Article
Immunology
Xiaofang Xu, Dianhua Qiao, Chenyang Dong, Morgan Mann, Roberto P. Garofalo, Sunduz Keles, Allan R. Brasier
Summary: The SMARCA4 complex is found to play a crucial role in the response of airway epithelial cells to RSV infection, with its depletion leading to cellular state transition and chromatin opening that affect gene expression within cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Wen-Yueh Hung, Wei-Jiunn Lee, Guo-Zhou Cheng, Ching-Han Tsai, Yi-Chieh Yang, Tsung-Ching Lai, Ji-Qing Chen, Chi-Li Chung, Jer-Hwa Chang, Ming-Hsien Chien
Summary: Our study showed that penfluridol can reduce the migration, invasion, and adhesion of LADC cells, potentially by inhibiting MMP-12 expression and reversing MMP-12-induced EMT. MMP-12 may serve as a useful biomarker for predicting LADC progression and as a promising penfluridol target for treating metastatic LADC.
Article
Pharmacology & Pharmacy
Rujun Jia, Tiegang Li, Nana Wang
Summary: The study revealed that in PQ-induced pulmonary EMT, HOTAIR acts as a ceRNA to regulate MMP2 expression by modulating miR-17-5p. MiR-17-5p negatively regulates HOTAIR and MMP2, while the downregulation of miR-17-5p increases the expression of HOTAIR and MMP2.
Article
Biochemistry & Molecular Biology
K. Srivastava, K. E. Lines, D. Jach, T. Crnogorac-Jurcevic
Summary: Loss of S100PBP leads to oncogenic transformation of pancreatic cells, and the expression levels of S100P and S100PBP are closely associated with the prognosis of pancreatic cancer patients.
Article
Oncology
Yi-Ching Chuang, Ming-Chang Hsieh, Chia-Chieh Lin, Yu-Sheng Lo, Hsin-Yu Ho, Ming-Ju Hsieh, Jen-Tsun Lin
Summary: The study demonstrated that pinosylvin inhibited migration and invasion in nasopharyngeal carcinoma cells, potentially through modulation of multiple signaling pathways.
Article
Oncology
Satoru Furuhashi, Yoshifumi Morita, Shinya Ida, Ryuta Muraki, Ryo Kitajima, Makoto Takeda, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Mitsutoshi Setou, Hiroya Takeuchi
Summary: This study aimed to identify the mechanisms of perineural invasion in PDAC. Through in vitro co-culture models, EPHA4 was identified as a potential target gene to regulate perineural invasion, with its expression affected by DRG-CM treatment and crucial for migration, invasion, and neurotropism in MIA Paca2 cells.
ANTICANCER RESEARCH
(2021)
Article
Oncology
Shuai Huang, Xudong Zhang, Kai Luo, Li Jiang, Jianhua Jiang, Renfeng Li
Summary: In this study, OSBP2 was found to be highly expressed in PDAC and its upregulation promoted the progression of PDAC, including increased cell migration, invasion, proliferation, chemotherapy resistance, and decreased apoptosis. Furthermore, overexpression of OSBP2 resulted in downregulation of the cell adhesion molecule E-cadherin and upregulation of other transcription factors. Therefore, OSBP2 may serve as a potential diagnostic and therapeutic target for PDAC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Reproductive Biology
Qiao Ping Xu, Kui Deng, Zhen Zhang, Hongkai Shang
Summary: Ovarian cancer is a growing global disease, and there is an urgent need for chemotherapy and targeted therapy. SLFN5 plays an important role in malignancy, but its specific function in ovarian cancer cells is still unclear. This study suggests that SLFN5 expression is related to the progression and malignancy of ovarian cancer, and its silencing has a significant inhibitory effect on the invasion and metastasis ability of ovarian cancer cells. Therefore, SLFN5 may serve as a potential target for future drug development in the treatment of ovarian cancer.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Multidisciplinary Sciences
Tianying Zheng, Wenfei Han, Aijun Wang, Yonggang Wang
Summary: This study reveals that miR-128-3p inhibits epithelial-mesenchymal transition, invasion, and migration of pancreatic cancer cells by targeting ZEB1.
Article
Medical Laboratory Technology
Xiaoqing Xu, Xiaomin Lu, Liping Chen, Ke Peng, Fuhai Ji
Summary: Matrix metalloproteinase-1 (MMP1) plays a role in perineural invasion (PNI) of pancreatic cancer (PC). This study found that MMP1 is highly expressed in PC tissues and is positively associated with PNI. Silencing MMP1 inhibits the migration and invasion of PC cells and prevents EMT and Schwann-like cell differentiation by blocking the activation of the NT-3/TrkC signaling pathway, thereby alleviating PNI.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Oncology
Jing Zhang, Zhimin Hu, Calista A. Horta, Jing Yang
Summary: Epithelial-mesenchymal transition (EMT) is involved in various aspects of tumor development. The tumor microenvironment, consisting of different stroma cells and biochemical factors, influences the EMT program and tumor progression. This review explores the effects of tumor microenvironmental signals on EMT regulation, discusses the molecular mechanisms of EMT in therapy resistance, and proposes new therapeutic approaches targeting the tumor microenvironment to impact EMT and tumor progression.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Braxton Noll, Farah Bahrani Mougeot, Michael T. Brennan, Jean-Luc C. Mougeot
Summary: This study found that the degradation of salivary epithelium in primary Sjogren's syndrome (pSS) patients is initially caused by overexpression of MMP9. The expression of MMP9 and its associated transcription factor ETS1 was assessed in primary salivary gland epithelial cells (SGECs) and potential regulatory mechanisms were investigated in immortalized SGECs. It was found that ETS1 and MMP9 were overexpressed in SGECs of pSS patients. Knocking down ETS1 resulted in reduced mRNA and protein levels of MMP9. ETS1 overexpression affected the expression of markers associated with epithelial-mesenchymal transition (EMT) and progenitor cells.
SCIENTIFIC REPORTS
(2022)
Article
Integrative & Complementary Medicine
Yih-Shou Hsieh, Shu-Chen Chu, Shih-Chien Huang, Shao-Hsuan Kao, Meng-Shuan Lin, Pei-Ni Chen
Summary: The research showed that gossypol inhibited the invasion and migration of human cervical cancer cells by targeting the FAK signaling pathway and reversing TGF-beta 1-induced EMT.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Aitao Sun, JinBo Li, Weijing Kong, Xiaodong Jiang
Summary: This study investigates the expression and underlying mechanisms of the immunoglobulin superfamily containing leucine-rich repeat (ISLR) in gastric cancer (GC). The findings suggest that ISLR is overexpressed in GC tumor tissues and cells and is associated with lymph node metastasis, tumor size, and clinical stage. Additionally, ISLR regulates the epithelial-mesenchymal transition (EMT) signaling pathway and affects cell viability, proliferation, migration, and invasion in GC cells. These results provide new evidence for the role of ISLR in GC progression.
Article
Biophysics
Naba Mukhtar, Eric N. Cytrynbaum, Leah Edelstein-Keshet
Summary: Epithelial-mesenchymal transition (EMT) plays a crucial role in wound healing, embryonic development, and cancer metastasis. This study presents a multiscale model that investigates the role of the protein YAP in promoting EMT and validates the simulation results with experimental observations.
BIOPHYSICAL JOURNAL
(2022)
