Article
Cell & Tissue Engineering
Yasaman Aghazadeh, Frankie Poon, Farida Sarangi, Frances T. M. Wong, Safwat T. Khan, Xuetao Sun, Rupal Hatkar, Brian J. Cox, Sara S. Nunes, M. Cristina Nostro
Summary: This study enhanced islet transplantation by using microvessels from adipose tissue, resulting in improved cell survival and glucose response in both human islets and hESC-derived pancreatic cells, ameliorating preexisting diabetes in three mouse models of T1D.
Article
Chemistry, Analytical
Yuanbiao Tu, Zhihao Han, Rongbin Pan, Kuncheng Zhou, Ji Tao, Peifei Liu, Ray P. S. Han, Shuaichang Gong, Yueqing Gu
Summary: The novel peptide GB-6 labeled with NIR fluorescent dye and radionuclide technetium-99m showed efficient targeting to pancreatic cancer cells through the gastrin-releasing peptide receptor. It exhibited selective and specific uptake by tumors in vivo, allowing for clear tumor visualization and potential application in molecular-targeted therapy.
ANALYTICAL CHEMISTRY
(2023)
Article
Oncology
Jessica Lage Fernandez, Sara Arbogen, Mohammad Javad Sadeghinia, Margrete Haram, Sofie Snipstad, Sverre Helge Torp, Caroline Einen, Melina Muhlenpfordt, Matilde Maardalen, Krister Vikedal, Catharina de Lange Davies
Summary: Pancreatic tumours pose challenges for treatment due to their resistance to chemotherapy and complex tumour microenvironment. This study compared orthotopic and subcutaneous pancreatic tumour models and their suitability for drug delivery studies. The findings indicated that the subcutaneous model had advantages for drug delivery studies due to its reproducibility and efficient drug uptake facilitated by collagen organization and well-perfused vasculature. Understanding the diverse characteristics of these models and their impact on drug delivery is crucial for designing clinically relevant experiments and improving our understanding of pancreatic cancer biology.
Article
Immunology
Jin Wang, Xingchen Liu, Junsong Ji, Jianhua Luo, Yuanyu Zhao, Xiaonan Zhou, Jianming Zheng, Meng Guo, Yanfang Liu
Summary: This study describes the construction of a novel orthotopic PDAC model through implantation of tissue slices and discusses the resistance to immunotherapy from the perspective of a PDAC microenvironment. Results show that elimination of MDSCs by NKG2D CAR can rescue impaired CAR-T cell activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biophysics
Stefan Markovic, Tangi Roussel, Lilach Agemy, Keren Sasson, Dina Preise, Avigdor Scherz, Lucio Frydman
Summary: The study utilizes deuterium metabolic imaging techniques for pancreatic tumor metabolic imaging, showing the ability to detect lactate signal within the tumors, peaking at 60 minutes. Additionally, the water resonance signal continuously increases throughout the experiment and can be imaged in the entire abdomen, particularly in the tumor, kidney, and bladder.
NMR IN BIOMEDICINE
(2021)
Article
Oncology
Anna Klimaszewska-Wisniewska, Izabela Neska-Dlugosz, Karolina Buchholz, Justyna Durslewicz, Dariusz Grzanka, Anna Kasperska, Paulina Antosik, Jan Zabrzynski, Alina Grzanka, Maciej Gagat
Summary: The study found that KIF11 and KIF14 expression patterns in PAC are associated with patient prognosis, potentially serving as prognostic biomarkers. A five-gene panel was also identified to be associated with prognosis.
Article
Chemistry, Multidisciplinary
Kevin de Aquino Dias, Marcus Vinicius Pinto Pereira Junior, Leandro Helgueira Andrade
Summary: A polymer-bound organocatalyst for Baeyer-Villiger reaction and phenol oxidation under continuous flow conditions has been described for the first time. This catalyst showed high catalytic activities, selectivities, recyclability, and productivity, enabling the generation of a novel approach for the synthesis of benzoquinones from beta-O-4 lignin models.
Article
Biochemistry & Molecular Biology
Jaesung Heo, O. Kyu Noh
Summary: This study found that the initial absolute lymphocyte count (ALC) level has a significant impact on clinical outcomes in patients with pancreatic adenocarcinoma receiving adjuvant RT. The high ALC group had higher survival rates and locoregional recurrence-free survival rates compared to the low ALC group.
Article
Multidisciplinary Sciences
David Osuna de la Pena, Sara Maria David Trabulo, Estelle Collin, Ying Liu, Shreya Sharma, Marianthi Tatari, Diana Behrens, Mert Erkan, Rita T. Lawlor, Aldo Scarpa, Christopher Heeschen, Alvaro Mata, Daniela Loessner
Summary: Personalized cancer medicine lacks custom platforms that mimic the microenvironment of human tissues. The authors developed a highly tuneable ex vivo model of pancreatic cancer based on self-assembly of patient-derived models, showing better reproduction of in vivo drug responses. These findings support the use of tuneable self-assembling platforms in cancer research, paving the way for future precision medicine approaches.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Lisa Gherardini, Veronica Vetri Buratti, Mirko Maturi, Giovanni Inzalaco, Erica Locatelli, Letizia Sambri, Sara Gargiulo, Virginia Barone, Denise Bonente, Eugenio Bertelli, Silvia Tortorella, Lorenzo Franci, Antonio Fioravanti, Mauro Comes Franchini, Mario Chiariello
Summary: This study aimed to design a new negative temperature-responsive gel formulation for the local release of TMZ beyond the blood-brain barrier. The newly designed gel-based local therapy showed promising potential for the treatment of GBM.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Lisa Gherardini, Veronica Vetri Buratti, Mirko Maturi, Giovanni Inzalaco, Erica Locatelli, Letizia Sambri, Sara Gargiulo, Virginia Barone, Denise Bonente, Eugenio Bertelli, Silvia Tortorella, Lorenzo Franci, Antonio Fioravanti, Mauro Comes Franchini, Mario Chiariello
Summary: The study aimed to design new negative temperature-responsive gel formulations to locally release TMZ for the treatment of GBM. The biocompatibility of the gel formulations containing nanoparticles or microparticles was confirmed in vitro and in vivo, and the therapeutic potential of these formulations was tested in a glioblastoma resection and recurrence mouse model. The gel formulations showed promising results in inducing cell death in vitro and significantly reducing tumor recurrence in vivo.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Ying Ren, Shicheng Wang, Bo Wu, Zhan Wang
Summary: This study aims to uncover the clinicopathological features and identify prognostic risk factors among patients with pancreatic cancer bone metastasis (PCBM). The results show that age, pathological type, chemotherapy, liver metastasis, lung metastasis, and marital status are independent prognostic factors for PCBM patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Hongye Zhang, Mengyu Li, Keying Zhang, Xuemei Ding, Shiping Bai, Qiufeng Zeng, Licui Chu, Danxi Hou, Yue Xuan, Huadong Yin, Jianping Wang
Summary: The objective of this study was to investigate the effects of dietary supplementation with benzoic acid, Enterococcus faecium, and essential oil complex (BEC) on laying hens recovering from coccidia and Clostridium perfringens challenge. Results showed that the addition of BEC improved egg-laying rate, reduced gut damage, and modulated microbial composition. The genera Faecalibacterium and Asterolplasma were positively correlated with egg-laying rate, while the genera Bacteroides and Romboutsia were negatively correlated. The addition of BEC to the diet demonstrated positive effects on the production performance and gut health of laying hens recovering from the challenge.
Article
Cell Biology
Kazuyoshi Yanagihara, Yuki Iino, Hiroshi Yokozaki, Takanori Kubo, Tatsuya Oda, Takashi Kubo, Masayuki Komatsu, Hiroki Sasaki, Hitoshi Ichikawa, Takeshi Kuwata, Toshio Seyama, Atsushi Ochiai
Summary: This study successfully established 13 matched patient-derived tumor models of PDA, including PDX, PDCL, and CDX. By comparing the histological and molecular alterations in these model systems, researchers found that PDX tumors had similar molecular alterations to PDCL and CDX tumors, while OI tumors showed specific immunohistochemical profiles. These patient-derived tumor models provide useful tools for monitoring responses to antineoplastic agents and studying the biology of PDA.
Article
Medicine, General & Internal
Takashi Terao, Teru Kumagi, Ichinosuke Hyodo, Tomoyuki Yokota, Nobuaki Azemoto, Hideki Miyata, Taira Kuroda, Yoshinori Ohno, Yoshinori Tanaka, Naozumi Shibata, Yoshiki Imamura, Kozue Kanemitsu, Teruki Miyake, Mitsuhito Koizumi, Yoichi Hiasa
Summary: The study analyzed prognostic factors in 196 patients with unresectable pancreatic cancer, showing that in patients receiving palliative chemotherapy, liver metastasis, neutrophil-to-lymphocyte ratio, and CA19-9 were independent prognostic factors, while in patients receiving palliative care alone, lung and peritoneum metastases, as well as C-reactive protein-to-albumin ratio, were independent prognostic factors. Patients with multiple factors had worse prognosis in both groups.
