Article
Medicine, General & Internal
Xia Zhong, Xue-Hua Tu, Gu-Ha A-Lai, Ze-Guo Zhuo, Peng Yao, Ying Zhang, Zhi-Jie Xu, Yi-Dan Lin
Summary: This study found that the distance between the lower tumor margin and esophagogastric junction is associated with the risk of abdominal lymph node metastasis in patients with esophageal cancer, providing guidance for surgeons in preoperative risk assessment and lymph node dissection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Shuang Liu, Zheng Lin, Wenqing Rao, Jing Zheng, Qianwen Xie, Yulan Lin, Xi Lin, Huilin Chen, Yuanmei Chen, Zhijian Hu
Summary: The study identified that the expression levels of serum exosomal hsa_circ_0026611 are related to lymph node metastasis in ESCC, and can serve as a prognostic predictor for ESCC patients.
Article
Oncology
Xiaofeng Duan, Xiaobin Shang, Jie Yue, Zhao Ma, Chuangui Chen, Peng Tang, Hongjing Jiang, Zhentao Yu
Summary: A nomogram was developed to predict lymph node metastasis for patients with early-stage esophageal squamous cell carcinoma, which was validated by an independent cohort. The study confirms the accuracy of the nomogram in predicting the risk of lymph node metastasis for these patients.
Article
Oncology
Zhao Shu, Junfeng Guo, Qian Xue, Qi Tang, Bingqiang Zhang
Summary: This study constructed a single-cell atlas of ESCC and revealed a novel subpopulation of SAA1+ malignant cells that are closely associated with distant metastasis of ESCC. A prediction model based on the gene expression pattern of SAA1+ cells was also established to identify high-risk patients with worse prognosis. These findings enhance our understanding of the mechanisms underlying distant metastasis in ESCC and provide a theoretical basis for improved therapies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Huochun Yi, Hongbing Duan, Wensheng Shi, Zhengjin Liu, Yali Liu
Summary: DEK protein is overexpressed in ESCC tissues, associated with poor prognosis, and can independently predict the prognosis of ESCC patients.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Medicine, Research & Experimental
Wenying Liu, Yu Xia, Mengyan Li, Gulinaer Abulajiang, Hui Wang, Liping Su, Chao Li, Yan Shi, Wenjing Zhang, Shanshan Xu, Yuqing Ma
Summary: This study investigated the impact of MTA1, SOX4, and EZH2 on the prognosis of patients with ESCC. The results suggest that MTA1 may serve as a prognostic and diagnostic marker for ESCC, and that MTA1-SOX4 signaling is associated with prognosis in ESCC. However, no significant association was found between SOX4 and EZH2 in this study, indicating the need for further investigation into the function of the MTA1-SOX4-EZH2 axis and the interactions of the proteins involved.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Hang Wang, Zheng Lin, Yimin Lin, Ruigang Huang, Moliang Qiu, Xiane Peng, Fei He, Liping Huang, Zhisheng Xiang, Wanting Lu, Siyou Yan, Shuang Liu, Huimin Yang, Zhihui Zhang, Zhijian Hu
Summary: The study proposed a new diagnostic criterion and LN clinical staging system for better prognostic prediction in nonsurgically treated ESCC patients. The new system showed better homogeneity, discriminatory ability, and clinical value compared to the original staging system.
Article
Oncology
Hao-Ji Yan, Wen-Jun Mao, Rui-Xuan Yu, Kai-Yuan Jiang, Heng Huang, Zheng-Dong Zong, Qin-Chun Qian, Xiao-Guang Guo, Hong-Ying Wen, Dong Tian
Summary: A nomogram developed using preoperative clinical characteristics showed good performance in predicting recurrent laryngeal nerve lymph node metastasis and prognosis in patients with esophageal squamous cell carcinoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Wan Duan, Zhangxia Wu, Xueying Mei, Jingyuan Li, Huanzi Lu, Yujie Liang, Xiaomei Lao, Guiqing Liao
Summary: This study examined the role of platelets in the tumor microenvironment of oral squamous cell carcinoma (OSCC) and found that intratumoral platelet microthrombi (PLT-MT) were associated with clinicopathological characteristics and predictive value. PLT-MT was also correlated with lymph node metastasis and prognosis prediction.
Article
Oncology
Xiaohui Tan, Shuchang Ren, Melinda Z. Fu, Shuyang Ren, Canyuan Yang, Xiaoling Wu, Tao Chen, Patricia S. Latham, Stephen J. Meltzer, Sidney W. Fu
Summary: Esophageal cancer, particularly ESCC and EAC, is highly aggressive with low survival rates. The upregulation of miR-196b in both ESCC and EAC suggests its potential as a molecular target for EC treatment, acting as an oncomiR by targeting the tumor suppressor EPHA7.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Yusuke Sato, Satoru Motoyama, Yuki Wada, Akiyuki Wakita, Yuta Kawakita, Yushi Nagaki, Kaori Terata, Kazuhiro Imai, Akira Anbai, Manabu Hashimoto, Yoshihiro Minamiya
Summary: NACRT followed by esophagectomy with three-field lymph node dissection is feasible and offers the potential for long-term survival of clinical Stage III patients and even clinical Stage IVB patients with supraclavicular LN metastasis as the only distant metastatic factor. At least in patients with upper and middle thoracic ESCC, treating supraclavicular LNs as regional LNs seems to be appropriate.
Article
Dentistry, Oral Surgery & Medicine
Simone E. S. Faustino, Kellen C. Tjioe, Agnes Assao, Michele C. Pereira, Andre L. Carvalho, Luiz P. Kowalski, Denise T. Oliveira
Summary: ILVD and PLVD showed no significant association with occult lymph node metastasis or clinical follow-up, but ILVD was significantly associated with regional recurrence. PLVD was related to perineural invasion and had significant associations with disease-specific and disease-free survivals.
Article
Oncology
Seong Yong Park, Junghee Lee, Yeong Jeong Jeon, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi, Jae Il Zo, Young Mog Shim
Summary: The presence of supraclavicular lymph node metastasis did not significantly impact the overall survival of esophageal squamous cell carcinoma patients who underwent 3-field lymph node dissection, regardless of clinical suspicion or pathologic confirmation.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Dongxian Jiang, Haixing Wang, Minying Deng, Qi Song, Yufeng Liu, Rui Peng, Lei Xu, Jieakesu Su, Chen Xu, Yingyong Hou
Summary: The number of diagnosed esophageal basaloid squamous cell carcinoma (EBSCC) has been increasing recently, but available data on EBSCC are limited. A retrospective analysis of 165 EBSCC and 515 conventional esophageal squamous cell carcinoma (ESCC) showed that EBSCC had similar prognosis to ESCC in pIA-B stage, pIIA-B stage, pIIIA-B stage, and pIVA-B stage. Pure EBSCC did not have poorer survival compared to mixed EBSCC with concomitant ESCC or other components.
Article
Oncology
Yoshihisa Numata, Tetsuya Abe, Eiji Higaki, Takahiro Hosoi, Hironori Fujieda, Takuya Nagao, Nobuhiro Hanai, Hidenori Suzuki, Daisuke Nishikawa, Keitaro Matsuo, Tsutomu Fujii, Yasuhiro Shimizu
Summary: Metastases to supraclavicular lymph nodes have a significant impact on the prognosis of patients with cervical esophageal cancer. These lymph nodes may be considered extra-regional in this patient population.
ANNALS OF SURGICAL ONCOLOGY
(2021)
