Article
Oncology
Xiaoyan Bai, Xiao Jiang, Yuting Liu, Yiting Wang, Xuewei Jiang, Guang Song, Hongmei Qiu, Qinggao Zhang
Summary: The aberrant expression of KLF9 is frequently found in certain types of cancer and is implicated in cancer initiation and progression. This study demonstrated that KLF9 inhibits breast cancer cell migration and invasion by activating the E-cadherin promoter. KLF9 also suppresses lung metastasis of breast cancer and upregulates E-cadherin expression in breast cancer cells, providing new insights into potential aggressive treatment strategies for breast cancer targeting the KLF9/E-cadherin axis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Obstetrics & Gynecology
Nora Karsten, Thomas Kolben, Sven Mahner, Susanne Beyer, Sarah Meister, Christina Kuhn, Elisa Schmoeckel, Rachel Wuerstlein, Nadia Harbeck, Nina Ditsch, Udo Jeschke, Klaus Friese, Theresa Maria Kolben
Summary: The study revealed that increased E-Cadherin expression in primary tumor tissue of breast cancer patients is associated with poor prognosis, contrary to previous beliefs that loss of E-Cadherin promotes metastasis and invasiveness.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Oncology
Jiming Tian, Xiaolei Liang, Dalin Wang, Jinglin Tian, Haiping Liang, Ting Lei, Zeyu Yan, Dan Wu, Xiaoli Liu, Shujuan Liu, Yongxiu Yang
Summary: This study found that TBC1D2 is upregulated in ovarian cancer (OC) and promotes tumor metastasis through E-cadherin degradation. Additionally, miR-373-3p inhibits OC cell invasion by negatively regulating TBC1D2.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Giuseppina Daniela Naimo, Martina Forestiero, Alessandro Paoli, Rocco Malivindi, Luca Gelsomino, Balazs Gyorffy, Adele Elisabetta Leonetti, Francesca Giordano, Salvatore Panza, Francesca Luisa Conforti, Paola Ruffo, Maria Luisa Panno, Loredana Mauro, Sebastiano Ando
Summary: Adiponectin enhances ERa-positive breast cancer cell growth and distant metastasis by promoting E-cadherin expression and altering cell polarity through the ERa/LKB1 complex. The presence of E-cadherin is crucial for the proliferative effects of adiponectin on breast cancer cells. Furthermore, adiponectin treatment leads to the colocalization of LKB1 and Cdc42 in the nucleus, impairing their cytosolic cooperation in maintaining cell polarity. These findings highlight the importance of adiponectin in breast cancer progression and metastasis.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Tobias Wijshake, Zhongju Zou, Beibei Chen, Lin Zhong, Guanghua Xiao, Yang Xie, John G. Doench, Lynda Bennett, Beth Levine
Summary: The study revealed previously unrecognized cooperation between Beclin 1 and E-cadherin in mediating tumor suppression in breast cancer cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Thomas Brock, Elisabeth Boudriot, Anke Klawitter, Marianne Grosser, Trang T. P. Nguyen, Sindy Giebe, Erik Klapproth, Achim Temme, Ali El-Armouche, Georg Breier
Summary: VE-cadherin enhances the adhesion of breast cancer cells to endothelial cells but does not affect their transmigration, indicating that cancer cell adhesion and incorporation are distinct processes governed by different molecular mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Xiao-Qing Li, Rui Zhang, Hong Lu, Xiao-Min Yue, Yu-Fan Huang
Summary: This study provides mechanistic insights into the generation of an osteogenic premetastatic niche by breast cancer-derived EVs and identifies potential EV-derived diagnostic biomarkers and targets for breast cancer bone metastasis.
