Xenotransplantation: Current Status in Preclinical Research

Progress in multiple genetically modified minipigs for xenotransplantation in China

(2019) Dengke Pan et al.   XENOTRANSPLANTATION

The desirable donor pig to eliminate all xenoreactive antigens

(2019) Joseph Ladowski et al.   XENOTRANSPLANTATION

Long-Term Survival of Pig-to-Rhesus Macaque Renal Xenografts is Dependent on CD4 T cell Depletion

(2019) S C Kim et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Third WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials, Changsha, Hunan, China December 12–14, 2018

(2019) Wayne J. Hawthorne et al.   XENOTRANSPLANTATION

The complex functioning of the complement system in xenotransplantation

(2019) Hongmin Zhou et al.   XENOTRANSPLANTATION

3D bioprinting of collagen to rebuild components of the human heart

(2019) A. Lee et al.   SCIENCE

The CRISPR animal kingdom

(2019) Jon Cohen   SCIENCE

Intra‐bone bone marrow transplantation from hCD47 transgenic pigs to baboons prolongs chimerism to >60 days and promotes increased porcine lung transplant survival

(2019) Hironosuke Watanabe et al.   XENOTRANSPLANTATION

Characterization of porcine endogenous retrovirus particles released by the CRISPR/Cas9 inactivated cell line PK15 clone 15

(2019) Antonia W. Godehardt et al.   XENOTRANSPLANTATION

Reducing immunoreactivity of porcine bioprosthetic heart valves by genetically-deleting three major glycan antigens, GGTA1/β4GalNT2/CMAH

(2018) Runjie Zhang et al.   Acta Biomaterialia

Tissue Factor at the crossroad of coagulation and cell signaling

(2018) Hortensia Zelaya et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Generation of GTKO Diannan Miniature Pig Expressing Human Complementary Regulator Proteins hCD55 and hCD59 via T2A Peptide-Based Bicistronic Vectors and SCNT

(2018) Fengjuan Liu et al.   MOLECULAR BIOTECHNOLOGY

Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?

(2018) Joachim Denner   Retrovirology

Evolution of sialic acids: Implications in xenotransplant biology

(2018) Anu Paul et al.   XENOTRANSPLANTATION

B4GALNT2 and xenotransplantation: A newly appreciated xenogeneic antigen

(2018) Guerard Byrne et al.   XENOTRANSPLANTATION

GalT-KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels

(2018) Hironosuke Watanabe et al.   XENOTRANSPLANTATION

Perspectives on the Optimal Genetically-Engineered pig in 2018 for Initial Clinical Trials of Kidney or Heart Xenotransplantation

(2018) David K.C. Cooper et al.   TRANSPLANTATION

Porcine endogenous retroviruses: Quantification of the copy number in cell lines, pig breeds, and organs

(2018) Uwe Fiebig et al.   XENOTRANSPLANTATION

Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 Gene Editing Technique in Xenotransplantation

(2018) Meisam Naeimi Kararoudi et al.   Frontiers in Immunology

Xenoantigen Deletion and Chemical Immunosuppression Can Prolong Renal Xenograft Survival

(2018) Andrew B. Adams et al.   ANNALS OF SURGERY

Consistent success in life-supporting porcine cardiac xenotransplantation

(2018) Matthias Längin et al.   NATURE

Amino acid and lipid profiles following pig-to-primate liver xenotransplantation

(2018) Jigesh A. Shah et al.   XENOTRANSPLANTATION

Cardiac xenografts show reduced survival in the absence of transgenic human thrombomodulin expression in donor pigs

(2018) Avneesh K. Singh et al.   XENOTRANSPLANTATION

Genetically Modified Pigs as Organ Donors for Xenotransplantation

(2017) Magdalena Hryhorowicz et al.   MOLECULAR BIOTECHNOLOGY

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

(2017) Dong Niu et al.   SCIENCE

Role of human CD200 overexpression in pig-to-human xenogeneic immune response compared with human CD47 overexpression

(2017) Ji-Jing Yan et al.   TRANSPLANTATION

Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs

(2017) Gregory R. Martens et al.   TRANSPLANTATION

Regulation of Clinical Xenotransplantation—Time for a Reappraisal

(2017) David K.C. Cooper et al.   TRANSPLANTATION

Prolonged Survival of Pig Skin on Baboons After Administration of Pig Cells Expressing Human CD47

(2017) Aseda A. Tena et al.   TRANSPLANTATION

No PERV transmission during a clinical trial of pig islet cell transplantation

(2017) Vladimir A. Morozov et al.   VIRUS RESEARCH

Transgenic expression of human leukocyte antigen-E attenuates GalKO.hCD46 porcine lung xenograft injury

(2017) Christopher T. Laird et al.   XENOTRANSPLANTATION

PERV inactivation is necessary to guarantee absence of pig-to-patient PERVs transmission in xenotransplantation

(2017) Marc Güell et al.   XENOTRANSPLANTATION

Safe use of anti-CD154 monoclonal antibody in pig islet xenotransplantation in monkeys

(2017) Rita Bottino et al.   XENOTRANSPLANTATION

Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts

(2017) Hayato Iwase et al.   XENOTRANSPLANTATION

The Role of NK Cells in Pig-to-Human Xenotransplantation

(2017) Gisella Puga Yung et al.   Journal of Immunology Research

The Role of Costimulation Blockade in Solid Organ and Islet Xenotransplantation

(2017) Kannan P. Samy et al.   Journal of Immunology Research

Potential Antigens Involved in Delayed Xenograft Rejection in a Ggta1/Cmah Dko Pig-to-Monkey Model

(2017) Junfang Zhang et al.   Scientific Reports

Cell Therapy for Parkinson's Disease: A Translational Approach to Assess the Role of Local and Systemic Immunosuppression

(2016) R. Aron Badin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Contact system revisited: an interface between inflammation, coagulation, and innate immunity

(2016) A. T. Long et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Stem cells and interspecies chimaeras

(2016) Jun Wu et al.   NATURE

Silencing Porcine CMAH and GGTA1 Genes Significantly Reduces Xenogeneic Consumption of Human Platelets by Porcine Livers

(2016) James Russell Butler et al.   TRANSPLANTATION

The pathobiology of pig-to-primate xenotransplantation: a historical review

(2016) David K.C. Cooper et al.   XENOTRANSPLANTATION

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

Xenotransplantation in Orthopaedic Surgery

(2016) Cato T. Laurencin et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Efficient production of multi-modified pigs for xenotransplantation by ‘combineering’, gene stacking and gene editing

(2016) Konrad Fischer et al.   Scientific Reports

Lamellar Keratoplasty Treatment of Fungal Corneal Ulcers With Acellular Porcine Corneal Stroma

(2015) M.-C. Zhang et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Recent advances in understanding xenotransplantation: implications for the clinic

(2015) David KC Cooper et al.   Expert Review of Clinical Immunology

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

(2015) L. Yang et al.   SCIENCE

The immunological barriers to xenotransplantation

(2015) M. Vadori et al.   TISSUE ANTIGENS

The Role of Natural Killer Cells in Humoral Rejection

(2015) Thomas Resch et al.   TRANSPLANTATION

Transgenic expression of human CD46: does it reduce the primate T-cell response to pig endothelial cells?

(2015) Mohamed B Ezzelarab et al.   XENOTRANSPLANTATION

Reduced human platelet uptake by pig livers deficient in the asialoglycoprotein receptor 1 protein

(2015) Leela L. Paris et al.   XENOTRANSPLANTATION

Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein

(2015) Agnes M. Azimzadeh et al.   XENOTRANSPLANTATION

Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model

(2015) Laura Higginbotham et al.   XENOTRANSPLANTATION

Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes

(2015) Jose L. Estrada et al.   XENOTRANSPLANTATION

Systemic inflammation in xenograft recipients (SIXR): A new paradigm in pig-to-primate xenotransplantation?

(2015) Mohamed B. Ezzelarab et al.   International Journal of Surgery

Immunobiological barriers to xenotransplantation

(2015) David K.C. Cooper et al.   International Journal of Surgery

A brief history of clinical xenotransplantation

(2015) David K.C. Cooper et al.   International Journal of Surgery

Expression of Human CD46 Modulates Inflammation Associated With GalTKO Lung Xenograft Injury

(2014) L. Burdorf et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Transgenic Expression of Human CD47 Markedly Increases Engraftment in a Murine Model of Pig-to-Human Hematopoietic Cell Transplantation

(2014) A. Tena et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Reduced Binding of Human Antibodies to Cells From GGTA1/CMAH KO Pigs

(2014) C. Burlak et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Parallel evolution of a self-signal: humans and new world monkeys independently lost the cell surface sugar Neu5Gc

(2014) Stevan A. Springer et al.   IMMUNOGENETICS

Xenotransplantation: immunological hurdles and progress toward tolerance

(2014) Adam Griesemer et al.   IMMUNOLOGICAL REVIEWS

Creating Class I MHC–Null Pigs Using Guide RNA and the Cas9 Endonuclease

(2014) Luz M. Reyes et al.   JOURNAL OF IMMUNOLOGY

Transgenic expression of human cytoxic T-lymphocyte associated antigen4-Immunoglobulin (hCTLA4Ig) by porcine skin for xenogeneic skin grafting

(2014) Yong Wang et al.   TRANSGENIC RESEARCH

Meta-analysis of the independent and cumulative effects of multiple genetic modifications on pig lung xenograft performance during ex vivo perfusion with human blood

(2014) Donald G. Harris et al.   XENOTRANSPLANTATION

Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection

(2014) Ping Li et al.   XENOTRANSPLANTATION

Porcine endogenous retrovirus infection of human peripheral blood mononuclear cells

(2014) Joachim Denner   XENOTRANSPLANTATION

Progress in pig-to-non-human primate transplantation models (1998-2013): a comprehensive review of the literature

(2014) David K. C. Cooper et al.   XENOTRANSPLANTATION

One-Year Heterotopic Cardiac Xenograft Survival in a Pig to Baboon Model

(2013) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

(2013) Eric O. Long et al.   Annual Review of Immunology

Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T-cell immune response and immune status

(2013) Hidetaka Hara et al.   IMMUNOLOGY

Long-Term IgG Response to Porcine Neu5Gc Antigens without Transmission of PERV in Burn Patients Treated with Porcine Skin Xenografts

(2013) L. Scobie et al.   JOURNAL OF IMMUNOLOGY

Thromboelastographic evaluation of coagulative profiles in pig-to-monkey kidney xenotransplantation

(2013) Luca Spiezia et al.   XENOTRANSPLANTATION

Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model

(2013) Muhammad M. Mohiuddin et al.   XENOTRANSPLANTATION

Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

(2013) Andrew J. Lutz et al.   XENOTRANSPLANTATION

Regulation of human platelet aggregation by genetically modified pig endothelial cells and thrombin inhibition

(2013) Hayato Iwase et al.   XENOTRANSPLANTATION

Production of biallelic CMP-Neu5Ac hydroxylase knock-out pigs

(2013) Deug-Nam Kwon et al.   Scientific Reports

Transgenic swine: Expression of human CD39 protects against myocardial injury

(2012) Debra G. Wheeler et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation

(2012) Burcin Ekser et al.   TRANSPLANT INTERNATIONAL

Human CD55 Expression Blocks Hyperacute Rejection and Restricts Complement Activation in Gal Knockout Cardiac Xenografts

(2012) Christopher G.A. McGregor et al.   TRANSPLANTATION

T-cell-mediated immunological barriers to xenotransplantation

(2012) Joseph Scalea et al.   XENOTRANSPLANTATION

Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons

(2012) Karen Kim et al.   XENOTRANSPLANTATION

The effect of Gal expression on pig cells on the human T-cell xenoresponse

(2012) Tyler Wilhite et al.   XENOTRANSPLANTATION

B-Cell Depletion Extends the Survival of GTKO.hCD46Tg Pig Heart Xenografts in Baboons for up to 8 Months

(2011) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Relative efficiency of porcine and human cytotoxic T-lymphocyte antigen 4 immunoglobulin in inhibiting human CD4+ T-cell responses co-stimulated by porcine and human B7 molecules

(2011) Tadatsura Koshika et al.   IMMUNOLOGY

Pathologic Characteristics of Transplanted Kidney Xenografts

(2011) A. Shimizu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Clinical xenotransplantation: the next medical revolution?

(2011) Burcin Ekser et al.   LANCET

Changes in cardiac gene expression after pig-to-primate orthotopic xenotransplantation

(2011) Guerard W. Byrne et al.   XENOTRANSPLANTATION

Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys

(2011) Björn Petersen et al.   XENOTRANSPLANTATION

Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk

(2011) Vered Padler-Karavani et al.   XENOTRANSPLANTATION

Cloning and functional characterization of pig CMP-N-acetylneuraminic acid hydroxylase for the synthesis ofN-glycolylneuraminic acid as the xenoantigenic determinant in pig–human xenotransplantation

(2010) Kwon-Ho Song et al.   BIOCHEMICAL JOURNAL

Coagulation, platelet activation and thrombosis in xenotransplantation

(2010) Moritz Schmelzle et al.   Current Opinion in Organ Transplantation

Overcoming the barriers to xenotransplantation: prospects for the future

(2010) Burcin Ekser et al.   Expert Review of Clinical Immunology

Atorvastatin or transgenic expression of TFPI inhibits coagulation initiated by anti-nonGal IgG binding to porcine aortic endothelial cells

(2010) C. C. LIN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Hepatic Function After Genetically Engineered Pig Liver Transplantation in Baboons

(2010) Burcin Ekser et al.   TRANSPLANTATION

Identification of New Carbohydrate and Membrane Protein Antigens in Cardiac Xenotransplantation

(2010) Guerard W. Byrne et al.   TRANSPLANTATION

Potential value of human thrombomodulin and DAF expression for coagulation control in pig-to-human xenotransplantation

(2010) Yuko Miwa et al.   XENOTRANSPLANTATION

Deficiency of N-glycolylneuraminic acid and Galα1-3Galβ1-4GlcNAc epitopes in xenogeneic cells attenuates cytotoxicity of human natural antibodies

(2010) Nabin B. Basnet et al.   XENOTRANSPLANTATION

Renal and Cardiac Endothelial Heterogeneity Impact Acute Vascular Rejection in Pig-to-Baboon Xenotransplantation

(2009) C. Knosalla et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Impact of Thrombocytopenia on Survival of Baboons with Genetically Modified Pig Liver Transplants: Clinical Relevance

(2009) B. Ekser et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Complement activation and coagulation in xenotransplantation

(2009) Peter J Cowan et al.   IMMUNOLOGY AND CELL BIOLOGY

The discovery of the endothelial cell protein C receptor

(2009) C. T. ESMON   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Pig-to-nonhuman primate islet xenotransplantation

(2009) Bernhard J. Hering et al.   TRANSPLANT IMMUNOLOGY

The Innate Immune Response and Activation of Coagulation in α1,3-Galactosyltransferase Gene-Knockout Xenograft Recipients

(2009) Mohamed Ezzelarab et al.   TRANSPLANTATION

Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs

(2009) Jagdeece Ramsoondar et al.   XENOTRANSPLANTATION

Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli

(2009) Marianne Oropeza et al.   XENOTRANSPLANTATION

Pigs transgenic for human thrombomodulin have elevated production of activated protein C

(2009) Björn Petersen et al.   XENOTRANSPLANTATION

Production and characterization of transgenic pigs expressing porcine CTLA4-Ig

(2009) Carol J. Phelps et al.   XENOTRANSPLANTATION

Current status of xenotransplantation and prospects for clinical application

(2009) Richard N. Pierson et al.   XENOTRANSPLANTATION

Pig Thrombomodulin Binds Human Thrombin but Is a Poor Cofactor for Activation of Human Protein C and TAFI

(2008) J. C. Roussel et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Recombinant porcine endogenous retroviruses (PERV-A/C): a new risk for xenotransplantation?

(2008) Joachim Denner   ARCHIVES OF VIROLOGY

Mechanisms of Thrombus Formation

(2008) Bruce Furie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression of Tissue Factor and Initiation of Clotting by Human Platelets and Monocytes After Incubation With Porcine Endothelial Cells

(2008) Chih Che Lin et al.   TRANSPLANTATION

The Role of Macrophages in Xenograft Rejection

(2008) A. Cadili et al.   TRANSPLANTATION PROCEEDINGS

Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantation

(2008) Guerard W. Byrne et al.   XENOTRANSPLANTATION

Knockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs

(2008) Britta Dieckhoff et al.   XENOTRANSPLANTATION