TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass

Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand

(2012) Sylvia F. Boj et al.   CELL

Dominant-negative isoforms of Tcf/Lef proteins in development and disease

(2012) Tomas Vacik et al.   CELL CYCLE

Cell-Context Dependent TCF/LEF Expression and Function: Alternative Tales of Repression, De-Repression and Activation Potentials

(2012) Catherine D. Mao et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

The Wnt Signaling Pathway Effector TCF7L2 Controls Gut and Brain Proglucagon Gene Expression and Glucose Homeostasis

(2012) W. Shao et al.   DIABETES

Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice

(2012) G. da Silva Xavier et al.   DIABETOLOGIA

Reduction in Tcf7l2 Expression Decreases Diabetic Susceptibility in Mice

(2012) Hyekyung Yang et al.   International Journal of Biological Sciences

FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization

(2012) Osamu Kikuchi et al.   PLoS One

TCF7L2 Modulates Glucose Homeostasis by Regulating CREB- and FoxO1-Dependent Transcriptional Pathway in the Liver

(2012) Kyoung-Jin Oh et al.   PLoS Genetics

Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism

(2011) L. Norton et al.   DIABETOLOGIA

An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes

(2011) J. M. Locke et al.   DIABETOLOGIA

A novel mechanism for the transcriptional regulation of Wnt signaling in development

(2011) T. Vacik et al.   GENES & DEVELOPMENT

Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism

(2011) D. Savic et al.   GENOME RESEARCH

TCF7L2 splice variants have distinct effects on β-cell turnover and function

(2011) Olivier Le Bacquer et al.   HUMAN MOLECULAR GENETICS

MafA and MafB activity in pancreatic β cells

(2011) Yan Hang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Insulin treatment and high-fat diet feeding reduces the expression of three Tcf genes in rodent pancreas

(2010) Joshua Columbus et al.   JOURNAL OF ENDOCRINOLOGY

A map of open chromatin in human pancreatic islets

(2010) Kyle J Gaulton et al.   NATURE GENETICS

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

(2010) Toshimasa Yamauchi et al.   NATURE GENETICS

The what, where, when and how of Wnt/β-catenin signaling in pancreas development

(2010) L. Charles Murtaugh   Organogenesis

Role of MafA in pancreatic β-cells

(2009) Hideaki Kaneto et al.   ADVANCED DRUG DELIVERY REVIEWS

TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action

(2009) D. T. Villareal et al.   DIABETES

Lack of β-catenin in early life induces abnormal glucose homeostasis in mice

(2009) S. Dabernat et al.   DIABETOLOGIA

Unique splicing pattern of the TCF7L2 gene in human pancreatic islets

(2009) P. Osmark et al.   DIABETOLOGIA

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

(2009) Luan Shu et al.   HUMAN MOLECULAR GENETICS

Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia

(2009) Hoang Nguyen et al.   NATURE GENETICS

Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insulin Signaling during Fasting and Feeding

(2008) Naoto Kubota et al.   Cell Metabolism

The WNT signalling pathway and diabetes mellitus

(2008) T. Jin   DIABETOLOGIA

Glucagon-like Peptide-1 Activation of TCF7L2-dependent Wnt Signaling Enhances Pancreatic Beta Cell Proliferation

(2008) Zhengyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt signaling: relevance to β-cell biology and diabetes

(2008) Hannah J. Welters et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM