Review
Biochemistry & Molecular Biology
Mohammad Badran, David Gozal
Summary: Obstructive sleep apnea is associated with cardiovascular risk and mortality. The plasminogen activator inhibitor-1 (PAI-1) is a key regulator that may contribute to endothelial dysfunction and atherosclerosis in OSA patients. This study suggests PAI-1 as a potential therapeutic target for OSA-induced cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yun-yun Yang, Hua-hui Yu, Xiao-lu Jiao, Lin-yi Li, Yun-hui Du, Juan Li, Qian-wen Lv, Hui-na Zhang, Jing Zhang, Chao-wei Hu, Xiao-ping Zhang, Yong-xiang Wei, Yan-wen Qin
Summary: The lack of ANGPTL8 can prevent CIH-induced aortic vascular remodeling, possibly through the inhibition of the ERS pathway. Therefore, ANGPTL8 may be a potential target in CIH-induced aortic vascular remodeling.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Li-Pang Chuang, Huang-Pin Wu, Li-Ang Lee, Li-Chung Chiu, Shih-Wei Lin, Han-Chung Hu, Kuo-Chin Kao, Ning-Hung Chen, Jung-Wei Tsai, Jong-Hwei Su Pang
Summary: This study found that under intermittent hypoxia conditions, the expression of IL-8 was enhanced in monocytes of adult OSA patients, leading to an increase in the migration ability of monocytes towards IL-8.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Yang Ji, Yingmin Liang, Judith C. W. Mak, Mary S. M. Ip
Summary: Obesity is a strong risk factor for both obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD). Intermittent hypoxia plays an important role in the development of NAFLD in OSA. Understanding the roles of obesity and intermittent hypoxia in NAFLD is crucial for gaining more knowledge about the health consequences of OSA and devising effective therapeutic strategies.
Article
Physiology
Ming Deng, Yi-teng Huang, Jian-qing Xu, Xiao Ke, Yi-fei Dong, Xiao-shu Cheng
Summary: The study found that patients with severe OSAHS were more likely to have hypertension and higher LV mass and LV mass index. The association between intermittent hypoxia and left ventricular remodeling was significant, with oxygen desaturation index (ODI) being the most relevant parameter to LV remodeling among various intermittent hypoxia parameters.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Neurosciences
Andrew E. Beaudin, Patrick J. Hanly, Jill K. Raneri, Magdy Younes, Matiram Pun, Todd J. Anderson, Marc J. Poulin
Summary: Exposure to intermittent hypoxia (IH) is believed to increase the risk of cerebrovascular and cardiovascular disease, but sleep accompanied by IH does not significantly alter vascular responses to hypoxia and hypercapnia in healthy young individuals. However, IH sleep does lead to an increased heart rate response to hypoxia upon waking.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Critical Care Medicine
Gino S. Panza, Shipra Puri, Ho-Sheng Lin, M. Safwan Badr, Jason H. Mateika
Summary: Daily exposure to mild intermittent hypoxia (MIH) shows beneficial cardiovascular and autonomic outcomes in males with obstructive sleep apnea (OSA) and concurrent hypertension. This study demonstrates that after 15 days of MIH treatment, participants experienced a reduction in blood pressure, accompanied by increased parasympathetic activity and decreased sympathetic activity.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Nutrition & Dietetics
Charlotte Breuillard, Sophie Moulin, Sophie Bouyon, Morgane Couchet, Christophe Moinard, Elise Belaidi
Summary: Obstructive sleep apnea syndrome (OSAS) is associated with chronic intermittent hypoxia (cIH) that causes slight impairment of nutritional status and immunity.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
M. Leentjens, Abdulmohsen Alterki, Mohamed Abu-Farha, P. F. N. Bosschieter, CAL. de Raaff, CEE. de Vries, Eman Al Shawaf, Thangavel Alphonse Thanaraj, Irina Al-Khairi, Preethi Cherian, Arshad Channanath, Sina Kavalakatt, B. A. van Wagensveld, N. de Vries, Jehad Abubaker
Summary: This study found significantly increased levels of ANGPTL7 in both the circulation and adipose tissue of patients with OSA, which were associated with increased inflammation and OSA severity. Bariatric surgery was shown to significantly reduce ANGPTL7 levels and improve OSA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Viseslav Popadic, Milica Brajkovic, Slobodan Klasnja, Natasa Milic, Nina Rajovic, Danica Popovic Lisulov, Anica Divac, Tatjana Ivankovic, Andrea Manojlovic, Novica Nikolic, Lidija Memon, Marija Brankovic, Maja Popovic, Ana Sekulic, Jelica Bjekic Macut, Olivera Markovic, Sinisa Djurasevic, Maja Stojkovic, Zoran Todorovic, Marija Zdravkovic
Summary: In a retrospective cohort study involving 328 patients with newly diagnosed obstructive sleep apnea, significant associations were found between lipid abnormalities, inflammatory markers, and other clinically important data with the severity of obstructive sleep apnea. These findings may contribute to a better understanding of the underlying pathophysiological processes and potential therapeutic modalities.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nan-Ni Chen, Chau-Yin Chen, Jin-Jhe Wang, Heng-Chiao Huang, Wei-Dar Chen, Ching-Lung Chen, Yao-Hsu Yang, Meng-Hung Lin, Ting-Yu Kuo, Chien-Hsiung Lai
Summary: This study investigated the outcomes of anti-VEGF treatment in patients with exudative AMD with or without OSA. The results showed that patients with OSA had a higher rate of subretinal fluid resorption compared to patients without OSA, but there were no significant differences in other imaging biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Nicole Kye Wen Tan, Dominic Wei Ting Yap, Benjamin Kye Jyn Tan, Yao Hao Teo, Elisabeth Ker Hsuen Tan, Jason Yongsheng Chan, Haur Yueh Lee, Anna See, Song Tar Toh
Summary: Meta-analysis of the association between obstructive sleep apnea (OSA) and melanoma suggests a higher risk of melanoma in patients with OSA. Future studies should focus on exploring the differential risk of melanoma for varying severity of OSA.
Article
Gastroenterology & Hepatology
Sha-Sha Tang, Cheng-Hong Liang, Ya-Lei Liu, Wei Wei, Xin-Ru Deng, Xiao-Yang Shi, Li-Min Wang, Li-Jun Zhang, Hui-Juan Yuan
Summary: For T2DM patients with OSAHS, IH may contribute to specific changes in the gut microbiota, which can affect the pathophysiological development of T2DM and its related complications.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Clinical Neurology
Ting Xie, Dan Guo, Jinmei Luo, Zijian Guo, Sumei Zhang, Anqi Wang, Xiaoxi Wang, Xiaona Wang, Wenhao Cao, Linfan Su, Junwei Guo, Rong Huang, Yi Xiao
Summary: This study investigated the relationship between hypoxia-inducible factor 1 alpha, circadian clock genes, and obstructive sleep apnea. The findings suggest that patients with OSA or nocturnal hypoxemia tend to develop circadian rhythm disorders that may be induced by the hypoxia-mediated augmentation of HIF1 alpha gene expression.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Biochemistry & Molecular Biology
Danielle Regev, Sharon Etzion, Hen Haddad, Jacob Gopas, Aviv Goldbart
Summary: Cardiovascular morbidity is a major cause of death in patients with obstructive sleep apnea (OSA) syndrome. This study demonstrates that substances present in the serum of OSA patients can induce changes in cardiomyocytes and lead to inflammatory responses. The findings from this study provide a new approach and targets for improving the diagnosis and treatment of OSA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Respiratory System
Ramon Farre, Antonio Artigas, Antoni Torres, Guillermo M. Albaiceta, Anh Tuan Dinh-Xuang, David Gozal
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Editorial Material
Respiratory System
Olga Mediano, Manel Lujan, Sonia Lopez-Monzoni
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Article
Respiratory System
