Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors

Pre-eclampsia: pathogenesis, novel diagnostics and therapies

(2019) Elizabeth A. Phipps et al.   Nature Reviews Nephrology

Maternal-fetal cross talk through cell-free fetal DNA, telomere shortening, microchimerism, and inflammation

(2018) Shi-Bin Cheng et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Liraglutide attenuates NLRP3 inflammasome-dependent pyroptosis via regulating SIRT1/NOX4/ROS pathway in H9c2 cells

(2018) Ao Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts

(2018) G. S. Stødle et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Induction of systemic inflammation by hyaluronan and hsp70 in women with pre-eclampsia

(2018) Mariana Romão-Veiga et al.   CYTOKINE

Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression

(2018) Mi Jeong Heo et al.   GUT

Systemic activation of NLRP3 inflammasome in patients with severe primary Sjögren's syndrome fueled by inflammagenic DNA accumulations

(2018) Aigli G. Vakrakou et al.   JOURNAL OF AUTOIMMUNITY

Autophagy-Based Diagnosis of Pregnancy Hypertension and Pre-Eclampsia

(2018) Surendra Sharma   AMERICAN JOURNAL OF PATHOLOGY

Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1β secretion in human trophoblasts

(2017) Kazuhiro Tamura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Autophagy regulation in preeclampsia: Pros and cons

(2017) Akitoshi Nakashima et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Increased expression of NLRP3 inflammasome in placentas from pregnant women with severe preeclampsia

(2017) Ingrid C.Weel et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis

(2017) Liane Jennifer Bailey et al.   Cell Death & Disease

Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia

(2017) Mancy Tong et al.   Scientific Reports

Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts

(2016) S. Kohli et al.   BLOOD

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Pyroptosis

(2016) Lieselotte Vande Walle et al.   CURRENT BIOLOGY

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Differential expression of thioredoxin binding protein-2/Txnip in human placenta: Possible involvement of hypoxia in its suppression during early pregnancy

(2016) Haruta Mogami et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Preeclampsia and health risks later in life: an immunological link

(2016) Shi-Bin Cheng et al.   Seminars in Immunopathology

The gasdermin-D pore: Executor of pyroptotic cell death

(2016) Sebastian Rühl et al.   Oncotarget

Understanding Pre-Eclampsia Using Alzheimer's Etiology: An Intriguing Viewpoint

(2015) Shi-Bin Cheng et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

Endoplasmic Reticulum Stress Interacts With Inflammation in Human Diseases

(2015) Stewart Siyan Cao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ER stress induces NLRP3 inflammasome activation and hepatocyte death

(2015) C Lebeaupin et al.   Cell Death & Disease

Transthyretin Is Dysregulated in Preeclampsia, and Its Native Form Prevents the Onset of Disease in a Preclinical Mouse Model

(2013) Satyan S. Kalkunte et al.   AMERICAN JOURNAL OF PATHOLOGY

Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia

(2013) Akitoshi Nakashima et al.   Autophagy

Redefining Preeclampsia Using Placenta-Derived Biomarkers

(2013) Anne Cathrine Staff et al.   HYPERTENSION

Hypertension in Pregnancy

(2013)   OBSTETRICS AND GYNECOLOGY

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

TXNIP Switches Tracks toward a Terminal UPR

(2012) Tracy G. Anthony et al.   Cell Metabolism

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Villous trophoblast apoptosis is elevated and restricted to cytotrophoblasts in pregnancies complicated by preeclampsia, IUGR, or preeclampsia with IUGR

(2012) M.S. Longtine et al.   PLACENTA

Bacterial LPS Differently Modulates Inflammasome Gene Expression and IL-1β Secretion in Trophoblast Cells, Decidual Stromal Cells, and Decidual Endothelial Cells

(2012) A. Pontillo et al.   Reproductive Sciences

ER stress-induced inflammation: does it aid or impede disease progression?

(2012) Abhishek D. Garg et al.   TRENDS IN MOLECULAR MEDICINE

Uric Acid Induces Trophoblast IL-1β Production Via the Inflammasome: Implications for the Pathogenesis of Preeclampsia

(2011) Melissa J. Mulla et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

A Critical Role of Interleukin-10 in Modulating Hypoxia-Induced Preeclampsia-Like Disease in Mice

(2011) Zhongbin Lai et al.   HYPERTENSION

Sera from Preeclampsia Patients Elicit Symptoms of Human Disease in Mice and Provide a Basis for an in Vitro Predictive Assay

(2010) Satyan Kalkunte et al.   AMERICAN JOURNAL OF PATHOLOGY

Pre-eclampsia

(2010) Eric AP Steegers et al.   LANCET

Inflammatory Stimuli Regulate Caspase Substrate Profiles

(2010) Nicholas J. Agard et al.   MOLECULAR & CELLULAR PROTEOMICS

Endoplasmic reticulum stress in the pathogenesis of early-onset pre-eclampsia

(2010) Graham J. Burton et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Pregnancy as a Window to Future Health

(2009) George R. Saade   OBSTETRICS AND GYNECOLOGY

An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Preeclampsia and the Risk of End-Stage Renal Disease

(2008) Bjørn Egil Vikse et al.   NEW ENGLAND JOURNAL OF MEDICINE