Article
Chemistry, Medicinal
Tingting Fan, Boqiang Liang, Lingling Nie, Juan Wang, Huijun Zhang, Aaron Ciechanover, Yan Xu, Jing An, Ziwei Huang
Summary: The interaction between EphB4 and EFNB2 plays a crucial role in cancer by controlling bidirectional signaling that affects tumor growth and angiogenesis. In this study, researchers designed a bivalent ligand that showed higher binding affinity to EphB4 and successfully inhibited cancer cell motility and tube formation.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Dongdong Yan, Di Cui, Yun Zhu, Cecilia Ka Wing Chan, Chung Hang Jonathan Choi, Tengfei Liu, Nikki P. Y. Lee, Simon Law, Sai Wah Tsao, Stephanie Ma, Annie Lai Man Cheung
Summary: This study found that the expression of Cation-dependent mannose-6-phosphate receptor (M6PR) and ephrin type-B receptor 4 (EphB4) was significantly upregulated in exosomes derived from serglycin (SRGN)-overexpressing esophageal squamous cell carcinoma (ESCC) cells (SRGN Exo). SRGN Exo promoted ESCC cell invasion and tumor angiogenesis by upregulating M6PR, and enhanced ESCC cell invasion through upregulating EphB4. The expression levels of M6PR and EphB4 in the serum were positively correlated with SRGN expression levels in ESCC patients, and high serum M6PR levels were associated with poor overall survival rates.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chongbiao Huang, Hui Li, Yang Xu, Chao Xu, Huizhi Sun, Zengxun Li, Yi Ge, Hongwei Wang, Tiansuo Zhao, Song Gao, Xiuchao Wang, Shengyu Yang, Peiqing Sun, Zhe Liu, Jing Liu, Antao Chang, Jihui Hao
Summary: VEGF inhibitors have been successful in treating solid tumors, but pancreatic adenocarcinoma (PAAD) cells can activate VEGF-independent pathways to reinstate tumor angiogenesis, leading to resistance to VEGF inhibitors. BICC1 is a top gene involved in PAAD-specific angiogenesis. Overexpression of BICC1 in human PAAD tissues is associated with increased microvessel density, tumor growth, and worse prognosis. BICC1 promotes angiogenesis in pancreatic cancer through a VEGF-independent mechanism. Its binding to LCN2 mRNA up-regulates LCN2 expression, leading to the activation of the JAK2/STAT3 signal pathway and increased production of the angiogenic factor CXCL1. Blocking the BICC1/LCN2 signaling reduces microvessel density and tumor volume, and enhances the suppressive effect of gemcitabine. BICC1/LCN2 signaling may be a promising therapeutic target for anti-angiogenesis in pancreatic cancer patients.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Chemistry, Medicinal
Di Chen, Martijn A. van der Ent, Nathaniel L. Lartey, Philip D. King
Summary: Ephrin receptors are a family of receptor tyrosine kinases that regulate various cellular responses. In the cardiovascular system, Ephrin receptor B4 (EPHB4) plays a critical role in blood and lymphatic vascular development and function. Instead of acting as a growth factor receptor, EPHB4 inhibits the Ras-MAPK pathway in endothelial cells through its interaction with RASA1. Loss of EPHB4-RASA1 signaling leads to vascular abnormalities and mutations in these genes cause vascular anomalies in humans. Drug therapy targeting EPHB4 and RASA1 may offer potential treatment options for these vascular anomalies.
Article
Multidisciplinary Sciences
Duk Ki Kim, Juhee Jeong, Dong Sun Lee, Do Young Hyeon, Geon Woo Park, Suwan Jeon, Kyung Bun Lee, Jin-Young Jang, Daehee Hwang, Ho Min Kim, Keehoon Jung
Summary: Chemotherapy-induced fibrosis in PDAC is elucidated and a combinatorial therapeutic strategy for desmoplastic cancers is highlighted.
NATURE COMMUNICATIONS
(2022)
Article
Plant Sciences
Qi Su, Jingjing Wang, Qing Wu, Asmat Ullah, Mohsin Ahmad Ghauri, Ammar Sarwar, Li Chen, Feng Liu, Yanmin Zhang
Summary: This study found that sanguinarine can effectively inhibit the activation of hypoxia-induced EphB4 and HIF-1 alpha pathways in breast cancer. By inhibiting the activation of downstream protein STAT3, degrading HIF-1 alpha protein, and accelerating the dephosphorylation of STAT3, sanguinarine shows potential in inhibiting breast cancer growth.
Article
Oncology
Wenrun Cai, Xugang Sun, Fanjie Jin, Di Xiao, Hui Li, Huizhi Sun, Yifei Wang, Yang Lu, Jing Liu, Chongbiao Huang, Xiuchao Wang, Song Gao, Hongwei Wang, Chuntao Gao, Tiansuo Zhao, Jihui Hao
Summary: CAFs in PDAC promote tumor angiogenesis through MEndoT, with their phenotypic transition being regulated by the PERK-eIF2 alpha-ERK1/2 axis. Pharmacological inhibition of PERK may limit the transition of CAFs, suggesting they could be therapeutic targets for improving PDAC prognosis.