Carolina Cubillos-Zapata, Miguel Angel Martinez-Garcia, Elena Diaz-Garcia, Sara Garcia-Tovar, Francisco Campos-Rodriguez, Manuel Sanchez-de-la-Torre, Eduardo Nagore, Antonio Martorell-Calatayud, Luis Hernandez Blasco, Esther Pastor, Jorge Abad-Capa, Josep Maria Montserrat, Valentin Cabriada-Nuno, Irene Cano-Pumarega, Jaime Corral-Penafiel, Eva Arias, Olga Mediano, Maria Somoza-Gonzalez, Joan Dalmau-Arias, Isaac Almendros, Ramon Farre, David Gozal, Francisco Garcia-Rio
Summary: In patients with obstructive sleep apnoea (OSA), high levels of paraspeckle component (PSPC)1 are associated with increased tumor aggressiveness in cutaneous melanoma. Intermittent hypoxia and soluble PSPC1 play a role in promoting epithelial-mesenchymal transition (EMT) and acquisition of cancer stem cell (CSC)-like features in melanoma cells. These findings suggest a potential link between OSA severity, PSPC1 levels, and melanoma aggressiveness.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Letter
Dermatology
Neus Calbet-Llopart, Gemma Tell-Marti, Judit Mateu, Marta Feito, Silvestre Martinez, Susana Puig, Josep Malvehy, Cristina Carrera, Joan A. Puig-Butille
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Allergy
Wei-jie Guan, Grace Oscullo, Meng-zhang He, Dan-yuan Xu, Jose Daniel Gomez-Olivas, Miguel Angel Martinez-Garcia
Summary: Bronchiectasis is a complex and heterogeneous disease with various causes. It is characterized by neutrophilic inflammation but can also involve eosinophilic inflammation. Eosinophilic diseases, such as asthma and allergic bronchopulmonary aspergillosis, may coexist with bronchiectasis. Additionally, some bronchiectasis patients exhibit eosinophilia without identified concomitant diseases, and the role of eosinophils in this condition is not fully understood.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Editorial Material
Respiratory System
David J. Durgan, Ramon Farre
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Dermatology
Francesc Alamon-Reig, Marc Combalia, Raquel Albero-Gonzalez, Llucia Alos, Cristina Carrera, Joan Anton Puig-Butille, Jose Luis Villanueva-Canas, Susana Puig, Josep Malvehy, Sebastian Podlipnik
Summary: This study described the clinical evolution of blue nevi over time and assessed the need for monitoring these lesions. Using an artificial intelligence algorithm and neural network, it was found that most blue nevi remain stable during their evolution, while a small percentage may show growth.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Critical Care Medicine
Martino F. Pengo, Grace Oscullo, Jose Daniel Gomez-Olivas, Grzegorz Bilo, Gianfranco Parati, Miguel Angel Martinez-Garcia
Article
Critical Care Medicine
Miguel Angel Martinez-Garcia, Raul Mendez, Casilda Olveira, Rosa Giron, Marta Garcia-Clemente, Luis Maiz, Oriol Sibila, Rafael Golpe, Juan Luis Rodriguez-Hermosa, Esther Barreiro, Concepcion Prados, Juan Rodriguez-Lopez, Grace Oscullo, Gonzalo Labarca, David de la Rosa
Summary: This study found a significant U-shaped relationship between BEC and severity and exacerbations in bronchiectasis, which was more prominent in the eosinopenic group. IC treatment only decreased the number and severity of exacerbations in the eosinophilic group.
Letter
Critical Care Medicine
Miguel Angel Martinez-Garcia, Alvar Agusti
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Editorial Material
Allergy
Grace Oscullo, Jose Daniel Gomez-Olivas, Miguel Angel Martinez-Garcia
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Article
Dermatology
F. Perino, R. Suarez, J. Perez-Anker, C. Carrera, G. G. Rezze, C. A. Primiero, L. L. Alos, A. Diaz, A. Barreiro, S. Puig, K. Peris, J. Malvehy
Summary: This study aims to evaluate the concordance between in vivo RCM and histopathological transverse sections, and the results show significant agreement between the two, reinforcing the utility of RCM as a diagnostic tool.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Editorial Material
Clinical Neurology
Grace Oscullo, Jose Daniel Gomez-Olivas, Miguel Angel Martinez-Garcia
SLEEP AND BREATHING
(2023)
Editorial Material
Clinical Neurology
Grace Oscullo, Jose Daniel Gomez-Olivas, Miguel Angel Martinez-Garcia