Article
Biochemistry & Molecular Biology
Jae-Hyung Park, Jaechan Leem, Sun-Jae Lee
Summary: Renal fibrosis, a common feature of chronic kidney disease, is a promising therapeutic target. This study found that carnosol (CS), a compound found in rosemary plants, improved renal function and reduced renal tubular injury and interstitial fibrosis in a murine model of unilateral ureteral obstruction (UUO). CS achieved this by suppressing oxidative stress, endoplasmic reticulum stress, apoptotic and necroptotic cell death, as well as cytokine production and immune cell infiltration in the kidneys.
Article
Fisheries
Xiaojing Li, Yichen Bai, Yanju Bi, Qian Wu, Shiwen Xu
Summary: Chlorpyrifos (CPF) pollution is widespread and harmful to non-target organisms. Baicalein (BAI) is a flavonoid extract with antioxidant and anti-inflammatory properties. The study finds that BAI can alleviate gill damage caused by CPF exposure, through the inhibition of inflammation and necroptosis pathways.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Oncology
Huan Chen, Gui-Mei Chen, Yu-Juan Liu, Jian-Xu Rao, Si-Zhen Zhou, Shuang Chen, Ping-Ting Chen, Fang-Wan Yang, Qi-Jiao Cheng, Yi-Huai He
Summary: The study found that ER stress leads to the accumulation of AFP protein, which in turn helps to alleviate apoptosis and necroptosis and restore cell proliferation. Knockdown of AFP exacerbates ER stress-induced cell death and reduces proliferation.
Article
Gastroenterology & Hepatology
Yun-Fen Chen, Si-Ying Liu, Qi-Jiao Cheng, Yu-Jiao Wang, Shuang Chen, Yi-Yang Zhou, Xia Liu, Zhi-Gang Jiang, Wei-Wei Zhong, Yi-Huai He
Summary: This study investigates the regulation of endoplasmic reticulum (ER) stress and hepatocyte injury by alpha-fetoprotein (AFP). It is found that high levels of intracellular AFP are detected in liver tissues of patients with chronic liver diseases and mice with induced ER stress. ER stress induces AFP expression in cells and decreases cell viability. AFP upregulates intra-hepatocyte AFP expression by activating ATF6, thereby alleviating ER stress-induced hepatocyte apoptosis and necroptosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Environmental Sciences
Zaiwei Wu, Fang Wang, Liwen Hu, Jianrong Zhang, Daojun Chen, Sujuan Zhao
Summary: This study demonstrates that MCLR causes damage to the male reproductive system and enhances autophagy, indicating the essential role of autophagy in MCLR-induced cell death. Furthermore, the study reveals the involvement of ER stress-related autophagy pathway in MCLR-induced apoptosis and injury in the male reproductive system.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Xiaojing Fu, Wenwen Zhao, Kangkang Li, Jingyi Zhou, Xuehong Chen
Summary: The study reveals the anticancer effects of cryptotanshinone (CPT) in colorectal cancer (CRC) by activating autophagy signaling mediated by ER stress. CPT selectively inhibits the growth and proliferation of HCT116 and SW620 cells while having little effect on SW480 cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Qiaoni Hu, Jifang Zheng, Xiao Na Xu, Chaohao Gu, Wanting Li
Summary: Uranium contamination induces excessive intracellular reactive oxygen species (ROS) generation, which is considered as a possible mediator of kidney tubular cells injury and nephrotoxicity. This study found that U exposure triggers endoplasmic reticulum stress, apoptosis, and down-regulation of PI3K/AKT/mTOR signaling. Administration of antioxidant N-acetylcysteine (NAC) effectively blocks ROS generation, ER stress, and apoptosis, and reverses the down-regulation of phosphorylated PI3K induced by U exposure.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Meng Li, Jing Feng, Ying Cheng, Nisha Dong, Xiaolin Tian, Penghui Liu, Yannan Zhao, Yulan Qiu, Fengjie Tian, Yi Lyu, Qian Zhao, Cailing Wei, Meng Wang, Jiyu Yuan, Xiaodong Ying, Xuefeng Ren, Xiaoyan Yan
Summary: Exposure to arsenic and fluoride induced early apoptosis and endoplasmic reticulum expansion in myocardial cells. Endoplasmic reticulum stress (ERS) and apoptosis pathways were involved in the damage caused by co-exposure to arsenic and fluoride.
Article
Agriculture, Dairy & Animal Science
Jun Bai, Jun Li, Ning Liu, Hai Jia, Xuemeng Si, Yusong Zhou, Zhian Zhai, Ying Yang, Fazheng Ren, Zhenlong Wu
Summary: This study investigated the toxicological effect and mechanism of Zearalenone (ZEA) exposure on reproduction in pigs during early stages of pregnancy. It was found that ZEA can cause cell cycle arrest, apoptosis, endoplasmic reticulum (ER) stress, and autophagy in trophoblast ectoderm cells. Furthermore, inhibiting ER stress can reduce cell death, suggesting a critical role of ER stress in the activation of autophagy.
Article
Cell Biology
Wei Chen, Zhiyi Wang, Junfeng Ji, Tao Shi, Hong ye Jiao, You Cheng, Li Xu, Rui Wang
Summary: This study found that the regulatory role of HSP70 in ER level has different significance in pepsin-treated laryngeal epithelial cells and LC cells. Inhibition of HSP70 reduces the expression of GRP78 in pepsin-stimulated laryngeal epithelial cells and LC cells, and only inhibits apoptosis-related pathways in laryngeal epithelial cells. Inhibition of HSP70 and ER can promote apoptosis and inhibit tumor growth.
Article
Nutrition & Dietetics
Bo Zhang, Jun-Ting Cao, Yong-Bao Wu, Ke-Xin Gao, Ming Xie, Zheng-Kui Zhou, Jing Tang, Shui-Sheng Hou
Summary: Riboflavin deficiency induces cell apoptosis by triggering endoplasmic reticulum stress and the CHOP pathway.
Article
Agriculture, Dairy & Animal Science
Weihan Yang, Runfeng Liu, Qinqiang Sun, Xingchen Huang, Junjun Zhang, Liangfeng Huang, Pengfei Zhang, Ming Zhang, Qiang Fu
Summary: This study found that quercetin could attenuate the effects of endoplasmic reticulum stress on granulosa cells by the PERK/CHOP signaling pathway, providing a novel strategy for inhibiting the apoptosis of granulosa cells.
Article
Biochemistry & Molecular Biology
Shuai Zhang, Shuang Wang, Yu-ying Fan, Wen-cong Liu, Yi-nan Zheng, Zi Wang, Shen Ren, Wei Li
Summary: In this study, high molecular weight neutral arabinogalactan was isolated and characterized for its antioxidant activity. The results showed that AG-40-I-II has good antioxidant activity by reducing ROS production, decreasing cell damage, and inhibiting cell apoptosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Hui Qi, Xing Zhang, Huanhuan Liu, Meng Han, Xuzhen Tang, Shulan Qu, Xiaoyu Wang, Yifu Yang
Summary: Shikonin inhibits proliferation of colorectal cancer cells by activating ROS-mediated ER stress and inducing cell apoptosis. In vivo experiments also showed that shikonin effectively inhibits tumor growth.
Article
Biochemistry & Molecular Biology
Jie Wang, Hancong Liu, Liuchong Zhu, Jingyi Wang, Xiongming Luo, Wenbin Liu, Yan Ma
Summary: The study found that prodigiosin (PG) promotes apoptosis of hepatocellular carcinoma by inducing endoplasmic reticulum stress. PG is localized in the endoplasmic reticulum of HepG2 cells and induces the release of Ca2+. In addition, PG affects the expression of key unfolded response proteins and related apoptotic proteins.