Article
Engineering, Biomedical
Cort H. Thompson, Blake M. Evans, Dorothy X. Zhao, Erin K. Purcell
Summary: Implantation of electrodes in the brain can be used to record from or stimulate neural tissues to treat neurological disease and injury. Recent RNA-seq datasets identify genes associated with gliosis, neuronal function, myelination, and cellular metabolism following the insertion of microelectrodes. This study validates mRNA as a predictor of protein expression and provides insight into the spatiotemporal distribution of proteins in neural tissues after implantation.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Yan Xu, Dorothea Robev, Nayanendu Saha, Bingcheng Wang, Matthew B. Dalva, Kai Xu, Juha P. Himanen, Dimitar B. Nikolov
Summary: Eph receptor tyrosine kinases and ephrin ligands play crucial roles in cell communication, with dysfunctional signaling leading to disease. The formation of extensive signaling assemblies regulates neuronal migration and axon pathfinding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Zhimin Huang, Simeng Liu, Anna Tang, Laith Al-Rabadi, Mark Henkemeyer, Patrice N. Mimche, Yufeng Huang
Summary: The study reveals that EphB2 receptor tyrosine kinase plays a key role in renal fibrosis, with its expression and activation being closely associated with fibrotic development following kidney injury.
Article
Cell Biology
Lorena Suarez-Artiles, Tilman Breiderhoff, Rossana Girardello, Hannes Gonschior, Sophie Rodius, Antoine Lesur, Ulf Reimer, Evelyn Ramberger, Daniel Perez-Hernandez, Dominik Muller, Philipp Mertins, Gunnar Dittmar
Summary: This study investigates the interaction of the C-terminal tails of the Claudin family with other proteins, revealing their potential involvement in specific biological processes in epithelial cells and their regulation by post-translational modifications.
Article
Biochemistry & Molecular Biology
Dong-Bei Xu, Ya-Nan Ma, Teng-Fei Qin, Wei-Lin Tang, Xi-Wu Qi, Xia Wang, Rui-Cen Liu, Hai-Ling Fang, Ze-Qun Chen, Cheng-Yuan Liang, Wei Wu
Summary: Jasmonate ZIM-domain (JAZ) proteins are crucial transcriptional repressors in the jasmonic acid (JA) signaling process, and play important roles in plant development, defense, and metabolism. The study identified seven non-redundant JAZ genes in Mentha canadensis L., showing differential expression patterns in plant tissues, preferential expression in flowers, and variable responses to MeJA, ABA, drought, and salt treatments. Subcellular localization analysis demonstrated that McJAZ proteins are localized in the nucleus or cytoplasm, and yeast two-hybrid assays showed interactions between McJAZ proteins and McCOI1a.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Shuai Lu, Cong Gao, Yongzhou Wang, Yingying He, Junrong Du, Moxian Chen, Hua Zhao, Hui Fang, Baohua Wang, Yunying Cao
Summary: This study identified U2AF65A in plant species, conducted phylogenetic and bioinformatic analyses, and studied the localization and stress responses of OsU2AF65A in rice. Using Arabidopsis and rice mutants, the importance of U2AF65A in plant growth and stress responses was demonstrated. These findings provide an overview of the U2AF65 gene family and its role in plant development and stress tolerance.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Gui-Zhen Chen, Jie Huang, Zhi-Cong Lin, Fei Wang, Song-Min Yang, Xiao Jiang, Sagheer Ahmad, Yu-Zhen Zhou, Siren Lan, Zhong-Jian Liu, Dong-Hui Peng
Summary: This study identified 15 WOX transcription factors in sacred lotus and analyzed their gene structures, conservation motifs, and promoter regions' regulatory elements. The findings suggest that NnWOXs are involved in organ development and differentiation of sacred lotus, as well as potential roles in growth, development, and metabolic regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Xuehao Cui, Tingyi Liang, Xunda Ji, Yan Shao, Peiquan Zhao, Xiaorong Li
Summary: The study revealed that LINC00488 confers oncogenic activity in retinoblastoma by binding to miR-30a-5p and targeting EPHB2.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Multidisciplinary Sciences
Guoxin Cui, Migle K. Konciute, Lorraine Ling, Luke Esau, Jean -Baptiste Raina, Baoda Han, Octavio R. Salazar, Jason S. Presnell, Nils Raedecker, Huawen Zhong, Jessica Menzies, Phillip A. Cleves, Yi Jin Liew, Cory J. Krediet, Val Sawiccy, Maha J. Cziesielski, Paul Guagliardo, Jeremy Bougoure, Mathieu Pernice, Heribert Hirt, Christian R. Voolstra, Virginia M. Weis, John R. Pringle, Manuel Aranda
Summary: Symbiotic cnidarians, such as corals and anemones, have evolved efficient molecular mechanisms for nutrient distribution and recycling in order to thrive in nutrient-poor ocean environments. Using the sea anemone Aiptasia, researchers have discovered that glucose and the presence of algae induce the up-regulation and relocalization of glucose and ammonium transporters, which are critical for symbiont functioning and organism-wide nitrogen assimilation. These findings provide insight into the molecular mechanisms underlying nitrogen conservation and recycling in symbiotic cnidarians.
Article
Plant Sciences
Qianqian Hu, Mengting Zeng, Miao Wang, Xiaoyu Huang, Jiayi Li, Changhui Feng, Lijie Xuan, Lu Liu, Gengqing Huang
Summary: Multiple C2 domain and transmembrane region proteins (MCTPs) are evolutionarily conserved proteins with emerging roles in mediating protein trafficking and signaling transduction. Among them, GhMCTP7, GhMCTP12, and GhMCTP17 are highly expressed in the main stem apex of cotton, suggesting their crucial roles in shoot development. Through analyzing different cotton species, it is found that plant heights are closely related to the expression levels of these MCTPs, further emphasizing their significance in cotton growth and development.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Genetics & Heredity
Yanping Hu, Tingting Zhang, Ying Liu, Yuxin Li, Min Wang, Baibi Zhu, Daolong Liao, Tianhai Yun, Wenfeng Huang, Wen Zhang, Yang Zhou
Summary: Pumpkin HSP20 genes were comprehensively analyzed, revealing their distribution across 13 chromosomes and division into nine subfamilies. Segmental duplication events played a key role in gene family expansion, and synteny analysis showed collinearity with cucumber and melon genomes. Certain CmoHSP20 genes showed differential expression levels under heat stress, with potential as candidate genes for heat tolerance.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Anelya Kh Alieva, Elena Filatova, Margarita M. Rudenok, Petr A. Slominsky, Maria Shadrina
Summary: Selecting the correct housekeeping genes is crucial for normalizing gene expression data in real-time PCR. In Parkinson's disease, different housekeeping genes are stably expressed in different parts of the brain and in similar tissues of different organisms.
Review
Microbiology
Sophia C. Parks, Susan Nguyen, Martin J. Boulanger, Adler R. Dillman
Summary: Fatty acid-and retinol-binding proteins (FARs) are a class of secreted proteins found exclusively in nematodes. Recent research has shown their involvement in immunomodulation.
Article
Plant Sciences
Lars H. Kruse, Benjamin Fehr, Jason D. Chobirko, Gaurav D. Moghe
Summary: This study provides insights into the functional evolution and prediction of the BAHD acyltransferase family in flowering plants. The expansion of BAHDs in land plants is associated with significant changes in gene features, and different plant groups exhibit clade expansions related to specific metabolite classes. Co-expression analysis and metabolic pathway models contribute to the recovery of metabolic processes and novel functional predictions for BAHD acyltransferases.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Danny Bergeron, Cedric Laforest, Stacey Carpentier, Annabelle Calve, Etienne Fafard-Couture, Gabrielle Deschamps-Francoeur, Michelle S. Scott
Summary: The study reveals that snoRNA copy regulation affects family sizes, genomic location of the members, and controls both member and total family abundance to meet the needs of individual tissues. Additionally, the expression variability of individual snoRNA family members is preferred over the total variability of the family, pointing towards differential regulation mechanisms exist to ensure uniformity of the total family abundance across tissues.
Article
Multidisciplinary Sciences
Ulrich Elling, Reiner A. Wimmer, Andreas Leibbrandt, Thomas B. Urkard, Georg Michlits, Alexandra Leopoldi, Thomas Micheler, Dana Abdeen, Sergei Zhuk, Irene M. Aspalter, Cornelia Handl, Julia Liebergesell, Maria Hubmann, Anna-Maria Husa, Manuela Kinzer, Nicole Schuller, Ellen Wetzel, Nina van de Loo, Jorge Arturo Zepeda Martinez, David Estoppey, Ralph Riedl, Fengtang Yang, Beiyuan Fu, Thomas Dechat, Zoltan Ivics, Chukwuma A. Agu, Oliver Bell, Dieter Blaas, Holger Gerhardt, Dominic Hoepfner, Alexander Stark, Josef M. Penninger
Article
Cell & Tissue Engineering
Anna-Maria Husa, Maria Regina Strobl, Agata Strajeriu, Matthias Wieser, Sabine Strehl, Klaus Fortschegger
STEM CELLS AND DEVELOPMENT
(2018)
Article
Peripheral Vascular Disease
Sabrina Rohringer, Pablo Hofbauer, Karl H. Schneider, Anna-Maria Husa, Georg Feichtinger, Anja Peterbauer-Scherb, Heinz Redl, Wolfgang Holnthoner
Article
Cell & Tissue Engineering
Gudrun Hager, Wolfgang Holnthoner, Susanne Wolbank, Anna-Maria Husa, Kathrin Godthardt, Heinz Redl, Christian Gabriel
Article
Cell & Tissue Engineering
Wolfgang Holnthoner, Karin Hohenegger, Anna-Maria Husa, Severin Muehleder, Alexandra Meinl, Anja Peterbauer-Scherb, Heinz Redl
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2015)