The tumour-promoting receptor tyrosine kinase, EphB4, regulates expression of Integrin-β8 in prostate cancer cells

Cisplatin, 5-fluorouracil, and cetuximab (PFE) with or without cilengitide in recurrent/metastatic squamous cell carcinoma of the head and neck: results of the randomized phase I/II ADVANTAGE trial (phase II part)

(2014) J. B. Vermorken et al.   ANNALS OF ONCOLOGY

Integrin Cytoplasmic Tail Interactions

(2014) Elizabeth M. Morse et al.   BIOCHEMISTRY

Cilengitide treatment of newly diagnosed glioblastoma patients does not alter patterns of progression

(2014) Günter Eisele et al.   JOURNAL OF NEURO-ONCOLOGY

Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells

(2013) Andrey Makarov et al.   CELL BIOLOGY INTERNATIONAL

αv-Integrin isoform expression in primary human tumors and brain metastases

(2013) Alexander Vogetseder et al.   INTERNATIONAL JOURNAL OF CANCER

αvβ8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion

(2013) Steve B. Reyes et al.   MOLECULAR BIOLOGY OF THE CELL

Alteration in Metastasis Potential and Gene Expression in Human Lung Cancer Cell Lines by ITGB8 Silencing

(2012) Zhaoguo Xu et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Randomized phase II study of three doses of the integrin inhibitor cilengitide versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer

(2012) Christian Manegold et al.   INVESTIGATIONAL NEW DRUGS

Phenotypic Characterization of Prostate Cancer LNCaP Cells Cultured within a Bioengineered Microenvironment

(2012) Shirly Sieh et al.   PLoS One

Integrins as therapeutic targets

(2012) Simon L. Goodman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Matched rabbit monoclonal antibodies against  v-series integrins reveal a novel  v 3-LIBS epitope, and permit routine staining of archival paraffin samples of human tumors

(2012) S. L. Goodman et al.   Biology Open

Evidence for a dual function of EphB4 as tumor promoter and suppressor regulated by the absence or presence of the ephrin-B2 ligand

(2011) Raphael Rutkowski et al.   INTERNATIONAL JOURNAL OF CANCER

Eph-2B, acting as an extracellular ligand, induces differentiation markers in epidermal keratinocytes

(2011) Rebecca Walsh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

TGF-β in cancer and bone: Implications for treatment of bone metastases

(2010) Patricia Juárez et al.   BONE

Phase II study of Cilengitide (EMD 121974, NSC 707544) in patients with non-metastatic castration resistant prostate cancer, NCI-6735. A study by the DOD/PCF prostate cancer clinical trials consortium

(2010) Ajjai Alva et al.   INVESTIGATIONAL NEW DRUGS

Transcription of the Transforming Growth Factor β Activating Integrin β8 Subunit Is Regulated by SP3, AP-1, and the p38 Pathway

(2010) Jennifer A. Markovics et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells

(2010) Jonathan W. Astin et al.   NATURE CELL BIOLOGY

MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8

(2010) L Fang et al.   ONCOGENE

Integrin-Mediated Transforming Growth Factor-β Activation, a Potential Therapeutic Target in Fibrogenic Disorders

(2009) Stephen L. Nishimura   AMERICAN JOURNAL OF PATHOLOGY

Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor

(2009) Nicole K. Noren et al.   BIOCHEMICAL JOURNAL

The Receptor Tyrosine Kinase EPHB4 Has Tumor Suppressor Activities in Intestinal Tumorigenesis

(2009) H. Dopeso et al.   CANCER RESEARCH

Control of extracellular matrix assembly along tissue boundaries via Integrin and Eph/Ephrin signaling

(2009) D. Julich et al.   DEVELOPMENT

Targeting TGF-β in prostate cancer: therapeutic possibilities during tumor progression

(2009) Elisabeth Jones et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A Six-Gene Signature Predicting Breast Cancer Lung Metastasis

(2008) T. Landemaine et al.   CANCER RESEARCH