Article
Oncology
Qing Li, Zhi-Wei Zhou, Wei Duan, Cheng-Yuan Qian, Shu-Nan Wang, Meng-Sheng Deng, Dan Zi, Jian-Min Wang, Cheng-Yi Mao, Guanbin Song, Dong Wang, Kenneth D. Westover, Cheng-Xiong Xu
Summary: High APE1 expression is associated with lymph node metastasis in cervical cancer and linked to epithelial to mesenchymal transition (EMT). APE1 promotes invasion and metastasis of cervical cancer cells, while inhibiting APE1 may suppress EMT. Targeting APE1 redox function could be a novel strategy for inhibiting cervical cancer metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Meng Luo, Jinfan Li, Qi Yang, Song Xu, Kun Zhang, Jing Chen, Suzhan Zhang, Shu Zheng, Jiaojiao Zhou
Summary: This study identifies N4BP3 as a new regulator that promotes breast cancer metastasis by regulating the ubiquitination and degradation of E-cadherin. It uncovers an unprecedented role for N4BP3 in breast cancer metastasis and elucidates the underlying molecular mechanisms.
Article
Oncology
Alison E. Obr, Joseph J. Bulatowicz, Yun-Juan Chang, Virginia Ciliento, Alexander Lemenze, Krystopher Maingrette, Quan Shang, Emily J. Gallagher, Derek LeRoith, Teresa L. Wood
Summary: The reduction of IGF1R expression is associated with the upregulation of pathways necessary for promoting metastasis in breast cancer. Functional analysis reveals that decreased IGF1R signaling leads to a dysregulation of cadherin expression, resulting in reduced cell adhesion.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Xiaoqing Wan, Jiaxin Hou, Shurong Liu, Yanli Zhang, Wenqing Li, Yanru Zhang, Yi Ding
Summary: Resistance to anthracyclines, such as doxorubicin, is commonly observed in ER alpha-positive breast cancer patients. EMT plays a role in chemotherapy-induced drug resistance, with ER alpha-positive cells showing lower sensitivity to doxorubicin compared to ER alpha-negative cells. The regulation of E-cadherin expression in response to doxorubicin treatment varies depending on ER alpha status, with potential implications for treatment strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
John Alexander, Odette Mariani, Celine Meaudre, Laetitia Fuhrmann, Hui Xiao, Kalnisha Naidoo, Andrea Gillespie, Ioannis Roxanis, Anne Vincent-Salomon, Syed Haider, Rachael Natrajan
Summary: This study found that invasive lobular breast cancers with heterogeneous E-cadherin expression are composed of different components with a common ancestor. CDH1 gene mutations and loss of E-cadherin protein expression are characteristic of these tumors. Regardless of E-cadherin protein expression, these tumors should be considered part of the spectrum of invasive lobular breast cancers.
Article
Oncology
Rui Chi, Chengcheng Yao, Si Chen, Yunxia Liu, Yanqi He, Jin Zhang, Lesley G. Ellies, Xuefeng Wu, Qian Zhao, Cixiang Zhou, Ying Wang, Haipeng Sun
Summary: The elevated levels of BCAAs can suppress tumor growth and lung metastasis of breast cancer. The expression of BCAA catabolic genes is associated with the long-term outcomes in breast cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sung Chul Lee, Hee Cheol Kim, Woo Yong Lee, Seong Hyeon Yun, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park, Jung Kyong Shin
Summary: Synchronous isolated PALN dissection in patients with colorectal cancer metastasis can significantly improve survival rates without increasing postoperative complications, especially in cases of right colon cancer with PALN metastasis.
