Article
Biochemistry & Molecular Biology
Elena G. Varlamova, Mikhail Goltyaev, Valentina N. Mal'tseva, Egor A. Turovsky, Ruslan M. Sarimov, Alexander Simakin, Sergey Gudkov
Summary: Selenium nanoparticles (SeNP) have gained popularity for their high biocompatibility, stability, and selectivity, with numerous studies proving their anticarcinogenic effects. This study investigated the molecular mechanisms regulating SeNP-induced cytotoxic effects on four human cancer cell lines, highlighting varied concentration-dependent outcomes and the induction of apoptosis through different signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Laura Zein, Simone Fulda, Donat Koegel, Sjoerd J. L. van Wijk
Summary: Autophagy is a conserved catabolic process that plays a crucial role in degrading cellular components, but excessive activation can lead to autophagy-dependent cell death. ADCD is involved in the development of lower organisms and in the response of cancer cells to certain drugs, offering a potential therapeutic option for apoptosis-resistant cancer types. The mechanisms of ADCD are complex and involve mitochondrial and ER-specific killing mechanisms triggered by certain drugs.
Article
Cardiac & Cardiovascular Systems
Christoph Hofmann, Zoe Loewenthal, Marjan Aghajani, Randal J. J. Kaufman, Hugo A. A. Katus, Norbert Frey, Christopher C. C. Glembotski, Mirko Voelkers, Shirin Doroudgar
Summary: The mechanistic target of rapamycin complex 1 (mTORC1) coordinates cellular metabolism with environmental conditions by regulating protein synthesis. It is inhibited during endoplasmic reticulum (ER) stress, but shows transient activation in cardiomyocytes at the onset of ER stress before being inhibited during chronic ER stress. The dynamic regulation of mTORC1 is mediated, in part, by ATF6 and plays a crucial role in posttranscriptional induction of unfolded protein response genes. Inhibiting mTORC1 during ER stress leads to increased cell death, highlighting its adaptive function in controlling the expression of protective unfolded protein response genes.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Sheau-Chung Tang, Jiunn-Liang Ko, Chun-Te Lu, Pui-Ying Leong, Chu-Chyn Ou, Chih-Ting Hsu, Yu-Ping Hsiao
Summary: This study examined the pathway of cell death caused by skin burns in human skin cells and the role of chloroquine in wound healing. The findings suggest that autophagy and the Wnt/β-catenin pathway play important roles in cell repair and wound healing. Chloroquine can promote wound healing and restore cell migration activity.
Review
Cell Biology
Nicole Rufo, Yihan Yang, Steven De Vleeschouwer, Patrizia Agostinis
Summary: Disrupted endoplasmic reticulum (ER) homeostasis in cancer cells is characterized by maladaptive unfolded protein response (UPR) signaling, which sustains proteostasis and metabolism reprogramming, and fosters proinflammatory pathways promoting tissue repair and protumorigenic immune responses. However, when cancer cells are exposed to conditions causing irreparable ER homeostasis, the UPR switches to a cell death program, eliciting immunogenic cell death (ICD) with proinflammatory traits.
Article
Medicine, Research & Experimental
Anna Visa, Lia Alza, Carles Canti, Judit Herreros
Summary: It was found that NNC-55-0396 can induce cell death in GBM cells through the activation of IRE1 alpha and calcium signaling pathway. Understanding the signaling pathway involved in the sudden cell death triggered by this compound can contribute to the development of new therapies for GBM.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Subramaniam Jayanthi, Atul P. Daiwile, Jean Lud Cadet
Summary: METH is an illicit psychostimulant that is abused worldwide, with serious neuropsychiatric consequences. Neurological and psychiatric complications of METH abuse may be related to METH-induced neurotoxic effects.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Madhuri Basak, Abhishek Singh Sengar, Kiran Das, Tarun Mahata, Manish Kumar, Dinesh Kumar, Sayan Biswas, Subhasish Sarkar, Pranesh Kumar, Priyadip Das, Adele Stewart, Biswanath Maity
Summary: This study identifies RGS7 as a key driver of chemotherapy-induced oxidative stress, cell loss, and fibrosis in the heart. Importantly, RGS7 does not impact the sensitivity of cancer cells to chemotherapeutic drugs. Therefore, RGS7 emerges as a potential therapeutic target for detecting or mitigating chemotherapy-associated cardiac damage.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Tae Woo Kim
Summary: CA induces cell death in gastric cancer cells through ER stress and Ca2+ release, and inhibiting ER stress can mitigate the cytotoxicity of CA. CA also triggers autophagic cell death by inhibiting G9a and activating LC3B.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Adrian Zajac, Joanna Sumorek-Wiadro, Ewa Langner, Iwona Wertel, Aleksandra Maciejczyk, Bozena Pawlikowska-Pawlega, Jaroslaw Pawelec, Magdalena Wasiak, Monika Hulas-Stasiak, Dorota Badziul, Wojciech Rzeski, Michal Reichert, Joanna Jakubowicz-Gil
Summary: Inhibition of the PI3K/Akt/mTOR pathway sensitizes glioma cells to apoptosis with temozolomide treatment, while Hsp27 increases resistance to cell death. Different cell lines showed varying responses to LY294002 and temozolomide treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Xiaohan Zhang, Crystal Young, Yoshiaki Morishita, Kookjoo Kim, Omer O. Kabil, Oliver B. Clarke, Bruno Di Jeso, Peter Arvan
Summary: The thyroid gland's primary functional units are follicles filled with thyroglobulin. Thyroglobulin's appearance is synchronous with vertebrate thyroid follicular architecture and is the most highly expressed thyroid gene and protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Engineering, Multidisciplinary
Tamana Yousof, Jae Hyun Byun, Jack Chen, Richard C. Austin
Summary: PHLDA1 is a multifaceted intracellular protein that belongs to the evolutionarily conserved pleckstrin homology-related domain family. It is associated with obesity, fatty liver disease, diabetes, atherosclerosis, and cancer. Accumulating evidence supports its role in endoplasmic reticulum stress signaling pathways, apoptosis, autophagy, and cell proliferation. This review highlights the pro- and anti-apoptotic roles of PHLDA1 that contribute to a wide range of metabolic diseases.
Review
Biochemistry & Molecular Biology
Chun-Yan Kong, Zhen Guo, Peng Song, Xin Zhang, Yu-Pei Yuan, Teng Teng, Ling Yan, Qi-Zhu Tang
Summary: This review provides a comprehensive overview of the mechanisms underlying the oxidative stress and cell death pathways induced by doxorubicin, which are the major factors responsible for the acute cardiotoxicity. The authors aim to offer new insights for researchers to discover potential therapeutic strategies to prevent or reverse doxorubicin-induced cardiotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Mateo Glumac, Vedrana Cikes Culic, Ivana Marinovic-Terzic, Mila Radan
Summary: The aim of this study was to investigate the antitumor activity of nerolidol, a naturally occurring sesquiterpene alcohol, in bladder carcinoma cell lines and elucidate the underlying cell death pathways. The results showed that nerolidol inhibited cell proliferation and induced two distinct cell death mechanisms, involving caspase-dependent and caspase-independent pathways. This study suggests that nerolidol has promising antitumor properties and offers a potential therapeutic approach to target resistant forms of bladder cancer.
Review
Biochemistry & Molecular Biology
Christian Gaiddon, Isabelle Gross, Xiangjun Meng, Marjorie Sidhoum, Georg Mellitzer, Benoit Romain, Jean-Batiste Delhorme, Aina Venkatasamy, Alain C. Jung, Michel Pfeffer
Summary: Metal complexes have been used in cancer treatment since the 1960s. Recent studies on organo-ruthenium/osmium complexes have shed light on their biological activity and ability to induce cell death mechanisms, laying the groundwork for safer therapeutic approaches.
Review
Hematology
Gewil Daniella Olipas Allas, Joekeem Del Rosario Arizala, Rafael Vincent Mercado Manalo
Summary: This paper discusses the clotting phenomenon in COVID-19 and differentiates it from VITT, provides an overview of the clinical manifestations of VITT compared to other thrombotic thrombocytopenic syndromes, and briefly explores the role of adenoviral vectors and vaccine constituents.
HEMATOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Rafael Vincent Manalo, Maries Ann Silvestre, Aza Lea Anne Barbosa, Paul Mark Medina
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)