The Small Molecule Ephrin Receptor Inhibitor, GLPG1790, Reduces Renewal Capabilities of Cancer Stem Cells, Showing Anti-Tumour Efficacy on Preclinical Glioblastoma Models

Tyrosine kinase activity of EphA2 promotes its S897 phosphorylation and glioblastoma cell proliferation

(2018) Yuho Hamaoka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

New aspects of glioblastoma multiforme revealed by similarities between neural and glioblastoma stem cells

(2018) Yoichiro Kawamura et al.   CELL BIOLOGY AND TOXICOLOGY

This article was mistakenly published online early. It will be republished in due course in the Survivorship supplement issue.

(2018)   NEURO-ONCOLOGY

UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice

(2018) Claudio Festuccia et al.   Oncotarget

Immune Microenvironment in Glioblastoma Subtypes

(2018) Zhihong Chen et al.   Frontiers in Immunology

Therapeutic potential of targeting the Eph/ephrin signaling complex

(2018) Nayanendu Saha et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Targeting Eph/ephrin system in cancer therapy

(2017) Alessio Lodola et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma

(2017) Yujie Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

The brain-penetrating CXCR4 antagonist, PRX177561, increases the antitumor effects of bevacizumab and sunitinib in preclinical models of human glioblastoma

(2017) Giovanni Luca Gravina et al.   Journal of Hematology & Oncology

Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells

(2017) Francesca Megiorni et al.   Journal of Hematology & Oncology

Influence of neutrophil–lymphocyte ratio in prognosis of glioblastoma multiforme

(2017) Marta Lopes et al.   JOURNAL OF NEURO-ONCOLOGY

Neutrophil–lymphocyte ratio dynamics during concurrent chemo-radiotherapy for glioblastoma is an independent predictor for overall survival

(2017) Matthew Mason et al.   JOURNAL OF NEURO-ONCOLOGY

Prognostic importance of temozolomide-induced neutropenia in glioblastoma, IDH-wildtype patients

(2017) Taiichi Saito et al.   NEUROSURGICAL REVIEW

Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models

(2017) Giovanni Luca Gravina et al.   Oncotarget

Macrophage migration inhibitory factor promotes vasculogenic mimicry formation induced by hypoxia via CXCR4/AKT/EMT pathway in human glioblastoma cells

(2017) Xing Guo et al.   Oncotarget

hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells

(2017) Saswati Karmakar et al.   Oncotarget

EphrinB2/EphB4 pathway in postnatal angiogenesis: a potential therapeutic target for ischemic cardiovascular disease

(2016) Du Yang et al.   ANGIOGENESIS

Eph Receptor Tyrosine Kinases in Tumor Immunity

(2016) Eileen Shiuan et al.   CANCER RESEARCH

A first-in-human phase I study of sEphB4-HSA in patients with advanced solid tumors with expansion at the maximum tolerated dose (MTD) or recommended phase II dose (RP2D)

(2016) A. El-Khoueiry et al.   EUROPEAN JOURNAL OF CANCER

Truncated EphA2 likely potentiates cell adhesion via integrins as well as infiltration and/or lodgment of a monocyte/macrophage cell line in the red pulp and marginal zone of the mouse spleen, where ephrin-A1 is prominently expressed in the vasculature

(2016) Naoko Konda et al.   HISTOCHEMISTRY AND CELL BIOLOGY

HIF-2α mediates a marked increase in migration and stemness characteristics in a subset of glioma cells under hypoxia by activating an Oct-4/Sox-2-Mena (INV) axis

(2016) Mohita Bhagat et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sox2, a stemness gene, regulates tumor-initiating and drug-resistant properties in CD133-positive glioblastoma stem cells

(2016) Wen-Shin Song et al.   Journal of the Chinese Medical Association

KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study

(2016) Ronan T. Swords et al.   LEUKEMIA RESEARCH

Glioblastoma multiforme: Effect of hypoxia and hypoxia inducible factors on therapeutic approaches

(2016) Wen-Juan Huang et al.   Oncology Letters

Simultaneous targeting of Eph receptors in glioblastoma

(2016) Sara Ferluga et al.   Oncotarget

Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma

(2016) Sébastien Bougnaud et al.   Oncotarget

Tumor-associated mesenchymal stem-like cells provide extracellular signaling cue for invasiveness of glioblastoma cells

(2016) Eun-Jung Lim et al.   Oncotarget

EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells

(2016) Benjamin Krusche et al.   eLife

Inhibition of nestin suppresses stem cell phenotype of glioblastomas through the alteration of post-translational modification of heat shock protein HSPA8/HSC71

(2015) Yoko Matsuda et al.   CANCER LETTERS

Eph receptor tyrosine kinases in cancer stem cells

(2015) Jin Chen et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph–ephrin system

(2015) Riccardo Castelli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting osteopontin suppresses glioblastoma stem-like cell character and tumorigenicityin vivo