COLORECTAL DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Somayeh Sedaghati Burkhani, Mahdieh Salimi
Summary: The study found that miR-888 is significantly upregulated in breast cancer patients, while E-cadherin expression is downregulated. miR-888 has an inverse correlation with E-cadherin mRNA levels and is significantly increased in nodal involvement and distant metastasis status.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2022)
Article
Oncology
Zongyuan Yang, Ping Jin, Sen Xu, Taoran Zhang, Xin Yang, Xiaoting Li, Xiao Wei, Chaoyang Sun, Gang Chen, Ding Ma, Qinglei Gao
Article
Biochemistry & Molecular Biology
Wenqian Li, Yunhui Lu, Xiaohui Yu, Minjie Yong, Ding Ma, Qinglei Gao
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Meeting Abstract
Hematology
Rafet Basar, May Daher, Nadima Uprety, Elif Gokdemir, Abdullah Saleh Alsuliman, Mayela Carolina Mendt, Lucila Kerbauy, Mayra Shanley, Gonca Ozcan, Emily Ensley, Ana Karen Nunez Cortes, Li Li, Junjun Lu, Mecit Kaplan, Vandana Nandivada, Mustafa Bdaiwi, Ye Li, Luciana Melo Garcia, Enli Liu, Sonny Ang, Pinaki P. Banerjee, Richard E. Champlin, Elizabeth J. Shpall, Katayoun Rezvani
Article
Hematology
Rafet Basar, May Daher, Nadima Uprety, Elif Gokdemir, Abdullah Alsuliman, Emily Ensley, Gonca Ozcan, Mayela Mendt, Mayra Hernandez Sanabria, Lucila Nassif Kerbauy, Ana Karen Nunez Cortes, Li Li, Pinaki P. Banerjee, Luis Muniz-Feliciano, Sunil Acharya, Natalie W. Fowlkes, Junjun Lu, Sufang Li, Stephan Mielke, Mecit Kaplan, Vandana Nandivada, Mustafa Bdaiwi, Alexander D. Kontoyiannis, Ye Li, Enli Liu, Sonny Ang, David Marin, Lorenzo Brunetti, Michael C. Gundry, Rolf Turk, Mollie S. Schubert, Garrett R. Rettig, Matthew S. McNeill, Gavin Kurgan, Mark A. Behlke, Richard Champlin, Elizabeth J. Shpall, Katayoun Rezvani
Article
Hematology
May Daher, Rafet Basar, Elif Gokdemir, Natalia Baran, Nadima Uprety, Ana Karen Nunez Cortes, Mayela Mendt, Lucila Nassif Kerbauy, Pinaki P. Banerjee, Mayra Shanley, Nobuhiko Imahashi, Li Li, Francesca Lorraine Wei Inng Lim, Mohsen Fathi, Ali Rezvan, Vakul Mohanty, Yifei Shen, Hila Shaim, Junjun Lu, Gonca Ozcan, Emily Ensley, Mecit Kaplan, Vandana Nandivada, Mustafa Bdiwi, Sunil Acharya, Yuanxin Xi, Xinhai Wan, Duncan Mak, Enli Liu, Xin Ru Jiang, Sonny Ang, Luis Muniz-Feliciano, Ye Li, Jing Wang, Shahram Kordasti, Nedyalko Petrov, Navin Varadarajan, David Marin, Lorenzo Brunetti, Richard J. Skinner, Shangrong Lyu, Leiser Silva, Rolf Turk, Mollie S. Schubert, Garrett R. Rettig, Matthew S. McNeill, Gavin Kurgan, Mark A. Behlke, Heng Li, Natalie W. Fowlkes, Ken Chen, Marina Konopleva, Richard E. Champlin, Elizabeth J. Shpall, Katayoun Rezvani
Summary: The study combined targeting of CIS protein with CAR engineering of NK cells, leading to improved NK cell effector function and successful antitumor activity in a lymphoma mouse model. This approach represents a promising milestone in the development of next-generation NK cells for cancer immunotherapy.
Article
Immunology
Enli Liu, Sonny O. T. Ang, Lucila Kerbauy, Rafet Basar, Indreshpal Kaur, Mecit Kaplan, Li Li, Yijiu Tong, May Daher, Emily L. Ensley, Nadima Uprety, Ana Karen Nunez Cortes, Ryan Z. Yang, Ye Li, Hila Shaim, Francia Reyes Silva, Paul Lin, Vakul Mohanty, Sunil Acharya, Mayra Shanley, Luis Muniz-Feliciano, Pinaki P. Banerjee, Ken Chen, Richard E. Champlin, Elizabeth J. Shpall, Katayoun Rezvani
Summary: Research has genetically engineered a universal antigen presenting cell (uAPC) to stimulate the expansion and enhance the effector function of NK cells, showing promising results for generating GMP-grade CAR NK cells for cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Ye Li, Katherine L. Cook, Wei Yu, Lu Jin, Kerrie B. Bouker, Robert Clarke, Leena Hilakivi-Clarke
Summary: Elevated expression of VDR in pretreatment tumors of ER+ breast cancer patients treated with TAM is associated with longer recurrence-free survival. Differentially expressed pathways such as autophagy and unfolded protein response (UPR) were identified between high and low VDR-expressing ER+ cancers.