Review
Biochemistry & Molecular Biology
Damon Fard, Enrico Giraudo, Luca Tamagnone
Summary: This article discusses the role of Semaphorins and their receptors, Plexin and Neuropilin, in the progression of pancreatic cancer. These signaling molecules regulate neurons, endothelial cells, immune cells, and the microenvironment of tumors.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xiangyuan Pu, Pengwei Zhu, Xuhao Zhou, Yangyan He, Hong Wu, Luping Du, Hui Gong, Xiaotong Sun, Ting Chen, Jianhua Zhu, Qingbo Xu, Hongkun Zhang
Summary: This study provides insights into the heterogeneous nature and functions of CD34(+) cells in both physiological and pathological conditions, highlighting their involvement in angiogenesis and organ fibrosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Shilpa Bhatia, Diemmy Nguyen, Laurel B. Darragh, Benjamin Van Court, Jaspreet Sharma, Michael W. Knitz, Miles Piper, Sanjana Bukkapatnam, Jacob Gadwa, Thomas E. Bickett, Shiv Bhuvane, Sophia Corbo, Brian Wu, Yichien Lee, Mayumi Fujita, Molishree Joshi, Lynn E. Heasley, Robert L. Ferris, Olga Rodriguez, Christopher Albanese, Mohit Kapoor, Elena B. Pasquale, Sana D. Karam
Summary: The study reveals that EphB4 acts as tumor suppressor and ephrinB2 acts as tumor promoter in head and neck squamous cell carcinoma. Manipulating these signaling pathways can have an impact on tumor growth and angiogenesis.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Lucio Diaz-Flores, Ricardo Gutierrez, Maria Pino Garcia, Miriam Gonzalez-Gomez, Lucio Diaz-Flores, Jose Luis Carrasco, Juan Francisco Madrid, Aixa Rodriguez Bello
Summary: Perivascular cells, including pericytes and CD34+ stromal cells/telocytes, play an important role in angiogenesis. The behavior and changes of these cells differ depending on the type of angiogenesis, involving various cell-to-cell interactions and signaling pathways. Perivascular cells and CD34+ stromal cells/telocytes have important functions in vessel development and tissue repair, while their involvement in intussusceptive angiogenesis is limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Medicine, General & Internal
Donjete Simnica, Sebastian Kobold
Summary: This letter discusses a study on the treatment of pancreatic ductal adenocarcinoma with lung metastases using anti-KRAS G12D T-cell therapy. Two points are brought up: firstly, patients with lung-only metastases from pancreatic ductal adenocarcinoma have favorable clinical outcomes, possibly due to immunity; secondly, the T cells used in the study had a tissue-resident phenotype with high CD103 expression, which is closely correlated to the treatment response.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Yifan Wang, Weiye Deng, Daeyong Lee, Long Yan, Yifei Lu, Shiyan Dong, Kristin Huntoon, Abin Antony, Xuefeng Li, Rui Ye, Yan Zhao, Feiyan Zhao, Benjamin R. Schrank, Jonghoon Ha, Minjeong Kang, Mingming Yang, Ping Gong, Philip L. Lorenzi, Lin Tan, Thomas D. Gallup, Sarah K. Tang, Zhaogang Yang, Jing Li, Nina N. Sanford, Hongmei Wang, Betty Y. S. Kim, Wen Jiang
Summary: This study reveals an age-associated disparity in the clearance of nanotherapeutics in the liver, showing that old mice have better tumor delivery and antitumor efficacy of cancer nanomedicine due to age-related downregulation of the scavenger receptor MARCO. This highlights the importance of considering age as a factor in cancer nanomedicine therapeutics.
NATURE NANOTECHNOLOGY
(2023)
Article
Oncology
Joy Sarkar, Hiroaki Aoki, Rongrong Wu, Masayo Aoki, Phillip Hylemon, Huiping Zhou, Kazuaki Takabe
Summary: This study found that conjugated bile acids (CBAs) accumulated in cholestasis accelerate the growth of pancreatic cancer (PC) through S1PR2, indicating S1PR2 as a potential therapeutic target for metastatic pancreatic cancer.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Joy Sarkar, Hiroaki Aoki, Rongrong Wu, Masayo Aoki, Phillip Hylemon, Huiping Zhou, Kazuaki Takabe
Summary: This study found that conjugated bile acids (CBAs) accelerate the growth of S1PR2 predominant pancreatic cancer, suggesting that S1PR2 may be a potential therapeutic target for metastatic pancreatic cancer.
ANNALS OF SURGICAL ONCOLOGY
(2023)