(2015) Virginie Lamour et al.   INTERNATIONAL JOURNAL OF CANCER

Quantum Dots-Based Quantitative and In Situ Multiple Imaging on Ki67 and Cytokeratin to Improve Ki67 Assessment in Breast Cancer

(2015) Jing Ping Yuan et al.   PLoS One

Immunohistochemical quantification of the cobalamin transport protein, cell surface receptor and Ki-67 in naturally occurring canine and feline malignant tumors and in adjacent normal tissues

(2015) Annette M. Sysel et al.   Oncotarget

Antibody-Dependent Cell-Mediated Cytotoxicity Effector-Enhanced EphA2 Agonist Monoclonal Antibody Demonstrates Potent Activity against Human Tumors

(2015) Elizabeth M. Bruckheimer et al.   NEOPLASIA

Eph receptors as therapeutic targets in glioblastoma

(2014) B W Day et al.   BRITISH JOURNAL OF CANCER

UniPR129 is a competitive small molecule Eph-ephrin antagonist blockingin vitroangiogenesis at low micromolar concentrations

(2014) I Hassan-Mohamed et al.   BRITISH JOURNAL OF PHARMACOLOGY

Diagnostic and prognostic value of preoperative combined GFAP, IGFBP-2, and YKL-40 plasma levels in patients with glioblastoma

(2014) Jaime Gállego Pérez-Larraya et al.   CANCER

The role of the Eph/ephrin-system in atherosclerotic plaque development: a complex puzzle

(2014) Georg Ende et al.   CARDIOVASCULAR PATHOLOGY

Ginsenoside Rg3 inhibition of vasculogenic mimicry in pancreatic cancer through downregulation of VE-cadherin/EphA2/MMP9/MMP2 expression

(2014) JING-QIANG GUO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

XPO1/CRM1-Selective Inhibitors of Nuclear Export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa)

(2014) Giovanni Gravina et al.   Journal of Hematology & Oncology

Strong therapeutic potential of γ-secretase inhibitor MRK003 for CD44-high and CD133-low glioblastoma initiating cells

(2014) Shingo Tanaka et al.   JOURNAL OF NEURO-ONCOLOGY

EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties

(2014) H Miao et al.   ONCOGENE

Inhibition of Tumor Vasculogenic Mimicry and Prolongation of Host Survival in Highly Aggressive Gallbladder Cancers by Norcantharidin via Blocking the Ephrin Type a Receptor 2/Focal Adhesion Kinase/Paxillin Signaling Pathway

(2014) Hui Wang et al.   PLoS One

EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma Multiforme

(2013) Bryan W. Day et al.   CANCER CELL

Target Hopping as a Useful Tool for the Identification of Novel EphA2 Protein-Protein Antagonists

(2013) Massimiliano Tognolini et al.   ChemMedChem

Efficacy of rapamycin against glioblastoma cancer stem cells

(2013) M. Mendiburu-Eliçabe et al.   Clinical & Translational Oncology

Amino Acid Conjugates of Lithocholic Acid As Antagonists of the EphA2 Receptor

(2013) Matteo Incerti et al.   JOURNAL OF MEDICINAL CHEMISTRY

EphB and Ephrin-B Interactions Mediate Human Mesenchymal Stem Cell Suppression of Activated T-Cells

(2013) Thao M. Nguyen et al.   STEM CELLS AND DEVELOPMENT

Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo

(2013) Adarsh Shankar et al.   Chinese Journal of Cancer

CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma

(2012) Stuart J. Smith et al.   ACTA NEUROPATHOLOGICA

The EphA2 Receptor Drives Self-Renewal and Tumorigenicity in Stem-like Tumor-Propagating Cells from Human Glioblastomas

(2012) Elena Binda et al.   CANCER CELL

Expression of EphrinB2 and EphB4 in glioma tissues correlated to the progression of glioma and the prognosis of glioblastoma patients

(2012) Yanyang Tu et al.   Clinical & Translational Oncology

Eosinophils in glioblastoma biology

(2012) Colleen S Curran et al.   Journal of Neuroinflammation

Anti-Tumor Effect against Human Cancer Xenografts by a Fully Human Monoclonal Antibody to a Variant 8-Epitope of CD44R1 Expressed on Cancer Stem Cells

(2012) Kazue Masuko et al.   PLoS One

CD90 is Identified as a Candidate Marker for Cancer Stem Cells in Primary High-Grade Gliomas Using Tissue Microarrays

(2011) Jintang He et al.   MOLECULAR & CELLULAR PROTEOMICS

An in vivo patient-derived model of endogenous IDH1-mutant glioma

(2011) H. A. Luchman et al.   NEURO-ONCOLOGY

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

(2010) Mitomu Kioi et al.   JOURNAL OF CLINICAL INVESTIGATION

Combined modality treatment of newly diagnosed glioblastoma multiforme in a regional neurosurgical centre

(2009) Andrew J. Gauden et al.   JOURNAL OF CLINICAL NEUROSCIENCE

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL