Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells

Inhibition of PKR impairs angiogenesis through a VEGF pathway

(2015) Zhaowei Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inhibitor of differentiation proteins protect against oxidative stress by regulating the antioxidant–mitochondrial response in mouse beta cells

(2015) Mohammed Bensellam et al.   DIABETOLOGIA

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms

(2015) Flora Brozzi et al.   DIABETOLOGIA

The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK

(2015) Jeng Yie Chan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Regulation of G1 Arrest and Apoptosis in Hypoxia by PERK and GCN2-Mediated eIF2α Phosphorylation

(2015) Yan Liu et al.   NEOPLASIA

Moderate Hypoxia Induces β-Cell Dysfunction with HIF-1–Independent Gene Expression Changes

(2014) Yoshifumi Sato et al.   PLoS One

Aberrant islet unfolded protein response in type 2 diabetes

(2014) Feyza Engin et al.   Scientific Reports

Influence of chronic hyperglycemia on the loss of the unfolded protein response in transplanted islets

(2013) Stacey N Walters et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

ER stress in rodent islets of Langerhans is concomitant with obesity and β-cell compensation but not with β-cell dysfunction and diabetes

(2013) O Omikorede et al.   Nutrition & Diabetes

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Hypoxia-Inducible Factor-1α (HIF-1α) Potentiates β-Cell Survival after Islet Transplantation of Human and Mouse Islets

(2012) Rebecca A. Stokes et al.   CELL TRANSPLANTATION

HDLs Protect Pancreatic β-Cells Against ER Stress by Restoring Protein Folding and Trafficking

(2012) Jannick Pétremand et al.   DIABETES

Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in  -Cell Gene Expression and Progression to Diabetes

(2012) J. Y. Chan et al.   DIABETES

The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions

(2012) Mohammed Bensellam et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Glucose-Induced O2 Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells

(2012) Mohammed Bensellam et al.   PLoS One

Distinct Cytoplasmic and Nuclear Functions of the Stress Induced Protein DDIT3/CHOP/GADD153

(2012) Alexandra Jauhiainen et al.   PLoS One

Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP

(2012) X Zheng et al.   Cell Death & Disease

A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking

(2011) Ebru Boslem et al.   BIOCHEMICAL JOURNAL

Increased Numbers of Low-Oxygenated Pancreatic Islets After Intraportal Islet Transplantation

(2011) R. Olsson et al.   DIABETES

cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets

(2011) S. L. Subramanian et al.   DIABETOLOGIA

Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells

(2011) J. Y. Chan et al.   DIABETOLOGIA

Cellular Hypoxia of Pancreatic β-Cells Due to High Levels of Oxygen Consumption for Insulin Secretionin Vitro

(2011) Yoshifumi Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of insulin secretion: role of mitochondrial signalling

(2010) S. Jitrapakdee et al.   DIABETOLOGIA

PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells

(2010) Claire E. Moore et al.   MOLECULAR ENDOCRINOLOGY

Glucose regulation of islet stress responses and β-cell failure in type 2 diabetes

(2009) J. C. Jonas et al.   DIABETES OBESITY & METABOLISM

Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload

(2009) A. M. Preston et al.   DIABETOLOGIA

Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations

(2009) M. Bensellam et al.   DIABETOLOGIA

A decrease in cellular energy status stimulates PERK-dependent eIF2α phosphorylation and regulates protein synthesis in pancreatic β-cells

(2008) Edith Gomez et al.   BIOCHEMICAL JOURNAL

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS

Glucose and leptin induce apoptosis in human β-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases

(2008) Kathrin Maedler et al.   FASEB JOURNAL

Hypoxia response and microRNAs: no longer two separate worlds

(2008) Mircea Ivan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION