Article
Physics, Multidisciplinary
T. Tanaka, D. J. Hinde, M. Dasgupta, E. Williams, K. Vo-Phuoc, C. Simenel, E. C. Simpson, D. Y. Jeung, I. P. Carter, K. J. Cook, N. R. Lobanov, D. H. Luong, C. Palshetkar, D. C. Rafferty, K. Ramachandran
Summary: The mass and angle distributions for the Cr-52 + Pt-198 and Cr-54 + (19)6Pt reactions forming No-250 were measured and subtracted. The experimental mass distributions unexpectedly extended to symmetric splits, while the peak yield remained close to the initial masses, indicating a strong role of fluctuations in mass division early in the collision. This provides insights into the transition from fast energy dissipative deep-inelastic collisions to quasifission.
PHYSICAL REVIEW LETTERS
(2021)
Article
Nutrition & Dietetics
Ciro Menale, Giovanna Trinchese, Immacolata Aiello, Giulia Scalia, Monica Dentice, Maria Pina Mollica, Nal Ae Yoon, Sabrina Diano
Summary: In this study, it was found that the addition of non-lipotoxic levels of 25 μM palmitic acid (PA) to glucose (G) increased mineralization in osteoblasts (OBs). It was also discovered that G+25 μM PA reduced mitochondria size in OBs and increased mitochondria respiration and ATP production, as well as the expression of oxidative phosphorylation genes. Treatment with the mitochondrial fission inhibitor Mdivi-1 reduced osteogenesis and mitochondrial respiration in OBs.
Article
Physics, Multidisciplinary
Hardev Vikas, Hardev Singh
Summary: We conducted a systematic study on the widths of fission fragment mass distributions in compound nucleus fission in the pre-actinide region. We analyzed different reaction variables, such as mass asymmetry, ZPZT, N/Z ratio, and excitation energy. The results indicate non-equilibrated fission process or mass asymmetric fission in cases where the mass width shows anomalous behavior with fissioning nuclei excitation energy. The study demonstrates the systematic dependence of the reaction mechanism on entrance channel parameters.
EUROPEAN PHYSICAL JOURNAL PLUS
(2023)
Article
Multidisciplinary Sciences
Lisa Tilokani, Fiona M. Russell, Stevie Hamilton, Daniel M. Virga, Mayuko Segawa, Vincent Paupe, Anja V. Gruszczyk, Margherita Protasoni, Luis -Carlos Tabara, Mark Johnson, Hanish Anand, Michael P. Murphy, D. Grahame Hardie, Franck Polleux, Julien Prudent
Summary: This study identifies MTFR1L as a critical mitochondrial protein that transduces AMPK-dependent metabolic changes through regulation of mitochondrial dynamics. The phosphorylation of MTFR1L by AMPK controls its function in regulating mitochondrial morphology and stress-induced AMPK-dependent mitochondrial fragmentation.
Article
Neurosciences
Neelam Sharma, Rupkatha Banerjee, Ronald L. Davis
Summary: This study found that mitochondrial function and dynamics are altered at early stages of Alzheimer's disease, which may be related to the development of other pathologies. These findings provide early biomarkers for diagnosis, aid in understanding the temporal cascade of pathologies and sex-specific differences, and enable testing of mitochondrial therapeutics.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biology
M. L. Bond, D. E. Lee, D. R. Farine, A. Ozgul, B. Konig
Summary: Survival of adult female giraffes is primarily driven by individual social factors, particularly gregariousness. The act of grouping with more females, even with frequent changes in group membership, correlates with better survival for adult female giraffes, indicating that sociability plays a more important role in their survival than natural or anthropogenic environmental factors.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Nahuel Zamponi, Emiliano Zamponi, Sergio A. Cannas, Dante R. Chialvo
Summary: Evidence from models and experiments suggests that the networked structure observed in mitochondria emerges at the critical point of a phase transition controlled by fission and fusion rates. In this study, we provide a theoretical framework to interpret the scaling behavior of mitochondrial network quantities and validate it through experiments. The obtained scaling exponents are comparable with critical exponents from models and theory. Overall, we offer a universal description of the structural phase transition in mammalian mitochondria.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Katsuyuki Shizu, Chihaya Adachi, Hironori Kaji
Summary: Singlet fission materials have the potential to overcome traditional efficiency limits of OLEDs, with 55BT showing efficient SF in a locally excited singlet state. Its covalent bonding of tetracene units makes it a promising triplet sensitizer for near-infrared OLEDs, compared to other SF systems like the tetracene dimer.
Article
Chemistry, Medicinal
Xiawei Dang, Sidney B. Williams, Sriram Devanathan, Antonietta Franco, Lijun Fu, Peter R. Bernstein, Daniel Walters, Gerald W. Dorn
Summary: Fragmentation of mitochondria due to defective fusion or unopposed fission contributes to neurodegenerative diseases. Rational redesign based on pharmacophores generated a novel class of mitofusin activators, with analogue 5 incorporating a cycloalkyl linker group showing improved pharmacokinetic properties. Stereoisomeric studies revealed that the biological activity of analogue 5 resides in the trans-R/R configuration, 5B, which may have potential therapeutic implications for neurological conditions.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Roberta A. Gottlieb, Honit Piplani, Jon Sin, Savannah Sawaged, Syed M. Hamid, David J. Taylor, Juliana de Freitas Germano
Summary: Mitochondrial quality control relies on various mechanisms such as selective elimination of damaged mitochondria, mitochondrial biogenesis, fusion, and fission, which are crucial for maintaining heart health.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Mary Adebayo, Seema Singh, Ajay Pratap Singh, Santanu Dasgupta
Summary: Mitochondria are dynamic organelles inherited maternally, fulfilling cellular energy demand and playing roles in cell signaling, metabolism, and apoptosis. Maintenance of mitochondrial integrity and homeostasis through fusion and fission is crucial, and imbalance can lead to various diseases.
Review
Biochemistry & Molecular Biology
Jirapong Vongsfak, Wasana Pratchayasakul, Nattayaporn Apaijai, Tanat Vaniyapong, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Cerebral ischemia and reperfusion injury can lead to poor oxygen supply, brain infarction, and an imbalance in mitochondrial dynamics, which plays a crucial role in cell survival and infarct area size regulation. Understanding and regulating mitochondrial dynamics may help prevent or treat cerebral injury.
Review
Biochemistry & Molecular Biology
Giovanni Fajardo, Michael Coronado, Melia Matthews, Daniel Bernstein
Summary: Alterations in mitochondrial function and morphology are critical adaptations to cardiovascular stress, working in concert in an attempt to restore organelle-level and cellular-level homeostasis. Processes that alter mitochondrial morphology include fission, fusion, mitophagy, and biogenesis, and these interact to maintain mitochondrial quality control. Both pathological stressors like ischemia and physiological stressors like aerobic exercise can induce morphologic adaptations in mitochondria, but with different outcomes for mitochondrial health. Understanding the mechanisms underlying alterations in mitochondrial quality control under diverse cardiovascular stressors can aid in developing pharmacologic interventions for restoring cellular homeostasis.
Review
Biochemistry & Molecular Biology
Styliana Kyriakoudi, Anthi Drousiotou, Petros P. Petrou
Summary: Mitochondrial dynamics play a crucial role in regulating mitochondrial morphology and function, with dysregulation implicated in various diseases. Defects in mitochondrial fusion and fission components have been associated with conditions such as obesity, neurodegenerative diseases, and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Rebecca Cheung, Grazia Pizza, Pauline Chabosseau, Delphine Rolando, Alejandra Tomas, Thomas Burgoyne, Zhiyi Wu, Anna Salowka, Anusha Thapa, Annabel Macklin, Yufei Cao, Marie-Sophie Nguyen-Tu, Matthew T. Dickerson, David A. Jacobson, Piero Marchetti, James Shapiro, Lorenzo Piemonti, Eelco de Koning, Isabelle Leclerc, Karim Bouzakri, Kei Sakamoto, David M. Smith, Guy A. Rutter, Aida Martinez-Sanchez
Summary: This study demonstrates that the elevated expression of miR-125b-5p is associated with impaired pancreatic beta-cell function in type 2 diabetes, and overexpression of this miRNA impairs glucose-stimulated insulin secretion. Screening identifies multiple targets of miR-125b-5p, including a transporter and a regulator of organelle dynamics. In human beta cells, silencing miR-125b-5p enhances insulin secretion, while overexpression in a mouse model leads to hyperglycemia and glucose intolerance.