Mechanisms of ephrin–Eph signalling in development, physiology and disease

Eph Receptors and Ephrins: Therapeutic Opportunities

(2015) Antonio Barquilla et al.   Annual Review of Pharmacology and Toxicology

Mechanisms of boundary formation by Eph receptor and ephrin signaling

(2015) Jordi Cayuso et al.   DEVELOPMENTAL BIOLOGY

 2-Chimaerin Is Required for Eph Receptor-Class-Specific Spinal Motor Axon Guidance and Coordinate Activation of Antagonistic Muscles

(2015) T.-J. Kao et al.   JOURNAL OF NEUROSCIENCE

EphrinB2 controls vessel pruning through STAT1-JNK3 signalling

(2015) Ombretta Salvucci et al.   Nature Communications

EphA4 Receptor Shedding Regulates Spinal Motor Axon Guidance

(2014) Graziana Gatto et al.   CURRENT BIOLOGY

Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals

(2014) H. Lindskog et al.   DEVELOPMENT

The composition of EphB2 clusters determines the strength in the cellular repulsion response

(2014) Andreas Schaupp et al.   JOURNAL OF CELL BIOLOGY

Spinal Glutamatergic Neurons Defined by EphA4 Signaling Are Essential Components of Normal Locomotor Circuits

(2014) L. Borgius et al.   JOURNAL OF NEUROSCIENCE

Multiple EphB receptors mediate dorsal–ventral retinotopic mapping via similar bi-functional responses to ephrin-B1

(2014) Todd McLaughlin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Direct cell–cell contact with the vascular niche maintains quiescent neural stem cells

(2014) Cristina Ottone et al.   NATURE CELL BIOLOGY

Target-Independent EphrinA/EphA-Mediated Axon-Axon Repulsion as a Novel Element in Retinocollicular Mapping

(2014) Philipp Suetterlin et al.   NEURON

Ensembl 2015

(2014) Fiona Cunningham et al.   NUCLEIC ACIDS RESEARCH

EphB receptor forward signaling regulates area-specific reciprocal thalamic and cortical axon pathfinding

(2014) Michael A. Robichaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EphA7 signaling guides cortical dendritic development and spine maturation

(2014) Meredith A. Clifford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer’s disease

(2014) Amy K. Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of cell differentiation by Eph receptor and ephrin signaling

(2014) David G Wilkinson   Cell Adhesion & Migration

Beyond boundaries—Eph:ephrin signaling in neurogenesis

(2014) J Laussu et al.   Cell Adhesion & Migration

Variable Combinations of Specific Ephrin Ligand/Eph Receptor Pairs Control Embryonic Tissue Separation

(2014) Nazanin Rohani et al.   PLOS BIOLOGY

Reelin induces EphB activation

(2013) Elisabeth Bouché et al.   CELL RESEARCH

Molecular guidance of retinotopic map development in the midbrain

(2013) Jason W Triplett   CURRENT OPINION IN NEUROBIOLOGY

Ephrin B1 maintains apical adhesion of neural progenitors

(2013) D. N. Arvanitis et al.   DEVELOPMENT

EphA/ephrin A reverse signaling promotes the migration of cortical interneurons from the medial ganglionic eminence

(2013) A. Steinecke et al.   DEVELOPMENT

A Molecular Base for Cell Sorting at Embryonic Boundaries: Contact Inhibition of Cadherin Adhesion by Ephrin/Eph-Dependent Contractility

(2013) François Fagotto et al.   DEVELOPMENTAL CELL

Upregulation of axon guidance molecules in the adult central nervous system of Nogo-A knockout mice restricts neuronal growth and regeneration

(2013) Anissa Kempf et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ephrin-B2 controls PDGFR  internalization and signaling

(2013) A. Nakayama et al.   GENES & DEVELOPMENT

Eph receptors and ephrin class B ligands are expressed at tissue boundaries in Hydra vulgaris

(2013) Susanne Tischer et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Spatial regulation of VEGF receptor endocytosis in angiogenesis

(2013) Masanori Nakayama et al.   NATURE CELL BIOLOGY

Therapeutic targeting of EPH receptors and their ligands

(2013) Andrew W. Boyd et al.   NATURE REVIEWS DRUG DISCOVERY

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses

(2013) Elena Seiradake et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ephrin-B1 Controls the Columnar Distribution of Cortical Pyramidal Neurons by Restricting Their Tangential Migration

(2013) Jordane Dimidschstein et al.   NEURON

Contact Repulsion Controls the Dispersion and Final Distribution of Cajal-Retzius Cells

(2013) Verona Villar-Cerviño et al.   NEURON

EphrinB3/EphA4-Mediated Guidance of Ascending and Descending Spinal Tracts

(2013) Sónia Paixão et al.   NEURON

Zic2-Dependent Axon Midline Avoidance Controls the Formation of Major Ipsilateral Tracts in the CNS

(2013) Augusto Escalante et al.   NEURON

Ret Is a Multifunctional Coreceptor that Integrates Diffusible- and Contact-Axon Guidance Signals

(2012) Dario Bonanomi et al.   CELL

Flow control in our vessels: vascular valves make sure there is no way back

(2012) Eleni Bazigou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Eph/ephrin signalling during development

(2012) R. Klein   DEVELOPMENT

Genetic Evidence for a Contribution of EphA:EphrinA Reverse Signaling to Motor Axon Guidance

(2012) I. Dudanova et al.   JOURNAL OF NEUROSCIENCE

EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

(2012) Annelies Van Hoecke et al.   NATURE MEDICINE

A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development

(2012) Michael J Soskis et al.   NATURE NEUROSCIENCE

Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling

(2012) Randolph S Ashton et al.   NATURE NEUROSCIENCE

Targeted Disruption of Ephrin B1 in Cells of Myeloid Lineage Increases Osteoclast Differentiation and Bone Resorption in Mice

(2012) Shaohong Cheng et al.   PLoS One

Myelin-derived ephrinB3 restricts axonal regeneration and recovery after adult CNS injury

(2012) P. Duffy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Eph-Receptor A7 Is a Soluble Tumor Suppressor for Follicular Lymphoma

(2011) Elisa Oricchio et al.   CELL

Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice

(2011) Eleni Bazigou et al.   JOURNAL OF CLINICAL INVESTIGATION

Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration

(2011) Aycan Sentürk et al.   NATURE

Ephrin-Mediated cis-Attenuation of Eph Receptor Signaling Is Essential for Spinal Motor Axon Guidance

(2011) Tzu-Jen Kao et al.   NEURON

Anatomical Coupling of Sensory and Motor Nerve Trajectory via Axon Tracking

(2011) Liang Wang et al.   NEURON

EphA4 Blockers Promote Axonal Regeneration and Functional Recovery Following Spinal Cord Injury in Mice

(2011) Yona Goldshmit et al.   PLoS One

Critical roles for EphB and ephrin-B bidirectional signalling in retinocollicular mapping

(2011) Sonal Thakar et al.   Nature Communications

EphB-Mediated Degradation of the RhoA GEF Ephexin5 Relieves a Developmental Brake on Excitatory Synapse Formation

(2010) Seth S. Margolis et al.   CELL

EphB Signaling Directs Peripheral Nerve Regeneration through Sox2-Dependent Schwann Cell Sorting

(2010) Simona Parrinello et al.   CELL

Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets

(2010) Cristina García-Frigola et al.   EMBO JOURNAL

Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries

(2010) J. O. Bush et al.   GENES & DEVELOPMENT

Eph/ephrin molecules--a hub for signaling and endocytosis

(2010) M. E. Pitulescu et al.   GENES & DEVELOPMENT

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

(2010) Suphansa Sawamiphak et al.   NATURE

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

(2010) Moustapha Cissé et al.   NATURE

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells

(2010) Jonathan W. Astin et al.   NATURE CELL BIOLOGY

An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly

(2010) Elena Seiradake et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Architecture of Eph receptor clusters

(2010) J. P. Himanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2

(2010) K. Salaita et al.   SCIENCE

EphA2 Mediates Ligand-Dependent Inhibition and Ligand-Independent Promotion of Cell Migration and Invasion via a Reciprocal Regulatory Loop with Akt

(2009) Hui Miao et al.   CANCER CELL

Dissociation of EphB2 Signaling Pathways Mediating Progenitor Cell Proliferation and Tumor Suppression

(2009) Maria Genander et al.   CELL

Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling

(2009) H. A. North et al.   DEVELOPMENT

Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex

(2009) Juha P Himanen et al.   EMBO REPORTS

Bidirectional Signaling through EphrinA2-EphA2 Enhances Osteoclastogenesis and Suppresses Osteoblastogenesis

(2009) Naoko Irie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Src Family Kinases Are Required for Limb Trajectory Selection by Spinal Motor Axons

(2009) T.-J. Kao et al.   JOURNAL OF NEUROSCIENCE

Specificity and Sufficiency of EphB1 in Driving the Ipsilateral Retinal Projection

(2009) T. J. Petros et al.   JOURNAL OF NEUROSCIENCE

Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling

(2009) Masaaki Torii et al.   NATURE

Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning

(2009) Nan-Jie Xu et al.   NATURE NEUROSCIENCE

Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport

(2009) Alessandro Filosa et al.   NATURE NEUROSCIENCE

Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport

(2009) M. A. Carmona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-Specific Information Processing in Segregating Populations of Eph Receptor Ephrin-Expressing Cells

(2009) C. Jorgensen et al.   SCIENCE

Arterial-Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation

(2009) S. P. Herbert et al.   SCIENCE

EPHA2 Is Associated with Age-Related Cortical Cataract in Mice and Humans

(2009) Gyungah Jun et al.   PLoS Genetics

Zic2 promotes axonal divergence at the optic chiasm midline by EphB1-dependent and -independent mechanisms

(2008) C. Garcia-Frigola et al.   DEVELOPMENT

Ephrin-B2-induced Cleavage of EphB2 Receptor Is Mediated by Matrix Metalloproteinases to Trigger Cell Repulsion

(2008) Kai-Ti Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of neural progenitor cell state by ephrin-B

(2008) Runxiang Qiu et al.   JOURNAL OF CELL BIOLOGY

A TrkB/EphrinA Interaction Controls Retinal Axon Branching and Synaptogenesis

(2008) K. J. M. Marler et al.   JOURNAL OF NEUROSCIENCE

Bidirectional modulation of synaptic functions by Eph/ephrin signaling

(2008) Rüdiger Klein   NATURE NEUROSCIENCE

EphB Receptors Couple Dendritic Filopodia Motility to Synapse Formation

(2008) Matthew S. Kayser et al.   NEURON

Specification of Motor Axon Trajectory by Ephrin-B:EphB Signaling: Symmetrical Control of Axonal Patterning in the Developing Limb

(2008) Victor Luria et al.   NEURON

p75NTR Mediates Ephrin-A Reverse Signaling Required for Axon Repulsion and Mapping

(2008) Yoo-Shick Lim et al.   NEURON

Ephrins as negative regulators of adult neurogenesis in diverse regions of the central nervous system

(2008) J.-w. Jiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA