The Biology of YAP/TAZ: Hippo Signaling and Beyond

Expression and Yes-Associated Protein in Gastric Adenocarcinoma and Inhibitory Effects of its Knockdown on Gastric Cancer Cell Proliferation and Metastasis

(2017) J. Zhang et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

YAP1 acts as oncogenic target of 11q22 amplification in multiple cancer subtypes.

(2015) Erica Lorenzetto et al.   Oncotarget

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

(2014) Fa-Xing Yu et al.   CANCER CELL

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

Merlin/NF2 Loss-Driven Tumorigenesis Linked to CRL4DCAF1-Mediated Inhibition of the Hippo Pathway Kinases Lats1 and 2 in the Nucleus

(2014) Wei Li et al.   CANCER CELL

A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer

(2014) Shi Jiao et al.   CANCER CELL

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

(2014) Avnish Kapoor et al.   CELL

KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

(2014) Diane D. Shao et al.   CELL

Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer

(2014) Masaki Mori et al.   CELL

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

(2014) Wenjing Zhang et al.   CELL RESEARCH

Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis

(2014) A. N. Lau et al.   EMBO JOURNAL

A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis

(2014) Q. Chen et al.   GENES & DEVELOPMENT

Angiomotins link F-actin architecture to Hippo pathway signaling

(2014) Sebastian Mana-Capelli et al.   MOLECULAR BIOLOGY OF THE CELL

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma

(2014) Miwako Kakiuchi et al.   NATURE GENETICS

Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers

(2014) Francesca Cottini et al.   NATURE MEDICINE

Knockdown of YAP1 inhibits the proliferation of osteosarcoma cells in vitro and in vivo

(2014) ZHI YANG et al.   ONCOLOGY REPORTS

YAP Promotes Ovarian Cancer Cell Tumorigenesis and Is Indicative of a Poor Prognosis for Ovarian Cancer Patients

(2014) Yan Xia et al.   PLoS One

Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma

(2014) W. Zhang et al.   Science Signaling

The Hippo Transducer TAZ Interacts with the SWI/SNF Complex to Regulate Breast Epithelial Lineage Commitment

(2014) Adam Skibinski et al.   Cell Reports

Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma

(2014) Su-xia Han et al.   Journal of Immunology Research

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

(2013) Feng Yin et al.   CELL

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells

(2013) Hui Cai et al.   Cell Communication and Signaling

The Hippo Pathway Member Nf2 Is Required for Inner Cell Mass Specification

(2013) Katie Cockburn et al.   CURRENT BIOLOGY

Polarity-Dependent Distribution of Angiomotin Localizes Hippo Signaling in Preimplantation Embryos

(2013) Yoshikazu Hirate et al.   CURRENT BIOLOGY

Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators

(2013) A. Lavado et al.   DEVELOPMENT

Hippo signaling impedes adult heart regeneration

(2013) T. Heallen et al.   DEVELOPMENT

The Hippo Effector Yorkie Controls Normal Tissue Growth by Antagonizing Scalloped-Mediated Default Repression

(2013) Laura M. Koontz et al.   DEVELOPMENTAL CELL

Control of the Hippo Pathway by Set7-Dependent Methylation of Yap

(2013) Menno J. Oudhoff et al.   DEVELOPMENTAL CELL

MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis

(2013) Yi Tang et al.   DEVELOPMENTAL CELL

Hippo Signaling Regulates Differentiation and Maintenance in the Exocrine Pancreas

(2013) Tao Gao et al.   GASTROENTEROLOGY

Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma

(2013) Darjus Felix Tschaharganeh et al.   GASTROENTEROLOGY

Phosphorylation of Angiomotin by Lats1/2 Kinases Inhibits F-actin Binding, Cell Migration, and Angiogenesis

(2013) Xiaoming Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Actin-binding and Cell Proliferation Activities of Angiomotin Family Members Are Regulated by Hippo Pathway-mediated Phosphorylation

(2013) Siew Wee Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hippo Pathway Effectors TAZ/YAP Regulate Dicer Expression and MicroRNA Biogenesis through Let-7

(2013) Steven G. Chaulk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pro-Invasive Activity of the Hippo Pathway Effectors YAP and TAZ in Cutaneous Melanoma

(2013) Flore Nallet-Staub et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway

(2013) Morvarid Mohseni et al.   NATURE CELL BIOLOGY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development

(2013) Silvia Cappello et al.   NATURE GENETICS

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2

(2013) Yasuhiro Maejima et al.   NATURE MEDICINE

A self-organization framework for symmetry breaking in the mammalian embryo

(2013) Sebastian Wennekamp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo

(2013) I A Elsum et al.   ONCOGENE

TAZ Expression as a Prognostic Indicator in Colorectal Cancer

(2013) Hiu-Fung Yuen et al.   PLoS One

The Tyrosine Phosphatase PTPN14 Is a Negative Regulator of YAP Activity

(2013) Chrysiis Michaloglou et al.   PLoS One

Overexpression of YAP and TAZ Is an Independent Predictor of Prognosis in Colorectal Cancer and Related to the Proliferation and Metastasis of Colon Cancer Cells

(2013) Lijuan Wang et al.   PLoS One

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

(2013) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo pathway effector Yap promotes cardiac regeneration

(2013) Mei Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription

(2013) B. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases

(2013) J. J. Adler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The p130 Isoform of Angiomotin Is Required for Yap-Mediated Hepatic Epithelial Cell Proliferation and Tumorigenesis

(2013) C. Yi et al.   Science Signaling

Mesenchymal Stem Cell and Chondrocyte Fates in a Multishear Microdevice Are Regulated by Yes-Associated Protein

(2013) Weiliang Zhong et al.   STEM CELLS AND DEVELOPMENT

Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms

(2013) Chuen Yan Leung et al.   Nature Communications

Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer

(2013) Eva J. Vlug et al.   CELLULAR ONCOLOGY

Genome-wide Association of Yorkie with Chromatin and Chromatin-Remodeling Complexes

(2013) Hyangyee Oh et al.   Cell Reports

Bile Acids Activate YAP to Promote Liver Carcinogenesis

(2013) Sayeepriyadarshini Anakk et al.   Cell Reports

LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction

(2013) Jiong Li et al.   Cell Reports

The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense

(2013) Hongtan Wu et al.   Cell Reports

Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development

(2013) Antoine Reginensi et al.   PLoS Genetics

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

Role of TAZ as Mediator of Wnt Signaling

(2012) Luca Azzolin et al.   CELL

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Cancer Stem Cells: Current Status and Evolving Complexities

(2012) Jane E. Visvader et al.   Cell Stem Cell

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling

(2012) Masamichi Imajo et al.   EMBO JOURNAL

Mitotic and mitogenic Wnt signalling

(2012) Christof Niehrs et al.   EMBO JOURNAL

Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs)

(2012) J.-S. Mo et al.   GENES & DEVELOPMENT

PTPN14 is required for the density-dependent control of YAP1

(2012) W. Wang et al.   GENES & DEVELOPMENT

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

(2012) B. Zhao et al.   GENES & DEVELOPMENT

Yes-associated protein regulates the hepatic response after bile duct ligation

(2012) Haibo Bai et al.   HEPATOLOGY

Yes-associated Protein Isoform 1 (Yap1) Promotes Cardiomyocyte Survival and Growth to Protect against Myocardial Ischemic Injury

(2012) Dominic P. Del Re et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice

(2012) Miki Nishio et al.   JOURNAL OF CLINICAL INVESTIGATION

Prognostic Significance of TAZ Expression in Resected Non-Small Cell Lung Cancer

(2012) Mian Xie et al.   Journal of Thoracic Oncology

Hippo Signaling Regulates Pancreas Development through Inactivation of Yap

(2012) N. M. George et al.   MOLECULAR AND CELLULAR BIOLOGY

Restriction of intestinal stem cell expansion and the regenerative response by YAP

(2012) Evan R. Barry et al.   NATURE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker

(2012) Dahu Chen et al.   NATURE MEDICINE

KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals

(2012) S Moleirinho et al.   ONCOGENE

YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes

(2012) T Mizuno et al.   ONCOGENE

YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14

(2012) J-M Huang et al.   ONCOGENE

PTPN14 interacts with and negatively regulates the oncogenic function of YAP

(2012) X Liu et al.   ONCOGENE

Down-Regulation of Yes Associated Protein 1 Expression Reduces Cell Proliferation and Clonogenicity of Pancreatic Cancer Cells

(2012) Caroline H. Diep et al.   PLoS One

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

(2012) J. M. Lamar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy

(2012) A. von Gise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo signaling pathway and stem cell biology

(2012) Azucena Ramos et al.   TRENDS IN CELL BIOLOGY

The Hippo Pathway

(2012) K. F. Harvey et al.   Cold Spring Harbor Perspectives in Biology

The Hippo pathway and apico–basal cell polarity

(2011) Alice Genevet et al.   BIOCHEMICAL JOURNAL

Biophysical Analysis of Binding of WW Domains of the YAP2 Transcriptional Regulator to PPXY Motifs within WBP1 and WBP2 Adaptors

(2011) Caleb B. McDonald et al.   BIOCHEMISTRY

A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin's Regulation of Mitogenic Signaling and Tumor Suppressive Functions

(2011) Chunling Yi et al.   CANCER CELL

Taxol Resistance in Breast Cancer Cells Is Mediated by the Hippo Pathway Component TAZ and Its Downstream Transcriptional Targets Cyr61 and CTGF

(2011) D. Lai et al.   CANCER RESEARCH

LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma

(2011) H. Murakami et al.   CANCER RESEARCH

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila

(2011) B. G. Fernandez et al.   DEVELOPMENT

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Modulating F-actin organization induces organ growth by affecting the Hippo pathway

(2011) Leticia Sansores-Garcia et al.   EMBO JOURNAL

The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma

(2011) K. P. L. Bhat et al.   GENES & DEVELOPMENT

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

(2011) B. Zhao et al.   GENES & DEVELOPMENT

Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin

(2011) Siew Wee Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KIBRA Regulates Hippo Signaling Activity via Interactions with Large Tumor Suppressor Kinases

(2011) Ling Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia

(2011) Helen B. Pearson et al.   JOURNAL OF CLINICAL INVESTIGATION

The c-Abl-MST1 Signaling Pathway Mediates Oxidative Stress-Induced Neuronal Cell Death

(2011) L. Xiao et al.   JOURNAL OF NEUROSCIENCE

Mutant K-Ras Activation of the Proapoptotic MST2 Pathway Is Antagonized by Wild-Type K-Ras

(2011) David Matallanas et al.   MOLECULAR CELL

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP

(2011) T Oka et al.   ONCOGENE

The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene

(2011) X Zhang et al.   ONCOGENE

Yes-Associated Protein 65 (YAP) Expands Neural Progenitors and Regulates Pax3 Expression in the Neural Plate Border Zone

(2011) Stephen T. Gee et al.   PLoS One

PP1A-Mediated Dephosphorylation Positively Regulates YAP2 Activity

(2011) Pei Wang et al.   PLoS One

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

(2011) D. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components

(2011) N.-G. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

 -Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1

(2011) M. R. Silvis et al.   Science Signaling

Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling

(2010) Tsutomu Oka et al.   BIOCHEMICAL JOURNAL

Hippo Pathway Effector Yap Is an Ovarian Cancer Oncogene

(2010) C. A. Hall et al.   CANCER RESEARCH

LATS tumor suppressor: A new governor of cellular homeostasis

(2010) Stacy Visser et al.   CELL CYCLE

Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms

(2010) Nicola A. Grzeschik et al.   CURRENT BIOLOGY

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded

(2010) Jianzhong Yu et al.   DEVELOPMENTAL CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network

(2010) Alice Genevet et al.   DEVELOPMENTAL CELL

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

(2010) Mikala Egeblad et al.   DEVELOPMENTAL CELL

TAZ interacts with zonula occludens-1 and -2 proteins in a PDZ-1 dependent manner

(2010) Eline Remue et al.   FEBS LETTERS

The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1

(2010) Y. Aylon et al.   GENES & DEVELOPMENT

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

(2010) J. Cai et al.   GENES & DEVELOPMENT

Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver

(2010) S. Benhamouche et al.   GENES & DEVELOPMENT

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

(2010) I. Lian et al.   GENES & DEVELOPMENT

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

(2010) B. Zhao et al.   GENES & DEVELOPMENT

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Tumor Suppressor Ras Association Domain Family 5 (RASSF5/NORE1) Mediates Death Receptor Ligand-induced Apoptosis

(2010) Jikyoung Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCPE3 Ligase

(2010) Chen-Ying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiomotin-like Proteins Associate with and Negatively Regulate YAP1

(2010) Wenqi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PP1 Cooperates with ASPP2 to Dephosphorylate and Activate TAZ

(2010) Chen-Ying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma

(2010) M Z Xu et al.   ONCOGENE

WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ

(2010) S W Chan et al.   ONCOGENE

Structural and functional analysis of the YAP-binding domain of human TEAD2

(2010) W. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

(2010) H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

(2010) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

(2010) K.-P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional Coactivator with PDZ-binding Motif Is Essential for Normal Alveolarization in Mice

(2009) Akihisa Mitani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma

(2009) Michelle Z. Xu et al.   CANCER

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

Both TEAD-Binding and WW Domains Are Required for the Growth Stimulation and Oncogenic Transformation Activity of Yes-Associated Protein

(2009) B. Zhao et al.   CANCER RESEARCH

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Cytoskeletal control of growth and cell fate switching

(2009) Akiko Mammoto et al.   CURRENT OPINION IN CELL BIOLOGY

Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms

(2009) Fangfang Ren et al.   DEVELOPMENTAL BIOLOGY

The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

(2009) Noriyuki Nishioka et al.   DEVELOPMENTAL CELL

Regulation of Neuronal Cell Death by MST1-FOXO1 Signaling

(2009) Zengqiang Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TEADs Mediate Nuclear Retention of TAZ to Promote Oncogenic Transformation

(2009) Siew Wee Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition

(2009) Heng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway

(2009) Jianmin Zhang et al.   NATURE CELL BIOLOGY

Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo

(2009) Magdalena Zernicka-Goetz et al.   NATURE REVIEWS GENETICS

Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation

(2009) Y Aylon et al.   ONCOGENE

Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development

(2009) K. Skouloudaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma

(2009) Z. S. Morris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells

(2008) S. W. Chan et al.   CANCER RESEARCH

YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation

(2008) Toshihiko Yokoyama et al.   CARCINOGENESIS

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma

(2008) Lixing Zhan et al.   CELL

SCALLOPED Interacts with YORKIE, the Nuclear Effector of the Hippo Tumor-Suppressor Pathway in Drosophila

(2008) Youlian Goulev et al.   CURRENT BIOLOGY

MOBKL1A/MOBKL1B Phosphorylation by MST1 and MST2 Inhibits Cell Proliferation

(2008) Maria Praskova et al.   CURRENT BIOLOGY

NDR Kinase Is Activated by RASSF1A/MST1 in Response to Fas Receptor Stimulation and Promotes Apoptosis

(2008) Anton Vichalkovski et al.   CURRENT BIOLOGY

Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling

(2008) M. Ota et al.   DEVELOPMENT

The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway

(2008) Shian Wu et al.   DEVELOPMENTAL CELL

The TEAD/TEF Family of Transcription Factor Scalloped Mediates Hippo Signaling in Organ Size Control

(2008) Lei Zhang et al.   DEVELOPMENTAL CELL

A crucial role of WW45 in developing epithelial tissues in the mouse

(2008) Joo-Hyeon Lee et al.   EMBO JOURNAL

TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation

(2008) Tina Di Palma et al.   EXPERIMENTAL CELL RESEARCH

YAP regulates neural progenitor cell number via the TEA domain transcription factor

(2008) X. Cao et al.   GENES & DEVELOPMENT

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Expression of Yes-associated protein in common solid tumors

(2008) Angela A. Steinhardt et al.   HUMAN PATHOLOGY

TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

(2008) Q.-Y. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY

Redundant Roles of Tead1 and Tead2 in Notochord Development and the Regulation of Cell Proliferation and Survival

(2008) A. Sawada et al.   MOLECULAR AND CELLULAR BIOLOGY

Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage

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