosine kinases by MGCD516 (Sitravatinib), a novel small molecule inhibitor, shows potent anti-tumor activity in preclinical models of sarcoma
- (2015) Parag P. Patwardhan et al. Oncotarget
- Abstract 1753: GLPG1790: The first Ephrin (EPH) receptor tyrosine kinase inhibitor for the treatment of triple negative breast cancer
- (2015) Philippe Pujuguet et al. CANCER RESEARCH
- The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study
- (2015) Rishil J. Kathawala et al. Oncotarget
- Dimerization of the EphA1 Receptor Tyrosine Kinase Transmembrane Domain: Insights into the Mechanism of Receptor Activation
- (2014) Matthieu Chavent et al. BIOCHEMISTRY
- Ligand stimulation induces clathrin- and Rab5-dependent downregulation of the kinase-dead EphB6 receptor preceded by the disruption of EphB6-Hsp90 interaction
- (2014) Odette Allonby et al. CELLULAR SIGNALLING
- EphB6 promotes anoikis by modulating EphA2 signaling
- (2014) Mai Akada et al. CELLULAR SIGNALLING
- Investigation of the interactions between the EphB2 receptor and SNEW peptide variants
- (2014) Buyong Ma et al. GROWTH FACTORS
- Generation and characterization of a single-chain anti-EphA2 antibody
- (2014) Yehuda Goldgur et al. GROWTH FACTORS
- Loss of EphB6 protein expression in human colorectal cancer correlates with poor prognosis
- (2014) Libo Peng et al. JOURNAL OF MOLECULAR HISTOLOGY
- Dynamic Interactions between Cancer Cells and the Embryonic Microenvironment Regulate Cell Invasion and Reveal EphB6 as a Metastasis Suppressor
- (2014) C. M. Bailey et al. MOLECULAR CANCER RESEARCH
- SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer
- (2014) Kerstin Rönsch et al. Molecular Oncology
- EphB4 regulates the growth and migration of pancreatic cancer cells
- (2014) Man Li et al. TUMOR BIOLOGY
- Involvement of ephrin receptor A4 in pancreatic cancer cell motility and invasion
- (2014) CHENGLI LIU et al. Oncology Letters
- EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma Multiforme
- (2013) Bryan W. Day et al. CANCER CELL
- Role of the EphB2 receptor in autophagy, apoptosis and invasion in human breast cancer cells
- (2013) Sahiti Chukkapalli et al. EXPERIMENTAL CELL RESEARCH
- EphB2 promotes cervical cancer progression by inducing epithelial-mesenchymal transition
- (2013) Qing Gao et al. HUMAN PATHOLOGY
- Ligand-dependent EphB1 signaling suppresses glioma invasion and correlates with patient survival
- (2013) L. Teng et al. NEURO-ONCOLOGY
- Design and Synthesis of Potent Bivalent Peptide Agonists Targeting the EphA2 Receptor
- (2013) Srinivas Duggineni et al. ACS Medicinal Chemistry Letters
- EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner
- (2012) Zhan Xiao et al. CANCER BIOLOGY & THERAPY
- Abstract 1195: EphA4 is a novel tumor suppressor in lung adenocarcinoma
- (2012) Shaohua Peng CANCER RESEARCH
- Eph receptors and ephrins as targets for cancer therapy
- (2012) Hong-Qing Xi et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Suppression of EphB4 improves the inhibitory effect of mTOR shRNA on the biological behaviors of ovarian cancer cells by down-regulating Akt phosphorylation
- (2012) Xiangyi Ma et al. Journal of Huazhong University of Science and Technology-Medical Sciences
- Effects of Cancer-Associated EPHA3 Mutations on Lung Cancer
- (2012) Guanglei Zhuang et al. JNCI-Journal of the National Cancer Institute
- Clinical implications of EphB4 receptor expression in pancreatic cancer
- (2012) Man Li et al. MOLECULAR BIOLOGY REPORTS
- Global Evaluation of Eph Receptors and Ephrins in Lung Adenocarcinomas Identifies EphA4 as an Inhibitor of Cell Migration and Invasion
- (2012) P. Saintigny et al. MOLECULAR CANCER THERAPEUTICS
- EphB2 activity plays a pivotal role in pediatric medulloblastoma cell adhesion and invasion
- (2012) Arend H. Sikkema et al. NEURO-ONCOLOGY
- EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinase
- (2012) S D Wang et al. ONCOGENE
- A Small Molecule Agonist of EphA2 Receptor Tyrosine Kinase Inhibits Tumor Cell Migration In Vitro and Prostate Cancer Metastasis In Vivo
- (2012) Aaron Petty et al. PLoS One
- Mutations of the EPHB6 Receptor Tyrosine Kinase Induce a Pro-Metastatic Phenotype in Non-Small Cell Lung Cancer
- (2012) Etmar Bulk et al. PLoS One
- Overexpression of the B-type Eph and ephrin genes correlates with progression and pain in human pancreatic cancer
- (2012) ZHENHUI LU et al. Oncology Letters
- EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex
- (2012) Guo Li et al. Nature Communications
- Promoted cancer growth by stimulating cell proliferation and decreasing apoptosis using a lentivirus-based EphB2 RNAi in pancreatic carcinoma CFPAC-1 cells
- (2011) Yong-qiang Hua et al. BIOMEDICINE & PHARMACOTHERAPY
- EphB3 Is Overexpressed in Non-Small-Cell Lung Cancer and Promotes Tumor Metastasis by Enhancing Cell Survival and Migration
- (2011) X.-D. Ji et al. CANCER RESEARCH
- A Disalicylic Acid-Furanyl Derivative Inhibits Ephrin Binding to a Subset of Eph Receptors
- (2011) Roberta Noberini et al. Chemical Biology & Drug Design
- Dasatinib: An Anti-Tumour Agent via Src Inhibition
- (2011) Antonio Gnoni et al. CURRENT DRUG TARGETS
- MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma
- (2011) Dong-Cai Liu et al. DIAGNOSTIC CYTOPATHOLOGY
- Crystal structure of the EphA4 protein tyrosine kinase domain in the apo- and dasatinib-bound state
- (2011) Carine Farenc et al. FEBS LETTERS
- Ectodomain structures of Eph receptors
- (2011) Juha P. Himanen SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis
- (2010) Georg Martiny-Baron et al. ANGIOGENESIS
- The EphB6 Receptor Cooperates with c-Cbl to Regulate the Behavior of Breast Cancer Cells
- (2010) L. Truitt et al. CANCER RESEARCH
- The EphB2 tumor suppressor induces autophagic cell death via concomitant activation of the ERK1/2 and PI3K pathways
- (2010) Mustapha Kandouz et al. CELL CYCLE
- The EPHB6 Receptor Tyrosine Kinase Is a Metastasis Suppressor That Is Frequently Silenced by Promoter DNA Hypermethylation in Non-Small Cell Lung Cancer
- (2010) J. Yu et al. CLINICAL CANCER RESEARCH
- EphA2 Targeted Chemotherapy Using an Antibody Drug Conjugate in Endometrial Carcinoma
- (2010) J. W. Lee et al. CLINICAL CANCER RESEARCH
- 400 Phase I study of JI-101, a novel oral tyrosine kinase inhibitor that selectively targets EphB4, VEGFR2, and PDGFRβ
- (2010) M. Gordon et al. EJC SUPPLEMENTS
- EphA2Mutation in Lung Squamous Cell Carcinoma Promotes Increased Cell Survival, Cell Invasion, Focal Adhesions, and Mammalian Target of Rapamycin Activation
- (2010) Leonardo Faoro et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells
- (2010) Jonathan W. Astin et al. NATURE CELL BIOLOGY
- Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival
- (2009) N I Herath et al. BRITISH JOURNAL OF CANCER
- EphA2 Mediates Ligand-Dependent Inhibition and Ligand-Independent Promotion of Cell Migration and Invasion via a Reciprocal Regulatory Loop with Akt
- (2009) Hui Miao et al. CANCER CELL
- Cell adhesion and EGFR activation regulate EphA2 expression in cancer
- (2009) Alice Bjerregaard Larsen et al. CELLULAR SIGNALLING
- Frequent epigenetic inactivation of the receptor tyrosine kinase EphA5 by promoter methylation in human breast cancer
- (2009) De-Yuan Fu et al. HUMAN PATHOLOGY
- EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility
- (2009) T. Yamazaki et al. JOURNAL OF CELL SCIENCE
- EphB6 receptor significantly alters invasiveness and other phenotypic characteristics of human breast carcinoma cells
- (2009) B P Fox et al. ONCOGENE
- Clinical Significance of Ephrin (Eph)-A1, -A2, -A4, -A5 and -A7 Receptors in Pancreatic Ductal Adenocarcinoma
- (2009) Constantinos Giaginis et al. PATHOLOGY & ONCOLOGY RESEARCH
- Increased expression of EphA7 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients
- (2008) Lin-Fang Wang et al. BMC CANCER
- Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer
- (2008) Q Chang et al. BRITISH JOURNAL OF CANCER
- A Human Antibody-Drug Conjugate Targeting EphA2 Inhibits Tumor Growth In vivo
- (2008) D. Jackson et al. CANCER RESEARCH
- Aberrant methylation ofEphA7in human prostate cancer and its relation to clinicopathologic features
- (2008) Ming Guan et al. INTERNATIONAL JOURNAL OF CANCER
- Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor
- (2008) Haina Qin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Small Molecules Can Selectively Inhibit Ephrin Binding to the EphA4 and EphA2 Receptors
- (2008) Roberta Noberini et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell lines
- (2008) Alex J Eustace et al. Journal of Translational Medicine
- EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line
- (2008) J. Fukai et al. MOLECULAR CANCER THERAPEUTICS
- EphB1 Is Underexpressed in Poorly Differentiated Colorectal Cancers
- (2008) Zhen Sheng et al. PATHOBIOLOGY
- Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers
- (2008) Mariko Oki et al. WORLD JOURNAL OF GASTROENTEROLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started