Article
Immunology
Mayela Mendt, May Daher, Rafet Basar, Mayra Shanley, Bijender Kumar, Francesca Lim Wei Inng, Sunil Acharya, Hila Shaim, Natalie Fowlkes, Jamie P. Tran, Elif Gokdemir, Nadima Uprety, Ana K. Nunez-Cortes, Emily Ensley, Thao Mai, Lucila N. Kerbauy, Luciana Melo-Garcia, Paul Lin, Yifei Shen, Vakul Mohanty, JunJun Lu, Sufang Li, Vandana Nandivada, Jing Wang, Pinaki Banerjee, Francia Reyes-Silva, Enli Liu, Sonny Ang, April Gilbert, Ye Li, Xinhai Wan, Jun Gu, Ming Zhao, Natalia Baran, Luis Muniz-Feliciano, Jeffrey Wilson, Indreshpal Kaur, Mihai Gagea, Marina Konopleva, David Marin, Guilin Tang, Ken Chen, Richard Champlin, Katayoun Rezvani, Elizabeth J. Shpall
Summary: This study optimized cord blood tissue derived MSCs (CBti MSCs) by priming them with inflammatory cytokines, leading to their metabolic reprogramming and enhanced glycolytic capacity. The metabolically reprogrammed CBti MSCs showed superior immunosuppressive potential, immunomodulatory properties, and homing capabilities, even after cryopreservation and thawing. These primed CBti MSCs significantly improved outcomes in a xenogenic mouse model of GVHD and could serve as a promising therapeutic option for GVHD and other autoimmune disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Rafet Basar, Nadima Uprety, Emily Ensley, May Daher, Kimberly Klein, Fernando Martinez, Fleur Aung, Mayra Shanley, Bingqian Hu, Elif Gokdemir, Mayela Mendt, Francia Reyes Silva, Sunil Acharya, Tamara Laskowski, Luis Muniz-Feliciano, Pinaki Banerjee, Ye Li, Sufang Li, Luciana Melo Garcia, Paul Lin, Hila Shaim, Sean G. Yates, David Marin, Indreshpal Kaur, Sheetal Rao, Duncan Mak, Angelique Lin, Qi Miao, Jinzhuang Dou, Ken Chen, Richard Champlin, Elizabeth J. Shpall, Katayoun Rezvani
Summary: Adoptive cell therapy with virus-specific T cells has been successful in treating life-threatening viral infections, and expanding SARS-CoV-2 T cells using IL-2/4/7 culture conditions resulted in over 1,000-fold expansion with retained phenotype and function. The expanded cytotoxic T lymphocytes (CTLs) target structural proteins of SARS-CoV-2.
Article
Biochemistry & Molecular Biology
Ye Li, Rafet Basar, Guohui Wang, Enli Liu, Judy S. Moyes, Li Li, Lucila N. Kerbauy, Nadima Uprety, Mohsen Fathi, Ali Rezvan, Pinaki P. Banerjee, Luis Muniz-Feliciano, Tamara J. Laskowski, Emily Ensley, May Daher, Mayra Shanley, Mayela Mendt, Sunil Acharya, Bin Liu, Alexander Biederstadt, Hind Rafei, Xingliang Guo, Luciana Melo Garcia, Paul Lin, Sonny Ang, David Marin, Ken Chen, Laura Bover, Richard E. Champlin, Navin Varadarajan, Elizabeth J. Shpall, Katayoun Rezvani
Summary: The activation of chimeric antigen receptor (CAR) in natural killer (NK) cells promotes the transfer of tumor-specific antigen from tumor cells to NK cells, resulting in decreased tumor antigen density and impaired CAR-NK cell targeting ability. This phenomenon can lead to self-recognition and continuous CAR-mediated engagement, causing cell death in NK cells expressing the trogocytic antigen (NKTROG+) and reduced NK cell responsiveness. However, a dual-CAR system that incorporates both an activating CAR against the tumor antigen and an inhibitory NK self-recognizing CAR can prevent trogocytic antigen-mediated cell death in NK cells, while maintaining activation signaling against the tumor antigen, thereby enhancing CAR-NK cell activity.
Article
Oncology
Nobuhiko Imahashi, Rafet Basar, Yuefan Huang, Fang Wang, Natalia Baran, Pinaki Prosad Banerjee, Junjun Lu, Ana Karen Nunez Cortes, Nadima Uprety, Emily Ensley, Luis Muniz-Feliciano, Tamara J. Laskowski, Judy S. Moyes, May Daher, Mayela Mendt, Lucila N. Kerbauy, Mayra Shanley, Li Li, Francesca Lorraine Wei Inng Lim, Hila Shaim, Ye Li, Marina Konopleva, Michael Green, Jennifer Wargo, Elizabeth J. Shpall, Ken Chen, Katayoun Rezvani
Summary: This study shows that activated B cells suppress T-cell responses through metabolic competition, including increased oxygen consumption and glucose deprivation. These findings provide new insights into immunometabolism and its potential implications for cancer immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Ye Li, Katayoun Rezvani, Hind Rafei
Summary: Adoptive cellular therapy using CAR T cells has revolutionized the treatment of hematologic malignancies, but its application for myeloid malignancies and solid cancers has been limited by the lack of tumor-specific antigens without cross-reactivity against normal tissues. Recent advancements in synthetic biology and genetic engineering have allowed for the reprogramming of immune effector cells, enhancing their selectivity towards tumors and reducing off-target toxicities. This review outlines current strategies being explored to improve CAR selectivity, with a focus on NK cells, and discusses the progress made in translating these strategies to clinical applications.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Medicine, Research & Experimental
Hila Shaim, Mayra Shanley, Rafet Basar, May Daher, Joy Gumin, Daniel B. Zamler, Nadima Uprety, Fang Wang, Yuefan Huang, Konrad Gabrusiewicz, Qi Miao, Jinzhuang Dou, Abdullah Alsuliman, Lucila N. Kerbauy, Sunil Acharya, Vakul Mohanty, Mayela Mendt, Sufang Li, JunJun Lu, Jun Wei, Natalie W. Fowlkes, Elif Gokdemir, Emily L. Ensley, Mecit Kaplan, Cynthia Kassab, Li Li, Gonca Ozcan, Pinaki P. Banerjee, Yifei Shen, April L. Gilbert, Corry M. Jones, Mustafa Bdiwi, Ana K. Nunez-Cortes, Enli Liu, Jun Yu, Nobuhiko Imahashi, Luis Muniz-Feliciano, Ye Li, Jian Hu, Giulio Draetta, David Marin, Dihua Yu, Stephan Mielke, Matthias Eyrich, Richard E. Champlin, Ken Chen, Frederick F. Lang, Elizabeth J. Shpall, Amy B. Heimberger, Katayoun Rezvani
Summary: Glioblastoma stem cells (GSCs) in the aggressive brain cancer Glioblastoma multiforme (GBM) evade immune responses by impairing the function of tumor-infiltrating NK cells through a direct cell-to-cell contact mechanism mediated by alpha v integrin and TGF-β activation. Treatment with inhibitors of integrin or TGF-β signaling, or with TGFBR2 gene-edited allogeneic NK cells, prevents GSC-induced NK cell dysfunction and tumor growth, suggesting a potential therapeutic strategy for GBM.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Immunology
May Daher, Luciana Melo Garcia, Ye Li, Katayoun Rezvani
Summary: CAR-NK cells, derived from non-αβ T-cell immune effector cells, are gaining interest as a promising alternative to CAR-T therapy in cancer treatment. Studies have shown the potential of CAR-NK cells in enhancing antitumor activity and novel strategies are being investigated to further improve their efficacy.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Hematology
Li Li, Han Chen, David Marin, Yuanxin Xi, Qi Miao, Jiangxing Lv, Pinaki Prosad Banerjee, Hila Shaim, May Daher, Rafet Basar, Nobuhiko Imahashi, Juan Jimenez, Bingqian Hu, Rohtesh S. Mehta, Lucila Nassif Kerbauy, Mecit Kaplan, Mayela Mendt, Gonca Ozcan, Elif Gokdemir, Mayra Hernandez Sanabria, Ye Li, Ken Chen, Jing Wang, Luis Muniz-Feliciano, Wei-Li Zhao, Richard E. Champlin, Elizabeth J. Shpall, Katayoun Rezvani
