Regenerative Medicine and Diabetes: Targeting the Extracellular Matrix Beyond the Stem Cell Approach and Encapsulation Technology

Lancet Commission: Stem cells and regenerative medicine

(2018) Giulio Cossu et al.   LANCET

The potential and challenges of alternative sources of β cells for the cure of type 1 diabetes

(2018) Monia Cito et al.   Endocrine Connections

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

(2017) Germán G Gornalusse et al.   NATURE BIOTECHNOLOGY

Bioengineering of an Intraabdominal Endocrine Pancreas

(2017) David A. Baidal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stem cells to restore insulin production and cure diabetes

(2017) V. Sordi et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

ImmunoCloak as a Paradigm of the Biomaterial Approach to Immunomodulation

(2017) Giuseppe Orlando   TRANSPLANTATION

Cold-perfusion decellularization of whole-organ porcine pancreas supports human fetal pancreatic cell attachment and expression of endocrine and exocrine markers

(2017) Erik Elebring et al.   Journal of Tissue Engineering

Engineering an endocrine Neo-Pancreas by repopulation of a decellularized rat pancreas with islets of Langerhans

(2017) H. Napierala et al.   Scientific Reports

Pancreas Transplantation: An Alarming Crisis in Confidence

(2016) R. J. Stratta et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Human Pancreas as a Source of Protolerogenic Extracellular Matrix Scaffold for a New-generation Bioartificial Endocrine Pancreas

(2016) Andrea Peloso et al.   ANNALS OF SURGERY

Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

(2016) Bernhard J. Hering et al.   DIABETES CARE

Advances in islet encapsulation technologies

(2016) Tejal Desai et al.   NATURE REVIEWS DRUG DISCOVERY

The Host Immune Response to Tissue-Engineered Organs: Current Problems and Future Directions

(2016) Katherine Wiles et al.   TISSUE ENGINEERING PART B-REVIEWS

OPTN/SRTR 2013 Annual Data Report: Pancreas

(2015) R. Kandaswamy et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Islet formation in mice and men: lessons for the generation of functional insulin-producing β-cells from human pluripotent stem cells

(2015) Gopika Nair et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Re-engineering islet cell transplantation

(2015) Nicoletta Fotino et al.   PHARMACOLOGICAL RESEARCH

Insulin-Producing Endocrine Cells Differentiated In Vitro From Human Embryonic Stem Cells Function in Macroencapsulation Devices In Vivo

(2015) Alan D. Agulnick et al.   Stem Cells Translational Medicine

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Islet transplantation for Type 1 diabetes: where are we now?

(2014) Aaron J Ahearn et al.   Expert Review of Clinical Immunology

Scaffolds for islets and stem cells differentiated into insulin-secreting cells

(2014) Bernard Tuch   Frontiers in Bioscience-Landmark

Bone marrow mesenchymal stem cells promote the repair of islets from diabetic mice through paracrine actions

(2014) Xiaodong Gao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

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(2014) Melinda Magna et al.   MOLECULAR MEDICINE

Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells

(2014) Mitsutoshi Yamada et al.   NATURE

Differentiated human stem cells resemble fetal, not adult, β cells

(2014) Sinisa Hrvatin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges

(2014) James Shapiro et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Organ Bioengineering and Regeneration as the New Holy Grail for Organ Transplantation

(2013) Giuseppe Orlando et al.   ANNALS OF SURGERY

Multiple intravenous infusions of bone marrow mesenchymal stem cells reverse hyperglycemia in experimental type 2 diabetes rats

(2013) Haojie Hao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Porcine pancreas extracellular matrix as a platform for endocrine pancreas bioengineering

(2013) Sayed-Hadi Mirmalek-Sani et al.   BIOMATERIALS

Perfusion-decellularized pancreas as a natural 3D scaffold for pancreatic tissue and whole organ engineering

(2013) Saik-Kia Goh et al.   BIOMATERIALS

Macroporous Three-Dimensional PDMS Scaffolds for Extrahepatic Islet Transplantation

(2013) Eileen Pedraza et al.   CELL TRANSPLANTATION

Making β Cells from Adult Cells Within the Pancreas

(2013) Philippe A. Lysy et al.   Current Diabetes Reports

Engineering a local microenvironment for pancreatic islet replacement

(2013) Maria M Coronel et al.   CURRENT OPINION IN BIOTECHNOLOGY

Economic Costs of Diabetes in the U.S. in 2012

(2013)   DIABETES CARE

The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells

(2013) Monica Courtney et al.   PLoS Genetics

Transdifferentiation: a cell and molecular reprogramming process

(2012) Sajjad Sisakhtnezhad et al.   CELL AND TISSUE RESEARCH

Porous Scaffolds Support Extrahepatic Human Islet Transplantation, Engraftment, and Function in Mice

(2012) Romie F. Gibly et al.   CELL TRANSPLANTATION

Immune Regulatory Properties of Allogeneic Adipose-Derived Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Diabetes

(2012) E. J. Bassi et al.   DIABETES

Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010

(2012) F. B. Barton et al.   DIABETES CARE

Identification of human preformed antibody targets in GTKO pigs

(2012) Christopher Burlak et al.   XENOTRANSPLANTATION

An overview of tissue and whole organ decellularization processes

(2011) Peter M. Crapo et al.   BIOMATERIALS

Damage associated molecular patterns within xenogeneic biologic scaffolds and their effects on host remodeling

(2011) K.A. Daly et al.   BIOMATERIALS

Human oocytes reprogram somatic cells to a pluripotent state

(2011) Scott Noggle et al.   NATURE

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells

(2011) Olivia G Kelly et al.   NATURE BIOTECHNOLOGY

Matrix Components and Scaffolds for Sustained Islet Function

(2011) Jennifer Y.C. Cheng et al.   TISSUE ENGINEERING PART B-REVIEWS

Long-term in vitro human pancreatic islet culture using three-dimensional microfabricated scaffolds

(2010) Jamal T. Daoud et al.   BIOMATERIALS

Pancreas transplantation for type 2 diabetes mellitus

(2010) Giuseppe Orlando et al.   Current Opinion in Organ Transplantation

Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny

(2010) T Thatava et al.   GENE THERAPY

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Pretransplant Kidney-Specific Treatment to Eliminate the Need for Systemic Immunosuppression

(2010) Lauren Brasile et al.   TRANSPLANTATION

Bioengineering of a functional sheet of islet cells for the treatment of diabetes mellitus

(2009) Hirofumi Shimizu et al.   BIOMATERIALS

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Extracellular Matrix in Pancreatic Islets: Relevance to Scaffold Design and Transplantation

(2009) John C. Stendahl et al.   CELL TRANSPLANTATION

Changes in gene expression and morphology of mouse embryonic stem cells on differentiation into insulin-producing cellsin vitroandin vivo

(2009) Ortwin Naujok et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Stem Cells to Pancreatic β-Cells: New Sources for Diabetes Cell Therapy

(2009) Tingxia Guo et al.   ENDOCRINE REVIEWS

Pancreatic acellular matrix supports islet survival and function in a synthetic tubular device: In vitro and in vivo studies

(2009) De Carlo   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Generation and Transplantation of an Autologous Vascularized Bioartificial Human Tissue

(2009) Heike Mertsching et al.   TRANSPLANTATION

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

Pulmonary Passage is a Major Obstacle for Intravenous Stem Cell Delivery: The Pulmonary First-Pass Effect

(2008) Uwe M. Fischer et al.   STEM CELLS AND DEVELOPMENT

Cell–Matrix Interactions Improve β-Cell Survival and Insulin Secretion in Three-Dimensional Culture

(2008) Laney M. Weber et al.   TISSUE ENGINEERING PART A

Extracellular Matrix Protein-Coated Scaffolds Promote the Reversal of Diabetes After Extrahepatic Islet Transplantation

(2008) David M. Salvay et al.   TRANSPLANTATION