Shaping Pancreatic β-Cell Differentiation and Functioning: The Influence of Mechanotransduction

Applications of stem cells and bioprinting for potential treatment of diabetes

(2019) Shweta Anil Kumar et al.   World Journal of Stem Cells

Specifying the Pancreatic Islet through Biomechanical Forces

(2019) Ondine Cleaver   NEW ENGLAND JOURNAL OF MEDICINE

Charting cellular identity during human in vitro β-cell differentiation

(2019) Adrian Veres et al.   NATURE

Integrins as biomechanical sensors of the microenvironment

(2019) Jenny Z. Kechagia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells

(2019) Edwin A. Rosado-Olivieri et al.   Nature Communications

Matrix-guided control of mitochondrial function in cardiac myocytes

(2019) Davi M. Lyra-Leite et al.   Acta Biomaterialia

The Role of the Islet Niche on Beta Cell Structure and Function

(2019) Eckhard Lammert et al.   JOURNAL OF MOLECULAR BIOLOGY

Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology in vitro

(2019) Mostafa Bakhti et al.   Molecular Metabolism

Polymer scaffolds for pancreatic islet transplantation - Progress and challenges

(2018) Alexandra M. Smink et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The role of adherens junction proteins in the regulation of insulin secretion

(2018) Waruni C. Dissanayake et al.   BIOSCIENCE REPORTS

Mechanisms linking mechanotransduction and cell metabolism

(2018) Alicia M Salvi et al.   CURRENT OPINION IN CELL BIOLOGY

Clinical islet transplantation

(2018) Andrew R. Pepper et al.   Current Opinion in Organ Transplantation

Extracellular matrix molecules and their potential contribution to the function of transplanted pancreatic islets

(2018) L. Alberto Llacua et al.   DIABETOLOGIA

Lancet Commission: Stem cells and regenerative medicine

(2018) Giulio Cossu et al.   LANCET

YAP/TAZ upstream signals and downstream responses

(2018) Antonio Totaro et al.   NATURE CELL BIOLOGY

Report of the Key Opinion Leaders Meeting on Stem Cell-Derived Beta Cells

(2018) Jon Odorico et al.   TRANSPLANTATION

Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism

(2018) Amin Ardestani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The journey of islet cell transplantation and future development

(2018) Anissa Gamble et al.   Islets

Cluster-assembled zirconia substrates promote long-term differentiation and functioning of human islets of Langerhans

(2018) Alessandra Galli et al.   Scientific Reports

Cellular Mechanotransduction: From Tension to Function

(2018) Fabiana Martino et al.   Frontiers in Physiology

Pancreatic islet of Langerhans' cytoarchitecture and ultrastructure in normal glucose tolerance and in type 2 diabetes mellitus

(2018) Franco Folli et al.   DIABETES OBESITY & METABOLISM

Electrostatic Double-Layer Interaction at the Surface of Rough Cluster-Assembled Films: The Case of Nanostructured Zirconia

(2018) Francesca Borghi et al.   LANGMUIR

Transcription-driven genome organization: a model for chromosome structure and the regulation of gene expression tested through simulations

(2018) Peter R Cook et al.   NUCLEIC ACIDS RESEARCH

Rebuilding a better home for transplanted islets

(2018) Daniel M. Tremmel et al.   Organogenesis

Regenerative Medicine and Diabetes: Targeting the Extracellular Matrix Beyond the Stem Cell Approach and Encapsulation Technology

(2018) Andrea Peloso et al.   Frontiers in Endocrinology

Nanotopographical regulation of pancreatic islet-like cluster formation from human pluripotent stem cells using a gradient-pattern chip

(2018) Jong Hyun Kim et al.   Acta Biomaterialia

Mechanical forces on cellular organelles

(2018) Qian Feng et al.   JOURNAL OF CELL SCIENCE

Mechanosignalling via integrins directs fate decisions of pancreatic progenitors

(2018) Anant Mamidi et al.   NATURE

Regulation of Mitochondrial Structure and Dynamics by the Cytoskeleton and Mechanical Factors

(2017) Erzsébet Bartolák-Suki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Orientation and repositioning of chromosomes correlate with cell geometry–dependent gene expression

(2017) Yejun Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Force loading explains spatial sensing of ligands by cells

(2017) Roger Oria et al.   NATURE

Mechanobiology of collective cell behaviours

(2017) Benoit Ladoux et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of genome organization and gene expression by nuclear mechanotransduction

(2017) Caroline Uhler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanical forces direct stem cell behaviour in development and regeneration

(2017) Kyle H. Vining et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

How cells channel their stress: Interplay between Piezo1 and the cytoskeleton

(2017) Jamison L. Nourse et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mechanotransduction at the cell-matrix interface

(2017) K.A. Jansen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Epigenetic Erasing and Pancreatic Differentiation of Dermal Fibroblasts into Insulin-Producing Cells are Boosted by the Use of Low-Stiffness Substrate

(2017) Georgia Pennarossa et al.   Stem Cell Reviews and Reports

3D-Models of Insulin-Producing β-Cells: from Primary Islet Cells to Stem Cell-Derived Islets

(2017) Diana Ribeiro et al.   Stem Cell Reviews and Reports

Efficient Generation of Glucose-Responsive Beta Cells from Isolated GP2 + Human Pancreatic Progenitors

(2017) Jacqueline Ameri et al.   Cell Reports

Epigenetic Erasing and Pancreatic Differentiation of Dermal Fibroblasts into Insulin-Producing Cells are Boosted by the Use of Low-Stiffness Substrate

(2017) Georgia Pennarossa et al.   Stem Cell Reviews and Reports

3D-Models of Insulin-Producing β-Cells: from Primary Islet Cells to Stem Cell-Derived Islets

(2017) Diana Ribeiro et al.   Stem Cell Reviews and Reports

The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the Heart

(2017) Kate Herum et al.   Journal of Clinical Medicine

Superresolution imaging of nanoscale chromosome contacts

(2017) Yejun Wang et al.   Scientific Reports

Nanotopography Promotes Pancreatic Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells

(2016) Jong Hyun Kim et al.   ACS Nano

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

(2016) Lena Pernas et al.   Annual Review of Physiology

Mass production of functional human pancreatic β-cells: why and how?

(2016) R. Scharfmann et al.   DIABETES OBESITY & METABOLISM

Mechanosensing via cell-matrix adhesions in 3D microenvironments

(2016) Andrew D. Doyle et al.   EXPERIMENTAL CELL RESEARCH

The mechanical regulation of integrin–cadherin crosstalk organizes cells, signaling and forces

(2016) Keeley L. Mui et al.   JOURNAL OF CELL SCIENCE

Cell polarity defines three distinct domains in pancreatic β-cells

(2016) Wan J. Gan et al.   JOURNAL OF CELL SCIENCE

From nano to micro: topographical scale and its impact on cell adhesion, morphology and contact guidance

(2016) Anh Tuan Nguyen et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Asymmetric division of contractile domains couples cell positioning and fate specification

(2016) Jean-Léon Maître et al.   NATURE

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

(2016) Arturo J Vegas et al.   NATURE MEDICINE

Clinical pancreatic islet transplantation

(2016) A. M. James Shapiro et al.   Nature Reviews Endocrinology

The Human Endocrine Pancreas: New Insights on Replacement and Regeneration

(2016) Juan Domínguez-Bendala et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Conversion of nanoscale topographical information of cluster-assembled zirconia surfaces into mechanotransductive events promotes neuronal differentiation

(2016) Carsten Schulte et al.   JOURNAL OF NANOBIOTECHNOLOGY

Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells

(2015) Masatoshi Ohgushi et al.   Cell Stem Cell

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

Lamins at the crossroads of mechanosignaling

(2015) Selma Osmanagic-Myers et al.   GENES & DEVELOPMENT

Neurotransmitters and Neuropeptides: New Players in the Control of Islet of Langerhans' Cell Mass and Function

(2015) Eliana S. Di Cairano et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A gp130–Src–YAP module links inflammation to epithelial regeneration

(2015) Koji Taniguchi et al.   NATURE

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors

(2015) Inês Cebola et al.   NATURE CELL BIOLOGY

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

(2015) Edward R. Horton et al.   NATURE CELL BIOLOGY

Role of Connexins and Pannexins in the Pancreas

(2015) Valentina Cigliola et al.   PANCREAS

Mechanotransduction: Relevance to Physical Therapist Practice--Understanding Our Ability to Affect Genetic Expression Through Mechanical Forces

(2015) S. L. Dunn et al.   PHYSICAL THERAPY

Emerging properties of adhesion complexes: what are they and what do they do?

(2015) Jonathan D. Humphries et al.   TRENDS IN CELL BIOLOGY

The Edges of Pancreatic Islet β Cells Constitute Adhesive and Signaling Microdomains

(2015) Erez Geron et al.   Cell Reports

Insulin-Producing Endocrine Cells Differentiated In Vitro From Human Embryonic Stem Cells Function in Macroencapsulation Devices In Vivo

(2015) Alan D. Agulnick et al.   Stem Cells Translational Medicine

Cadherin Adhesion and Mechanotransduction

(2014) D.E. Leckband et al.   Annual Review of Cell and Developmental Biology

Spatial control of adult stem cell fate using nanotopographic cues

(2014) Eun Hyun Ahn et al.   BIOMATERIALS

Primary cilia in pancreatic development and disease

(2014) Sukanya Lodh et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Role of cilia in normal pancreas function and in diseased states

(2014) Philip diIorio et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Sensing the local environment: actin architecture and Hippo signalling

(2014) Pedro Gaspar et al.   CURRENT OPINION IN CELL BIOLOGY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate

(2014) Matthew J. Dalby et al.   NATURE MATERIALS

The integrin adhesome: from genes and proteins to human disease

(2014) Sabina E. Winograd-Katz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Differentiated human stem cells resemble fetal, not adult, β cells

(2014) Sinisa Hrvatin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification

(2014) S. Musah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7

(2014) Xiangwei Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compliant 3D Microenvironment Improves β-Cell Cluster Insulin Expression Through Mechanosensing and β-Catenin Signaling

(2014) Crystal E. Nyitray et al.   TISSUE ENGINEERING PART A

Mechanobiology and Developmental Control

(2013) Tadanori Mammoto et al.   Annual Review of Cell and Developmental Biology

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

Engineering a local microenvironment for pancreatic islet replacement

(2013) Maria M Coronel et al.   CURRENT OPINION IN BIOTECHNOLOGY

How to make a functional  -cell

(2013) F. W. Pagliuca et al.   DEVELOPMENT

 1 integrin is a crucial regulator of pancreatic  -cell expansion

(2013) G. R. Diaferia et al.   DEVELOPMENT

TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass

(2013) Iseki Takamoto et al.   DIABETOLOGIA

Pdx-1 Activates Islet  - and  -Cell Proliferation via a Mechanism Regulated by Transient Receptor Potential Cation Channels 3 and 6 and Extracellular Signal-Regulated Kinases 1 and 2

(2013) H. L. Hayes et al.   MOLECULAR AND CELLULAR BIOLOGY

Constructing stem cell microenvironments using bioengineering approaches

(2013) David A. Brafman   PHYSIOLOGICAL GENOMICS

Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility

(2013) N. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Switch Enhancers Interpret TGF-β and Hippo Signaling to Control Cell Fate in Human Embryonic Stem Cells

(2013) Tobias A. Beyer et al.   Cell Reports

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Hippo Signaling Regulates Pancreas Development through Inactivation of Yap

(2012) N. M. George et al.   MOLECULAR AND CELLULAR BIOLOGY

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

(2012) Georg Halder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Paracrine and autocrine interactions in the human islet: More than meets the eye

(2012) Alejandro Caicedo   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Making β cells from adult tissues

(2012) Shimon Efrat et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Highly Coordinated Proteome Dynamics during Reprogramming of Somatic Cells to Pluripotency

(2012) Jenny Hansson et al.   Cell Reports

Innervation Patterns of Autonomic Axons in the Human Endocrine Pancreas

(2011) Rayner Rodriguez-Diaz et al.   Cell Metabolism

PDGF signalling controls age-dependent proliferation in pancreatic β-cells

(2011) Hainan Chen et al.   NATURE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Connective tissue growth factor acts within both endothelial cells and   cells to promote proliferation of developing   cells

(2011) M. A. Guney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix Components and Scaffolds for Sustained Islet Function

(2011) Jennifer Y.C. Cheng et al.   TISSUE ENGINEERING PART B-REVIEWS

Regenerating pancreatic β-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis

(2010) Kirstine Juhl et al.   Current Opinion in Organ Transplantation

TRP-ing Down the Path to Insulin Secretion

(2010) P. E. MacDonald   DIABETES

Emerging concepts for the role of TRP channels in the cardiovascular system

(2010) Rudi Vennekens   JOURNAL OF PHYSIOLOGY-LONDON

Canonical TRP channels and mechanotransduction: from physiology to disease states

(2010) Amanda Patel et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

(2010) L.-J. Wu et al.   PHARMACOLOGICAL REVIEWS

The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells

(2009) Gen-hong Mao et al.   BIOMATERIALS

LKB1 Regulates Pancreatic β Cell Size, Polarity, and Function

(2009) Zvi Granot et al.   Cell Metabolism

Extracellular Matrix in Pancreatic Islets: Relevance to Scaffold Design and Transplantation

(2009) John C. Stendahl et al.   CELL TRANSPLANTATION

Mitochondrial Networking Protects  -Cells From Nutrient-Induced Apoptosis

(2009) A. J.A. Molina et al.   DIABETES

TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet  -Cells

(2009) G. da Silva Xavier et al.   DIABETES

Cell-cell interactions in the endocrine pancreas

(2009) R. Jain et al.   DIABETES OBESITY & METABOLISM

A Model for all Genomes: The Role of Transcription Factories

(2009) Peter R. Cook   JOURNAL OF MOLECULAR BIOLOGY

Complexity in biomaterials for tissue engineering

(2009) Elsie S. Place et al.   NATURE MATERIALS

Vimentin supports mitochondrial morphology and organization

(2008) Ho Lam Tang et al.   BIOCHEMICAL JOURNAL

Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling

(2008) M. Ota et al.   DEVELOPMENT

Unique basement membrane structure of human pancreatic islets: implications for β-cell growth and differentiation

(2008) T. Otonkoski et al.   DIABETES OBESITY & METABOLISM

Blood vessels of human islets of Langerhans are surrounded by a double basement membrane

(2008) I. Virtanen et al.   DIABETOLOGIA

Interplay between TRP channels and the cytoskeleton in health and disease

(2008) K CLARK et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness

(2008) P.J. Stewart-Hutchinson et al.   EXPERIMENTAL CELL RESEARCH

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

(2008) T. Dechat et al.   GENES & DEVELOPMENT

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction gone awry

(2008) Diana E. Jaalouk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Growth factor control of pancreatic islet regeneration and function

(2008) Anke Assmann et al.   PEDIATRIC DIABETES